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1. 发明授权

US08324265B2 Heterocyclic compounds having type I 11β hydroxysteroid dehydrogenase inhibitory activity 有权
标题翻译：具有I 11和bgr的杂环化合物羟类固醇脱氢酶抑制活性
公开(公告)号：US08324265B2
公开(公告)日：2012-12-04
申请号：US12093903
申请日：2006-11-20
申请人： Noriyuki Kurose , Mikayo Hayashi , Tomoyuki Ogawa , Koji Masuda , Eiichi Kojima
发明人： Noriyuki Kurose , Mikayo Hayashi , Tomoyuki Ogawa , Koji Masuda , Eiichi Kojima
IPC分类号： A61K31/551 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/427 , A61K31/4245 , A61K31/4178 , A61K31/4155 , A61K31/415 , C07D417/06 , C07D417/12 , C07D413/06 , C07D413/12 , C07D409/06 , C07D409/12 , C07D401/14 , C07D401/12 , C07D401/06 , C07D403/06 , C07D403/12 , C07D231/20 , C07D231/18
CPC分类号： C07D231/18 , C07D231/20 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D417/12 , C07D419/06 , C07D471/08 , C07D471/10 , C07D471/12
摘要： Disclosed is a compound useful as a type I 11βhydroxysteroid dehydrogenase inhibitor.A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R1 is optionally substituted alkyl or the like, one of R2 and R4 is a group of formula: —Y—R5, wherein Y is —O— or the like, R5 is substituted alkyl (the substituent is optionally substituted cycloalkyl or the like), optionally substituted branched alkyl or the like, the other of R2 and R4 is hydrogen or optionally substituted alkyl, R3 is a group of formula: —C(═O)—Z—R6, wherein Z is —NR7— or —NR7—W—, R6 is optionally substituted cycloalkyl or the like, R7 is hydrogen or optionally substituted alkyl, W is optionally substituted alkylene, X is ═N— or the like, with the proviso that compounds wherein R2 is 2-(morphorino)ethoxy, R3 is N-(1-adamantyl)carbamoyl and R1 is benzyl are excluded.
摘要翻译：公开了可用作I 11和Bgr的羟基类固醇脱氢酶抑制剂的化合物。由下式表示的化合物：其药学上可接受的盐或溶剂合物，其中R 1为任选取代的烷基等，R 2和R 4中的一个为下式基团：-Y-R 5，其中Y为-O-等，R 5是取代的烷基（取代基是任选取代的环烷基等），任选取代的支链烷基等，R 2和R 4中的另一个是氢或任选取代的烷基，R 3是下列基团：-C（= O ）-Z-R6，其中Z是-NR7-或-NR7-W-，R6是任选取代的环烷基等，R 7是氢或任选取代的烷基，W是任选取代的亚烷基，X是= N-等条件是其中R2是2-（吗啉基）乙氧基，R3是N-（1-金刚烷基）氨基甲酰基和R1是苄基的化合物被排除在外。

2. 发明申请

US20120259128A1 ADAMANTANAMINE DERIVATIVE 有权
公开(公告)号：US20120259128A1
公开(公告)日：2012-10-11
申请号：US13517924
申请日：2010-12-20
申请人： Tomoyuki Ogawa , Koji Masuda
发明人： Tomoyuki Ogawa , Koji Masuda
IPC分类号： C07D231/20 , C07D231/14 , C07C271/24 , C07C233/41 , C07C311/07
CPC分类号： C07C271/34 , C07C233/36 , C07C233/41 , C07C271/24 , C07C311/07 , C07C2603/74 , C07D231/20
摘要： Disclosed is an adamantanamine derivative which is useful as a significant intermediate of an 11βHSD-1 inhibitor.Disclosed is a compound represented by the formula (II): wherein R10 is a group represented by the formula: —(CR13R14)m-NR12—R11 or the like.
摘要翻译：公开了一种金刚烷胺衍生物，其可用作11重量％HSD-1抑制剂的重要中间体。公开了由式（II）表示的化合物：其中R 10是由下式表示的基团： - （CR 13 R 14）m -NR 12 R 11等。

