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1. 发明授权

US06712836B1 Apparatus and methods for closing septal defects and occluding blood flow 有权
标题翻译：用于闭合间隔缺损并阻塞血流的装置和方法
公开(公告)号：US06712836B1
公开(公告)日：2004-03-30
申请号：US09570358
申请日：2000-05-12
申请人： Todd A. Berg , Alex A. Peterson , William J. Swanson , Paul J. Hindrichs
发明人： Todd A. Berg , Alex A. Peterson , William J. Swanson , Paul J. Hindrichs
IPC分类号： A61B1704
CPC分类号： A61B17/0057 , A61B90/39 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2090/3941
摘要： Plugs and methods for plugging septal defects and blood vessels are provided. Plugs are delivered via catheter to a septal defect or a location where it is desired to occlude blood flow in a blood vessel. The plugs are positioned and expanded at the treatment site. The expansion of the plugs can be accomplished passively by using a heat-treated elastic frame or actively by using a balloon to deform a plastically-deforming frame. Plugging structures mounted to the frame span the defect or lumen and prevent blood flow. The plugs described herein have small profiles, and are more reliable than preceding intraluminal transcatheter methods.
摘要翻译：提供了堵塞间隔缺损和血管的插塞和方法。插头通过导管输送到隔膜缺损或希望阻塞血管中的血液流动的位置。栓塞在治疗部位定位和扩张。插塞的膨胀可以通过使用经热处理的弹性框架被动地完成，或者主动地通过使用气球来使塑性变形框架变形。安装在框架上的堵塞结构跨越缺陷或内腔，防止血液流动。本文所述的塞子具有小的轮廓，并且比先前的腔内经导管方法更可靠。

2. 发明授权

US06866674B2 Medical grafting methods and apparatus 有权
标题翻译：医疗移植方法和装置
公开(公告)号：US06866674B2
公开(公告)日：2005-03-15
申请号：US10084010
申请日：2002-02-27
申请人： Jason A. Galdonik , William J. Swanson , Paul J. Hindrichs , Gregory A. Boldenow , Todd A. Berg , Rick Cornelius , Luis Bonilla
发明人： Jason A. Galdonik , William J. Swanson , Paul J. Hindrichs , Gregory A. Boldenow , Todd A. Berg , Rick Cornelius , Luis Bonilla
IPC分类号： A61B17/00 , A61B17/064 , A61B17/11 , A61B17/115 , A61B17/04
CPC分类号： A61B17/115 , A61B17/0644 , A61B17/11 , A61B46/17 , A61B2017/00557 , A61B2017/0641 , A61B2090/0801
摘要： Methods and apparatus for making an anastomotic connection between a first conduit and a second conduit. A connector structure having a first end portion and a second end portion is positioned about a balloon catheter, which when pressurized, expands to a significant extent at the distal end thereof. The balloon enlarges the connector structure when positioned at the distal end portion of the balloon to create the anastomosis, and at the same time reduces the axial length of the connector, thereby compressing the first conduit to the second conduit, creating a hemodynamic seal and a firm attachment of the two conduits. After enlargement, the connector structure remains in place and adds structure to the anastomosis. During introduction, the second end portion of the connector is covered by a nosecone assembly to prevent trauma to the second conduit while the apparatus is being introduced. The nosecone assembly has a flexible structure which may change configuration to expose the second set of members after insertion into the second conduit and to allow removal of the nosecone after deployment.
摘要翻译：用于在第一导管和第二导管之间进行吻合连接的方法和装置。具有第一端部部分和第二端部部分的连接器结构围绕球囊导管定位，当加压时，其在其远端处显着扩张。当定位在球囊的远端部分时，气囊扩大连接器结构以产生吻合，并且同时减小连接器的轴向长度，从而将第一导管压缩到第二导管，产生血流动力学密封和坚固的连接两个管道。放大后，连接器结构保持原位，并将结构添加到吻合中。在引入期间，连接器的第二端部被鼻锥组件覆盖，以在装置被引入时防止对第二导管的创伤。鼻锥组件具有柔性结构，其可以改变配置以在插入第二导管之后暴露第二组构件，并且在展开之后允许去除鼻锥。

