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1. 发明申请

US20090120504A1 Liquid plugs 有权
标题翻译：液塞
公开(公告)号：US20090120504A1
公开(公告)日：2009-05-14
申请号：US11911408
申请日：2006-04-13
申请人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
IPC分类号： B81B1/00
CPC分类号： F16K99/0017 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2200/0684 , B01L2300/0806 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , F16K99/0001 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086 , Y10T137/0753
摘要： A rotatable microfluidic device that comprises a hydrophilic microchannel structure in which there is a) an upstream microcavity I with a liquid outlet I, b) a microconduit I connected to liquid outlet I, and c) a capillary valve I associated with microconduit I. The inlet end of the microconduit is closer to the spin axis than the outlet end of the microconduit. The difference in radial distance between the inlet end and the outlet end of microconduit I is typically ≧5%, such as ≧10% or ≧100% or ≧500%, of the difference in radial distance between the uppermost part of the upstream microcavity and liquid outlet I.
摘要翻译：一种可旋转微流体装置，其包括亲水性微通道结构，其中存在a）具有液体出口I的上游微腔I，b）连接到液体出口I的微型管I，以及c）与微型管I相关联的毛细管阀I. 微型管道的入口端比微型管道的出口端更靠近旋转轴线。微通道I的入口端和出口端之间的径向距离差异通常>最大部分之间的径向距离差> = 5％，例如> = 10％或> = 100％或> = 500％的上游微腔和液体出口I.

2. 发明授权

US07947235B2 Microfluidic device with finger valves 有权
标题翻译：带手指阀的微流体装置
公开(公告)号：US07947235B2
公开(公告)日：2011-05-24
申请号：US11911414
申请日：2006-04-13
申请人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
IPC分类号： G01N1/10
CPC分类号： G01N21/07 , B01L3/502738 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/0627 , B01L2300/0806 , B01L2300/087 , B01L2300/161 , B01L2400/0409 , B01L2400/0688 , F16K99/0001 , F16K99/0017 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086 , G01N21/05 , G01N2021/0325 , G01N2021/0346
摘要： A microfluidic device (1) comprising a hydrophilic microchannel structure (2) in which there is a functional unit that comprises a microconduit I (17) in which there is an inlet end (16), an outlet end (18), and a capillary stop function I (24) in the form of a local non-wettable surface area (44). The capillary stop function (24) defines a segment of microconduit I (17). Microconduit I (17) is within at least a part of this segment (46) divided into two or more microchannels (42). A part of the non-wettable surface area (44a,b) is associated with an inner wall of each of the microchannels (42).
摘要翻译：一种微流体装置（1），包括亲水性微通道结构（2），其中存在包括其中存在入口端（16），出口端（18）和毛细管（18）的微管I（17）的功能单元停止功能I（24）以局部不可润湿表面区域（44）的形式。毛细管停止功能（24）限定了微管I（17）的一段。微通道I（17）在该段（46）的至少一部分内分成两个或更多个微通道（42）。不可润湿表面区域（44a，b）的一部分与每个微通道（42）的内壁相关联。

3. 发明授权

US07833478B2 Separation structure 有权
公开(公告)号：US07833478B2
公开(公告)日：2010-11-16
申请号：US11871614
申请日：2007-10-12
申请人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
IPC分类号： G01N9/30 , G01N33/00 , F16K17/36
摘要： A centrifugal-based microfluidic device (1) that comprises a hydrophilic microchannel structure (2) in which there is a A) a separation microcavity I (4) that comprises i) a liquid inlet I (5), and ii) a liquid outlet I (6) that is at a level below the level of liquid inlet I (5) and above the level of the bottom (8) of the microcavity (4) thereby defining a lower part (4b) and an upper part (4a) of the microcavity (4), and B) a microconduit I (17) that has an inlet end I (16) directly connected to liquid outlet I (6), and an outlet end I (18) that is at a lower level than inlet end I (6). A capillary valve I (24) is associated with microconduit I (17). The flow direction through liquid outlet I (6) is directed upwards and/or liquid outlet I (6) is placed in a downwardly turned part of an inner wall of the separation microcavity (4), and/or the part of microconduit I (17) next to liquid outlet I (6) is directed upwards.

