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1. 发明申请

US20070154488A1 Compositions and methods for the therapy and diagnosis of lung cancer 失效
公开(公告)号：US20070154488A1
公开(公告)日：2007-07-05
申请号：US11603929
申请日：2006-11-22
申请人： Tongtong Wang , Robert Henderson , Teresa Foy , Patricia McNeill , Yoshihiro Watanabe , Michael Kalos , Gary Fanger , Chaitanya Bangur
发明人： Tongtong Wang , Robert Henderson , Teresa Foy , Patricia McNeill , Yoshihiro Watanabe , Michael Kalos , Gary Fanger , Chaitanya Bangur
IPC分类号： A61K48/00 , C12Q1/68 , G01N33/574 , C07H21/04 , C07K14/82
CPC分类号： G01N33/57411 , A61K39/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/545 , C07K14/47 , C07K14/4748 , C07K16/3023 , C07K2317/21 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/40 , C12N15/86 , C12N2710/10343 , C12N2710/10371 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/5088 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

2. 发明申请

US20060088527A1 Compositions and methods for the therapy and diagnosis of lung cancer 失效
公开(公告)号：US20060088527A1
公开(公告)日：2006-04-27
申请号：US11301554
申请日：2005-12-13
申请人： Robert Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael Kalos , Paul Sleath , Jeffrey Johnson , Marc Retter , Margarita Durham , Darrick Carter , Gary Fanger , Thomas Vedvick , Chaitanya Bangur , Andria McNabb
发明人： Robert Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael Kalos , Paul Sleath , Jeffrey Johnson , Marc Retter , Margarita Durham , Darrick Carter , Gary Fanger , Thomas Vedvick , Chaitanya Bangur , Andria McNabb
IPC分类号： A61K39/395 , C07H21/04 , C12N5/06 , C07K16/30
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K14/47 , C07K16/3023 , C07K2317/34 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12Q1/6886 , C12Q2600/158 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

3. 发明申请

US20060269532A1 Compositions and methods for the therapy and diagnosis of prostate cancer 审中-公开
公开(公告)号：US20060269532A1
公开(公告)日：2006-11-30
申请号：US11344932
申请日：2006-02-01
申请人： Jiangchun Xu , Davin Dillon , Jennifer Mitcham , Susan Harlocker , Yuqiu Jiang , Robert Henderson , Michael Kalos , Gary Fanger , Marc Retter , John Stolk , Craig Day , Thomas Vedvick , Darrick Carter , Samuel Li , Aijun Wang , Yasir Skeiky , William Hepler , John Hural , Patricia McNeill , Raymond Houghton , Carlota Vinals y de Bassols , Teresa Foy , Yoshihiro Watanabe , Madeleine Meagher , Ta Deng
发明人： Jiangchun Xu , Davin Dillon , Jennifer Mitcham , Susan Harlocker , Yuqiu Jiang , Robert Henderson , Michael Kalos , Gary Fanger , Marc Retter , John Stolk , Craig Day , Thomas Vedvick , Darrick Carter , Samuel Li , Aijun Wang , Yasir Skeiky , William Hepler , John Hural , Patricia McNeill , Raymond Houghton , Carlota Vinals y de Bassols , Teresa Foy , Yoshihiro Watanabe , Madeleine Meagher , Ta Deng
IPC分类号： A61K48/00 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/82 , C07K16/30
CPC分类号： C07K14/4748 , A61K2039/505 , C07K16/3069 , C07K2317/34 , C12Q1/68 , C12Q1/6886 , G01N33/57434
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

4. 发明授权

US08753697B2 Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals 有权
标题翻译：使用合成代谢剂，抗分解代谢剂，抗氧化剂和止痛剂来保护，治疗和修复人类和动物中的结缔组织
公开(公告)号：US08753697B2
公开(公告)日：2014-06-17
申请号：US12566449
申请日：2009-09-24
申请人： Todd R. Henderson , Tarek Hammad , Medhat Soliman , Barbara Corson , Louis Lippiello , Robert Henderson
发明人： Todd R. Henderson , Tarek Hammad , Medhat Soliman , Barbara Corson , Louis Lippiello , Robert Henderson
IPC分类号： A61K31/737 , A61K31/70 , A61K36/48
CPC分类号： A61K31/00 , A61K45/06
摘要： The present invention relates to compositions for the protection, treatment and repair of connective tissues in humans and animals comprising any or all of anabolic, anti-catabolic, anti-oxidant and analgesic agents, including aminosugars, S-adenosylmethionine, arachadonic acid, GAGs, including pentosan, collagen type II, tetracyclines or tetracycline-like compounds, diacerin, super oxide dismutase, L-ergothionine, one or more avocado/soybean unsaponifiables, and an analgesic, e.g., acetaminophen, and to methods of treating humans and animals by administration of these novel compositions to humans and animals in need thereof.
摘要翻译：本发明涉及用于保护，治疗和修复包括氨基糖，S-腺苷甲硫氨酸，花生四烯酸，GAGs，合成代谢，抗氧化和止痛剂中任何一种或全部的人和动物结缔组织的组合物，包括戊聚糖，II型胶原，四环素或四环素类化合物，diacerin，超氧化物歧化酶，L-麦角硫酸，一种或多种鳄梨/大豆不皂化物，以及止痛剂，例如对乙酰氨基酚，以及通过给药治疗人和动物的方法的这些新型组合物用于有需要的人和动物。