3. 发明授权

US06602263B1 Medical grafting methods and apparatus 有权
公开(公告)号：US06602263B1
公开(公告)日：2003-08-05
申请号：US09693578
申请日：2000-10-20
申请人： William J. Swanson , Jason A. Galdonik , Paul J. Hindrichs , Gregory A. Boldenow , Todd A. Berg , Rick Cornelius , Luis Bonilla
发明人： William J. Swanson , Jason A. Galdonik , Paul J. Hindrichs , Gregory A. Boldenow , Todd A. Berg , Rick Cornelius , Luis Bonilla
IPC分类号： A61B1712
CPC分类号： A61B17/115 , A61B17/0644 , A61B17/11 , A61B46/17 , A61B2017/00557 , A61B2017/0641 , A61B2090/0801
摘要： Methods and apparatus for making an anastomotic connection between a first conduit and a second conduit. A connector structure having a first end portion and a second end portion is positioned about a balloon catheter, which when pressurized, expands to a significant extent at the distal end thereof. The balloon enlarges the connector structure when positioned at the distal end portion of the balloon to create the anastomosis, and at the same time reduces the axial length of the connector, thereby compressing the first conduit to the second conduit, creating a hemodynamic seal and a firm attachment of the two conduits. After enlargement, the connector structure remains in place and adds structure to the anastomosis. During introduction, the second end portion of the connector is covered by a nosecone assembly to prevent trauma to the second conduit while the apparatus is being introduced. The nosecone assembly has a flexible structure which may change configuration to expose the second set of members after insertion into the second conduit and to allow removal of the nosecone after deployment.

4. 发明授权

US08114123B2 Apparatus and methods for tissue gathering and securing 有权
标题翻译：用于组织收集和固定的装置和方法
公开(公告)号：US08114123B2
公开(公告)日：2012-02-14
申请号：US10943352
申请日：2004-09-17
申请人： Michael P. Brenzel , Paul J. Hindrichs , Theodore P. Dale , Todd A. Krinke , Steven D. Kruse , David M. Costello , Todd A. Berg , John A. Roop
发明人： Michael P. Brenzel , Paul J. Hindrichs , Theodore P. Dale , Todd A. Krinke , Steven D. Kruse , David M. Costello , Todd A. Berg , John A. Roop
IPC分类号： A61B17/08
CPC分类号： A61B17/1285 , A61B17/0057 , A61B17/1227 , A61B2017/00349 , A61B2017/00575
摘要： Methods and apparatus are provided that gather a patient's body tissue and then secure the gathered tissue in a reduced area utilizing a securing structure. The securing structure mainly resides on one side of the tissue to minimize or eliminate both foreign material and the amount of manipulation or activity on the other side of the tissue. The securing device is matched to the desired amount of tissue manipulation to minimize the structure. The gathered and secured tissue can surround a septal defect to obstruct or close the defect itself.
摘要翻译：提供了收集患者身体组织然后利用固定结构将聚集的组织固定在缩小区域中的方法和装置。固定结构主要位于组织的一侧，以最小化或消除外来物质和组织另一侧的操作或活动量。固定装置与所需的组织操作量匹配，以最小化结构。收集和固定的组织可以围绕隔膜缺陷以阻碍或闭合缺陷本身。

