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1. 发明授权

US08920491B2 Medical devices having a coating of inorganic material 有权
标题翻译：具有无机材料涂层的医疗器械
公开(公告)号：US08920491B2
公开(公告)日：2014-12-30
申请号：US12425791
申请日：2009-04-17
申请人： Aiden Flanagan , John Kilcooley , Tim O'Connor , Barry O'Brien , Dominique Seidel , Michael Kuehling , Torsten Scheuermann , Jan Weber
发明人： Aiden Flanagan , John Kilcooley , Tim O'Connor , Barry O'Brien , Dominique Seidel , Michael Kuehling , Torsten Scheuermann , Jan Weber
IPC分类号： A61F2/06 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/16
CPC分类号： A61L29/10 , A61L29/16 , A61L31/082 , A61L31/16 , A61L2300/602 , A61L2300/61
摘要： In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating. In yet another aspect, a medical device has a polymer layer comprising a block co-polymer, wherein the polymer layer contains a therapeutic agent, and a barrier layer disposed over the polymer layer, wherein the barrier layer comprises an inorganic material, and wherein the barrier layer has a plurality of discontinuities. Methods of forming coatings on medical devices and methods of delivering therapeutic agents to body sites are also disclosed.
摘要翻译：在一个方面，医疗装置具有第一构造和第二构造，包含治疗剂的贮存器和设置在贮存器上方的阻挡层，其中阻挡层包括无机材料。在另一方面，医疗装置具有容纳治疗剂的储存器，设置在贮存器上方的阻挡层，其中所述阻挡层包括无机材料，以及设置在所述阻挡层和所述医疗装置的表面之间的可溶胀材料，其中可膨胀材料是暴露于含水环境时膨胀的材料。在另一方面，医疗装置具有多层涂层，其具有交替的储层和阻挡层，以及穿透多层涂层的至少部分厚度的多个挖掘区域。在另一方面，医疗装置具有包含嵌段共聚物的聚合物层，其中聚合物层含有治疗剂，以及设置在聚合物层上的阻挡层，其中阻挡层包含无机材料，其中，阻挡层具有多个不连续性。还公开了在医疗装置上形成涂层的方法和将治疗剂递送到身体部位的方法。

2. 发明授权

US08932346B2 Medical devices having inorganic particle layers 有权
标题翻译：具有无机颗粒层的医疗装置
公开(公告)号：US08932346B2
公开(公告)日：2015-01-13
申请号：US12428775
申请日：2009-04-23
申请人： Michael Kuehling , Dominique Seidel , Torsten Scheuermann , Jan Weber
发明人： Michael Kuehling , Dominique Seidel , Torsten Scheuermann , Jan Weber
IPC分类号： A61F2/82 , A61L31/08 , A61L31/16
CPC分类号： A61L31/16 , A61L31/08 , A61L2300/61 , A61L2300/62 , A61L2420/02
摘要： An expandable medical device having a particle layer disposed over a reservoir containing a therapeutic agent. The particle layer has a first porosity when the medical device is in the unexpanded configuration and a second porosity when the medical device is in the expanded configuration. The particle layer comprises a plurality of micron-sized or nano-sized particles. In certain embodiments, the particles are not connected to each other, and as such, the different porosities are provided by changes in the spacing between the particles as the medical device is expanded/unexpanded. Also disclosed are medical devices having a particle layer, wherein the particle layer comprises a plurality of encapsulated particles, and methods of coating medical devices with particles.
摘要翻译：一种可膨胀医疗装置，其具有设置在含有治疗剂的贮器上的颗粒层。当医疗装置处于未膨胀构型时，颗粒层具有第一孔隙度，并且当医疗装置处于膨胀构型时具有第二孔隙率。颗粒层包含多个微米级或纳米尺寸的颗粒。在某些实施方案中，颗粒彼此不连接，因此，当医疗装置膨胀/未膨胀时，由颗粒之间的间隔的变化提供不同的孔隙度。还公开了具有颗粒层的医疗装置，其中所述颗粒层包含多个包封的颗粒，以及用颗粒涂覆医疗装置的方法。

