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1. 发明申请

US20090018183A1 N-phenylpyrrole guanidine derivatives as melanocortin receptor ligands 审中-公开
标题翻译： N-苯基吡咯胍衍生物作为黑皮质素受体配体
公开(公告)号：US20090018183A1
公开(公告)日：2009-01-15
申请号：US12232399
申请日：2008-09-17
申请人： Torbjorn Lundstedt , Anna Skottner , Arne Boman , Per Andersson , Elisabeth Seifert , Victor Andrianov
发明人： Torbjorn Lundstedt , Anna Skottner , Arne Boman , Per Andersson , Elisabeth Seifert , Victor Andrianov
IPC分类号： A61K31/40 , A61P3/00 , A61P25/00
CPC分类号： C07D207/335 , C07D207/34 , C07D207/36 , C07D207/38 , C07D207/42
摘要： The present invention provides novel compounds of the general Formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is (CH2)n where n is 0, 1 or 2; R1, R2, R3, R4 and R5 may be the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, alkylsulphonyloxy, cyano, nitro, trihaloalkyl, sulpho or one of the structures given in Scheme 1; or two of R1, R2, R3, R4 and R5 may together form a methylenedioxy or ethylenedioxy moiety; R6, R7, R8 and R9 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, amines (primary, secondary or tertiary) having 0, 1 or 2 carbon atoms, cyano, nitro, trihaloalkyl, amide or sulpho, and z where shown represents the point of attachment of the residue to the phenyl or pyrrole ring; and the pharmacologically active salts thereof.
摘要翻译：本发明提供了作为黑皮质素受体配体和/或用于治疗黑皮质素系统中的病症的通式（I）的新化合物：其中X是（CH 2）n，其中n是0,1或2; R 1，R 2，R 3，R 4和R 5可以相同或不同，并且选自氢，卤素，具有1-5个碳原子的烷基，具有1至5个碳原子的烷氧基，羟基，烷基磺酰氧基，氰基，硝基，三卤代烷基，磺基或方案1中给出的结构之一; 或者R 1，R 2，R 3，R 4和R 5中的两个可以一起形成亚甲二氧基或亚乙二氧基部分; R 6，R 7，R 8和R 9相同或不同，并且选自氢，卤素，具有1至5个碳原子的烷基，具有1至5个碳原子的烷氧基，羟基，具有0,1 或2个碳原子，氰基，硝基，三卤代烷基，酰胺或磺基，z表示残基与苯基或吡咯环的连接点; 及其药理学活性盐。

2. 发明申请

US20060148798A1 N-phenylpyrrole guanidine derivatives as melanocortin receptor ligands 失效
标题翻译： N-苯基吡咯胍衍生物作为黑皮质素受体配体
公开(公告)号：US20060148798A1
公开(公告)日：2006-07-06
申请号：US11374956
申请日：2006-03-15
申请人： Torbjorn Lundstedt , Anna Skottner , Arne Boman , Per Andersson , Elisabeth Seifert , Victor Andrianov
发明人： Torbjorn Lundstedt , Anna Skottner , Arne Boman , Per Andersson , Elisabeth Seifert , Victor Andrianov
IPC分类号： A61K31/5377 , A61K31/4025 , C07D413/02 , C07D403/02 , C07D207/30
CPC分类号： C07D207/335 , C07D207/34 , C07D207/36 , C07D207/38 , C07D207/42
摘要： The present invention provides novel compounds of the general Formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is (CH2)n where n is 0, 1 or 2; R1, R2, R3, R4 and R5 may be the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, alkylsulphonyloxy, cyano, nitro, trihaloalkyl, sulpho or one of the structures given in Scheme 1; or two of R1, R2, R3, R4 and R5 may together form a methylenedioxy or ethylenedioxy moiety; R6, R7, R8 and R9 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, amines (primary, secondary or tertiary) having 0, 1 or 2 carbon atoms, cyano, nitro, trihaloalkyl, amide or sulpho, and z where shown represents the point of attachment of the residue to the phenyl or pyrrole ring; and the pharmacologically active salts thereof.
摘要翻译：本发明提供了作为黑皮质素受体的配体和/或用于治疗黑皮质素系统中的病症的通式（I）的新化合物：其中X是（CH 2） / SUB>其中n为0,1或2; R 1，R 2，R 3，R 4和R 5可以是羟基，烷基磺酰氧基，氰基，硝基，三卤代烷基，磺基或方案1中给出的结构之一;其中R 1，R 2，或R 1，R 2，R 3，R 4和R 5中的两个，可以一起形成亚甲二氧基或亚乙二氧基部分; R 6，R 7，R 8和R 9相同或不同，并且选自氢，卤素，具有1至5个碳原子的烷基，具有1至5个碳原子的烷氧基，羟基，具有0,1或2个碳原子的胺（伯，仲或叔），氰基，硝基，三卤代烷基，酰胺或磺基，和z 显示残基与苯基或吡咯环的连接点; 及其药理学活性盐。

