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1. 发明授权

US08744579B2 LV threshold measurement and capture management 有权
标题翻译： LV阈值测量和捕获管理
公开(公告)号：US08744579B2
公开(公告)日：2014-06-03
申请号：US12700454
申请日：2010-02-04
申请人： Purvee P. Parikh , John C. Stroebel , Todd J. Sheldon , Karen J. Kleckner
发明人： Purvee P. Parikh , John C. Stroebel , Todd J. Sheldon , Karen J. Kleckner
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： The invention provides methods and apparatus for determining in a non-tracking pacing mode (e.g., DDI/R, VVI/R) whether a ventricular pacing stimulus is capturing a paced ventricle, including some or all of the following aspects. For example, increasing a ventricular pacing rate a nominal amount to an overdrive pacing rate higher than a most recent heart rate and evaluating a conduction interval from a first pacing ventricle to a second sensing ventricle and then continuing to monitor the underlying rate to ensure that a threshold testing pacing rate will not exceed a predetermined minimum interval and providing pacing stimulation to the first ventricle and sensing the second ventricle to determine whether the pacing stimulation to the first ventricle was one of sub-threshold and supra-threshold. The methods and apparatus are especially useful in conjunction with ensuring actual delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or “CRT”).
摘要翻译：本发明提供了用于在非跟踪起搏模式（例如，DDI / R，VVI / R）中确定心室起搏刺激是否捕获节奏心室的方法和装置，包括以下方面中的一些或全部。例如，将心室起搏速率提高到高于最近心率的超速起搏速率的标称值，并评估从第一起搏心室到第二感测心室的传导间隔，然后继续监测潜在速率，以确保阈值测试起搏速率不会超过预定的最小间隔，并且向第一脑室提供起搏刺激并且感测第二脑室以确定对第一脑室的起搏刺激是否是子阈值和超阈值之一。所述方法和装置与确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的实际递送相结合特别有用。

2. 发明授权

US07684863B2 LV threshold measurement and capture management 有权
标题翻译： LV阈值测量和捕获管理
公开(公告)号：US07684863B2
公开(公告)日：2010-03-23
申请号：US11311984
申请日：2005-12-20
申请人： Purvee P. Parikh , John C. Stroebel , Todd J. Sheldon , Karen J. Kleckner
发明人： Purvee P. Parikh , John C. Stroebel , Todd J. Sheldon , Karen J. Kleckner
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： The invention provides methods and apparatus for determining in a non-tracking pacing mode (e.g., DDI/R, VVI/R) whether a ventricular pacing stimulus is capturing a paced ventricle, including some or all of the following aspects. For example, increasing a ventricular pacing rate a nominal amount to an overdrive pacing rate higher than a most recent heart rate and evaluating a conduction interval from a first pacing ventricle to a second sensing ventricle and then continuing to monitor the underlying rate to ensure that a threshold testing pacing rate will not exceed a predetermined minimum interval and providing pacing stimulation to the first ventricle and sensing the second ventricle to determine whether the pacing stimulation to the first ventricle was one of sub-threshold and supra-threshold. The methods and apparatus are especially useful in conjunction with ensuring actual delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or “CRT”).
摘要翻译：本发明提供了用于在非跟踪起搏模式（例如，DDI / R，VVI / R）中确定心室起搏刺激是否捕获节奏心室的方法和装置，包括以下方面中的一些或全部。例如，将心室起搏速率提高到高于最近心率的超速起搏速率的标称值，并评估从第一起搏心室到第二感测心室的传导间隔，然后继续监测潜在速率，以确保阈值测试起搏速率不会超过预定的最小间隔，并且向第一脑室提供起搏刺激并且感测第二脑室以确定对第一脑室的起搏刺激是否是子阈值和超阈值之一。所述方法和装置与确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的实际递送相结合特别有用。

