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1. 发明授权

US08119676B2 Substituted benzimidazolone derivatives, medicaments comprising them and their use 有权
标题翻译：取代的苯并咪唑酮衍生物，包含它们的药物及其用途
公开(公告)号：US08119676B2
公开(公告)日：2012-02-21
申请号：US12438712
申请日：2007-08-24
申请人： Torsten Arndt , Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Alfred Hahn, legal representative , Wilfried Hornberger , Liliane Unger , Juliana Ruiz Caro
发明人： Torsten Arndt , Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Juliana Ruiz Caro
IPC分类号： A61K31/4184 , C07D235/24
CPC分类号： A61K31/4184 , C07D235/26
摘要： The present invention relates to novel benzimidazolone derivatives of the general formula (I) in which the substituents R1, R2, R3, A1, A2, and B are as defined in claim 1, medicaments comprising these, and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent diseases.
摘要翻译：本发明涉及通式（I）的新型苯并咪唑酮衍生物，其中取代基R 1，R 2，R 3，A 1，A 2和B如权利要求1中所定义，其组合物及其用于预防和 /或加压素依赖性疾病的治疗。

2. 发明申请

US20100152168A1 SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE 有权
标题翻译：取代的苄嘧磺隆衍生物，包括它们的药物及其用途
公开(公告)号：US20100152168A1
公开(公告)日：2010-06-17
申请号：US12438712
申请日：2007-08-24
申请人： Torsten Arndt , Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Juliana Ruiz Caro
发明人： Torsten Arndt , Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Juliana Ruiz Caro
IPC分类号： A61K31/551 , C07D409/14 , C07D251/02 , C07D211/06 , C07D243/00 , A61K31/497 , A61K31/53 , A61K31/454 , A61P25/22 , A61P25/24
CPC分类号： A61K31/4184 , C07D235/26
摘要： The present invention relates to novel benzimidazolone derivatives of the general formula (I) in which the substituents R1, R2, R3, A1, A2, and B are as defined in claim 1, medicaments comprising these, and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent diseases.
摘要翻译：本发明涉及通式（I）的新型苯并咪唑酮衍生物，其中取代基R 1，R 2，R 3，A 1，A 2和B如权利要求1中所定义，其组合物及其用于预防和 /或加压素依赖性疾病的治疗。

3. 发明申请

US20120172335A1 SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE 有权
标题翻译：取代的苄嘧磺隆衍生物，包括它们的药物及其用途
公开(公告)号：US20120172335A1
公开(公告)日：2012-07-05
申请号：US13302194
申请日：2011-11-22
申请人： Torsten Arndt , Thorsten Oost , Wilfried Lubisch , Wilfried Homberger , Liliane Unger , Juliana Ruiz Caro , Wolfgang Wernet , ALfred Hahn
发明人： Torsten Arndt , Thorsten Oost , Wilfried Lubisch , Wilfried Homberger , Liliane Unger , Juliana Ruiz Caro , Wolfgang Wernet , ALfred Hahn
IPC分类号： A61K31/69 , A61P13/00 , A61P7/02 , A61P9/12 , A61P9/00 , A61P13/12 , A61P1/00 , A61P1/04 , A61P25/22 , A61P25/00 , A61P25/28 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/30 , A61P3/10
CPC分类号： A61K31/4184 , C07D235/26
摘要： The present invention relates to novel benzimidazolone derivatives of the general formula (I) in which the substituents R1, R2, R3, A1, A2, and B are as defined in claim 1, medicaments comprising these, and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent diseases.
摘要翻译：本发明涉及通式（I）的新型苯并咪唑酮衍生物，其中取代基R 1，R 2，R 3，A 1，A 2和B如权利要求1中所定义，其组合物及其用于预防和 /或加压素依赖性疾病的治疗。

4. 发明授权

US08791148B2 Substituted benzimidazolone derivatives, medicaments comprising them and their use 有权
标题翻译：取代的苯并咪唑酮衍生物，包含它们的药物及其用途
公开(公告)号：US08791148B2
公开(公告)日：2014-07-29
申请号：US13302194
申请日：2011-11-22
申请人： Torsten Arndt , Thorsten Oost , Wilfried Lubisch , Wilfried Homberger , Liliane Unger , Juliana Ruiz Caro , Alfred Hahn
发明人： Torsten Arndt , Thorsten Oost , Wilfried Lubisch , Wilfried Homberger , Liliane Unger , Juliana Ruiz Caro , Wolfgang Wernet
IPC分类号： A61K31/4184 , C07D235/26
CPC分类号： A61K31/4184 , C07D235/26
摘要： The present invention relates to novel benzimidazolone derivatives of the general formula (I) in which the substituents R1, R2, R3, A1, A2, and B are as defined in claim 1, medicaments comprising these, and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent diseases.
摘要翻译：本发明涉及通式（I）的新型苯并咪唑酮衍生物，其中取代基R 1，R 2，R 3，A 1，A 2和B如权利要求1中所定义，其组合物及其用于预防和 /或加压素依赖性疾病的治疗。

