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1. 发明申请

US20120109235A1 CAPTURE DETECTION IN RESPONSE TO LEAD RELATED CONDITIONS 审中-公开
标题翻译：对领导相关条件的响应能力的检测
公开(公告)号：US20120109235A1
公开(公告)日：2012-05-03
申请号：US12913400
申请日：2010-10-27
申请人： Todd J. Sheldon , Bruce D. Gunderson
发明人： Todd J. Sheldon , Bruce D. Gunderson
IPC分类号： A61N1/37 , A61N1/39
CPC分类号： A61N1/371 , A61N1/3706 , A61N1/3712 , A61N1/3962 , A61N2001/083
摘要： Various techniques for detecting cardiac capture in response to a detected lead related condition are described. One example method described includes delivering a pacing therapy to a heart of a patient, periodically determining whether the pacing therapy captures the heart of the patient, detecting a lead related condition, and, in response to the detected lead related condition, increasing a frequency of determining whether the pacing therapy captures the heart.
摘要翻译：描述了响应于检测到的铅相关状况来检测心脏捕获的各种技术。所描述的一个示例性方法包括将起搏治疗递送到患者的心脏，周期性地确定起搏疗法是否捕获患者的心脏，检测引线相关状况，并且响应于检测到的引线相关状况，增加频率确定起搏治疗是否捕获心脏。

2. 发明授权

US09037238B2 Method for efficient delivery of dual site pacing 有权
标题翻译：双位置起搏有效运送的方法
公开(公告)号：US09037238B2
公开(公告)日：2015-05-19
申请号：US13301084
申请日：2011-11-21
申请人： Robert W. Stadler , Wade M. Demmer , Vincent E. Splett , Todd J. Sheldon
发明人： Robert W. Stadler , Wade M. Demmer , Vincent E. Splett , Todd J. Sheldon
IPC分类号： A61N1/00 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3684 , A61N1/368 , A61N1/3686 , A61N1/3712
摘要： An implantable device and associated method for delivering a multi-site pacing therapy includes electrodes for sensing cardiac signals and delivering cardiac pacing pulses to a first pacing site along a heart chamber and a therapy delivery module for delivering cardiac pacing pulses to a patient's heart via the electrodes. A sensing module measures an activation time at multiple pacing electrode sites along the heart chamber in response to delivering pacing pulses at the first pacing site. A controller is configured to identify a second pacing site from the plurality of pacing electrode sites in response to the activation times measured during pacing at the first site.
摘要翻译：用于递送多部位起搏治疗的可植入装置和相关联的方法包括用于感测心脏信号并将心脏起搏脉冲输送到沿着心脏室的第一起搏部位的电极和用于经由心脏起搏器将心脏起搏脉冲输送到患者心脏的治疗递送模块电极。响应于在第一起搏部位输送起搏脉冲，感测模块测量沿着心室的多个起搏电极部位的激活时间。控制器被配置为响应于在第一站点的起搏期间测量的激活时间，从多个起搏电极位置识别第二起搏部位。

3. 发明授权

US08744579B2 LV threshold measurement and capture management 有权
标题翻译： LV阈值测量和捕获管理
公开(公告)号：US08744579B2
公开(公告)日：2014-06-03
申请号：US12700454
申请日：2010-02-04
申请人： Purvee P. Parikh , John C. Stroebel , Todd J. Sheldon , Karen J. Kleckner
发明人： Purvee P. Parikh , John C. Stroebel , Todd J. Sheldon , Karen J. Kleckner
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： The invention provides methods and apparatus for determining in a non-tracking pacing mode (e.g., DDI/R, VVI/R) whether a ventricular pacing stimulus is capturing a paced ventricle, including some or all of the following aspects. For example, increasing a ventricular pacing rate a nominal amount to an overdrive pacing rate higher than a most recent heart rate and evaluating a conduction interval from a first pacing ventricle to a second sensing ventricle and then continuing to monitor the underlying rate to ensure that a threshold testing pacing rate will not exceed a predetermined minimum interval and providing pacing stimulation to the first ventricle and sensing the second ventricle to determine whether the pacing stimulation to the first ventricle was one of sub-threshold and supra-threshold. The methods and apparatus are especially useful in conjunction with ensuring actual delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or “CRT”).
摘要翻译：本发明提供了用于在非跟踪起搏模式（例如，DDI / R，VVI / R）中确定心室起搏刺激是否捕获节奏心室的方法和装置，包括以下方面中的一些或全部。例如，将心室起搏速率提高到高于最近心率的超速起搏速率的标称值，并评估从第一起搏心室到第二感测心室的传导间隔，然后继续监测潜在速率，以确保阈值测试起搏速率不会超过预定的最小间隔，并且向第一脑室提供起搏刺激并且感测第二脑室以确定对第一脑室的起搏刺激是否是子阈值和超阈值之一。所述方法和装置与确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的实际递送相结合特别有用。