3. 发明申请

US20100137935A1 LV THRESHOLD MEASUREMENT AND CAPTURE MANAGEMENT 有权
标题翻译： LV阈值测量和捕获管理
公开(公告)号：US20100137935A1
公开(公告)日：2010-06-03
申请号：US12700454
申请日：2010-02-04
申请人： Purvee P. Parikh , John C. Stroebel , Todd J. Sheldon , Karen J. Kleckner
发明人： Purvee P. Parikh , John C. Stroebel , Todd J. Sheldon , Karen J. Kleckner
IPC分类号： A61N1/08 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： The invention provides methods and apparatus for determining in a non-tracking pacing mode (e.g., DDI/R, VVI/R) whether a ventricular pacing stimulus is capturing a paced ventricle, including some or all of the following aspects. For example, increasing a ventricular pacing rate a nominal amount to an overdrive pacing rate higher than a most recent heart rate and evaluating a conduction interval from a first pacing ventricle to a second sensing ventricle and then continuing to monitor the underlying rate to ensure that a threshold testing pacing rate will not exceed a predetermined minimum interval and providing pacing stimulation to the first ventricle and sensing the second ventricle to determine whether the pacing stimulation to the first ventricle was one of sub-threshold and supra-threshold. The methods and apparatus are especially useful in conjunction with ensuring actual delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or “CRT”).
摘要翻译：本发明提供了用于在非跟踪起搏模式（例如，DDI / R，VVI / R）中确定心室起搏刺激是否捕获节奏心室的方法和装置，包括以下方面中的一些或全部。例如，将心室起搏速率提高到高于最近心率的超速起搏速率的标称值，并评估从第一起搏心室到第二感测心室的传导间隔，然后继续监测潜在速率，以确保阈值测试起搏速率不会超过预定的最小间隔，并且向第一脑室提供起搏刺激并且感测第二脑室以确定对第一脑室的起搏刺激是否是子阈值和超阈值之一。所述方法和装置与确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的实际递送相结合特别有用。

4. 发明授权

US07899538B2 Methods and apparatus for automatically tracking heart failure status 有权
标题翻译：自动跟踪心力衰竭状态的方法和装置
公开(公告)号：US07899538B2
公开(公告)日：2011-03-01
申请号：US11691266
申请日：2007-03-26
申请人： Lynn A. Davenport , Purvee P. Parikh , Todd J. Sheldon
发明人： Lynn A. Davenport , Purvee P. Parikh , Todd J. Sheldon
IPC分类号： A61N1/37
CPC分类号： A61N1/3627
摘要： Assessing symptomatic and asymptomatic physiologic changes due to chronic heart failure involves apparatus and methods for gauging degradation and possible improvement using automated measurement of inter-ventricular conduction time, both alone and in combination with other automated physiologic tests. Conduction times increase due to the greater distance a wavefront must traverse as a heart enlarges. Analysis of conduction time can be used to verify the occurrence of cardiac remodeling due to heart failure as well as beneficial reverse remodeling due to successful heart failure therapy delivery. Patient activity level(s) and presence/increase in pulmonary fluids can also be used to automatically determine changes in heart failure status and/or predict hospitalization. Conduction time is monitored between electrodes positioned in the left and right ventricles of the heart via endocardial or epicardial electrodes.
摘要翻译：评估因慢性心力衰竭引起的症状和无症状的生理变化涉及用于测量降解的设备和方法，并且可以通过自动测量心室间传导时间来单独测量并与其他自动化生理测试结合使用。由于随着心脏的扩大，波前必须穿越的距离越大，传导时间就会增加。传导时间分析可以用于验证由于心力衰竭导致的心脏重构的发生以及由于成功的心力衰竭治疗递送而导致的有益的反向重建。患者活动水平和肺流体的存在/增加也可用于自动确定心力衰竭状态的变化和/或预测住院治疗。通过心内膜或心外膜电极监测位于心脏左心室和右心室的电极之间的传导时间。

5. 发明授权

US08249709B2 Methods and apparatus for automatically tracking heart failure status 有权
标题翻译：自动跟踪心力衰竭状态的方法和装置
公开(公告)号：US08249709B2
公开(公告)日：2012-08-21
申请号：US13037817
申请日：2011-03-01
申请人： Lynn A. Davenport , Purvee P. Parikh , Todd J. Sheldon
发明人： Lynn A. Davenport , Purvee P. Parikh , Todd J. Sheldon
IPC分类号： A61N1/37
CPC分类号： A61N1/3627
摘要： Assessing symptomatic and asymptomatic physiologic changes due to chronic heart failure involves apparatus and methods for gauging degradation and possible improvement using automated measurement of inter-ventricular conduction time, both alone and in combination with other automated physiologic tests. Conduction times increase due to the greater distance a wavefront must traverse as a heart enlarges. Analysis of conduction time can be used to verify the occurrence of cardiac remodeling due to heart failure as well as beneficial reverse remodeling due to successful heart failure therapy delivery. Patient activity level(s) and presence/increase in pulmonary fluids can also be used to automatically determine changes in heart failure status and/or predict hospitalization. Conduction time is monitored between electrodes positioned in the left and right ventricles of the heart via endocardial or epicardial electrodes.
摘要翻译：评估因慢性心力衰竭引起的症状和无症状的生理变化涉及用于测量降解的设备和方法，并且可以通过自动测量心室间传导时间来单独测量并与其他自动化生理测试结合使用。由于随着心脏的扩大，波前必须穿越的距离越大，传导时间就会增加。传导时间分析可以用于验证由于心力衰竭导致的心脏重构的发生以及由于成功的心力衰竭治疗递送而导致的有益的反向重建。患者活动水平和肺流体的存在/增加也可用于自动确定心力衰竭状态的变化和/或预测住院治疗。通过心内膜或心外膜电极监测位于心脏左心室和右心室的电极之间的传导时间。