5. 发明申请

US20120205522A1 MULTI-MODE PHOTODETECTOR 有权
标题翻译：多模式光电转换器
公开(公告)号：US20120205522A1
公开(公告)日：2012-08-16
申请号：US13368473
申请日：2012-02-08
申请人： Justin Richardson , Robert Henderson
发明人： Justin Richardson , Robert Henderson
IPC分类号： H01L31/107
CPC分类号： H04N5/374 , H04N5/355 , H04N5/378
摘要： A photodetector includes a photodiode and output circuitry coupled to the photodiode. The photodetector is configurable for operation in at least two modes. A first configurable mode operates the photodetector as an integrating sensor. In this first mode, a bias voltage across the photodiode is set below the breakdown voltage of the photodiode and the output circuitry is configured to read an analog integration output voltage from the photodiode. A second configurable mode operates the photodetector as a single photon avalanche detector. In this second mode, the bias voltage across the photodiode is set above the breakdown voltage of the photodiode and the output circuitry is configured to read an avalanche output voltage.
摘要翻译：光电检测器包括耦合到光电二极管的光电二极管和输出电路。光电检测器可配置为在至少两种模式下操作。第一可配置模式将光电检测器作为积分传感器进行操作。在该第一模式中，将光电二极管两端的偏置电压设置为低于光电二极管的击穿电压，并且输出电路被配置为从光电二极管读取模拟积分输出电压。第二可配置模式将光电检测器操作为单个光子雪崩检测器。在该第二模式中，将光电二极管两端的偏置电压设置在光电二极管的击穿电压之上，并且输出电路被配置为读取雪崩输出电压。

6. 发明授权

US07830432B2 Image sensor for mobile use and associated methods 有权
标题翻译：用于移动使用的图像传感器和相关方法
公开(公告)号：US07830432B2
公开(公告)日：2010-11-09
申请号：US11144112
申请日：2005-06-03
申请人： Robert Henderson
发明人： Robert Henderson
IPC分类号： H04N3/14
CPC分类号： H04N5/37457 , H04N5/3741
摘要： The image sensor includes an array of pixels. Each pixel has a pinned photodiode which transfers charge via a transfer gate to a floating diffusion, from which output is provided by a source follower. Each column has a voltage supply line and a signal line. Each row has a transfer gate control line, a read/reset control line, and a read/reset voltage line which receives alternately zero volts and a predetermined positive voltage from a decoder circuit.
摘要翻译：图像传感器包括像素阵列。每个像素具有钉扎光电二极管，其通过传输栅极将电荷传输到浮动扩散，从源极跟随器输出该输出。每列具有电源线和信号线。每行具有传输门控制线，读/复位控制线和从解码器电路交替接收零伏特和预定正电压的读/复电压线。

7. 发明授权

US07649560B2 Solid state image sensors 有权
标题翻译：固态图像传感器
公开(公告)号：US07649560B2
公开(公告)日：2010-01-19
申请号：US11145438
申请日：2005-06-03
申请人： Robert Henderson
发明人： Robert Henderson
IPC分类号： H04N3/14 , H01L31/113
CPC分类号： H04N9/045 , H04N5/37457 , H04N5/376
摘要： A pinned-photodiode image sensor using shared output amplifiers, for example output amplifiers in the 2.5T arrangement has transfer gate control lines alternating or cross-coupled between successive columns or adjacent rows. This assists in removing row-row mismatches. In preferred embodiments, the approach is applied to Bayer pattern RGB sensors, and allows the gain and/or the exposure of green pixels to be controlled separately from those of red and blue pixels.
摘要翻译：使用共享输出放大器（例如2.5T布置的输出放大器）的钉扎式光电二极管图像传感器具有在连续列或相邻行之间交替或交叉耦合的传输门控制线。这有助于删除行行不匹配。在优选实施例中，该方法应用于拜耳图案RGB传感器，并且允许与红色和蓝色像素的增益和/或绿色像素的曝光分开控制。

