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1. 发明授权

US08934968B2 Neurostimulation and coronary artery disease treatment 有权
标题翻译：神经刺激和冠状动脉疾病治疗
公开(公告)号：US08934968B2
公开(公告)日：2015-01-13
申请号：US11779769
申请日：2007-07-18
申请人： Todd K. Whitehurst , James R. Thacker , James P. McGivern , Kelly H. McClure
发明人： Todd K. Whitehurst , James R. Thacker , James P. McGivern , Kelly H. McClure
IPC分类号： A61N1/362 , A61N1/36 , A61M5/142
CPC分类号： A61N1/36114 , A61M5/14276 , A61M2205/054 , A61M2205/3523 , A61M2205/8206 , A61M2230/06
摘要： A method for treating a patient may include treating coronary artery disease in combination with angina pectoris and/or the control of angina pain by delivering chemical and/or electrical stimulation pulses to the cardiac and/or nervous tissue of the patient in a coordinated manner. A system for treating a patient suffering from coronary artery disease and angina may include a stimulator that generates at least one pulse in accordance with prescribed parameters, a catheter, a lead, and/or a sensor.
摘要翻译：用于治疗患者的方法可以包括通过以协调的方式将化学和/或电刺激脉冲递送到患者的心脏和/或神经组织来治疗与心绞痛联合的冠状动脉疾病和/或控制心绞痛。用于治疗患有冠状动脉疾病和心绞痛的患者的系统可以包括根据规定参数产生至少一个脉冲的刺激器，导管，引线和/或传感器。

2. 发明授权

US07155284B1 Treatment of hypertension 有权
标题翻译：治疗高血压
公开(公告)号：US07155284B1
公开(公告)日：2006-12-26
申请号：US10346538
申请日：2003-01-16
申请人： Todd K Whitehurst , Kelly H. McClure , James R Thacker , James P McGivern
发明人： Todd K Whitehurst , Kelly H. McClure , James R Thacker , James P McGivern
IPC分类号： A61N1/18
CPC分类号： A61N1/36117 , A61N1/36135 , A61N1/37205 , A61N1/37211 , A61N1/3787
摘要： Treatment of hypertension includes implantation of the discharge portion(s) of a catheter and/or electrical stimulation electrode(s) adjacent the tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and/or electrical pulses, are supplied by one or more implanted stimulators, through the catheter and possibly also a lead, tunneled subcutaneously between the stimulator and stimulation site. A microstimulator(s) may also/instead deliver electrical stimulation pulses. Stimulation sites include the carotid sinus and carotid body, among other locations. Treatments include drugs used for acute and/or chronic treatment of hypertension. In a number of embodiments, a need for or response to treatment is sensed, and the electrical and/or infusion pulses adjusted accordingly.
摘要翻译：高血压的治疗包括植入邻近待刺激的组织的导管和/或电刺激电极的放电部分。刺激脉冲，即药物输注脉冲和/或电脉冲由一个或多个注入的刺激器通过导管提供，并且可能还包括引线，在刺激器和刺激部位之间皮下隧穿。微型激励器也可以/替代地递送电刺激脉冲。刺激部位包括颈动脉窦和颈动脉体等。治疗包括用于急性和/或慢性治疗高血压的药物。在多个实施例中，感测对治疗的需要或响应，并且相应地调整电和/或输注脉冲。

3. 发明授权

US06970741B1 Monitoring, preventing, and treating rejection of transplanted organs 失效
标题翻译：监测，预防和治疗移植器官的排斥
公开(公告)号：US06970741B1
公开(公告)日：2005-11-29
申请号：US10246554
申请日：2002-09-17
申请人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure , Goran N. Marnfeldt , James R. Thacker
发明人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure , Goran N. Marnfeldt , James R. Thacker
IPC分类号： A61M5/00 , A61M5/142 , A61M5/172 , A61N1/00 , A61N1/30 , A61N1/32
CPC分类号： A61B5/413 , A61B5/053 , A61B5/0538 , A61B5/41 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/4244 , A61B2560/0219 , A61M5/14276 , A61M5/1723 , A61N1/30 , A61N1/32
摘要： An implantable system control unit (SCU) includes means for measuring tissue impedance or other condition to determine allograft health, in order to predict or detect allograft rejection. The SCU also includes at least two electrodes coupled to means for delivering electrical stimulation to a patient within whom the device is implanted, and may also include a reservoir for holding one or more drugs and a driver means for delivering the drug(s) to the patient. In certain embodiments, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters. Alternatively, this sensory “SCU” sounds an alarm, communicates an alarm to an external device, and/or is responsive to queries regarding sensed information, such as tissue impedance.
摘要翻译：可植入系统控制单元（SCU）包括用于测量组织阻抗或其他条件以确定同种异体移植物健康的装置，以便预测或检测同种异体移植排斥。 SCU还包括至少两个电极，其耦合到用于将电刺激递送到其中植入该装置的患者的装置，并且还可以包括用于容纳一种或多种药物的储存器和用于将药物递送至患者。在某些实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。或者，该感官“SCU”发出警报，向外部设备通报警报，和/或响应关于感测信息（例如组织阻抗）的查询。