3. 发明申请

US20100240659A1 NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE HAVING 11SS-HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORY ACTIVITY 有权
标题翻译：含有11SS-羟基脱氢酶脱氢酶I型抑制活性的含氮杂环衍生物
公开(公告)号：US20100240659A1
公开(公告)日：2010-09-23
申请号：US12599133
申请日：2008-05-07
申请人： Koji Masuda , Tomoyuki Ogawa , Takuji Nakatani
发明人： Koji Masuda , Tomoyuki Ogawa , Takuji Nakatani
IPC分类号： A61K31/5377 , C07D231/10 , A61K31/415 , C07D271/10 , A61K31/4245 , C07D263/04 , A61K31/421 , C07D413/12 , A61P3/10
CPC分类号： C07D231/14 , C07D231/16 , C07D231/18 , C07D231/20 , C07D231/38 , C07D405/12 , C07D413/06
摘要： Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor.A compound represented by the formula: , its pharmaceutically acceptable salt, or a solvate thereof, wherein Ring A is a group represented by the formula: Ring B is optionally substituted heteroaryl, provided that optionally substituted isoxazole is excluded, or optionally substituted heterocycle, R1 is hydrogen or optionally substituted alkyl, R2 is —OR5, —SR5, halogen, halogenated alkyl or the like, R3 is optionally substituted alkyl or the like, R4 is optionally substituted alkyl or the like, R5 is optionally substituted alkyl or the like, R6 is hydrogen or the like, R7 and R8 are each independently hydrogen or the like, R10 and R11 are each independently hydrogen or the like, R12 is optionally substituted alkyl or the like, m and p are each independently integer of 1 to 3.
摘要翻译：公开了可用作11-羟基类固醇脱氢酶1型抑制剂的化合物。由下式表示的化合物，其药学上可接受的盐或其溶剂合物，其中环A是下式表示的基团：环B是任选取代的杂芳基，条件是排除任选取代的异唑或任选取代的杂环，R 1 R 3为任选取代的烷基等，R 4为任选取代的烷基等，R 5为任选取代的烷基等，R 5为任选取代的烷基， R 6是氢等，R 7和R 8各自独立地为氢等，R 10和R 11各自独立地为氢等，R 12为任选取代的烷基等，m和p各自为1〜3的整数。

