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1. 发明申请

US20140128799A1 PHOTODYNAMIC THERAPY USING PHOTOSENSITIZING AGENT OR 5-AMINOLEVULINIC ACID 有权
标题翻译：光敏性治疗使用光敏剂或5-氨基酸
公开(公告)号：US20140128799A1
公开(公告)日：2014-05-08
申请号：US14126929
申请日：2012-06-20
申请人： Tohru Tanaka , Katsushi Inoue , Takuya Ishii , Tokato Yoshida
发明人： Tohru Tanaka , Katsushi Inoue , Takuya Ishii , Tokato Yoshida
IPC分类号： A61N5/06 , A61K41/00
CPC分类号： A61N5/062 , A61K31/197 , A61K41/0061 , A61K41/0071 , A61K49/0052
摘要： It is to provide photodynamic therapy (PDT) and photodynamic diagnosis (PDD) which are suitable for the diagnosis and therapy of a part requiring a certain degree of deep penetration, such as subcutaneous cancer and lymph nodes surrounded by blood vessels and fat. This is solved by performing PDT and PDD targeting cancer by administering a composition comprising a photosensitizing agent such as a tetrapyrrole-based compound (photofrin, protoporphyrin IX, etc.) or ALAs such as 5-aminolevulinic acid (ALA), ALA methyl ester, ALA ethyl ester, ALA propyl ester, ALA butyl ester, ALA pentyl ester, or a hydrochloride, phosphate, or sulfate thereof followed by irradiation with excitation light at a wavelength of 480 to 580 nm.
摘要翻译：它是提供光动力疗法（PDT）和光动力学诊断（PDD），适用于诊断和治疗需要一定程度深度穿透的部位，如皮下癌和由血管和脂肪包围的淋巴结。通过施用包含光敏剂如四吡咯基化合物（光调节素，原卟啉IX等）或ALA的组合物，例如5-氨基乙酰丙酸（ALA），ALA甲酯， ALA乙酯，ALA丙酯，ALA丁酯，ALA戊酯或其盐酸盐，磷酸盐或硫酸盐，然后用波长480〜580nm的激发光照射。

2. 发明授权

US09550073B2 Therapeutic agent for allergic rhinitis 有权
标题翻译：过敏性鼻炎治疗剂
公开(公告)号：US09550073B2
公开(公告)日：2017-01-24
申请号：US14125744
申请日：2012-06-15
申请人： Tohru Tanaka , Katsushi Inoue , Kiwamu Takahashi , Takuya Ishii , Tsutomu Numata , Mariko Shibuya , Takeshi Suzuki
发明人： Tohru Tanaka , Katsushi Inoue , Kiwamu Takahashi , Takuya Ishii , Tsutomu Numata , Mariko Shibuya , Takeshi Suzuki
IPC分类号： A61N5/06 , A61K9/06 , A61K41/00 , A61K9/00
CPC分类号： A61N5/062 , A61K9/0043 , A61K9/06 , A61K41/0061 , F04C2270/0421
摘要： Provided is a therapeutic agent capable of treating allergic rhinitis in a safe, simple, and noninvasive manner substantially without side effects and physical distress to patients. Provided is a therapeutic agent for allergic rhinitis for 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) comprising 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt of the 5-aminolevulinic acid or the derivative as an active ingredient, and used in ALA-PDT in which light having a wavelength of 400 nm to 700 nm is irradiated; and particularly provided is a therapeutic agent for allergic rhinitis in a locally applied solution form, a water-soluble ointment-dissolved form, a jelly-dissolved form, or the like. The therapeutic agent does not require the conduct of 5-aminolevulinic acid-based photodynamic diagnosis (ALA-PDD) for detecting a site of protoporphyrin IX (PpIX) accumulation radiating light having a wavelength of 610 nm to 650 nm under irradiation of excitation light having a wavelength of 380 nm to 420 nm before ALA-PDT.
摘要翻译：本发明提供能够以安全，简单，无创的方式治疗过敏性鼻炎的治疗剂，其基本上无副作用和对患者的身体伤害。本发明提供了包含5-氨基乙酰丙酸（ALA）或其衍生物的5-氨基乙酰丙酸类光动力治疗（ALA-PDT）或5-氨基乙酰丙酸或其衍生物的活性成分的过敏性鼻炎的治疗剂成分，并用于其中照射波长为400nm至700nm的光的ALA-PDT中; 并且特别提供了局部施用的溶液形式的过敏性鼻炎的治疗剂，溶于水的软膏溶解形式，果冻溶解形式等。治疗剂不需要进行基于5-氨基乙酰丙酸的光动力学诊断（ALA-PDD），用于检测在具有610nm至650nm的波长的照射下发射具有波长为610nm至650nm的光的原卟啉IX（PpIX）积累的位点，在ALA-PDT之前的波长为380nm至420nm。

