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1. 发明授权

US07481759B2 Systems and methods for treatment of coronary artery disease 失效
标题翻译：用于治疗冠状动脉疾病的系统和方法
公开(公告)号：US07481759B2
公开(公告)日：2009-01-27
申请号：US10211463
申请日：2002-08-02
申请人： Todd K. Whitehurst , James P McGivern , Kelly H McClure , Mark R. Stultz
发明人： Todd K. Whitehurst , James P McGivern , Kelly H McClure , Mark R. Stultz
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61M5/14276 , A61M2205/3523 , A61M2205/8206 , A61M2230/06
摘要： Methods and systems for treatment of coronary artery disease (CAD) include implantation of the discharge portion(s) of a catheter and, optionally, electrodes on a lead, near the tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and optional electrical pulses, are supplied by a stimulator implanted remotely, and through the catheter or lead, which is tunneled subcutaneously between the stimulator and stimulation site. Stimulation sites include the coronary arteries, the aorta, the left ventricle, the left atrium, and/or the pulmonary veins, among other locations. Disclosed treatments include drugs used for acute treatment of CAD, for chronic treatment of CAD, to promote angiogenesis, and/or as AGE Crosslink Breakers, among other drugs. For instance, the systems and methods reduce or eliminate the incidence of CAD and related morbidities, improve symptoms resulting from CAD, and/or improve cardiac blood flow, cardiac function, and patient quality of life.
摘要翻译：用于治疗冠状动脉疾病（CAD）的方法和系统包括将导管的放电部分和可选地在导线上的电极植入，以被刺激的组织附近。刺激脉冲，即药物输注脉冲和可选的电脉冲由远程植入的刺激器，以及通过在刺激器和刺激部位之间皮下隧穿的导管或引线提供。刺激部位包括冠状动脉，主动脉，左心室，左心房和/或肺静脉等。公开的治疗包括用于急性治疗CAD，用于慢性CAD治疗，促进血管发生的药物和/或作为AGE交联断裂剂等药物。例如，系统和方法可减少或消除CAD和相关疾病的发生率，改善由CAD引起的症状和/或改善心脏血流量，心脏功能和患者生活质量。

2. 发明授权

US07155284B1 Treatment of hypertension 有权
标题翻译：治疗高血压
公开(公告)号：US07155284B1
公开(公告)日：2006-12-26
申请号：US10346538
申请日：2003-01-16
申请人： Todd K Whitehurst , Kelly H. McClure , James R Thacker , James P McGivern
发明人： Todd K Whitehurst , Kelly H. McClure , James R Thacker , James P McGivern
IPC分类号： A61N1/18
CPC分类号： A61N1/36117 , A61N1/36135 , A61N1/37205 , A61N1/37211 , A61N1/3787
摘要： Treatment of hypertension includes implantation of the discharge portion(s) of a catheter and/or electrical stimulation electrode(s) adjacent the tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and/or electrical pulses, are supplied by one or more implanted stimulators, through the catheter and possibly also a lead, tunneled subcutaneously between the stimulator and stimulation site. A microstimulator(s) may also/instead deliver electrical stimulation pulses. Stimulation sites include the carotid sinus and carotid body, among other locations. Treatments include drugs used for acute and/or chronic treatment of hypertension. In a number of embodiments, a need for or response to treatment is sensed, and the electrical and/or infusion pulses adjusted accordingly.
摘要翻译：高血压的治疗包括植入邻近待刺激的组织的导管和/或电刺激电极的放电部分。刺激脉冲，即药物输注脉冲和/或电脉冲由一个或多个注入的刺激器通过导管提供，并且可能还包括引线，在刺激器和刺激部位之间皮下隧穿。微型激励器也可以/替代地递送电刺激脉冲。刺激部位包括颈动脉窦和颈动脉体等。治疗包括用于急性和/或慢性治疗高血压的药物。在多个实施例中，感测对治疗的需要或响应，并且相应地调整电和/或输注脉冲。