4. 发明申请

US20090170832A1 HETEROCYCLIC COMPOUNDS HAVING TYPE I 11beta HYDROXYSTEROID DEHYDROGENASE INHIBITORY ACTIVITY 有权
标题翻译：具有I型11beta羟化酶脱氢酶抑制活性的杂环化合物
公开(公告)号：US20090170832A1
公开(公告)日：2009-07-02
申请号：US12093903
申请日：2006-11-20
申请人： Noriyuki Kurose , Mikayo Hayashi , Tomoyuki Ogawa , Koji Masuda , Eiichi Kojima
发明人： Noriyuki Kurose , Mikayo Hayashi , Tomoyuki Ogawa , Koji Masuda , Eiichi Kojima
IPC分类号： A61K31/55 , C07D231/14 , A61K31/415 , C07D257/04 , A61K31/41 , A61K31/4709 , A61K31/454 , C07D401/06 , C07D403/06 , A61K31/496
CPC分类号： C07D231/18 , C07D231/20 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D417/12 , C07D419/06 , C07D471/08 , C07D471/10 , C07D471/12
摘要： Disclosed is a compound useful as a type I 11βhydroxysteroid dehydrogenase inhibitor.A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R1 is optionally substituted alkyl or the like, one of R2 and R4 is a group of formula: —Y—R5, wherein Y is —O— or the like, R5 is substituted alkyl (the substituent is optionally substituted cycloalkyl or the like), optionally substituted branched alkyl or the like, the other of R2 and R4 is hydrogen or optionally substituted alkyl, R3 is a group of formula: —C(═O)-Z-R6, wherein Z is —NR7— or —NR7—W—, R6 is optionally substituted cycloalkyl or the like, R7 is hydrogen or optionally substituted alkyl, W is optionally substituted alkylene, X is ═N— or the like, with the proviso that compounds wherein R2 is 2-(morphorino)ethoxy, R3 is N-(1-adamantyl)carbamoyl and R1 is benzyl are excluded.
摘要翻译：公开了可用作I型11β-羟基甾类脱氢酶抑制剂的化合物。由下式表示的化合物：其药学上可接受的盐或溶剂合物，其中R 1为任选取代的烷基等，R 2和R 4中的一个为下式基团：-Y-R 5，其中Y为-O-等，R 5为取代烷基（取代基为任选取代的环烷基等），任意取代的支链烷基等，R 2和R 4中的另一个为氢或任意取代的烷基，R 3为下列基团：-C（-O ）-Z-R6，其中Z是-NR7-或-NR7-W-，R6是任选取代的环烷基等，R 7是氢或任选取代的烷基，W是任选取代的亚烷基，X是-N-等条件是其中R2是2-（吗啉基）乙氧基，R3是N-（1-金刚烷基）氨基甲酰基和R1是苄基的化合物被排除在外。

5. 发明授权

US08796468B2 Adamantanamine derivative 有权
标题翻译：金刚烷胺衍生物
公开(公告)号：US08796468B2
公开(公告)日：2014-08-05
申请号：US13517924
申请日：2010-12-20
申请人： Tomoyuki Ogawa , Koji Masuda
发明人： Tomoyuki Ogawa , Koji Masuda
IPC分类号： C07C233/36 , C07C233/41 , C07C271/34 , C07C311/07
CPC分类号： C07C271/34 , C07C233/36 , C07C233/41 , C07C271/24 , C07C311/07 , C07C2603/74 , C07D231/20
摘要： Disclosed is an adamantanamine derivative which is useful as a significant intermediate of an 11βHSD-1 inhibitor.Disclosed is a compound represented by the formula (II): wherein R10 is a group represented by the formula: —(CR13R14)m-NR12—R11 or the like.
摘要翻译：公开了一种金刚烷胺衍生物，其可用作11重量％HSD-1抑制剂的重要中间体。公开了由式（II）表示的化合物：其中R 10是由下式表示的基团： - （CR 13 R 14）m -NR 12 R 11等。

6. 发明申请

US20090131491A1 ISOXAZOLE DERIVATIVE AND ISOTHIAZOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11(beta)-HYDROXYSTEROID DEHYDROGENASE TYPE I 有权
标题翻译：含有11（β） - 羟基脱氢酶脱氢酶I型的异噻唑衍生物和异噻唑衍生物具有抑制活性
公开(公告)号：US20090131491A1
公开(公告)日：2009-05-21
申请号：US12293246
申请日：2007-03-28
申请人： Tomoyuki Ogawa , Nobuo Chomei , Koji Masuda , Satoru Tanaka
发明人： Tomoyuki Ogawa , Nobuo Chomei , Koji Masuda , Satoru Tanaka
IPC分类号： A61K31/42 , C07D261/02 , A61P3/10
CPC分类号： C07D261/18 , C07D275/02 , C07D413/12 , C07D417/12 , C07D471/10
摘要： Disclosed is a compound useful as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1.A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R1 is a group of the formula: —C(═O)NR4R5, (wherein R4 and R5 are each independently, hydrogen, optionally substituted alkyl or the like) or a group of the formula: —NR6C(═O)R7, (wherein R6 and R7 are each independently, hydrogen, optionally substituted alkyl or the like), X and Y are each independently —O— or the like, Z is a bond or the like, R2 is optionally substituted alkyl, optionally substituted alkenyl or the like, R3 is optionally substituted alkyl, optionally substituted alkenyl or the like.
摘要翻译：公开了用作11β-羟类固醇脱氢酶1型抑制剂的化合物。下式表示的化合物：其药学上可接受的盐或溶剂合物，其中R 1是下式的基团：-C（-O）NR 4 R 5，（其中 R 4和R 5各自独立地为氢，任选取代的烷基等）或下式-NR 6 C（-O）R 7的基团（其中R 6和R 7各自独立地为氢，任选取代的烷基等）， X和Y各自独立地为-O-等，Z为键或类似物，R 2为任选取代的烷基，任选取代的烯基等，R 3为任选取代的烷基，任选取代的烯基等。

