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1. 发明授权

US07787120B2 Spectrophotometer and liquid chromatography system 失效
标题翻译：分光光度计和液相色谱系统
公开(公告)号：US07787120B2
公开(公告)日：2010-08-31
申请号：US12146920
申请日：2008-06-26
申请人： Motohiro Yamazaki , Ryoji Inaba , Kosaku Toyosaki , Shintaro Kubo , Takashi Gomi , Katsunobu Hama , Kiyotoshi Mori , Hideyuki Akiyama
发明人： Motohiro Yamazaki , Ryoji Inaba , Kosaku Toyosaki , Shintaro Kubo , Takashi Gomi , Katsunobu Hama , Kiyotoshi Mori , Hideyuki Akiyama
IPC分类号： G01J3/10 , G01J3/36 , G01N21/33
CPC分类号： G01J3/10 , G02B5/283 , G02B27/1006 , G02B27/1086 , G02B27/145 , G02B27/148
摘要： Detection sensitivity is improved by increasing the amount of light of beams that irradiate a sample cell without causing saturation of a detector with ultraviolet beams or visible beams. This spectrophotometer includes a sample cell, which stores a sample to be measured, a visible light source and an ultraviolet light source each for supplying an incident beam that enters the sample, a spectroscope, which disperses a beam that has passed through the sample, an optical detector, which detects beams dispersed from such beam (spectrum), and a dichroic element which reflects or transmits ultraviolet beams from the ultraviolet light source and which transmits or reflects visible beams from the visible light source. Optics are configured such that ultraviolet beams and visible beams that have passed through or have been reflected by the dichroic element enter the sample cell.
摘要翻译：通过增加照射样品池的光束的光量而不会使紫外线束或可见光束的检测器饱和而提高检测灵敏度。该分光光度计包括存储待测样品，可见光源和紫外光源的样品池，每个用于提供进入样品的入射光束，分散已经通过样品的光束的分光器，检测从这种光束（光谱）分散的光束的光检测器，以及从紫外光源反射或透射紫外光束并从可见光源透射或反射可见光束的二向色元件。光学构造使得已经通过或已被二色性元件反射的紫外光束和可见光束进入样品池。

2. 发明申请

US20090009761A1 SPECTROPHOTOMETER AND LIQUID CHROMATOGRAPHY SYSTEM 失效
标题翻译：分光光度计和液相色谱系统
公开(公告)号：US20090009761A1
公开(公告)日：2009-01-08
申请号：US12146920
申请日：2008-06-26
申请人： Motohiro Yamazaki , Ryoji Inaba , Kosaku Toyosaki , Shintaro Kubo , Takashi Gomi , Katsunobu Hama , Kiyotoshi Mori , Hideyuki Akiyama
发明人： Motohiro Yamazaki , Ryoji Inaba , Kosaku Toyosaki , Shintaro Kubo , Takashi Gomi , Katsunobu Hama , Kiyotoshi Mori , Hideyuki Akiyama
IPC分类号： G01J3/26
CPC分类号： G01J3/10 , G02B5/283 , G02B27/1006 , G02B27/1086 , G02B27/145 , G02B27/148
摘要： Detection sensitivity is improved by increasing the amount of light of beams that irradiate a sample cell without causing saturation of a detector with ultraviolet beams or visible beams. This spectrophotometer includes a sample cell, which stores a sample to be measured, a visible light source and an ultraviolet light source each for supplying an incident beam that enters the sample, a spectroscope, which disperses a beam that has passed through the sample, an optical detector, which detects beams dispersed from such beam (spectrum), and a dichroic element which reflects or transmits ultraviolet beams from the ultraviolet light source and which transmits or reflects visible beams from the visible light source. Optics are configured such that ultraviolet beams and visible beams that have passed through or have been reflected by the dichroic element enter the sample cell.
摘要翻译：通过增加照射样品池的光束的光量而不会使紫外线束或可见光束的检测器饱和而提高检测灵敏度。该分光光度计包括存储待测样品，可见光源和紫外光源的样品池，每个用于提供进入样品的入射光束，分散已经通过样品的光束的分光器，检测从这种光束（光谱）分散的光束的光检测器，以及从紫外光源反射或透射紫外光束并从可见光源透射或反射可见光束的二向色元件。光学构造使得已经通过或已被二色性元件反射的紫外光束和可见光束进入样品池。