3. 发明授权

US07186748B2 N-phenylpyrrole guanidine derivatives as melanocortin receptor ligands 失效
标题翻译： N-苯基吡咯胍衍生物作为黑皮质素受体配体
公开(公告)号：US07186748B2
公开(公告)日：2007-03-06
申请号：US10484444
申请日：2002-08-06
申请人： Torbjörn Lundstedt , Anna Skottner , Arne Boman , Per Andersson , Elisabeth Seifert , Victor Andrianov
发明人： Torbjörn Lundstedt , Anna Skottner , Arne Boman , Per Andersson , Elisabeth Seifert , Victor Andrianov
IPC分类号： A61K31/402 , C07D207/335
CPC分类号： C07D207/335 , C07D207/34 , C07D207/36 , C07D207/38 , C07D207/42
摘要： The present invention provides novel compounds of the general Formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is (CH2)n where n is 0, 1 or 2; R1, R2, R3, R4 and R5 may be the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, alkylsulphonyloxy, cyano, nitro, trihaloalkyl, sulpho or one of the structures given in Scheme 1; or two of R1, R2, R3, R4 and R5 may together form a methylenedioxy or ethylenedioxy moiety; R6, R7, R8 and R9 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, amines (primary, secondary or tertiary) having 0, 1 or 2 carbon atoms, cyano, nitro, trihaloalkyl, amide or sulpho, and z where shown represents the point of attachment of the residue to the phenyl or pyrrole ring; and the pharmacologically active salts thereof.
摘要翻译：本发明提供了作为黑皮质素受体的配体和/或用于治疗黑皮质素系统中的病症的通式（I）的新化合物：其中X是（CH 2） / SUB>其中n为0,1或2; R 1，R 2，R 3，R 4和R 5可以是羟基，烷基磺酰氧基，氰基，硝基，三卤代烷基，磺基或方案1中给出的结构之一;其中R 1，R 2，或R 1，R 2，R 3，R 4和R 5中的两个，可以一起形成亚甲二氧基或亚乙二氧基部分; R 6，R 7，R 8和R 9相同或不同，并且选自氢，卤素，具有1至5个碳原子的烷基，具有1至5个碳原子的烷氧基，羟基，具有0,1或2个碳原子的胺（伯，仲或叔），氰基，硝基，三卤代烷基，酰胺或磺基，和z 显示残基与苯基或吡咯环的连接点; 及其药理学活性盐。

4. 发明授权

US07442807B2 N-phenylpyrrole guanidine derivatives as melanocortin receptor ligands 失效
标题翻译： N-苯基吡咯胍衍生物作为黑皮质素受体配体
公开(公告)号：US07442807B2
公开(公告)日：2008-10-28
申请号：US11374956
申请日：2006-03-15
申请人： Torbjörn Lundstedt , Anna Skottner , Arne Boman , Per Andersson , Elisabeth Seifert , Victor Andrianov
发明人： Torbjörn Lundstedt , Anna Skottner , Arne Boman , Per Andersson , Elisabeth Seifert , Victor Andrianov
IPC分类号： C07D207/325 , C07D207/335 , C07D413/10
CPC分类号： C07D207/335 , C07D207/34 , C07D207/36 , C07D207/38 , C07D207/42
摘要： The present invention provides novel compounds of the general Formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is (CH2)n where n is 0, 1 or 2; R1, R2, R3, R4 and R5 may be the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, alkylsulphonyloxy, cyano, nitro, trihaloalkyl, sulpho or one of the structures given in Scheme 1; or two of R1, R2, R3, R4 and R5 may together form a methylenedioxy or ethylenedioxy moiety; R6, R7, R8 and R9 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, amines (primary, secondary or tertiary) having 0, 1 or 2 carbon atoms, cyano, nitro, trihaloalkyl, amide or sulpho, and z where shown represents the point of attachment of the residue to the phenyl or pyrrole ring; and the pharmacologically active salts thereof.
摘要翻译：本发明提供了作为黑皮质素受体的配体和/或用于治疗黑皮质素系统中的病症的通式（I）的新化合物：其中X是（CH 2） / SUB>其中n为0,1或2; R 1，R 2，R 3，R 4和R 5可以是羟基，烷基磺酰氧基，氰基，硝基，三卤代烷基，磺基或方案1中给出的结构之一;其中R 1，R 2，或R 1，R 2，R 3，R 4和R 5中的两个，可以一起形成亚甲二氧基或亚乙二氧基部分; R 6，R 7，R 8和R 9相同或不同，并且选自氢，卤素，具有1至5个碳原子的烷基，具有1至5个碳原子的烷氧基，羟基，具有0,1或2个碳原子的胺（伯，仲或叔），氰基，硝基，三卤代烷基，酰胺或磺基，和z 显示残基与苯基或吡咯环的连接点; 及其药理学活性盐。