3. 发明授权

US09345904B2 Photodynamic therapy using photosensitizing agent or 5-aminolevulinic acid 有权
标题翻译：光敏疗法使用光敏剂或5-氨基乙酰丙酸
公开(公告)号：US09345904B2
公开(公告)日：2016-05-24
申请号：US14126929
申请日：2012-06-20
申请人： Tohru Tanaka , Katsushi Inoue , Takuya Ishii , Takato Yoshida
发明人： Tohru Tanaka , Katsushi Inoue , Takuya Ishii , Takato Yoshida
IPC分类号： A61K41/00 , A61N5/06 , A61K31/197 , A61K49/00
CPC分类号： A61N5/062 , A61K31/197 , A61K41/0061 , A61K41/0071 , A61K49/0052
摘要： It is to provide photodynamic therapy (PDT) and photodynamic diagnosis (PDD) which are suitable for the diagnosis and therapy of a part requiring a certain degree of deep penetration, such as subcutaneous cancer and lymph nodes surrounded by blood vessels and fat. This is solved by performing PDT and PDD targeting cancer by administering a composition comprising a photosensitizing agent such as a tetrapyrrole-based compound (photofrin, protoporphyrin IX, etc.) or ALAs such as 5-aminolevulinic acid (ALA), ALA methyl ester, ALA ethyl ester, ALA propyl ester, ALA butyl ester, ALA pentyl ester, or a hydrochloride, phosphate, or sulfate thereof followed by irradiation with excitation light at a wavelength of 480 to 580 nm.
摘要翻译：它是提供光动力疗法（PDT）和光动力学诊断（PDD），适用于诊断和治疗需要一定程度深度穿透的部位，如皮下癌和由血管和脂肪包围的淋巴结。通过施用包含光敏剂如四吡咯基化合物（光调节素，原卟啉IX等）或ALA的组合物，例如5-氨基乙酰丙酸（ALA），ALA甲酯， ALA乙酯，ALA丙酯，ALA丁酯，ALA戊酯或其盐酸盐，磷酸盐或硫酸盐，然后用波长480〜580nm的激发光照射。