3. 发明授权

US07776029B2 Microminiature infusion pump 有权
标题翻译：微型输液泵
公开(公告)号：US07776029B2
公开(公告)日：2010-08-17
申请号：US10057144
申请日：2002-01-24
申请人： Todd K Whitehurst , Kelly H McClure , James P McGivern
发明人： Todd K Whitehurst , Kelly H McClure , James P McGivern
IPC分类号： A61K9/22
CPC分类号： A61M5/14276 , A61M5/14224 , A61M5/14228 , A61M2005/14208 , A61M2205/0244 , A61M2205/054 , A61M2205/3523 , A61N1/32 , A61N1/36071
摘要： An implantable microminiature infusion device includes a reservoir for holding a therapeutic fluid or other substance and a driver, e.g., a pump, that delivers the therapeutic fluid or substance to a patient within whom the device is implanted. The device further includes at least two electrodes coupled to pulse generation circuitry, thereby allowing therapeutic electrical stimulation to also be delivered to the patient.
摘要翻译：植入式微型灌注装置包括用于保持治疗流体或其他物质的储存器以及将治疗流体或物质输送到装置内的患者的驱动器，例如泵。该装置还包括耦合到脉冲发生电路的至少两个电极，从而允许治疗性电刺激也被递送给患者。

4. 发明授权

US07151961B1 Treatment of movement disorders by brain stimulation 有权
标题翻译：通过脑刺激治疗运动障碍
公开(公告)号：US07151961B1
公开(公告)日：2006-12-19
申请号：US10428744
申请日：2003-05-02
申请人： Todd K Whitehurst , James P McGivern , Kelly H McClure
发明人： Todd K Whitehurst , James P McGivern , Kelly H McClure
IPC分类号： A61N1/00 , A61K9/22 , A61M31/00
CPC分类号： A61M5/14276 , A61K9/0085 , A61M2205/3523 , A61M2205/3569 , A61M2210/0693 , A61N1/0529 , A61N1/0534 , A61N1/325 , A61N1/36082 , A61N1/37205
摘要： Introducing one or more stimulating drugs to the brain and/or applying electrical stimulation to the brain is used to treat movement disorders. At least one implantable system control unit (SCU) produces electrical pulses delivered via electrodes implanted in the brain and/or drug infusion pulses delivered via a catheter implanted in the brain. The stimulation is delivered to targeted brain structures to adjust the activity of those structures. In some embodiments, one or more sensed conditions are used to adjust stimulation parameters.
摘要翻译：将一种或多种刺激性药物引入脑中和/或对脑施加电刺激来用于治疗运动障碍。至少一个可植入系统控制单元（SCU）产生通过植入在脑中的电极传送的电脉冲和/或通过植入在脑中的导管递送的药物输注脉冲。刺激被传递到目标脑结构以调节这些结构的活性。在一些实施例中，使用一个或多个感测到的条件来调整刺激参数。