4. 发明申请

US20100331807A1 TREATMENT OF MOVEMENT DISORDERS BY BRAIN STIMULATION 有权
标题翻译：通过脑刺激治疗运动障碍
公开(公告)号：US20100331807A1
公开(公告)日：2010-12-30
申请号：US12873170
申请日：2010-08-31
申请人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure
发明人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure
IPC分类号： A61N1/36 , A61M37/00
CPC分类号： A61M5/14276 , A61K9/0085 , A61M2205/3523 , A61M2205/3569 , A61M2210/0693 , A61N1/0529 , A61N1/0534 , A61N1/325 , A61N1/36082 , A61N1/37205
摘要： Systems for treating a movement disorder include a system control unit configured to be implanted at least partially within a patient and to generate at least one stimulus in accordance with one or more stimulation parameters adjusted to treat the movement disorder. The systems further include a programmable memory unit in communication with the system control unit and programmed to store the one or more stimulation parameters to at least partially define the stimulus such that the stimulus is configured to treat the movement disorder. A means for applying the stimulus to one or more stimulation sites within the patient is operably connected to the system control unit.
摘要翻译：用于治疗运动障碍的系统包括系统控制单元，该系统控制单元被配置为至少部分地植入患者体内，并根据被调整以治疗运动障碍的一个或多个刺激参数产生至少一个刺激。系统还包括与系统控制单元通信的可编程存储器单元，并被编程为存储一个或多个刺激参数以至少部分地限定刺激，使得刺激被配置为治疗运动障碍。将刺激施加到患者体内的一个或多个刺激部位的手段可操作地连接到系统控制单元。

5. 发明授权

US08401634B2 Treatment of movement disorders by brain stimulation 有权
标题翻译：通过脑刺激治疗运动障碍
公开(公告)号：US08401634B2
公开(公告)日：2013-03-19
申请号：US12873170
申请日：2010-08-31
申请人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure
发明人： Todd K. Whitehurst , James P. McGivern , Kelly H. McClure
IPC分类号： A61N1/00
CPC分类号： A61M5/14276 , A61K9/0085 , A61M2205/3523 , A61M2205/3569 , A61M2210/0693 , A61N1/0529 , A61N1/0534 , A61N1/325 , A61N1/36082 , A61N1/37205
摘要： Systems for treating a movement disorder include a system control unit configured to be implanted at least partially within a patient and to generate at least one stimulus in accordance with one or more stimulation parameters adjusted to treat the movement disorder. The systems further include a programmable memory unit in communication with the system control unit and programmed to store the one or more stimulation parameters to at least partially define the stimulus such that the stimulus is configured to treat the movement disorder. A means for applying the stimulus to one or more stimulation sites within the patient is operably connected to the system control unit.
摘要翻译：用于治疗运动障碍的系统包括系统控制单元，该系统控制单元被配置为至少部分地植入患者体内，并根据被调整以治疗运动障碍的一个或多个刺激参数产生至少一个刺激。系统还包括与系统控制单元通信的可编程存储器单元，并被编程为存储一个或多个刺激参数以至少部分地限定刺激，使得刺激被配置为治疗运动障碍。将刺激施加到患者体内的一个或多个刺激部位的手段可操作地连接到系统控制单元。