4. 发明申请

US20080206110A1 SEPARATION STRUCTURE 审中-公开
标题翻译：分离结构
公开(公告)号：US20080206110A1
公开(公告)日：2008-08-28
申请号：US11871614
申请日：2007-10-12
申请人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
IPC分类号： B01L11/00
CPC分类号： B01L3/502738 , B01L3/502723 , B01L3/50273 , B01L2200/0605 , B01L2200/0621 , B01L2200/0673 , B01L2200/0684 , B01L2300/0654 , B01L2300/0806 , B01L2300/0861 , B01L2300/161 , B01L2400/0409 , B01L2400/0688
摘要： A centrifugal-based microfluidic device (1) that comprises a hydrophilic microchannel structure (2) in which there is a A) a separation microcavity I (4) that comprises i) a liquid inlet I (5), and ii) a liquid outlet I (6) that is at a level below the level of liquid inlet I (5) and above the level of the bottom (8) of the microcavity (4) thereby defining a lower part (4b) and an upper part (4a) of the microcavity (4), and B) a microconduit I (17) that has an inlet end I (16) directly connected to liquid outlet I (6), and an outlet end I (18) that is at a lower level than inlet end I (6). A capillary valve I (24) is associated with microconduit I (17). The flow direction through liquid outlet I (6) is directed upwards and/or liquid outlet I (6) is placed in a downwardly turned part of an inner wall of the separation microcavity (4), and/or the part of microconduit I (17) next to liquid outlet I (6) is directed upwards.
摘要翻译：一种离心式微流体装置（1），其包括亲水性微通道结构（2），其中存在A）分离微腔I（4），其包括i）液体入口I（5），和ii）液体出口 I（6）处于低于液体入口I（5）的水平并且高于微腔（4）的底部（8）的水平的水平面，由此限定下部（4b）和上部（4） a）的微腔（4），以及B）具有直接连接到液体出口I（6）的入口端I（16）的微型管I（17）和位于下部的出口端I（18）水平高于入口端I（6）。毛细管阀I（24）与微管I（17）相关联。通过液体出口I（6）的流动方向被向上引导和/或液体出口I（6）放置在分离微腔（4）的内壁的向下转动的部分中，和/或微管I 液体出口I（6）旁边的图17所示向上。

5. 发明申请

US20090111190A1 Meander 审中-公开
标题翻译：蜿蜒
公开(公告)号：US20090111190A1
公开(公告)日：2009-04-30
申请号：US11911403
申请日：2006-04-13
申请人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
IPC分类号： G01N21/76 , B01J19/00 , G01N27/00 , G01N21/00
CPC分类号： F16K99/0017 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L2200/0621 , B01L2200/0684 , B01L2300/0806 , B01L2300/0864 , B01L2400/0688 , F16K99/0001 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086 , G01N35/00069
摘要： A centrifugal based microfluidic device that comprises a microchannel structure in which there is a detection microcavity which in the upstream direction is attached to an inlet microconduit for transport of liquid (transport microconduit) to the detection microcavity and which is used for detecting the result of a reaction taking place in the detection microcavity or in a reaction microcavity positioned upstream of the detection microcavity. The detection microcavity comprises a detection microconduit having an inlet part and an outlet part and therebetween an upward or a downward meander.
摘要翻译：一种基于离心的微流体装置，其包括微通道结构，其中存在检测微腔，其在上游方向上附接到用于将液体（运输微管）输送到检测微腔的入口微管，并且用于检测结果在检测微腔中或在位于检测微腔上游的反应微腔中发生反应。检测微腔包括具有入口部分和出口部分的检测微管，并且其间具有向上或向下弯曲。