5. 发明授权

US07795245B2 Heterobicyclic metalloprotease inhibitors 有权
标题翻译：异双环金属蛋白酶抑制剂
公开(公告)号：US07795245B2
公开(公告)日：2010-09-14
申请号：US12001043
申请日：2007-12-07
申请人： Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essors , Joshua Van Veldhuizen , Bert Nolte , Brian M. Gallagher, Jr. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
发明人： Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essors , Joshua Van Veldhuizen , Bert Nolte , Brian M. Gallagher, Jr. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
IPC分类号： A61K31/397 , A61K31/519 , A61K31/535 , A01N43/90 , C07D487/00 , C07D413/00
CPC分类号： C07D487/04
摘要： The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds having the following formulas: wherein R1, R2, R3, and R4 are as defined in the specification. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds amide containing heterobicyclic compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译：本发明一般涉及含酰胺基的药剂，特别涉及具有下式的含酰胺的杂双环金属蛋白酶抑制剂化合物：其中R1，R2，R3和R4如说明书中所定义。更具体地，本发明提供了一类新型的杂双环MMP-13抑制和MMP-3抑制化合物，其含有杂双环化合物的酰胺，其与当前已知的MMP-13和MMP-3抑制剂相比具有增强的效力。

6. 发明授权

US08835441B2 Heterobicyclic metalloprotease inhibitors 有权
标题翻译：异双环金属蛋白酶抑制剂
公开(公告)号：US08835441B2
公开(公告)日：2014-09-16
申请号：US13163457
申请日：2011-06-17
申请人： Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgürtel , Michael Essers , Joshua van Veldhuizen , Bert Nolte , Brian M. Gallagher, Jr. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
发明人： Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgürtel , Michael Essers , Joshua van Veldhuizen , Bert Nolte , Brian M. Gallagher, Jr. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： The present invention relates generally to amide containing heterobicyclic compounds having the following formulas: wherein R1, R2, D, and Q are as defined in the specification. More particularly, the present invention provides a new class of amide containing heterobicyclic compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译：本发明一般涉及具有下式的含酰胺的杂双环化合物：其中R1，R2，D和Q如说明书中所定义。更具体地说，本发明提供了一类新的含有杂双环化合物的酰胺，其表现出与目前已知的MMP-13和MMP-3抑制剂有关的效力。

7. 发明授权

US08721941B2 Arrangement and method for the electromechanical drive for molding closing systems and calibration blow mandrel systems in blow molding machines 有权
标题翻译：吹塑机中用于成型封闭系统和校准吹塑心轴系统的机电驱动装置和方法
公开(公告)号：US08721941B2
公开(公告)日：2014-05-13
申请号：US13319623
申请日：2010-05-12
申请人： Torsten Arndt , Norbert Nimpsch , Stefan Szczepanski
发明人： Torsten Arndt , Norbert Nimpsch , Stefan Szczepanski
IPC分类号： B29C49/56 , B29C49/76
CPC分类号： B29C49/4236 , B29C49/04 , B29C49/56 , B29C49/76
摘要： The invention relates to an arrangement and to a method for the electromechanical drive for mold closing systems and calibration blow mandrel systems in blow molding machines, wherein the arrangement for the drive of an extrusion blow molding machine includes a push mechanism (3; 11), a push rod (4; 12) and exactly one electric motor (1; 9), wherein the push rod (4; 12) is movable by the push mechanism (3; 11) which is driven by the electric motor (1; 9), wherein the electric motor (1; 9) has an additional braking device (2; 10) which can be activated on the reaching of a required torque or a required force of the electric motor (2; 10) to hold the push rod (4; 12) in a state of maximum tension in its instantaneous position.
摘要翻译：本发明涉及一种用于吹塑机中的闭模系统和校准吹塑心轴系统的机电驱动装置和方法，其中挤压吹塑机的驱动装置包括推动机构（3; 11），推杆（4; 12）和恰好一个电动机（1; 9），其中推杆（4; 12）可通过由电动机（1; 9）驱动的推动机构（3; 11）），其中所述电动机（1; 9）具有附加的制动装置（2; 10），所述另外的制动装置可以在达到所述电动机（2; 10）所需的扭矩或所需的力来启动，以将所述推杆（4; 12）处于其瞬时位置处最大张力的状态。