3. 发明授权

US08123496B2 Two-unit pump for liquid chromatograph with flow sensor arrangement 失效
标题翻译：液体色谱仪两单元泵，配有流量传感器
公开(公告)号：US08123496B2
公开(公告)日：2012-02-28
申请号：US12845487
申请日：2010-07-28
申请人： Kimihiko Ishii , Kiyotoshi Mori , Masahito Ito , Hironori Kaji , Takefumi Yokokura
发明人： Kimihiko Ishii , Kiyotoshi Mori , Masahito Ito , Hironori Kaji , Takefumi Yokokura
IPC分类号： F04B1/06 , F04B49/20 , B01D15/10
CPC分类号： G01N30/32 , G01N30/34 , G01N2030/322 , G01N2030/326
摘要： A pump device which accurately detects a flow rate of a pump, performs real-time control of the flow rate, and thus can suppress a flow rate error caused by occurrence of pulsation. Control of a pump rotation speed by a pressure sensor has low responsiveness in a low pressure region, and a correlation between a pressure and a flow rate is incomplete in a high flow rate region. With this taken into consideration, a flow rate sensor is disposed at an outlet port of a second pump. A position detection sensor detects a point where a first pump is shifted from a suction mode to a discharge mode. Moreover, the flow rate sensor detects that there is no discharge from the pump, and that there is discharge from the pump alone. Accordingly, a controller sets a rotation speed of a motor to a speed double the previous speed (double the normal rotation speed). When the flow rate sensor detects an increase in the flow rate at the outlet port of the second pump, the controller returns the rotation speed of the motor to a normal rotation speed. The rotation speed of the motor is controlled by accurate flow rate detection by the flow rate sensor. Thus, occurrence of pulsation can be suppressed.
摘要翻译：准确地检测泵的流量的泵装置，对流量进行实时控制，能够抑制由脉动发生引起的流量误差。通过压力传感器控制泵的转速在低压区域的响应性低，在高流量区域中压力与流量的相关性不完全。考虑到这一点，流量传感器设置在第二泵的出口处。位置检测传感器检测第一泵从吸入模式移动到排出模式的点。此外，流量传感器检测到没有来自泵的放电，并且仅从泵排出。因此，控制器将电动机的转速设定为与先前速度相同的速度（正常转速的两倍）。当流量传感器检测到第二泵的出口处的流量增加时，控制器将马达的转速恢复到正常的转速。通过流量传感器的精确流量检测来控制电动机的转速。因此，可以抑制脉动的发生。

4. 发明申请

US20100288027A1 PUMP FOR LIQUID CHROMATOGRAPH 失效
标题翻译：液相色谱泵
公开(公告)号：US20100288027A1
公开(公告)日：2010-11-18
申请号：US12845487
申请日：2010-07-28
申请人： Kimihiko Ishii , Kiyotoshi Mori , Masahito Ito , Hironori Kaji , Takefumi Yokokura
发明人： Kimihiko Ishii , Kiyotoshi Mori , Masahito Ito , Hironori Kaji , Takefumi Yokokura
IPC分类号： G01N30/00 , B01D35/157
CPC分类号： G01N30/32 , G01N30/34 , G01N2030/322 , G01N2030/326
摘要： A pump device is realized, which accurately detects a flow rate of a pump, performs real-time control of the flow rate, and thus can suppress a flow rate error caused by occurrence of pulsation. Control of a pump rotation speed by a pressure sensor has low responsiveness in a low pressure region, and a correlation between a pressure and a flow rate is incomplete in a high flow rate region. With this taken into consideration, a flow rate sensor 10 is disposed at an outlet port 9 of a second pump 4. A position detection sensor 14 detects a point where a first pump 3 is shifted from a suction mode to a discharge mode. Moreover, the flow rate sensor 10 detects that there is no discharge from the pump 3, and that there is discharge from the pump 4 alone. Accordingly, a controller 15 sets a rotation speed of a motor 12 to a speed double the previous speed (double the normal rotation speed). When the flow rate sensor 10 detects an increase in the flow rate at the outlet port 9 of the second pump 4, the controller 15 returns the rotation speed of the motor 12 to a normal rotation speed. The rotation speed of the motor 12 is controlled by accurate flow rate detection by the flow rate sensor 10. Thus, occurrence of pulsation can be suppressed.
摘要翻译：实现了能够精确地检测泵的流量的泵装置，实现流量的实时控制，能够抑制由脉动发生引起的流量误差。通过压力传感器控制泵的转速在低压区域的响应性低，在高流量区域中压力与流量的相关性不完全。考虑到这一点，流量传感器10设置在第二泵4的出口9处。位置检测传感器14检测第一泵3从吸入模式移动到放电模式的点。此外，流量传感器10检测到没有来自泵3的排出，并且仅从泵4排出。因此，控制器15将电动机12的转速设定为与先前速度（正常转速两倍）的速度。当流量传感器10检测到第二泵4的出口9处的流量增加时，控制器15将马达12的转速恢复到正常的转速。通过流量传感器10的精确的流量检测来控制电动机12的转速。因此，可以抑制脉动的发生。