4. 发明授权

US08682433B2 Method for efficient delivery of dual site pacing 有权
标题翻译：双位置起搏有效运送的方法
公开(公告)号：US08682433B2
公开(公告)日：2014-03-25
申请号：US13301113
申请日：2011-11-21
申请人： Todd J. Sheldon , Vincent E. Splett , Robert W. Stadler , Wade M. Demmer
发明人： Todd J. Sheldon , Vincent E. Splett , Robert W. Stadler , Wade M. Demmer
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3686 , A61N1/371
摘要： An implantable device and associated method for delivering a multi-site pacing therapy includes electrodes for sensing cardiac signals and delivering cardiac pacing pulses. Electrodes positioned at first and second selected pacing sites are used to deliver pacing pulses to a first heart chamber using a bipole comprising the first electrode and the second electrode. A controller is configured to determine if anodal and cathodal capture can be achieved during pacing using the bipole. Responsive to anodal and cathodal capture being achieved, the controller selects a multi-site pacing configuration comprising the bipole for singly pacing the first and second pacing sites.
摘要翻译：用于递送多部位起搏治疗的可植入装置和相关联的方法包括用于感测心脏信号和递送心脏起搏脉冲的电极。使用位于第一和第二选定的起搏部位的电极，使用包括第一电极和第二电极的双极将起搏脉冲输送到第一心室。控制器被配置为确定在使用双极的起搏期间是否可以实现阳极和阴极捕获。响应于实现阳极和阴极捕获，控制器选择包括用于单步起搏第一和第二起搏部位的双极的多位置起搏配置。

5. 发明授权

US08626291B2 Method for discriminating anodal and cathodal capture 有权
标题翻译：鉴别阳极和阴极捕获的方法
公开(公告)号：US08626291B2
公开(公告)日：2014-01-07
申请号：US13192713
申请日：2011-07-28
申请人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade M. Demmer
发明人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade M. Demmer
IPC分类号： A61N1/365
CPC分类号： A61N1/371 , A61N1/3684 , A61N1/3686 , A61N1/3712
摘要： An implantable device and associated method detect anodal capture during electrical stimulation. A first pacing pulse is delivered using a first cathode and a first anode. A second pacing pulse is delivered using the first cathode and a second anode. A first response to the first pacing pulse and a second response to the second pacing pulse are measured. Anodal capture of the first pacing pulse at the first anode is detected in response to a first difference between the first response and the second response.
摘要翻译：可植入装置和相关方法在电刺激期间检测阳极捕获。使用第一阴极和第一阳极传送第一起搏脉冲。使用第一阴极和第二阳极传送第二起搏脉冲。测量对第一起搏脉冲的第一响应和对第二起搏脉冲的第二响应。响应于第一响应和第二响应之间的第一差异来检测在第一阳极处的第一起搏脉冲的阳极捕获。

6. 发明申请

US20130131749A1 METHOD FOR EFFICIENT DELIVERY OF DUAL SITE PACING 有权
标题翻译：双层高效交付方法
公开(公告)号：US20130131749A1
公开(公告)日：2013-05-23
申请号：US13301113
申请日：2011-11-21
申请人： Todd J. Sheldon , Vincent E. Splett , Robert W. Stadler , Wade M. Demmer
发明人： Todd J. Sheldon , Vincent E. Splett , Robert W. Stadler , Wade M. Demmer
IPC分类号： A61N1/37 , A61N1/365
CPC分类号： A61N1/3627 , A61N1/3686 , A61N1/371
摘要： An implantable device and associated method for delivering a multi-site pacing therapy includes electrodes for sensing cardiac signals and delivering cardiac pacing pulses. Electrodes positioned at first and second selected pacing sites are used to deliver pacing pulses to a first heart chamber using a bipole comprising the first electrode and the second electrode. A controller is configured to determine if anodal and cathodal capture can be achieved during pacing using the bipole. Responsive to anodal and cathodal capture being achieved, the controller selects a multi-site pacing configuration comprising the bipole for singly pacing the first and second pacing sites
摘要翻译：用于递送多部位起搏治疗的可植入装置和相关联的方法包括用于感测心脏信号和递送心脏起搏脉冲的电极。使用位于第一和第二选定的起搏部位的电极，使用包括第一电极和第二电极的双极将起搏脉冲输送到第一心室。控制器被配置为确定在使用双极的起搏期间是否可以实现阳极和阴极捕获。响应于实现阳极和阴极捕获，控制器选择包括用于单步起搏第一和第二起搏部位的双极的多位置起搏配置

