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1. 发明授权

US08920491B2 Medical devices having a coating of inorganic material 有权
标题翻译：具有无机材料涂层的医疗器械
公开(公告)号：US08920491B2
公开(公告)日：2014-12-30
申请号：US12425791
申请日：2009-04-17
申请人： Aiden Flanagan , John Kilcooley , Tim O'Connor , Barry O'Brien , Dominique Seidel , Michael Kuehling , Torsten Scheuermann , Jan Weber
发明人： Aiden Flanagan , John Kilcooley , Tim O'Connor , Barry O'Brien , Dominique Seidel , Michael Kuehling , Torsten Scheuermann , Jan Weber
IPC分类号： A61F2/06 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/16
CPC分类号： A61L29/10 , A61L29/16 , A61L31/082 , A61L31/16 , A61L2300/602 , A61L2300/61
摘要： In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating. In yet another aspect, a medical device has a polymer layer comprising a block co-polymer, wherein the polymer layer contains a therapeutic agent, and a barrier layer disposed over the polymer layer, wherein the barrier layer comprises an inorganic material, and wherein the barrier layer has a plurality of discontinuities. Methods of forming coatings on medical devices and methods of delivering therapeutic agents to body sites are also disclosed.
摘要翻译：在一个方面，医疗装置具有第一构造和第二构造，包含治疗剂的贮存器和设置在贮存器上方的阻挡层，其中阻挡层包括无机材料。在另一方面，医疗装置具有容纳治疗剂的储存器，设置在贮存器上方的阻挡层，其中所述阻挡层包括无机材料，以及设置在所述阻挡层和所述医疗装置的表面之间的可溶胀材料，其中可膨胀材料是暴露于含水环境时膨胀的材料。在另一方面，医疗装置具有多层涂层，其具有交替的储层和阻挡层，以及穿透多层涂层的至少部分厚度的多个挖掘区域。在另一方面，医疗装置具有包含嵌段共聚物的聚合物层，其中聚合物层含有治疗剂，以及设置在聚合物层上的阻挡层，其中阻挡层包含无机材料，其中，阻挡层具有多个不连续性。还公开了在医疗装置上形成涂层的方法和将治疗剂递送到身体部位的方法。

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