8. 发明申请

US20070155738A1 Heterobicyclic metalloprotease inhibitors 审中-公开
标题翻译：异双环金属蛋白酶抑制剂
公开(公告)号：US20070155738A1
公开(公告)日：2007-07-05
申请号：US11602140
申请日：2006-11-20
申请人： Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochguertel , Michael Essers , Joshua Van Veldhuizen , Bert Nolte , Brian Gallagher , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur Taveras
发明人： Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochguertel , Michael Essers , Joshua Van Veldhuizen , Bert Nolte , Brian Gallagher , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur Taveras
IPC分类号： A61K31/538 , A61K31/5377 , A61K31/519 , C07D491/04 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译：本发明一般涉及含酰胺基的药剂，特别涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。更具体地，本发明提供了一类新型的杂双环MMP-13抑制和MMP-3抑制化合物，其与当前已知的MMP-13和MMP-3抑制剂相比具有增强的效力。

9. 发明授权

US06569000B1 Grinding machine for centerless grinding of workpieces 失效
标题翻译：用于无心磨削工件的磨床
公开(公告)号：US06569000B1
公开(公告)日：2003-05-27
申请号：US09648021
申请日：2000-08-25
申请人： Heinrich Mushardt , Torsten Arndt
发明人： Heinrich Mushardt , Torsten Arndt
IPC分类号： B24B4900
CPC分类号： B24B53/00 , B24B5/18 , Y10S451/909
摘要： A grinding machine for centerless grinding of workpieces is provided. The workpieces are disposed on a support in the area of a longitudinal plane of the grinding machine. A first slide is provided for a grinding wheel and positioned laterally relative to the longitudinal plane. A second slide is provided for a regulating wheel and is likewise positioned laterally with respect to the longitudinal plane. A first dressing tool is provided for dressing the grinding wheel at a first predetermined position and a second dressing tool for dressing the regulating wheel at a second predetermined position. The first and second predetermined positions are located in the area of the longitudinal plane.
摘要翻译：提供了一种用于工件无心研磨的磨床。工件设置在研磨机的纵向平面区域中的支撑件上。为砂轮提供第一滑动件并相对于纵向平面横向定位。为调节轮提供第二滑块，并且同样地相对于纵向平面横向定位。提供了一种用于在第一预定位置修整砂轮的第一修整工具和用于在第二预定位置修整调节轮的第二修整工具。第一和第二预定位置位于纵向平面的区域中。

10. 发明申请

US20120135097A1 Arrangement and method for the electromechanical drive for molding closing systems and calibration blow mandrel systems in blow molding machines 有权
标题翻译：吹塑机中用于成型封闭系统和校准吹塑心轴系统的机电驱动装置和方法
公开(公告)号：US20120135097A1
公开(公告)日：2012-05-31
申请号：US13319623
申请日：2010-05-12
申请人： Torsten Arndt , Norbert Nimpsch , Stefan Szczepanski
发明人： Torsten Arndt , Norbert Nimpsch , Stefan Szczepanski
IPC分类号： B29C49/78
CPC分类号： B29C49/4236 , B29C49/04 , B29C49/56 , B29C49/76
摘要： The invention relates to an arrangement and to a method for the electromechanical drive for mold closing systems and calibration blow mandrel systems in blow molding machines, wherein the arrangement for the drive of an extrusion blow molding machine includes a push mechanism (3; 11), a push rod (4; 12) and exactly one electric motor (1; 9), wherein the push rod (4; 12) is movable by the push mechanism (3; 11) which is driven by the electric motor (1; 9), wherein the electric motor (1; 9) has an additional braking device (2; 10) which can be activated on the reaching of a required torque or a required force of the electric motor (2; 10) to hold the push rod (4; 12) in a state of maximum tension in its instantaneous position.
摘要翻译：本发明涉及一种用于吹塑机中的闭模系统和校准吹塑心轴系统的机电驱动装置和方法，其中挤压吹塑机的驱动装置包括推动机构（3; 11），推杆（4; 12）和恰好一个电动机（1; 9），其中推杆（4; 12）可通过由电动机（1; 9）驱动的推动机构（3; 11）），其中所述电动机（1; 9）具有附加的制动装置（2; 10），所述另外的制动装置可以在达到所述电动机（2; 10）所需的扭矩或所需的力来启动，以将所述推杆（4; 12）处于其瞬时位置处最大张力的状态。

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