7. 发明申请

US20130131748A1 METHOD FOR EFFICIENT DELIVERY OF DUAL SITE PACING 有权
标题翻译：双层高效交付方法
公开(公告)号：US20130131748A1
公开(公告)日：2013-05-23
申请号：US13301084
申请日：2011-11-21
申请人： Robert W. Stadler , Wade M. Demmer , Vincent E. Splett , Todd J. Sheldon
发明人： Robert W. Stadler , Wade M. Demmer , Vincent E. Splett , Todd J. Sheldon
IPC分类号： A61N1/37 , A61N1/365
CPC分类号： A61N1/3684 , A61N1/368 , A61N1/3686 , A61N1/3712
摘要： An implantable device and associated method for delivering a multi-site pacing therapy includes electrodes for sensing cardiac signals and delivering cardiac pacing pulses to a first pacing site along a heart chamber and a therapy delivery module for delivering cardiac pacing pulses to a patient's heart via the electrodes. A sensing module measures an activation time at multiple pacing electrode sites along the heart chamber in response to delivering pacing pulses at the first pacing site. A controller is configured to identify a second pacing site from the plurality of pacing electrode sites in response to the activation times measured during pacing at the first site.
摘要翻译：用于递送多部位起搏治疗的可植入装置和相关联的方法包括用于感测心脏信号并将心脏起搏脉冲输送到沿着心脏室的第一起搏部位的电极和用于经由心脏起搏器将心脏起搏脉冲输送到患者心脏的治疗递送模块电极。响应于在第一起搏部位输送起搏脉冲，感测模块测量沿着心室的多个起搏电极部位的激活时间。控制器被配置为响应于在第一站点的起搏期间测量的激活时间，从多个起搏电极位置识别第二起搏部位。

8. 发明授权

US08401646B2 Method and apparatus to determine the relative energy expenditure for a plurality of pacing vectors 有权
标题翻译：确定多个起搏向量的相对能量消耗的方法和装置
公开(公告)号：US08401646B2
公开(公告)日：2013-03-19
申请号：US13194100
申请日：2011-07-29
申请人： Robert W. Stadler , Wade M. Demmer , Todd J. Sheldon
发明人： Robert W. Stadler , Wade M. Demmer , Todd J. Sheldon
IPC分类号： A61B1/00
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3686 , A61N1/3708
摘要： A medical device system determines and displays relative energy expenditure information for programmable parameter values. The system establishes a programmable parameter and multiple values of the parameter to be compared. A module performs a measurements for each of the multiple values and related to energy expenditure of a battery of an implantable medical device when operating according to each of the multiple parameter values. An energy expenditure for each of the values is computed using the measurements, and a graphical user interface is generated for displaying information corresponding to the computed energy expenditure for multiple parameter values.
摘要翻译：医疗设备系统确定并显示可编程参数值的相对能量消耗信息。系统建立可编程参数和要比较的参数的多个值。当根据多个参数值中的每个参数值进行操作时，模块对可植入医疗装置的电池的能量消耗进行测量。使用测量来计算每个值的能量消耗，并且生成用于显示与多个参数值的计算能量消耗相对应的信息的图形用户界面。

9. 发明授权

US07869872B2 System and method for determining intrinsic AV interval timing 有权
公开(公告)号：US07869872B2
公开(公告)日：2011-01-11
申请号：US11424395
申请日：2006-06-15
申请人： Todd J. Sheldon , Paul A. Belk , Michael O. Sweeney
发明人： Todd J. Sheldon , Paul A. Belk , Michael O. Sweeney
IPC分类号： A61N1/00
CPC分类号： A61N1/368 , A61N1/3682
摘要： An atrial based pacing protocol promotes intrinsic conduction. An entire cardiac cycle is monitored for ventricular activity and permitted to lapse with ventricular activity. Ventricular pacing is available in a cardiac cycle immediately subsequent to such a skipped beat. When monitoring for intrinsic ventricular events, an event is expected within a given window. If no such event is detected, the cardiac cycle is truncated, leading to a shorter cycle that is devoid of ventricular activity. The subsequent cycle has a high likelihood of a ventricular sensed event and a greater than normal AV interval is provided prior to pacing.

10. 发明授权

US07818059B2 Atrial capture management in minimal ventricular pacing system and method 有权
标题翻译：心房采集管理在最小心室起搏系统和方法
公开(公告)号：US07818059B2
公开(公告)日：2010-10-19
申请号：US11115628
申请日：2005-04-27
申请人： John C. Rueter , Todd J. Sheldon
发明人： John C. Rueter , Todd J. Sheldon
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61N1/3714
摘要： Embodiments of the invention provide systems and methods for an implantable medical device comprising means for selecting between an atrial chamber reset (ACR) test and an atrioventricular conduction (AVC) test to provide atrial capture management and means for switching between an atrial-based pacing mode and a dual chamber pacing mode based on detecting relatively reliable atrioventricular conduction.
摘要翻译：本发明的实施例提供了一种用于可植入医疗装置的系统和方法，包括用于在房室复位（ACR）测试和房室传导（AVC）测试之间进行选择以提供心房捕获管理的装置和用于在基于心房的起搏模式之间切换的装置以及基于检测相对可靠的房室传导的双室起搏模式。

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