5. 发明授权

US07153881B2 Compounds acting as melanocortin receptor ligands 有权
标题翻译：作为黑皮质素受体配体的化合物
公开(公告)号：US07153881B2
公开(公告)日：2006-12-26
申请号：US10343326
申请日：2001-08-07
申请人： Torbjörn Lundstedt , Anna Skottner , Arne Boman , Per Andersson , Victor Andrianov , Ivars Kalvins
发明人： Torbjörn Lundstedt , Anna Skottner , Arne Boman , Per Andersson , Victor Andrianov , Ivars Kalvins
IPC分类号： A61K31/415 , C07D231/56
CPC分类号： C07D213/53 , A61K31/155 , A61K31/40 , A61K31/44 , C07C281/18 , C07D209/14 , C07D209/40 , C07D213/74 , C07D401/12 , C07D405/12
摘要： The present invention provides novel compounds and use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: Wherein X and Y are independently chosen from O, N, S and (CH2)n, where n is 0, 1, 2, 3, 4, or 5, or a combination of these and may contain carbon-carbon multiple bonds and branched chains as well as alicyclic and heterocyclic groups; Q is H or OH; R1 and R2 can be either the same or different and are chosen from hydrogen or the residue of an aromatic group as listed in Scheme 1 and the pharmacologically active salts thereof
摘要翻译：本发明提供新的化合物和通式（I）的化合物作为黑皮质素受体的配体和/或用于治疗黑皮质素系统中的病症的用途：其中X和Y独立地选自O，N，S和（CH 其中n为0,1,2,3,4或5，或它们的组合，并且可以含有碳 - 碳多重键和支链以及脂环族和杂环基团; Q是H或OH; R 1和R 2可以相同或不同，并且选自氢或如方案1所列的芳族基团的残基和其药理学活性盐

6. 发明授权

US08573181B2 Throttle control systems and methods for internal combustion engines to reduce throttle oscillations 有权
标题翻译：节气门控制系统和内燃机的方法可减少油门振荡
公开(公告)号：US08573181B2
公开(公告)日：2013-11-05
申请号：US12565297
申请日：2009-09-23
申请人： Michael Arnett , Christopher E. Whitney , Per Andersson , Justin A. Zaydel
发明人： Michael Arnett , Christopher E. Whitney , Per Andersson , Justin A. Zaydel
IPC分类号： F02D41/00
CPC分类号： F02D11/105 , F02D41/0002 , F02D2200/0406 , F02D2200/703 , Y02T10/42
摘要： A throttle control system includes a pressure comparison module and a throttle plate control module. The pressure comparison module determines an inlet pressure upstream from a throttle body and an outlet pressure downstream from the throttle body. The throttle plate control module controls a position of a throttle plate based on the inlet pressure and the outlet pressure.
摘要翻译：节流控制系统包括压力比较模块和节流板控制模块。压力比较模块确定节气门体上游的入口压力和节气门体下游的出口压力。节流板控制模块基于入口压力和出口压力控制节流板的位置。

7. 发明授权

US08475435B2 Partial-length indwelling urinary catheter permitting selective urine discharge 有权
标题翻译：部分长度留置导尿管可以选择性排尿
公开(公告)号：US08475435B2
公开(公告)日：2013-07-02
申请号：US12648087
申请日：2009-12-28
申请人： Magnus Bolmsjö , Sonny Schelin , Per Andersson , Stephan Dymling
发明人： Magnus Bolmsjö , Sonny Schelin , Per Andersson , Stephan Dymling
IPC分类号： A61M27/00 , A61M1/00 , A61M29/00 , A61M29/02 , A61M25/00 , A61M25/10 , A61F2/04
CPC分类号： A61M25/0017 , A61M25/007 , A61M25/04 , A61M25/10 , A61M25/1002 , A61M2025/0175
摘要： A partial-length catheter, or an extendable tube or sleeve member of the catheter, is selectively movable within the prostatic urethra to open a urine drainage passageway through and obstructed portion of the prostatic urethra or to open the external urinary sphincter muscle and thereby discharge urine from the bladder. A control element is manipulated at a position exterior of the urinary canal to selectively move the catheter or the extendable tube or sleeve member, thereby selectively controlling urine discharge.
摘要翻译：部分长度的导管或导管的可延伸的管或套筒构件可选择性地在前列腺尿道内移动，以便打开通过并阻塞前列腺尿道部分的排尿通道，或者打开外部尿道括约肌，从而排出尿液从膀胱。在泌尿道外部的位置处操作控制元件以选择性地移动导管或可延伸的管或套筒构件，从而选择性地控制排尿。