3. 发明授权

US09220818B2 Medical devices having inorganic barrier coatings 有权
标题翻译：具有无机屏障涂层的医疗器械
公开(公告)号：US09220818B2
公开(公告)日：2015-12-29
申请号：US12501671
申请日：2009-07-13
申请人： Torsten Scheuermann , Michael Kuehling , Jan Weber , Dominique Seidel
发明人： Torsten Scheuermann , Michael Kuehling , Jan Weber , Dominique Seidel
IPC分类号： A61F2/82 , A61K9/22 , A61L27/34 , A61L31/16 , A61L31/08 , A61L31/14
CPC分类号： A61L31/16 , A61L31/082 , A61L31/146 , A61L2300/608 , A61L2420/08
摘要： Medical devices having a barrier layer comprising an inorganic material. The medical device has a reservoir containing a therapeutic agent and the barrier layer is disposed over the reservoir. In one aspect, the barrier layer has one permeability to the therapeutic agent at one portion of the medical device and a different permeability at another portion of the medical device. In another aspect, the dosage amount of the therapeutic agent in the reservoir at one portion of the medical device is different from the dosage amount of the therapeutic agent in the reservoir at another portion of the medical device. In another aspect, a bioresorbable layer is disposed over the barrier layer at one or more portions of the medical device, wherein the bioresorbable layer comprises a bioresorbable material. Also, methods of coating a medical device are disclosed, in which a barrier layer over a medical device is formed using a lithographic etching process where a plurality of particles serve as an etch mask.
摘要翻译：具有包含无机材料的阻挡层的医疗装置。医疗装置具有含有治疗剂的储液器，并且阻挡层设置在贮存器的上方。在一个方面，阻挡层在医疗装置的一部分处具有对治疗剂的一种渗透性，并且在医疗装置的另一部分具有不同的渗透性。另一方面，医疗器械的一部分处的储存器中的治疗剂的剂量与医疗器械的另一部分处的储存器中的治疗剂的剂量不同。在另一方面，生物可再吸收层设置在医疗装置的一个或多个部分的阻挡层之上，其中生物可再吸收层包括生物可再吸收材料。此外，公开了涂覆医疗装置的方法，其中使用光刻蚀刻工艺形成医疗装置上的阻挡层，其中多个颗粒用作蚀刻掩模。

4. 发明申请

US20100008970A1 Drug-Eluting Endoprosthesis 审中-公开
标题翻译：药物洗脱内假体
公开(公告)号：US20100008970A1
公开(公告)日：2010-01-14
申请号：US12334113
申请日：2008-12-12
申请人： Barry O'Brien , Ben Arcand , James Lee Shippy, III , Liliana Atanasoska , Aiden Flanagan , John T. Clarke , Tim O'Connor , Yixin Xu , Dave McMorrow , Jan Weber , John Kremer , Michael Kuehling , Dominique Seidel
发明人： Barry O'Brien , Ben Arcand , James Lee Shippy, III , Liliana Atanasoska , Aiden Flanagan , John T. Clarke , Tim O'Connor , Yixin Xu , Dave McMorrow , Jan Weber , John Kremer , Michael Kuehling , Dominique Seidel
IPC分类号： A61K31/337 , A61F2/00 , B05D1/02
CPC分类号： A61L31/088 , A61L31/16 , A61L2300/45 , A61L2300/61
摘要： A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent.
摘要翻译：包括生物腐蚀性金属部分和治疗剂的药物洗脱内用假体。在一些方面，内假体包括多个离散沉积物和多个覆盖层，每个覆盖层覆盖多个离散沉积物之一。每个离散沉积物包括一种或多种治疗剂，并且每个上覆层包括一种或多种生物可腐蚀金属。在其他方面，生物腐蚀性金属部分包括具有不同电负性的至少两个生物可腐蚀金属区域。所述至少两个生物浸渍金属区域彼此电接触。生物腐蚀性金属在生理环境中侵蚀以释放治疗剂。

5. 发明申请

US20090187238A1 SYSTEM AND METHOD FOR DEPLOYING SELF-EXPANDABLE MEDICAL DEVICE WITH COATING 审中-公开
标题翻译：用涂层自行开发的医疗装置的系统和方法
公开(公告)号：US20090187238A1
公开(公告)日：2009-07-23
申请号：US12354067
申请日：2009-01-15
申请人： Jan Weber , Dominique Seidel
发明人： Jan Weber , Dominique Seidel
IPC分类号： A61F2/84
CPC分类号： B05C1/022 , A61F2/95 , A61F2250/0067 , B05C1/06 , B05C1/08
摘要： A system and method for providing a coating on a self-expandable medical device such as a stent are disclosed. The system comprises a coating applicator at the distal end of a sheath which delivers coating material onto the stent as the stent is deployed from the sheath. Thus, the stent may be loaded into the sheath without a coating on the stent, thereby avoiding shearing off or damaging the coating during loading. Also, the coating is applied only as the stent exits the sheath, thereby avoiding shearing off or damaging the coating during deployment.
摘要翻译：公开了一种用于在诸如支架的自扩张医疗装置上提供涂层的系统和方法。系统包括在护套的远端处的涂布器，其在支架从护套展开时将涂层材料递送到支架上。因此，可以将支架装载到护套中而不需要在支架上涂覆，从而避免在加载期间剪切或损坏涂层。此外，只有当支架离开护套时才涂覆涂层，从而避免在展开期间剪切或损坏涂层。