8. 发明申请

US20090087503A1 Use of anabolic agents, anti-catabolic agents, antioxidant agents and analgesics for protection, treatment and repair of connective tissues in humans and animals 有权
标题翻译：使用合成代谢剂，抗分解代谢剂，抗氧化剂和止痛剂来保护，治疗和修复人类和动物中的结缔组织
公开(公告)号：US20090087503A1
公开(公告)日：2009-04-02
申请号：US12230001
申请日：2008-08-21
申请人： Todd R. Henderson , Tarek Hammad , Medhat Soliman , Barbara Corson , Louis Lippiello , Robert Henderson
发明人： Todd R. Henderson , Tarek Hammad , Medhat Soliman , Barbara Corson , Louis Lippiello , Robert Henderson
IPC分类号： A61K38/39 , A61K36/18
CPC分类号： A61K31/00 , A61K45/06
摘要： The present invention relates to compositions for the protection, treatment and repair of connective tissues in humans and animals comprising any or all of anabolic, anti-catabolic, anti-oxidant and analgesic agents, including aminosugars, S-adenosylmethionine, arachadonic acid, GAGs, including pentosan, collagen type II, tetracyclines or tetracycline-like compounds, diacerin, super oxide dismutase, L-ergothionine, one or more avocado/soybean unsaponifiables, and an analgesic, e.g., acetaminophen, and to methods of treating humans and animals by administration of these novel compositions to humans and animals in need thereof.
摘要翻译：本发明涉及用于保护，治疗和修复包括氨基糖，S-腺苷甲硫氨酸，花生四烯酸，GAGs，合成代谢，抗氧化和止痛剂中任何一种或全部的人和动物结缔组织的组合物，包括戊聚糖，II型胶原，四环素或四环素类化合物，diacerin，超氧化物歧化酶，L-麦角硫酸，一种或多种鳄梨/大豆不皂化物，以及止痛剂，例如对乙酰氨基酚，以及通过给药治疗人和动物的方法的这些新型组合物用于有需要的人和动物。

9. 发明授权

US07265329B2 Image sensors with distributed amplifiers and related methods 有权
标题翻译：具有分布式放大器和相关方法的图像传感器
公开(公告)号：US07265329B2
公开(公告)日：2007-09-04
申请号：US11223558
申请日：2005-09-09
申请人： Robert Henderson , Matthew Purcell
发明人： Robert Henderson , Matthew Purcell
IPC分类号： H01L37/00 , H03F3/08 , H04N3/14 , H03M1/12
CPC分类号： H03M1/1023 , H03M1/123 , H03M1/56 , H04N5/3575 , H04N5/361 , H04N5/3651 , H04N5/374 , H04N5/378
摘要： The image sensor makes use of a distributed amplifier having its non-inverting input provided by a pixel amplifier transistor, and its inverting input and output provided in the pixel's column circuitry. The distributed amplifier is directly integrated with the image sensor's ADC circuit, and sampling and autozero are performed in a single step, thus reducing the number of noise contributions made by the components of the image sensor's readout chain.
摘要翻译：图像传感器利用具有由像素放大器晶体管提供的其非反相输入的分布式放大器，并且其反相输入和输出设置在像素的列电路中。分布式放大器与图像传感器的ADC电路直接集成，采样和自动调零在一个步骤中执行，从而减少了图像传感器读出链组件产生的噪声数量。

10. 发明授权

US07253837B2 Active-pixel image sensors 有权
标题翻译：有源像素图像传感器
公开(公告)号：US07253837B2
公开(公告)日：2007-08-07
申请号：US10407871
申请日：2003-04-04
申请人： Robert Henderson , Jonathan Ephriam David Hurwitz
发明人： Robert Henderson , Jonathan Ephriam David Hurwitz
IPC分类号： H04N5/217 , H04N5/21 , H04N3/14 , H01L27/00
CPC分类号： H04N5/3653 , H04N5/3575
摘要： An image sensor has an array of pixels read by column circuits to provide reset and read samples on a pair of sample capacitors. To alleviate the effects of parasitic capacitance in the region of the sample capacitors, a modified timing arrangement is used. Both sample switches are operated simultaneously to pre-charge both sample capacitors with a pixel signal value. One sample switch is operated after reset to apply a reset value to one of the pre-charged sample capacitors.
摘要翻译：图像传感器具有由列电路读取的像素阵列，以在一对采样电容器上提供复位和读取样本。为了减轻样品电容器区域中的寄生电容的影响，使用修正的定时装置。两个采样开关同时工作，以预先给像素信号值的两个采样电容器预充电。一个采样开关在复位后运行，将一个复位值应用于一个预充电采样电容。

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