6. 发明申请

US20110152660A1 METHODS AND APPARATUS FOR AUTOMATICALLY TRACKING HEART FAILURE STATUS 有权
标题翻译：自动跟踪心脏失败状态的方法和装置
公开(公告)号：US20110152660A1
公开(公告)日：2011-06-23
申请号：US13037817
申请日：2011-03-01
申请人： Lynn A. Davenport , Purvee P. Parikh , Todd J. Sheldon
发明人： Lynn A. Davenport , Purvee P. Parikh , Todd J. Sheldon
IPC分类号： A61B5/044 , A61B5/042
CPC分类号： A61N1/3627
摘要： Assessing symptomatic and asymptomatic physiologic changes due to chronic heart failure involves apparatus and methods for gauging degradation and possible improvement using automated measurement of inter-ventricular conduction time, both alone and in combination with other automated physiologic tests. Conduction times increase due to the greater distance a wavefront must traverse as a heart enlarges. Analysis of conduction time can be used to verify the occurrence of cardiac remodeling due to heart failure as well as beneficial reverse remodeling due to successful heart failure therapy delivery. Patient activity level(s) and presence/increase in pulmonary fluids can also be used to automatically determine changes in heart failure status and/or predict hospitalization. Conduction time is monitored between electrodes positioned in the left and right ventricles of the heart via endocardial or epicardial electrodes.
摘要翻译：评估因慢性心力衰竭引起的症状和无症状的生理变化涉及用于测量降解的设备和方法，并且可以通过自动测量心室间传导时间来单独测量并与其他自动化生理测试结合使用。由于随着心脏的扩大，波前必须穿越的距离越大，传导时间就会增加。传导时间分析可以用于验证由于心力衰竭导致的心脏重构的发生以及由于成功的心力衰竭治疗递送而导致的有益的反向重建。患者活动水平和肺流体的存在/增加也可用于自动确定心力衰竭状态的变化和/或预测住院治疗。通过心内膜或心外膜电极监测位于心脏左心室和右心室的电极之间的传导时间。

7. 发明申请

US20070288059A1 METHODS AND APPARATUS FOR AUTOMATICALLY TRACKING HEART FAILURE STATUS 有权
标题翻译：自动跟踪心脏失败状态的方法和装置
公开(公告)号：US20070288059A1
公开(公告)日：2007-12-13
申请号：US11691266
申请日：2007-03-26
申请人： Lynn A. Davenport , Purvee P. Parikh , Todd J. Sheldon
发明人： Lynn A. Davenport , Purvee P. Parikh , Todd J. Sheldon
IPC分类号： A61N1/362
CPC分类号： A61N1/3627
摘要： Assessing symptomatic and asymptomatic physiologic changes due to chronic heart failure involves apparatus and methods for gauging degradation and possible improvement using automated measurement of inter-ventricular conduction time, both alone and in combination with other automated physiologic tests. Conduction times increase due to the greater distance a wavefront must traverse as a heart enlarges. Analysis of conduction time can be used to verify the occurrence of cardiac remodeling due to heart failure as well as beneficial reverse remodeling due to successful heart failure therapy delivery. Patient activity level(s) and presence/increase in pulmonary fluids can also be used to automatically determine changes in heart failure status and/or predict hospitalization. Conduction time is monitored between electrodes positioned in the left and right ventricles of the heart via endocardial or epicardial electrodes.
摘要翻译：评估因慢性心力衰竭引起的症状和无症状的生理变化涉及用于测量降解的设备和方法，并且可以通过自动测量心室间传导时间来单独测量并与其他自动化生理测试结合使用。由于随着心脏的扩大，波前必须穿越的距离越大，传导时间就会增加。传导时间分析可以用于验证由于心力衰竭导致的心脏重构的发生以及由于成功的心力衰竭治疗递送而导致的有益的反向重建。患者活动水平和肺流体的存在/增加也可以用于自动确定心力衰竭状态的变化和/或预测住院治疗。通过心内膜或心外膜电极监测位于心脏左心室和右心室的电极之间的传导时间。

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