4. 发明申请

US20140188034A1 THERAPEUTIC AGENT FOR ALLERGIC RHINITIS 有权
标题翻译：用于过敏性RHINITIS的治疗剂
公开(公告)号：US20140188034A1
公开(公告)日：2014-07-03
申请号：US14125744
申请日：2012-06-15
申请人： Tohru Tanaka , Katsushi Inoue , Kiwamu Takahashi , Takuya Ishii , Tsutomu Numata , Mariko Shibuya , Takeshi Suzuki
发明人： Tohru Tanaka , Katsushi Inoue , Kiwamu Takahashi , Takuya Ishii , Tsutomu Numata , Mariko Shibuya , Takeshi Suzuki
IPC分类号： A61K41/00 , A61N5/06
CPC分类号： A61N5/062 , A61K9/0043 , A61K9/06 , A61K41/0061 , F04C2270/0421
摘要： Provided is a therapeutic agent capable of treating allergic rhinitis in a safe, simple, and noninvasive manner substantially without side effects and physical distress to patients. Provided is a therapeutic agent for allergic rhinitis for 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) comprising 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt of the 5-aminolevulinic acid or the derivative as an active ingredient, and used in ALA-PDT in which light having a wavelength of 400 nm to 700 nm is irradiated; and particularly provided is a therapeutic agent for allergic rhinitis in a locally applied solution form, a water-soluble ointment-dissolved form, a jelly-dissolved form, or the like. The therapeutic agent does not require the conduct of 5-aminolevulinic acid-based photodynamic diagnosis (ALA-PDD) for detecting a site of protoporphyrin IX (PpIX) accumulation radiating light having a wavelength of 610 nm to 650 nm under irradiation of excitation light having a wavelength of 380 nm to 420 nm before ALA-PDT.
摘要翻译：本发明提供能够以安全，简单，无创的方式治疗过敏性鼻炎的治疗剂，其基本上无副作用和对患者的身体伤害。本发明提供了包含5-氨基乙酰丙酸（ALA）或其衍生物的5-氨基乙酰丙酸类光动力治疗（ALA-PDT）或5-氨基乙酰丙酸或其衍生物的活性成分的过敏性鼻炎的治疗剂成分，并用于其中照射波长为400nm至700nm的光的ALA-PDT中; 并且特别提供了局部施用的溶液形式的过敏性鼻炎的治疗剂，溶于水的软膏溶解形式，果冻溶解形式等。治疗剂不需要进行基于5-氨基乙酰丙酸的光动力学诊断（ALA-PDD），用于检测在具有610nm至650nm的波长的照射下发射具有波长为610nm至650nm的光的原卟啉IX（PpIX）积累的位点，在ALA-PDT之前的波长为380nm至420nm。

5. 发明授权

US09474770B2 Prophylactic agent and/or therapeutic agent for sepsis 有权
标题翻译：脓毒症的预防剂和/或治疗剂
公开(公告)号：US09474770B2
公开(公告)日：2016-10-25
申请号：US14237407
申请日：2012-08-10
申请人： Kosaku Kinoshita , Katsuhisa Tanjoh , Akihiro Noda , Atsushi Sakurai , Tohru Tanaka , Kiwamu Takahashi , Motowo Nakajima , Fuminori Abe
发明人： Kosaku Kinoshita , Katsuhisa Tanjoh , Akihiro Noda , Atsushi Sakurai , Tohru Tanaka , Kiwamu Takahashi , Motowo Nakajima , Fuminori Abe
IPC分类号： A61K33/26 , A61K31/197 , A61K31/28 , A61K31/295 , A61K45/06
CPC分类号： A61K33/26 , A61K31/197 , A61K31/28 , A61K31/295 , A61K45/06
摘要： The present invention provides a sepsis therapeutic drug useful for prophylaxis and treatment of sepsis. A prophylactic agent and/or a therapeutic agent for sepsis containing 5-aminolevulinic acid (5-ALA) or a derivative thereof or a pharmacologically acceptable salt of 5-ALA or the derivative as an active ingredient is prepared. The prophylactic agent and/or the therapeutic agent preferably contains a metal-containing compound such as ferrous sodium citrate in addition to the ALAs. Preferred examples of the ALAs include ALA; various esters of ALA such as methyl, ethyl, propyl, butyl, and pentyl esters; and hydrochlorides, phosphates, sulfates of ALA and the esters.
摘要翻译：本发明提供了可用于预防和治疗败血症的败血症治疗药物。制备含有5-氨基乙酰丙酸（5-ALA）或其衍生物或5-ALA或其衍生物作为活性成分的药理学上可接受的盐的败血症的预防剂和/或治疗剂。除ALA之外，预防剂和/或治疗剂优选含有含金属的化合物如柠檬酸亚铁。 ALA的优选实例包括ALA; 各种ALA的酯如甲基，乙基，丙基，丁基和戊酯; 和盐酸盐，磷酸盐，ALA的硫酸盐和酯。