5. 发明申请

US20120150214A1 METHODS AND APPARATUS FOR TREATING BODY TISSUE SPHINCTERS AND THE LIKE 审中-公开
标题翻译：用于治疗身体组织细胞的方法和装置
公开(公告)号：US20120150214A1
公开(公告)日：2012-06-14
申请号：US13403441
申请日：2012-02-23
申请人： Chad J. Kugler , Jerome K. Grudem, JR. , Todd A. Berg , William J. Swanson
发明人： Chad J. Kugler , Jerome K. Grudem, JR. , Todd A. Berg , William J. Swanson
IPC分类号： A61B17/12
CPC分类号： A61B17/12009 , A61B17/12013 , A61B2017/00827 , A61B2017/00876 , A61B2017/12018 , A61F2/0036 , A61F5/005 , A61F5/0069
摘要： A plurality of structures that resiliently attract one another are provided for implanting in a patient around a body tissue structure of the patient. For example, the body tissue structure may be the esophagus, and the plurality of structures may be implanted in an annulus around the outside of the esophagus, the annulus being substantially coaxial with the esophagus. The attraction may be between annularly adjacent ones of the structures in the annulus, and it may be provided, for example, by magnets or springs. The array of structures is preferably self-limiting with respect to the smallest area that it can encompass, and this smallest area is preferably large enough to prevent the apparatus from applying excessive pressure to tissue passing through that area.
摘要翻译：提供弹性地彼此吸引的多个结构，用于将患者周围的身体组织结构植入患者体内。例如，身体组织结构可以是食道，并且可以将多个结构植入围绕食管外侧的环带中，环与食道基本上同轴。吸引物可以在环形结构中的环形相邻结构之间，并且其可以例如由磁体或弹簧提供。结构的阵列优选地相对于其可以包围的最小面积是自限制的，并且该最小面积优选地足够大以防止装置对通过该区域的组织施加过大的压力。

6. 发明授权

US08187164B2 Methods and apparatus for treating body tissue sphincters and the like 有权
标题翻译：用于治疗身体组织括约肌等的方法和装置
公开(公告)号：US08187164B2
公开(公告)日：2012-05-29
申请号：US12610633
申请日：2009-11-02
申请人： Chad J. Kugler , Jerome K. Grudem, Jr. , Todd A. Berg , William J. Swanson
发明人： Chad J. Kugler , Jerome K. Grudem, Jr. , Todd A. Berg , William J. Swanson
IPC分类号： A61F2/00 , A61F13/00
CPC分类号： A61B17/12009 , A61B17/12013 , A61B2017/00827 , A61B2017/00876 , A61B2017/12018 , A61F2/0036 , A61F5/005 , A61F5/0069
摘要： A plurality of structures that resiliently attract one another are provided for implanting in a patient around a body tissue structure of the patient. For example, the body tissue structure may be the esophagus, and the plurality of structures may be implanted in an annulus around the outside of the esophagus, the annulus being substantially coaxial with the esophagus. The attraction may be between annularly adjacent ones of the structures in the annulus, and it may be provided, for example, by magnets or springs. The array of structures is preferably self-limiting with respect to the smallest area that it can encompass, and this smallest area is preferably large enough to prevent the apparatus from applying excessive pressure to tissue passing through that area.
摘要翻译：提供弹性地彼此吸引的多个结构，用于将患者周围的身体组织结构植入患者体内。例如，身体组织结构可以是食道，并且可以将多个结构植入围绕食管外侧的环带中，环与食道基本上同轴。吸引物可以在环形结构中的环形相邻结构之间，并且其可以例如由磁体或弹簧提供。结构的阵列优选地相对于其可以包围的最小面积是自限制的，并且该最小面积优选地足够大以防止装置对通过该区域的组织施加过大的压力。

7. 发明申请

US20100076573A1 METHODS AND APPARATUS FOR TREATING BODY TISSUE SPHINCTERS AND THE LIKE 有权
标题翻译：用于治疗身体组织细胞的方法和装置
公开(公告)号：US20100076573A1
公开(公告)日：2010-03-25
申请号：US12610633
申请日：2009-11-02
申请人： Chad J. Kugler , Jerome K. Grudem, JR. , Todd A. Berg , William J. Swanson
发明人： Chad J. Kugler , Jerome K. Grudem, JR. , Todd A. Berg , William J. Swanson
IPC分类号： A61F2/04 , A61B17/08
CPC分类号： A61B17/12009 , A61B17/12013 , A61B2017/00827 , A61B2017/00876 , A61B2017/12018 , A61F2/0036 , A61F5/005 , A61F5/0069
摘要： A plurality of structures that resiliently attract one another are provided for implanting in a patient around a body tissue structure of the patient. For example, the body tissue structure may be the esophagus, and the plurality of structures may be implanted in an annulus around the outside of the esophagus, the annulus being substantially coaxial with the esophagus. The attraction may be between annularly adjacent ones of the structures in the annulus, and it may be provided, for example, by magnets or springs. The array of structures is preferably self-limiting with respect to the smallest area that it can encompass, and this smallest area is preferably large enough to prevent the apparatus from applying excessive pressure to tissue passing through that area.
摘要翻译：提供弹性地彼此吸引的多个结构，用于将患者周围的身体组织结构植入患者体内。例如，身体组织结构可以是食道，并且可以将多个结构植入围绕食管外侧的环带中，环与食道基本上同轴。吸引物可以在环形结构中的环形相邻结构之间，并且其可以例如由磁体或弹簧提供。结构的阵列优选地相对于其可以包围的最小面积是自限制的，并且该最小面积优选地足够大以防止装置对通过该区域的组织施加过大的压力。