6. 发明授权

US08301248B1 Sequenced and simultaneous stimulation for treating congestive heart failure 有权
标题翻译：有序和同时刺激治疗充血性心力衰竭
公开(公告)号：US08301248B1
公开(公告)日：2012-10-30
申请号：US12163803
申请日：2008-06-27
申请人： James R. Thacker , Kelly H. McClure , Todd K. Whitehurst
发明人： James R. Thacker , Kelly H. McClure , Todd K. Whitehurst
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A patient's ejection fraction is maximized through simultaneous sensing and stimulating across multiple electrodes. In one exemplary embodiment, a catheter or lead having multiple electrodes connected to a pulse generator is used. The pulse generator provides individual current control of the stimulus applied to each electrode, and further includes the ability to sense intrinsic and evoked depolarization through multiple electrodes. In another exemplary embodiment, a multiplicity of individual implantable microstimulators, each having its own current source and/or sensor and electrodes, cooperate in concert to provide multi-site stimulation and sensing.
摘要翻译：患者的射血分数通过同时感测和刺激跨多个电极而最大化。在一个示例性实施例中，使用具有连接到脉冲发生器的多个电极的导管或引线。脉冲发生器提供对施加到每个电极的刺激的单独电流控制，并且还包括通过多个电极感测固有和诱发去极化的能力。在另一个示例性实施例中，多个单独的可植入微型激励器（各自具有其自身的电流源和/或传感器和电极）协同协作以提供多位点刺激和感测。

7. 发明申请

US20080286327A1 THOMBOLYSIS AND CHRONIC ANTICOAGULATION THERAPY 失效
标题翻译： THOMBOLYSIS和CHRONIC抗凝治疗
公开(公告)号：US20080286327A1
公开(公告)日：2008-11-20
申请号：US11949752
申请日：2007-12-03
申请人： Todd K. Whitehurst , Kelly H. McClure , James R. Thacker
发明人： Todd K. Whitehurst , Kelly H. McClure , James R. Thacker
IPC分类号： A61K9/00 , A61K31/727 , A61K31/353 , A61K31/60 , A61K38/48
CPC分类号： A61M5/14276 , A61M2205/3507 , A61M2205/3523 , A61M2205/8243 , A61M2230/04 , A61M2230/205 , A61M2230/30 , A61N1/362 , A61M2230/005
摘要： Method and systems of treating a patient with at least one of a myocardial infarction, a stroke, and a pulmonary embolism include providing a stimulator coupled to at least one electrode and a catheter, configuring one or more stimulation parameters to treat at least one of a myocardial infarction, a stroke, and a pulmonary embolism, programming the stimulator with the one or more stimulation parameters, delivering with the stimulator via the catheter at least one drug to at least one tissue in accordance with the one or more stimulation parameters, and limiting perfusion of the at least one tissue by delivering electrical stimulation with the stimulator via the at least one electrode to the at least one tissue.
摘要翻译：用心肌梗死，中风和肺栓塞中的至少一种治疗患者的方法和系统包括提供耦合到至少一个电极和导管的刺激器，配置一个或多个刺激参数以治疗下列中的至少一个：心肌梗塞，中风和肺栓塞，用一个或多个刺激参数对刺激器进行编程，根据该一个或多个刺激参数，通过导管将至少一种药物通过导管递送至至少一个组织，并限制通过将所述刺激器经由所述至少一个电极递送到所述至少一个组织的电刺激来灌注所述至少一个组织。

8. 发明授权

US08364280B2 Engagement tool for implantable medical devices 有权
标题翻译：可植入医疗器械的接合工具
公开(公告)号：US08364280B2
公开(公告)日：2013-01-29
申请号：US12506890
申请日：2009-07-21
申请人： Goran N. Marnfeldt , Rafael Carbunaru , Kelly H. McClure , Matthew I. Haller , Tom Xiaohai He , Todd K. Whitehurst , Meredith L. Anderson , James C. Makous , Kristen N. Jaax , Peter K. Johnson
发明人： Goran N. Marnfeldt , Rafael Carbunaru , Kelly H. McClure , Matthew I. Haller , Tom Xiaohai He , Todd K. Whitehurst , Meredith L. Anderson , James C. Makous , Kristen N. Jaax , Peter K. Johnson
IPC分类号： A61N1/00
CPC分类号： A61B17/3417 , A61B17/221 , A61B17/32056 , A61B17/3468 , A61B90/30 , A61B2017/00358 , A61B2017/22035 , A61B2017/2215 , A61B2017/320044 , A61N1/05 , A61N1/08
摘要： Systems for adjusting a position of an implanted medical device within a patient include an engagement tool configured to couple to the implanted medical device. The engagement tool adjusts the position of the medical device when coupled to the implanted medical device. Methods of adjusting a position of an implanted medical device within a patient include locating the implanted medical device, coupling an engagement tool to the medical device, and adjusting a position of the engagement tool to adjust the position of the medical device.
摘要翻译：用于调整患者内植入的医疗装置的位置的系统包括被配置为耦合到植入的医疗装置的接合工具。接合工具当耦合到植入的医疗装置时调节医疗装置的位置。调整患者内的植入医疗装置的位置的方法包括定位植入的医疗装置，将接合工具联接到医疗装置，以及调整接合工具的位置以调整医疗装置的位置。