5. 发明申请

US20070191402A1 Method of searching substrate having antidiabetic activity 审中-公开
标题翻译：检索具有抗糖尿病活性的底物的方法
公开(公告)号：US20070191402A1
公开(公告)日：2007-08-16
申请号：US10514119
申请日：2003-05-16
申请人： Hiroki Ishiguro , Yuko Saeki , Seiji Sugimoto , Masahiro Matsubara , Kimihisa Ueno , Kiyotoshi Mori , Satoshi Nakanishi , Hiroshi Yano
发明人： Hiroki Ishiguro , Yuko Saeki , Seiji Sugimoto , Masahiro Matsubara , Kimihisa Ueno , Kiyotoshi Mori , Satoshi Nakanishi , Hiroshi Yano
IPC分类号： A61K31/519 , A61K31/53 , C07D487/12 , G01N33/53
CPC分类号： C12Q1/32 , A61K31/53 , A61K31/5377 , A61K31/55 , C07D487/14 , G01N33/56966 , G01N2333/90209 , G01N2500/00
摘要： The present invention provides a screening method of a substance which inhibits binding of a condensed purine derivative to a pancreatic β cell or a treated product of the cell, a substance which inhibits binding of a condensed purine derivative to a protein capable of the condensed purine derivative, and a substance which inhibits the expression or enzymatic activity of a protein capable of a condensed purine derivative, which comprises using the condensed purine derivative and a pancreatic β cell or a treated product of the cell or a protein capable of binding to the condensed purine derivative.
摘要翻译：本发明提供了抑制冷凝的嘌呤衍生物与胰腺β细胞或细胞的处理产物的结合的物质的筛选方法，抑制结合的嘌呤衍生物与能够产生缩合嘌呤衍生物的蛋白质结合的物质以及抑制能够结合嘌呤衍生物的蛋白质的表达或酶活性的物质，其包括使用稠合的嘌呤衍生物和胰β细胞或能够结合浓缩的嘌呤的细胞或蛋白质的处理产物衍生物。

6. 发明授权

US07163379B2 Gradient liquid feed pump system, and liquid chromatograph 有权
标题翻译：梯度液体进料泵系统和液相色谱仪
公开(公告)号：US07163379B2
公开(公告)日：2007-01-16
申请号：US10504880
申请日：2003-03-17
申请人： Kiyotoshi Mori , Kenichiro Takahashi , Masanori Takaki , Masato Fukuda , Masahito Ito , Hironori Kaji
发明人： Kiyotoshi Mori , Kenichiro Takahashi , Masanori Takaki , Masato Fukuda , Masahito Ito , Hironori Kaji
IPC分类号： F04B41/06
CPC分类号： F04B11/0075 , F04B13/02 , F04B2201/1201 , F04B2201/1208 , F04B2205/05 , G01N30/32 , G01N30/34 , G01N2030/326
摘要： A gradient liquid feed pump system capable of liquid feed in a correct mixing ratio even in the case of liquid feed in which the mixing ratio varies. Specifically, it comprises a first plunger pump for sucking and delivering an eluate, a second the first and second plunger pumps through a cam, a first pressure sensor for measuring the pressure in the flow path of the second plunger pump, a second pressure sensor for measuring the pressure in the fist plunger pump, a cam position detecting sensor for detecting the cam position, wherein when the cam position is in a delivery interval, the rotary speed of the motor is increased, and the period for decreasing the rotary speed is determined on the basis of the difference between the pressure values obtained from the first and second pressure sensors, respectively. Thereby, liquid feed can be smoothly effected with correct mixing ratio while avoiding pressure interference between pumps.
摘要翻译：即使在混合比变化的液体进料的情况下，也能以正确的混合比液体进料的梯度液体供给泵系统。具体地，它包括用于吸入和输送洗脱液的第一柱塞泵，通过凸轮的第一和第二柱塞泵，用于测量第二柱塞泵的流动路径中的压力的第一压力传感器，用于测量第二柱塞泵的流路中的压力的第二压力传感器，测量第一柱塞泵中的压力，用于检测凸轮位置的凸轮位置检测传感器，其中当凸轮位置处于输送间隔时，马达的转速增加，并且确定用于降低转速的周期基于从第一和第二压力传感器获得的压力值之间的差异。由此，能够以正确的混合比平稳地进行液体供给，同时避免泵之间的压力干扰。