6. 发明授权

US09012502B2 Cancer heat therapy-enhancing agent 有权
标题翻译：癌症热疗增强剂
公开(公告)号：US09012502B2
公开(公告)日：2015-04-21
申请号：US13820303
申请日：2011-09-12
申请人： Taku Chibazakura , Tohru Tanaka , Kiwamu Takahashi , Motowo Nakajima , Fuminori Abe
发明人： Taku Chibazakura , Tohru Tanaka , Kiwamu Takahashi , Motowo Nakajima , Fuminori Abe
IPC分类号： A61K31/221 , C07C229/22 , A61K31/197
CPC分类号： C07C229/22 , A61K31/197
摘要： Provided is an enhancer for cancer thermotherapy not combined with photodynamic therapy. Cancer treatment not combined with photodynamic therapy is made available by using, as an enhancer for cancer thermotherapy, 5-aminolevulinic acids represented by formula (1): R2R1NCH2COCH2CH2COR3 (1) [wherein R1 and R2 each independently represent a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group] or a salt thereof.
摘要翻译：提供了不与光动力疗法结合的癌症热疗的增强剂。通过使用作为癌症热疗的增强剂，可以通过使用由式（1）表示的5-氨基乙酰丙酸获得癌症治疗：R2R1NCH2COCH2CH2COR3（1）[其中R1和R2各自独立地表示氢原子，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基）或其盐。

7. 发明申请

US20140186464A1 PROPHYLACTIC AGENT AND/OR THERAPEUTIC AGENT FOR SEPSIS 有权
标题翻译：预防剂和/或治疗剂
公开(公告)号：US20140186464A1
公开(公告)日：2014-07-03
申请号：US14237407
申请日：2012-08-10
申请人： Kosaku Kinoshita , Katsuhisa Tanjoh , Akihiro Noda , Atsushi Sakurai , Tohru Tanaka , Kiwamu Takahashi , Motowo Nakajima , Fuminori Abe
发明人： Kosaku Kinoshita , Katsuhisa Tanjoh , Akihiro Noda , Atsushi Sakurai , Tohru Tanaka , Kiwamu Takahashi , Motowo Nakajima , Fuminori Abe
IPC分类号： A61K33/26 , A61K45/06 , A61K31/197
CPC分类号： A61K33/26 , A61K31/197 , A61K31/28 , A61K31/295 , A61K45/06
摘要： The present invention provides a sepsis therapeutic drug useful for prophylaxis and treatment of sepsis. A prophylactic agent and/or a therapeutic agent for sepsis containing 5-aminolevulinic acid (5-ALA) or a derivative thereof or a pharmacologically acceptable salt of 5-ALA or the derivative as an active ingredient is prepared. The prophylactic agent and/or the therapeutic agent preferably contains a metal-containing compound such as ferrous sodium citrate in addition to the ALAs. Preferred examples of the ALAs include ALA; various esters of ALA such as methyl, ethyl, propyl, butyl, and pentyl esters; and hydrochlorides, phosphates, sulfates of ALA and the esters.
摘要翻译：本发明提供了可用于预防和治疗败血症的败血症治疗药物。制备含有5-氨基乙酰丙酸（5-ALA）或其衍生物或5-ALA或其衍生物作为活性成分的药理学上可接受的盐的败血症的预防剂和/或治疗剂。除ALA之外，预防剂和/或治疗剂优选含有含金属的化合物如柠檬酸亚铁。 ALA的优选实例包括ALA; 各种ALA的酯如甲基，乙基，丙基，丁基和戊酯; 和盐酸盐，磷酸盐，ALA的硫酸盐和酯。