5. 发明授权

US07904162B2 Monitoring, preventing, and treating rejection of transplanted organs 失效
标题翻译：监测，预防和治疗移植器官的排斥
公开(公告)号：US07904162B2
公开(公告)日：2011-03-08
申请号：US11246719
申请日：2005-10-07
申请人： Todd K Whitehurst , James P McGivern , Kelly H McClure , Goran N Marnfeldt , James R Thacker
发明人： Todd K Whitehurst , James P McGivern , Kelly H McClure , Goran N Marnfeldt , James R Thacker
IPC分类号： A61N1/08
CPC分类号： A61B5/413 , A61B5/053 , A61B5/0538 , A61B5/41 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/4244 , A61B2560/0219 , A61M5/14276 , A61M5/1723 , A61N1/30 , A61N1/32
摘要： An implantable system control unit (SCU) includes means for measuring tissue impedance or other condition to determine allograft health, in order to predict or detect allograft rejection. The SCU also includes at least two electrodes coupled to means for delivering electrical stimulation to a patient within whom the device is implanted, and may also include a reservoir for holding one or more drugs and a driver means for delivering the drug(s) to the patient. In certain embodiments, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters. Alternatively, this sensory “SCU” sounds an alarm, communicates an alarm to an external device, and/or is responsive to queries regarding sensed information, such as tissue impedance.
摘要翻译：可植入系统控制单元（SCU）包括用于测量组织阻抗或其他条件以确定同种异体移植物健康的装置，以便预测或检测同种异体移植排斥。 SCU还包括至少两个电极，其耦合到用于将电刺激递送到其中植入该装置的患者的装置，并且还可以包括用于容纳一种或多种药物的储存器和用于将药物递送至患者。在某些实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。或者，该感官“SCU”发出警报，向外部设备通报警报，和/或响应关于感测信息（例如组织阻抗）的查询。

6. 发明授权

US07054692B1 Fixation device for implantable microdevices 有权
标题翻译：可植入微型装置的固定装置
公开(公告)号：US07054692B1
公开(公告)日：2006-05-30
申请号：US10146332
申请日：2002-05-15
申请人： Todd K Whitehurst , James P McGivern
发明人： Todd K Whitehurst , James P McGivern
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/37205 , A61N1/3756
摘要： A fixation device fixes the position of an implantable microminiature device residing proximally to a target site such as a nerve or a muscle. In one embodiment, the device comprises a sheath and a means for attaching the device to adjacent tissue. The means for attaching may be any one of several embodiments including one or more grasping members, a combination of grasping members and one or more helices, or an extension adapted to accept a suture. In another embodiment, the fixation device comprises an assembly residing in the implantation pathway, behind the stimulation device, thus preventing retreat of the stimulation device in the pathway. In a preferred use, the fixation device fixes the position of a microstimulator component of a Peripheral Nerve Stimulation (PNS) system.
摘要翻译：固定装置将位于近端的可植入微型装置的位置固定到诸如神经或肌肉的目标部位。在一个实施例中，该装置包括护套和用于将该装置附接到相邻组织的装置。用于附接的装置可以是包括一个或多个抓握构件，抓握构件和一个或多个螺旋的组合的几个实施例中的任一个或适于接纳缝合线的延伸部。在另一个实施例中，固定装置包括驻留在植入通路中的组件，位于刺激装置后面，从而防止刺激装置在路径中的后退。在优选的使用中，固定装置固定外围神经刺激（PNS）系统的微型激励器部件的位置。

7. 发明授权

US07167751B1 Method of using a fully implantable miniature neurostimulator for vagus nerve stimulation 有权
标题翻译：使用完全可植入的微型神经刺激器进行迷走神经刺激的方法
公开(公告)号：US07167751B1
公开(公告)日：2007-01-23
申请号：US10993989
申请日：2004-11-19
申请人： Todd K Whitehurst , James P McGivern
发明人： Todd K Whitehurst , James P McGivern
IPC分类号： A61N1/08
CPC分类号： A61N1/3605 , A61N1/36082 , A61N1/36114 , A61N1/37205
摘要： A method of using a small implantable stimulator(s) with at least two electrodes small enough to have the electrodes located adjacent to the vagus nerve. The small stimulator provides a means of stimulating the vagus nerve when desired, and may be implanted via a minimal surgical procedure.
摘要翻译：使用具有足够小的至少两个电极的小型可植入刺激器的方法，以使电极位于与迷走神经相邻的位置。小刺激器在需要时提供刺激迷走神经的手段，并且可以通过最小的外科手术植入。