7. 发明授权

US08383622B2 Nitrogen-containing heterocyclic derivative having 11β-hydroxysteroid dehydrogenase type I inhibitory activity 有权
标题翻译：具有11β-羟基类固醇脱氢酶I型抑制活性的含氮杂环衍生物
公开(公告)号：US08383622B2
公开(公告)日：2013-02-26
申请号：US12599133
申请日：2008-05-07
申请人： Koji Masuda , Tomoyuki Ogawa , Takuji Nakatani
发明人： Koji Masuda , Tomoyuki Ogawa , Takuji Nakatani
IPC分类号： A61K31/5377 , A61K31/415 , A61K31/4245 , A61K31/421 , C07D231/10 , C07D271/10 , C07D263/04 , C07D413/12 , A61P3/10
CPC分类号： C07D231/14 , C07D231/16 , C07D231/18 , C07D231/20 , C07D231/38 , C07D405/12 , C07D413/06
摘要： Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor.A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein Ring A is a group represented by the formula: Ring B is optionally substituted heteroaryl, provided that optionally substituted isoxazole is excluded, or optionally substituted heterocycle, R1 is hydrogen or optionally substituted alkyl, R2 is —OR5, —SR5, halogen, halogenated alkyl or the like, R3 is optionally substituted alkyl or the like, R4 is optionally substituted alkyl or the like, R5 is optionally substituted alkyl or the like, R6 is hydrogen or the like, R7 and R8 are each independently hydrogen or the like, R10 and R11 are each independently hydrogen or the like, R12 is optionally substituted alkyl or the like, m and p are each independently integer of 1 to 3.
摘要翻译：公开了可用作11-羟基类固醇脱氢酶1型抑制剂的化合物。由下式表示的化合物：其药学上可接受的盐或其溶剂合物，其中环A是由下式表示的基团：环B是任选取代的杂芳基，条件是排除任选取代的异唑或任选取代的杂环，R 1是氢或任选取代的烷基，R 2是-OR 5，-SR 5，卤素，卤代烷基等，R 3是任选取代的烷基等，R 4是任选取代的烷基等，R 5是任选取代的烷基等，R 6 是氢等，R 7和R 8各自独立地为氢等，R 10和R 11各自独立地为氢等，R 12为任选取代的烷基等，m和p各自独立地为1〜3的整数。