8. 发明申请

US20130217913A1 Antimalarial Drug Comprising Alaremycin or Derivative Thereof as Active Ingredient 有权
标题翻译：包括阿拉霉素或其衍生物的抗疟药物作为活性成分
公开(公告)号：US20130217913A1
公开(公告)日：2013-08-22
申请号：US13883038
申请日：2011-11-09
申请人： Masaaki Wachi , Shigeharu Sato , Tohru Tanaka , Kiwamu Takahashi
发明人： Masaaki Wachi , Shigeharu Sato , Tohru Tanaka , Kiwamu Takahashi
IPC分类号： A61K31/197 , A61K31/16 , A61K31/221
CPC分类号： A61K31/197 , A61K9/0019 , A61K9/107 , A61K9/2018 , A61K9/2027 , A61K31/16 , A61K31/221 , Y02A50/411
摘要： Provided is a preventive and/or therapeutic agent for malaria, comprising, as an active ingredient, 5-acetamido-4-oxo-5-hexenoic acid (Alaremycin) or a derivative thereof. A preventive and/or therapeutic agent for malaria is used which comprises, as an active ingredient, Alaremycin or a derivative thereof represented by formula (I) (wherein R1 represents a hydroxy group, an amino group, or a substituted or unsubstituted straight chain or branched alkoxy group or alkylamino group having 1 to 8 carbons; R2 represents hydrogen, a substituted or unsubstituted straight chain or branched alkyl group having 1 to 8 carbons, or a substituted or unsubstituted aromatic group having 4 to 10 carbons; and R3 represents hydrogen or a methyl group).
摘要翻译：本发明提供疟疾的预防和/或治疗剂，其包含作为活性成分的5-乙酰氨基-4-氧代-5-己烯酸（阿拉霉霉素）或其衍生物。使用疟疾的预防和/或治疗剂，其包含作为活性成分的由式（I）表示的阿拉霉素或其衍生物（其中R 1表示羟基，氨基或取代或未取代的直链或支链烷氧基或碳原子数为1〜8的烷基氨基; R2表示氢，取代或未取代的碳原子数1〜8的直链或支链烷基或取代或未取代的碳原子数4〜10的芳基，R3表示氢或甲基）。

9. 发明申请

US20130108710A1 Antimalarial Drug Which Contains 5-Aminolevulinic Acid or Derivative Thereof as Active Ingredient 有权
公开(公告)号：US20130108710A1
公开(公告)日：2013-05-02
申请号：US13698090
申请日：2011-05-18
申请人： Tohru Tanaka , Satofumi Kawata , Takeo Kohda , Motowo Nakajima , Kiyoshi Kita
发明人： Tohru Tanaka , Satofumi Kawata , Takeo Kohda , Motowo Nakajima , Kiyoshi Kita
IPC分类号： A61K31/197 , A61K33/26
CPC分类号： A61K31/197 , A61K9/4866 , A61K31/221 , A61K33/06 , A61K33/26 , A61K33/30 , A61K45/06 , Y02A50/411 , A61K2300/00
摘要： Provided is an antimalarial drug which is useful for prevention and treatment of infectious diseases caused by malaria parasites. A preventive and/or therapeutic agent for malaria, which contains, as an active ingredient, 5-aminolevulinic acid (ALA), a derivative thereof, or a pharmacologically acceptable salt thereof, is used.

10. 发明申请

US20100105948A1 HOP ALPHA ACID OR HOP OIL CONTENT ENHANCER 审中-公开
标题翻译： HOP ALPHA酸或HOP油含量增强剂
公开(公告)号：US20100105948A1
公开(公告)日：2010-04-29
申请号：US12525167
申请日：2008-01-30
申请人： Tohru Tanaka , Satofumi Kawata
发明人： Tohru Tanaka , Satofumi Kawata
IPC分类号： C07C229/22
CPC分类号： A01N37/44
摘要： To provide a hop alpha acid or hop oil content enhancer, which increases the content of a hop alpha acid or a hop oil.A hop alpha acid or hop oil content enhancer, which comprises 5-aminolevulinic acid, or a derivative thereof represented by the following formula (1), or a salt thereof as an active ingredient: R2R1NCH2COCH2CH2COR3 (1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; R3 represents a hydroxyl group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group.
摘要翻译：提供一种啤酒花α酸或啤酒花油含量增强剂，其增加了啤酒花酸或啤酒花油的含量。包含由下式（1）表示的5-氨基乙酰丙酸或其衍生物或其盐作为活性成分的啤酒花α酸或啤酒花油含量增强剂：R2R1NCH2COCH2CH2COR3（1）其中R1和R2各自独立地表示氢原子，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基。

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