9. 发明申请

US20090281605A1 ENGAGEMENT TOOL FOR IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：可植入医疗器械的辅助工具
公开(公告)号：US20090281605A1
公开(公告)日：2009-11-12
申请号：US12506890
申请日：2009-07-21
申请人： Goran N. Marnfeldt , Rafael Carbunaru , Kelly H. McClure , Matthew I. Haller , Tom Xiaohai He , Todd K. Whitehurst , Meredith L. Anderson , James C. Makous , Kristen N. Jaax , Peter K. Johnson
发明人： Goran N. Marnfeldt , Rafael Carbunaru , Kelly H. McClure , Matthew I. Haller , Tom Xiaohai He , Todd K. Whitehurst , Meredith L. Anderson , James C. Makous , Kristen N. Jaax , Peter K. Johnson
IPC分类号： A61N1/00
CPC分类号： A61B17/3417 , A61B17/221 , A61B17/32056 , A61B17/3468 , A61B90/30 , A61B2017/00358 , A61B2017/22035 , A61B2017/2215 , A61B2017/320044 , A61N1/05 , A61N1/08
摘要： Systems for adjusting a position of an implanted medical device within a patient include an engagement tool configured to couple to the implanted medical device. The engagement tool adjusts the position of the medical device when coupled to the implanted medical device. Methods of adjusting a position of an implanted medical device within a patient include locating the implanted medical device, coupling an engagement tool to the medical device, and adjusting a position of the engagement tool to adjust the position of the medical device.
摘要翻译：用于调整患者内植入的医疗装置的位置的系统包括被配置为耦合到植入的医疗装置的接合工具。接合工具当耦合到植入的医疗装置时调节医疗装置的位置。调整患者内的植入医疗装置的位置的方法包括定位植入的医疗装置，将接合工具联接到医疗装置，以及调整接合工具的位置以调整医疗装置的位置。

10. 发明授权

US06522928B2 Physiologically based adjustment of stimulation parameters to an implantable electronic stimulator to reduce data transmission rate 有权
标题翻译：基于生理学的调整刺激参数到可植入电子刺激器以降低数据传输速率
公开(公告)号：US06522928B2
公开(公告)日：2003-02-18
申请号：US09812151
申请日：2001-03-19
申请人： Todd K. Whitehurst , Kelly H. McClure
发明人： Todd K. Whitehurst , Kelly H. McClure
IPC分类号： A61N132
CPC分类号： A61N1/36003 , Y10S128/903
摘要： A Functional Electro Stimulation (FES) system provides physiologically based adjustment of stimulation parameters to achieve a high update rate for nerve and muscle stimulation at a reduced data transmission rate. FES systems generate electrical signals to stimulate nerves and muscles to provide movement for paraplegics and quadriplegics. Known FES systems comprise a multiplicity of microstimulators that are controlled by a single master controller. Control signals are transmitted over an RF link. A complete set of stimulation parameters comprising pulse amplitude, pulse width, and pulse frequency is initially transmitted to set initial stimulation parameters. Subsequent functional control of muscles is achieved by transmitting an increment to a single stimulation parameter. In a preferred embodiment the physiological behavior of the human body is copied by incrementing the pulse rate.
摘要翻译：功能电刺激（FES）系统提供基于生理学的刺激参数调整，以在降低的数据传输速率下实现神经和肌肉刺激的高更新率。 FES系统产生电信号以刺激神经和肌肉，为截瘫和四肢麻痹提供运动。已知的FES系统包括由单个主控制器控制的多个微型激励器。控制信号通过RF链路传输。初始传输包括脉冲幅度，脉冲宽度和脉冲频率的完整的一组刺激参数以设定初始刺激参数。通过将增量传递到单个刺激参数来实现肌肉的后续功能控制。在优选实施例中，通过增加脉搏率来复制人体的生理行为。

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