7. 发明申请

US20050084386A1 Gradient liquid feed pump system, and liquid chromatograph 有权
标题翻译：梯度液体进料泵系统和液相色谱仪
公开(公告)号：US20050084386A1
公开(公告)日：2005-04-21
申请号：US10504880
申请日：2003-03-17
申请人： Kiyotoshi Mori , Kenichiro Takahashi , Masanori Takaki , Masato Fukuda , Masahito Ito , Hironori Kaji
发明人： Kiyotoshi Mori , Kenichiro Takahashi , Masanori Takaki , Masato Fukuda , Masahito Ito , Hironori Kaji
IPC分类号： F04B11/00 , F04B13/02 , G01N30/32 , G01N30/34 , F04B23/08 , F04B3/00
CPC分类号： F04B11/0075 , F04B13/02 , F04B2201/1201 , F04B2201/1208 , F04B2205/05 , G01N30/32 , G01N30/34 , G01N2030/326
摘要： A gradient liquid feed pump system capable of liquid feed in a correct mixing ratio even in the case of liquid feed in which the mixing ratio varies. Specifically, it comprises a first plunger pump for sucking and delivering an eluate, a second the first and second plunger pumps through a cam, a first pressure sensor for measuring the pressure in the flow path of the second plunger pump, a second pressure sensor for measuring the pressure in the fist plunger pump, a cam position detecting sensor for detecting the cam position, wherein when the cam position is in a delivery interval, the rotary speed of the motor is increased, and the period for decreasing the rotary speed is determined on the basis of the difference between the pressure values obtained from the first and second pressure sensors, respectively. Thereby, liquid feed can be smoothly effected with correct mixing ratio while avoiding pressure interference between pumps.
摘要翻译：即使在混合比变化的液体进料的情况下，也能以正确的混合比液体进料的梯度液体供给泵系统。具体地，它包括用于吸入和输送洗脱液的第一柱塞泵，通过凸轮的第一和第二柱塞泵，用于测量第二柱塞泵的流动路径中的压力的第一压力传感器，用于测量第二柱塞泵的流路中的压力的第二压力传感器，测量第一柱塞泵中的压力，用于检测凸轮位置的凸轮位置检测传感器，其中当凸轮位置处于输送间隔时，马达的转速增加，并且确定用于降低转速的周期基于从第一和第二压力传感器获得的压力值之间的差异。由此，能够以正确的混合比平稳地进行液体供给，同时避免泵之间的压力干扰。

8. 外观设计

USD692155S1 Column oven for liquid chromatograph analyzer 有权
标题翻译：色谱柱分析仪
公开(公告)号：USD692155S1
公开(公告)日：2013-10-22
申请号：US29429035
申请日：2012-08-07
申请人： Kosuke Matoba , Mitsuru Oonuma , Masaru Tomioka , Kiyotoshi Mori , Akira Owada , Yoko Sato , Hiroyuki Noda
设计人： Kosuke Matoba , Mitsuru Oonuma , Masaru Tomioka , Kiyotoshi Mori , Akira Owada , Yoko Sato , Hiroyuki Noda