8. 发明申请

US20120159947A1 METHOD AND APPARATUS FOR CONTROLLING TURBINE EFFICIENCY 审中-公开
标题翻译：控制涡轮机效率的方法和装置
公开(公告)号：US20120159947A1
公开(公告)日：2012-06-28
申请号：US13202361
申请日：2009-02-19
申请人： Per Andersson , Martin Bauer
发明人： Per Andersson , Martin Bauer
IPC分类号： F02B37/12 , F02B37/24
CPC分类号： F02M26/02 , F02B37/12 , F02B37/24 , F02D23/00 , F02D41/0007 , F02D41/0077 , F02M26/05 , F02M26/10 , Y02T10/144 , Y02T10/47
摘要： A method of controlling turbine efficiency in a turbo unit provided on an internal combustion engine includes providing a flow of gas in an area upstream a turbine at a direction different to the flow of exhaust gases in the same area, regulating the flow by a valve, and controlling the valve from a control unit having at least boost pressure and/or EGR flow as input parameters.
摘要翻译：在内燃机上设置的涡轮机单元的涡轮机效率的控制方法包括：在与涡轮机的上游侧不同的方向，在与涡轮机上游的区域相同的区域内设置气体流，通过阀调节流量，并且从具有至少增压压力和/或EGR流量的控制单元控制阀门作为输入参数。

9. 发明授权

US07947235B2 Microfluidic device with finger valves 有权
标题翻译：带手指阀的微流体装置
公开(公告)号：US07947235B2
公开(公告)日：2011-05-24
申请号：US11911414
申请日：2006-04-13
申请人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
IPC分类号： G01N1/10
CPC分类号： G01N21/07 , B01L3/502738 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/0627 , B01L2300/0806 , B01L2300/087 , B01L2300/161 , B01L2400/0409 , B01L2400/0688 , F16K99/0001 , F16K99/0017 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086 , G01N21/05 , G01N2021/0325 , G01N2021/0346
摘要： A microfluidic device (1) comprising a hydrophilic microchannel structure (2) in which there is a functional unit that comprises a microconduit I (17) in which there is an inlet end (16), an outlet end (18), and a capillary stop function I (24) in the form of a local non-wettable surface area (44). The capillary stop function (24) defines a segment of microconduit I (17). Microconduit I (17) is within at least a part of this segment (46) divided into two or more microchannels (42). A part of the non-wettable surface area (44a,b) is associated with an inner wall of each of the microchannels (42).
摘要翻译：一种微流体装置（1），包括亲水性微通道结构（2），其中存在包括其中存在入口端（16），出口端（18）和毛细管（18）的微管I（17）的功能单元停止功能I（24）以局部不可润湿表面区域（44）的形式。毛细管停止功能（24）限定了微管I（17）的一段。微通道I（17）在该段（46）的至少一部分内分成两个或更多个微通道（42）。不可润湿表面区域（44a，b）的一部分与每个微通道（42）的内壁相关联。

10. 发明授权

US07833478B2 Separation structure 有权
公开(公告)号：US07833478B2
公开(公告)日：2010-11-16
申请号：US11871614
申请日：2007-10-12
申请人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
IPC分类号： G01N9/30 , G01N33/00 , F16K17/36
摘要： A centrifugal-based microfluidic device (1) that comprises a hydrophilic microchannel structure (2) in which there is a A) a separation microcavity I (4) that comprises i) a liquid inlet I (5), and ii) a liquid outlet I (6) that is at a level below the level of liquid inlet I (5) and above the level of the bottom (8) of the microcavity (4) thereby defining a lower part (4b) and an upper part (4a) of the microcavity (4), and B) a microconduit I (17) that has an inlet end I (16) directly connected to liquid outlet I (6), and an outlet end I (18) that is at a lower level than inlet end I (6). A capillary valve I (24) is associated with microconduit I (17). The flow direction through liquid outlet I (6) is directed upwards and/or liquid outlet I (6) is placed in a downwardly turned part of an inner wall of the separation microcavity (4), and/or the part of microconduit I (17) next to liquid outlet I (6) is directed upwards.

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