6. 发明申请

US20130239956A1 AEROSOL GENERATOR 审中-公开
标题翻译：航空发电机
公开(公告)号：US20130239956A1
公开(公告)日：2013-09-19
申请号：US13989528
申请日：2011-11-23
申请人： Harald Schulz , Michael Hahn , Philipp Holzmann , Dominique Seidel
发明人： Harald Schulz , Michael Hahn , Philipp Holzmann , Dominique Seidel
IPC分类号： B01F3/04 , A61M11/00
CPC分类号： B01F3/04007 , A61M11/00 , A61M15/0018 , A61M15/0085 , B05B17/0646
摘要： Aerosol generator having a liquid reservoir (10) defining in a sealed state a volume VR configured to hold an initial volume of liquid VL; a membrane (5) having openings, the liquid reservoir (10) being connected to the membrane (5) to feed the liquid to one side of the membrane, the membrane being oscillatable to transport the liquid through the openings whereby the liquid is emitted in the form of an aerosol on the other side of the membrane, wherein the volume VR of the liquid reservoir (10) before the membrane (5) is oscillated is configured to contain more than 5 ml of gas at an initial volume of the liquid VL of at least 5 ml.
摘要翻译：气溶胶发生器具有限定处于密封状态的液体储存器（10），其构造成容纳液体VL的初始体积的体积VR; 具有开口的膜（5），所述液体储存器（10）连接到所述膜（5）以将所述液体供给到所述膜的一侧，所述膜可振荡以将液体输送通过所述开口，由此所述液体在在膜的另一侧上的气溶胶的形式，其中在膜（5）振动之前的储液器（10）的体积VR被构造成在液体VL的起始体积处含有多于5ml的气体至少5毫升。

7. 发明申请

US20140263721A1 AEROSOL GENERATOR 有权
标题翻译：航空发电机
公开(公告)号：US20140263721A1
公开(公告)日：2014-09-18
申请号：US14123634
申请日：2012-06-04
申请人： Harald Schulz , Philipp Holzmann , Dominique Seidel , Michael Hahn
发明人： Harald Schulz , Philipp Holzmann , Dominique Seidel , Michael Hahn
IPC分类号： B05B17/00
CPC分类号： B05B17/0646 , A61M11/005 , A61M15/00 , A61M15/0015 , A61M15/0018 , A61M15/0085
摘要： An aerosol generator for generating an aerosol from a fluid, comprising: a vibratable membrane (22) having a first side (24) for being in contact with the fluid and an opposite second side (25), the membrane having a plurality of through holes (26) penetrating the membrane in an extension direction (E) from the first side to the second side, whereby the fluid passes the through holes from the first side to the second side when the membrane is vibrated for generating the aerosol at the second side, each through hole (26) having along its extension direction (E) a smallest diameter (Ds), a larger diameter (DL) that is larger than the smallest diameter and defined by that diameter that is closest to triple, preferably twice said smallest diameter, each through hole having a nozzle portion (32) defined by that continuous portion of the through hole in the extension direction comprising the smallest diameter of the through hole and bordered by the larger diameter of the through hole, characterized in that the ratio of the total length of each through hole (26) in the extension direction to the length of a respective one of said nozzle portions (32) in the extension direction is at least (4), preferably at least (4.5) and most preferred equal to or larger than (5).
摘要翻译：一种用于从流体产生气溶胶的气溶胶发生器，包括：可振动膜（22），其具有用于与流体接触的第一侧（24）和相对的第二侧（25），所述膜具有多个通孔（26）从所述第一侧向所述第二侧沿延伸方向（E）穿透所述膜，由此当所述膜振动以在所述第二侧产生所述气溶胶时，所述流体从所述第一侧向所述第二侧通过所述通孔每个通孔（26）沿着其延伸方向（E）具有最小直径（Ds），大直径（DL）大于最小直径并且由最接近三倍的直径限定，优选地为最小直径的两倍每个通孔具有由延伸方向上的通孔的连续部分限定的喷嘴部分（32），该喷嘴部分包括通孔的最小直径并由通孔的较大直径界定，其特征在于，每个通孔（26）在延伸方向上的总长度与相应的一个所述喷嘴部分（32）在延伸方向上的长度的比率至少为（4），优选至少为（4.5）），最优选等于或大于（5）。

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