6. 发明申请

US20080286156A1 Upward Microconduits 审中-公开
标题翻译：向上微型管
公开(公告)号：US20080286156A1
公开(公告)日：2008-11-20
申请号：US11911417
申请日：2006-04-13
申请人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
IPC分类号： B01L3/02
CPC分类号： B01L3/502738 , B01L3/50273 , B01L2200/0605 , B01L2200/0621 , B01L2200/0684 , B01L2300/0806 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , F16K99/0001 , F16K99/0017 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086
摘要： A microfluidic device comprising a hydrophilic microchannel structure in which there is a functional unit that comprises a microconduit which a) is intended for the transportation of liquid aliquots, and b) has an inlet end and an outlet end between which there is a capillary valve I. Microconduit I comprises an upwardly directed section that extends over a part of or over the full length of microconduit I. Capillary valve I is preferably placed in this section.
摘要翻译：一种微流体装置，其包括亲水性微通道结构，其中存在包含用于输送液体等分试样的微管道的功能单元，以及b）具有入口端和出口端，在该入口端和出口端之间存在毛细管阀I 微通道I包括在微管1的整个长度上延伸的向上指向的部分。毛细管阀I优选放置在该部分中。

7. 发明申请

US20080226501A1 Microfluidic Device With Finger Valves 有权
标题翻译：带手指阀的微流控装置
公开(公告)号：US20080226501A1
公开(公告)日：2008-09-18
申请号：US11911414
申请日：2006-04-13
申请人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
IPC分类号： B01J19/00
CPC分类号： G01N21/07 , B01L3/502738 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/0627 , B01L2300/0806 , B01L2300/087 , B01L2300/161 , B01L2400/0409 , B01L2400/0688 , F16K99/0001 , F16K99/0017 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086 , G01N21/05 , G01N2021/0325 , G01N2021/0346
摘要： A microfluidic device (1) comprising a hydrophilic microchannel structure (2) in which there is a functional unit that comprises a microconduit I (17) in which there is an inlet end (16), an outlet end (18), and a capillary stop function I (24) in the form of a local non-wettable surface area (44). The capillary stop function (24) defines a segment of microconduit I (17). Microconduit I (17) is within at least a part of this segment (46) divided into two or more microchannels (42). A part of the non-wettable surface area (44a,b) is associated with an inner wall of each of the microchannels (42).
摘要翻译：一种微流体装置（1），包括亲水性微通道结构（2），其中存在包括其中存在入口端（16），出口端（18）和毛细管（18）的微管I（17）的功能单元停止功能I（24）以局部不可润湿表面区域（44）的形式。毛细管停止功能（24）限定了微管I（17）的一段。微通道I（17）在该段（46）的至少一部分内分成两个或更多个微通道（42）。不可润湿表面区域（44a，b）的一部分与每个微通道（42）的内壁相关联。

8. 发明申请

US20080101993A1 MICROFLUIDIC DEVICE WITH SERIAL VALVE 失效
标题翻译：带串联阀的微流量装置
公开(公告)号：US20080101993A1
公开(公告)日：2008-05-01
申请号：US11871577
申请日：2007-10-12
申请人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
发明人： Per Andersson , Gunnar Ekstrand , Gerald Jesson
IPC分类号： B04B5/00 , B01J19/00
CPC分类号： F16K99/0017 , B01L3/502738 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/0627 , B01L2300/0806 , B01L2300/087 , B01L2300/161 , B01L2400/0409 , B01L2400/0688 , F16K99/0001 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086 , G01N21/05 , G01N21/07 , G01N2021/0325 , G01N2021/0346
摘要： A microfluidic device comprising a hydrophilic microchannel structure in which there is a functional unit that comprises a microconduit which a) is intended for the transportation of liquid aliquots, and b) has an inlet end and an outlet end between which there is a capillary valve I, which preferably is based on the presence of a local non-wettable surface area. Microconduit I further comprises one or more additional capillary valves, typically one. At least one of the additional valves is upstream of capillary valve I, such as at the inlet end of the microconduit.
摘要翻译：一种微流体装置，其包括亲水性微通道结构，其中存在包含用于输送液体等分试样的微管道的功能单元，以及b）具有入口端和出口端，在该入口端和出口端之间存在毛细管阀I ，其优选基于局部不可润湿表面积的存在。微管道I还包括一个或多个另外的毛细阀，通常为一个。附加阀中的至少一个在毛细管阀I的上游，例如在微管的入口端。