8. 发明授权

US07890177B1 Device and therapy for erectile dysfunction and other sexual dysfunction 有权
公开(公告)号：US07890177B1
公开(公告)日：2011-02-15
申请号：US11338335
申请日：2006-01-24
申请人： Todd K Whitehurst , James P McGivern
发明人： Todd K Whitehurst , James P McGivern
IPC分类号： A61N1/08 , A61N1/00
CPC分类号： A61N1/372 , A61N1/36007 , A61N1/37205
摘要： An implantable stimulator(s) with at least one infusion outlet and/or at least one electrode, is implanted with the outlet(s) and/or electrode(s) located adjacent to a pudendal nerve(s) and potentially other nerve(s) innervating the reproductive organs, such as the cavernous nerve(s). Stimulation of such nerve(s) is provided via stimulating drugs and/or electrical stimulation as a therapy for erectile dysfunction. The stimulator uses a power source/storage device, such as a rechargeable battery. Periodic recharging of such a battery is accomplished, for example, by inductive coupling with an external appliance. The stimulator provides means of stimulating a nerve(s) when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the stimulator(s) and for the transmission of power. The system is capable of open- and closed-loop operation. In closed-loop operation, at least one implant includes a sensor, and the sensed condition is used to adjust stimulation parameters.

9. 发明授权

US07860570B2 Implantable microstimulators and methods for unidirectional propagation of action potentials 有权
标题翻译：可植入的微型激励器和动作电位单向传播的方法
公开(公告)号：US07860570B2
公开(公告)日：2010-12-28
申请号：US10178010
申请日：2002-06-20
申请人： Todd K Whitehurst , Rafael Carbunaru , James P McGivern , Matthew I Haller , Tom Xiaohai He , Kerry Bradley , Janusz A Kuzma
发明人： Todd K Whitehurst , Rafael Carbunaru , James P McGivern , Matthew I Haller , Tom Xiaohai He , Kerry Bradley , Janusz A Kuzma
IPC分类号： A61N1/375
CPC分类号： A61N1/37252 , A61N1/05 , A61N1/0556 , A61N1/36071 , A61N1/37205 , A61N1/37217 , A61N1/37288
摘要： Miniature implantable stimulators (i.e., microstimulators) are capable of producing unidirectionally propagating action potentials (UPAPs). The methods and configurations described may, for instance, arrest action potentials traveling in one direction, arrest action potentials of small diameters nerve fibers, arrest action potentials of large diameter nerve fibers. These methods and systems may limit side effects of bidirectional and/or less targeted stimulation.
摘要翻译：微型植入式刺激器（即微型刺激器）能够产生单向传播动作电位（UPAP）。所描述的方法和结构可以例如阻止在一个方向上行进的动作电位，阻止小直径神经纤维的动作电位，阻止大直径神经纤维的动作电位。这些方法和系统可以限制双向和/或较少靶向刺激的副作用。

10. 发明授权

US07660631B2 Methods and systems for electrical and/or drug stimulation as a therapy for erectile dysfunction 失效
标题翻译：用于电和/或药物刺激作为勃起功能障碍治疗的方法和系统
公开(公告)号：US07660631B2
公开(公告)日：2010-02-09
申请号：US11112630
申请日：2005-04-22
申请人： Todd K Whitehurst , James P McGivern
发明人： Todd K Whitehurst , James P McGivern
IPC分类号： A61N1/00
CPC分类号： A61N1/37211 , A61N1/36007 , A61N1/372 , A61N1/37205
摘要： Systems and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to tissue affecting the penis to treat erectile dysfunction (for instance, following prostate surgery) uses at least one implantable system control unit (SCU) producing electrical pulses delivered via electrodes and/or producing drug infusion pulses, wherein the stimulating drug(s) are delivered via one or more pumps and infusion outlets.
摘要翻译：用于引入一种或多种刺激性药物和/或对影响阴茎治疗勃起功能障碍的组织施加电刺激的系统和方法（例如，在前列腺手术之后）使用至少一个可植入系统控制单元（SCU），其产生经由电极传送的电脉冲和/或产生药物输注脉冲，其中所述刺激性药物通过一个或多个泵和输注口输送。

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