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    • 7. 发明申请
    • Optimal electrode contact polarity configurations for implantable stimulation systems
    • 可植入刺激系统的最佳电极接触极性配置
    • US20070049988A1
    • 2007-03-01
    • US11322788
    • 2005-12-30
    • Rafael CarbunaruKristen JaaxTodd WhitehurstJames Makous
    • Rafael CarbunaruKristen JaaxTodd WhitehurstJames Makous
    • A61N1/00
    • A61N1/375A61N1/3605A61N1/37205A61N1/3756
    • Systems for treating a patient with a medical condition include a lead having an array of electrode contacts each being programmable to have either a first polarity or a second polarity and a programming device configured to test a multiplicity of different electrode contact polarity configurations in which a programmed polarity of one or more of the electrode contacts is varied. Methods of using an implantable stimulator system include implanting a lead having an array of programmable electrode contacts disposed thereon in communication with a stimulation site, testing a multiplicity of different electrode contact polarity configurations in which a programmed polarity of one or more of the electrode contacts is varied, selecting an optimal electrode contact polarity configuration out of the multiplicity of different electrode contact polarity configurations, and applying the stimulation current via the optimal electrode contact polarity configuration to the stimulation site in accordance with one or more stimulation parameters.
    • 用于治疗患有医疗状况的患者的系统包括具有每个可编程为具有第一极性或第二极性的电极接触阵列的引线和被配置为测试多个不同电极接触极性配置的编程设备,其中编程 一个或多个电极触点的极性是变化的。 使用可植入刺激器系统的方法包括植入具有与刺激部位连通的可编程电极触点阵列的引线,测试多个不同的电极接触极性配置,其中一个或多个电极触点的编程极性为 根据一个或多个刺激参数,通过不同电极接触极性配置的多重性选择最佳电极接触极性配置,并通过最佳电极接触极性配置将刺激电流施加到刺激部位。
    • 8. 发明申请
    • METHODS AND APPARATUS FOR USING SENSORS WITH A DEEP BRAIN STIMULATION SYSTEM
    • 使用传感器与深层脑刺激系统的方法和装置
    • US20110137372A1
    • 2011-06-09
    • US12959890
    • 2010-12-03
    • James MakousBrett SchleicherRafael CarbunaruKristen JaaxAndrew DiGiore
    • James MakousBrett SchleicherRafael CarbunaruKristen JaaxAndrew DiGiore
    • A61N1/36
    • A61N1/36139A61N1/0534
    • A system and method for applying stimulation to a target stimulation site within a patient, while avoiding undesirable eye movement side effects of the stimulation, are provided. The method includes determining whether eye movement, sensed by internal or external electrodes, is a side effect of a conveyed electrical stimulus. If the eye movement is a side effect, the electrical current distribution of the stimulus is modified in order to steer a locus of the electrical stimulus from one tissue region of the patient to another different tissue region of the patient, thereby mitigating the eye movement side effects. For example, the locus of the electrical stimulus may be steered away from the oculomotor nerve. Eye movement side effects of DBS treatment may include apraxia of lid opening, downward movement and adduction of only one eyeball, and/or continuous deviation of both eyeballs.
    • 提供了一种用于将刺激应用于患者内的目标刺激部位同时避免刺激的不期望的眼睛运动副作用的系统和方法。 该方法包括确定由内部或外部电极感测的眼睛运动是否是所传送的电刺激的副作用。 如果眼睛运动是副作用,则刺激的电流分布被修改以便将电刺激的轨迹从患者的一个组织区域引导到患者的另一不同组织区域,从而减轻眼睛运动侧 效果。 例如,电刺激的轨迹可以被转向离开眼动神经。 DBS治疗的眼睛运动副作用可能包括盖开口的不适,仅有一只眼球的向下运动和内收,和/或两只眼球的连续偏差。
    • 9. 发明授权
    • Methods and apparatus for using sensors with a deep brain stimulation system
    • 使用具有深脑刺激系统的传感器的方法和装置
    • US08670833B2
    • 2014-03-11
    • US12959890
    • 2010-12-03
    • James MakousBrett SchleicherRafael CarbunaruKristen JaaxAndrew DiGiore
    • James MakousBrett SchleicherRafael CarbunaruKristen JaaxAndrew DiGiore
    • A61N1/00
    • A61N1/36139A61N1/0534
    • A system and method for applying stimulation to a target stimulation site within a patient, while avoiding undesirable eye movement side effects of the stimulation, are provided. The method includes determining whether eye movement, sensed by internal or external electrodes, is a side effect of a conveyed electrical stimulus. If the eye movement is a side effect, the electrical current distribution of the stimulus is modified in order to steer a locus of the electrical stimulus from one tissue region of the patient to another different tissue region of the patient, thereby mitigating the eye movement side effects. For example, the locus of the electrical stimulus may be steered away from the oculomotor nerve. Eye movement side effects of DBS treatment may include apraxia of lid opening, downward movement and adduction of only one eyeball, and/or continuous deviation of both eyeballs.
    • 提供了一种用于将刺激应用于患者内的目标刺激部位同时避免刺激的不期望的眼睛运动副作用的系统和方法。 该方法包括确定由内部或外部电极感测的眼睛运动是否是所传送的电刺激的副作用。 如果眼睛运动是副作用,则刺激的电流分布被修改以便将电刺激的轨迹从患者的一个组织区域引导到患者的另一不同组织区域,从而减轻眼睛运动侧 效果。 例如,电刺激的轨迹可以被转向离开眼动神经。 DBS治疗的眼睛运动副作用可能包括盖开口的不适,仅有一只眼球的向下运动和内收,和/或两只眼球的连续偏差。