8. 发明授权

US08017638B2 Isoxazole derivative and isothiazole derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1 有权
标题翻译：具有抑制活性的异恶唑衍生物和异噻唑衍生物
公开(公告)号：US08017638B2
公开(公告)日：2011-09-13
申请号：US12293246
申请日：2007-03-28
申请人： Tomoyuki Ogawa , Nobuo Chomei , Koji Masuda , Satoru Tanaka
发明人： Tomoyuki Ogawa , Nobuo Chomei , Koji Masuda , Satoru Tanaka
IPC分类号： A61K31/42 , C07D261/06
CPC分类号： C07D261/18 , C07D275/02 , C07D413/12 , C07D417/12 , C07D471/10
摘要： Disclosed is a compound useful as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1.A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R1 is a group of the formula: —C(═O)NR4R5, (wherein R4 and R5 are each independently, hydrogen, optionally substituted alkyl or the like) or a group of the formula: —NR6C(═O)R7, (wherein R6 and R7 are each independently, hydrogen, optionally substituted alkyl or the like), X and Y are each independently —O— or the like, Z is a bond or the like, R2 is optionally substituted alkyl, optionally substituted alkenyl or the like, R3 is optionally substituted alkyl, optionally substituted alkenyl or the like.
摘要翻译：公开了一种可用作11型β-羟基类固醇脱氢酶抑制剂的化合物。下式表示的化合物：其药学上可接受的盐或溶剂合物，其中R 1是下式的基团：-C（= O）NR 4 R 5，（其中R 4和R 5各自独立地为氢，任选取代的烷基等）或下式的基团：-NR 6 C（= O）R 7，（其中R 6和R 7各自独立地为氢，任选取代的烷基等） X和Y各自独立地为-O-等，Z为键或类似物，R 2为任选取代的烷基，任选取代的烯基等，R 3为任选取代的烷基，任选取代的烯基等。

9. 发明授权

US08421694B2 Composite antenna device 失效
标题翻译：复合天线装置
公开(公告)号：US08421694B2
公开(公告)日：2013-04-16
申请号：US12871437
申请日：2010-08-30
申请人： Naoki Iso , Haruyuki Watanabe , Morihiko Ikegaya , Tomoyuki Ogawa
发明人： Naoki Iso , Haruyuki Watanabe , Morihiko Ikegaya , Tomoyuki Ogawa
IPC分类号： H01Q21/00
CPC分类号： H01Q21/28
摘要： There is provided a composite antenna device for responding to waves in a plurality of radio frequency bands, including: a sheet of conductor plate; a first antenna provided on the sheet of conductor plate for responding to a linearly-polarized wave in at least one radio frequency band; and a second antenna provided on the sheet of conductor plate for responding to a circularly-polarized wave in a radio frequency band that is different from the at least one radio frequency band, wherein the first antenna has a ground portion, the second antenna is formed in an area in the ground portion, and each of the first antenna and the second antenna has a feeding point.
摘要翻译：提供了一种用于响应多个无线电频带中的波的复合天线装置，包括：导体板片; 设置在所述导体板片上的用于响应于至少一个射频带中的线偏振波的第一天线; 以及第二天线，其设置在所述导体板片上，用于对与所述至少一个射频区别的射频区域中的圆偏振波进行响应，其中，所述第一天线具有接地部，所述第二天线形成在接地部分的区域中，第一天线和第二天线中的每一个具有馈电点。

10. 发明申请

US20110057844A1 ANTENNA AND ELECTRONIC DEVICE EQUIPPED WITH SAME 有权
标题翻译：天线和电子设备配备相同
公开(公告)号：US20110057844A1
公开(公告)日：2011-03-10
申请号：US12718025
申请日：2010-03-05
申请人： Haruyuki WATANABE , Naoki Iso , Morihiko Ikegaya , Tomoyuki Ogawa
发明人： Haruyuki WATANABE , Naoki Iso , Morihiko Ikegaya , Tomoyuki Ogawa
IPC分类号： H01Q9/04
CPC分类号： H01Q21/08 , H01Q21/20
摘要： An antenna according to the present invention comprises: a conductor plate with an axisymmetrical shape; a slot formed on the conductor plate; and a feeding point provided on the axisymmetrical axis of the conductor plate, in which the conductor plate is folded along two locations that are parallel to the axisymmetrical axis toward mutually different directions.
摘要翻译：根据本发明的天线包括：具有轴对称形状的导体板; 形成在导体板上的槽; 以及设置在导体板的轴对称轴上的馈电点，其中导体板沿着彼此不同方向平行于轴对称轴线的两个位置折叠。

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