9. 发明申请

US20070086922A1 Compact dispenser 审中-公开
标题翻译：紧凑型分配器
公开(公告)号：US20070086922A1
公开(公告)日：2007-04-19
申请号：US10570491
申请日：2004-10-04
申请人： Per Andersson , Gerald Jesson
发明人： Per Andersson , Gerald Jesson
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01J2219/00353 , B01J2219/0036 , B01J2219/00414 , B01J2219/00418 , B01L3/0203 , B01L9/52 , B01L13/02 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2400/0439 , B01L2400/0478 , B01L2400/0487 , G01N35/00069 , G01N35/10 , G01N35/1016 , G01N35/1095 , G01N2035/1041 , G01N2035/1044
摘要： A flow through dispenser for the drop-wise dispensation of liquid which arrangement comprises: a housing (104) comprising: (i) a flow through microconduit (105) with an upstream end (106) and a downstream end (outlet) (107); and (ii) a dispenser orifice (108) between these two ends, and an inlet tube (110) which is attached to the upstream end (106) and provides an inlet (111) that can be connected to a liquid storage (112) for liquid (113) that is to be transported in flow through microconduit (105) and inlet tube (110) and/or dispensed through the orifice (108). The inner volume between the inlet and the downstream end is is ≦10 μl. An instrument set-up for drop-wise dispensation of liquid to target areas of a microdevice. The characteristic feature comprises: a) a flow through drop dispenser (202) comprising: one or more flow through paths (220) which each has an outlet (221), an inlet (222), and a dispenser orifice (208); and b) a generator for liquid transport (217) by aspirating or pushing liquid through said paths (220) from the inlet(s) (211) to the outlet(s) (221), pushing being accomplished by using over pressure of gas upstream the inlet end (211).
摘要翻译：一种用于液体逐滴分配的流通分配器，包括：壳体（104），包括：（i）具有上游端（106）和下游端（出口）（107）的微通道（105）的流动， ; 和（ii）在这两个端部之间的分配器孔口（108）和连接到上游端（106）并且提供可连接到液体存储器（112）的入口（111）的入口管（110）对于待流过微管道（105）和入口管（110）的流体和/或通过孔口（108）分配的液体（113）。入口和下游端之间的内部容积为<10 mul。用于将液体逐滴分配给微型设备的目标区域的仪器设置。该特征包括：a）一个通过液滴分配器（202）的流动通道，包括：一个或多个流动通道（220），每个流通路径具有出口（221），入口（222）和分配口（208）; 以及b）用于通过从所述入口（211）到所述出口（221）将所述路径（220）吸入或推动液体的液体输送发生器（217），通过使用气体的过压在入口端（211）的上游。

10. 发明申请

US20080073546A1 Enhanced magnetic particle steering 审中-公开
标题翻译：增强磁粉转向
公开(公告)号：US20080073546A1
公开(公告)日：2008-03-27
申请号：US11717056
申请日：2007-03-13
申请人： Per Andersson , Gerald Jesson
发明人： Per Andersson , Gerald Jesson
IPC分类号： H01J1/50
CPC分类号： B01L3/502761 , B01F13/0059 , B01F13/0809 , B01F15/0201 , B01F15/0233 , B01L2200/0647 , B01L2300/0806 , B01L2300/0867 , B01L2300/087 , B01L2400/0409 , B01L2400/043 , B01L2400/0688 , G01N21/07 , G01N35/00069 , G01N35/0098
摘要： The present invention relates to microfluidic systems using rotating microfluidic disc platforms comprising microchannel structures. More specifically, the present invention relates to a method and an arrangement for controlling magnetic particles in microchannel structures of a microfluidic device. The invention is based on the counterbalancing of the magnetic force and the centrifugal force on the beads when rotating the microchannel structures at different speeds close to an array of magnets.
摘要翻译：本发明涉及使用包括微通道结构的旋转微流体盘平台的微流体系统。更具体地，本发明涉及用于控制微流体装置的微通道结构中的磁性颗粒的方法和装置。本发明基于在以接近磁体阵列的不同速度旋转微通道结构时磁力和珠上的离心力的平衡。

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