9. 发明授权

US6106782A Chromatograph 失效
标题翻译：色谱仪
公开(公告)号：US6106782A
公开(公告)日：2000-08-22
申请号：US20703
申请日：1998-02-09
申请人： Yoshiaki Yamada , Kiyotoshi Mori
发明人： Yoshiaki Yamada , Kiyotoshi Mori
IPC分类号： G01N30/86 , G01N30/00 , B01D15/08 , G06F13/00
CPC分类号： G01N30/8651
摘要： A chromatograph is provided for accurately identifying components of a sample even with the use of a moving average method for noise reduction. A eluding solution is supplied to a column by a pump. In a sample injector, the sample injected into the column is separated into components by the column, and converted to an electric signal by a detector. A detected output signal is subjected to data processing in a data processor. The output signal is sampled at regular intervals and subjected to moving average processing in the detector. A sample injection signal from the sample injector is sent to the detector which generates a data processing start signal that is delayed by a time equal to a delay resulting from the moving average processing for the signal. The data processing start signal is sent to the data processor which starts the data processing in response to this signal.
摘要翻译：提供了一种用于精确地识别样品组分的色谱仪，即使使用移动平均方法进行降噪。通过泵将一个排出的溶液供应到塔中。在样品注射器中，注入到柱中的样品被柱分离成组分，并通过检测器转化成电信号。检测到的输出信号在数据处理器中进行数据处理。以规则的间隔对输出信号进行采样，并在检测器中进行移动平均处理。来自样品注射器的样品注入信号被发送到检测器，其产生延迟等于由信号的移动平均处理导致的延迟的时间的数据处理开始信号。数据处理开始信号被发送到响应于该信号开始数据处理的数据处理器。

10. 发明授权

US5970425A Liquid chromatograph system and liquid chromatograph analysis method 失效
标题翻译：液相色谱系统和液相色谱分析方法
公开(公告)号：US5970425A
公开(公告)日：1999-10-19
申请号：US828485
申请日：1997-03-31
申请人： Takayuki Ono , Kiyotoshi Mori
发明人： Takayuki Ono , Kiyotoshi Mori
IPC分类号： G01N30/86 , G01N30/02 , G01N30/30 , G01N30/88
CPC分类号： G01N30/88 , G01N2030/027 , G01N2030/3084 , G01N2030/8804
摘要： An analyzing method of a liquid chromatograph system which includes a plurality of chromatograph units each made up of a number of devices, obtains an analysis result by processing measurement data from chromatograph units using a data processor. System configurations are defined along with analysis parameters corresponding to the system configurations and stored in a main storage provided in the data processor. The stored analysis parameters are sent to chromatograph units as are requests to execute a measurement operations and, in the case of an error, requests to return peculiar information about each device. Each device of the chromatograph unit executes a measurement operation in response to a measurement operation request from the main controller and sends measurement data to the main controller for storage in the main storage in association with the analysis parameters. It also checks whether an error was produced in any of the devices during the measurement operation, and' upon detection of an error, sends the error information to the main controller, acquires the peculiar information about each device and sends the peculiar information to the main controller. The main controller creates an error analysis information file for analyzing the error on the basis of the error information, the peculiar information, and the analysis parameters, and stores the error analysis information file in the main storage in association with the system configuration. The information in this file may then be out put with an output device.
摘要翻译：一种液相色谱系统的分析方法，其包括多个由多个装置组成的色谱单元，通过使用数据处理器处理来自色谱仪单元的测量数据来获得分析结果。系统配置与对应于系统配置的分析参数一起定义并存储在数据处理器中提供的主存储器中。存储的分析参数被发送到色谱仪单元，就像执行测量操作的请求一样，并且在错误的情况下，请求返回关于每个设备的特殊信息。色谱仪单元的每个装置响应于来自主控制器的测量操作请求执行测量操作，并将测量数据发送到主控制器以与分析参数相关联地存储在主存储器中。它还检查在测量操作期间任何设备是否产生错误，并且“检测到错误后，将错误信息发送到主控制器，获取有关每个设备的特有信息，并将特殊信息发送到主服务器控制器。主控制器根据错误信息，特有信息和分析参数创建一个错误分析信息文件，用于分析错误，并将错误分析信息文件与系统配置相关联存储在主存储器中。该文件中的信息可能随输出设备一起出来。

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