8. 发明授权

US06960233B1 Methods and apparatus for improving the function of biological passages 有权
标题翻译：改善生物通道功能的方法和装置
公开(公告)号：US06960233B1
公开(公告)日：2005-11-01
申请号：US10732696
申请日：2003-12-09
申请人： Todd A. Berg , Jeffrey G. Torborg
发明人： Todd A. Berg , Jeffrey G. Torborg
IPC分类号： A61F2/04
CPC分类号： A61F2/04
摘要： Several methods and apparatus are available for treating patients that suffer from both gastro-esophageal reflux disorder and hiatal hernias. In order to treat these patients, an endoscopic probe may be used to push the herniated stomach below the diaphragm. In some embodiments, a two-part stent comprising a funnel stent and a reverse stent may be deployed to prevent a future re-herniation of the stomach and to reduce the annulus of the lower esophageal sphincter. In some embodiments, a reverse stent with perforating barbs may be deployed, in which the barbs penetrate the esophageal wall and attach to the diaphragm. In some embodiments, the crus muscles may be sutured together to reduce the hiatus size and a reverse stent may be deployed to reduce the annulus of the lower esophageal sphincter.
摘要翻译：几种方法和装置可用于治疗患有胃食管反流障碍和疝气疝的患者。为了治疗这些患者，可以使用内窥镜探针将疝气的胃推到隔膜下方。在一些实施例中，可以部署包括漏斗支架和反向支架的两部分支架，以防止将来的胃再狭窄并减少下食管括约肌的环。在一些实施例中，可以部署具有穿孔倒钩的反向支架，其中倒钩穿过食管壁并附接到隔膜。在一些实施例中，可以将小腿肌肉缝合在一起以减小间隙尺寸，并且可以部署反向支架以减少下食管括约肌的环。

9. 发明授权

US06212422B1 Catheter having a high tensile strength braid wire constraint and method of manufacture 有权
标题翻译：导管具有高拉伸强度编织线约束和制造方法
公开(公告)号：US06212422B1
公开(公告)日：2001-04-03
申请号：US09346973
申请日：1999-07-02
申请人： Todd A. Berg , Jason A. Galdonik , Henry Pepin , Brian Scovil
发明人： Todd A. Berg , Jason A. Galdonik , Henry Pepin , Brian Scovil
IPC分类号： A61B500
CPC分类号： A61M25/0012 , A61M25/0009 , A61M25/0015 , A61M25/005 , A61M39/10 , Y10T428/2935 , Y10T428/294
摘要： A tubing assembly for manufacture for a catheter of the type having an inner tubular member defining a lumen, an outer tubular member surrounding said inner member, and a support member mounted between the tubular members to provide rigidity to the flexible catheter. The support member comprises a high tensile strength wire braid, and in the preferred embodiment comprises a stainless steel wire braid which has been tempered or hardened. This higher tensile strength affords significantly greater kink resistance to the flexible catheter. One wire braid has a tensile strength in the range of 300 to 425 kpsi and a braid density of approximately 40 pic. The high tensile strength wire braid has the disadvantage of tending to flare out at its free ends. Therefore, means are provided for preventing the flaring of the wire braid during manufacture of the tubing assembly. One means includes adhesive applied over the free ends. Another means includes a restraining sleeve applied over the free ends.
摘要翻译：一种用于制造导管的管组件，其具有限定内腔的内部管状构件，围绕所述内部构件的外部管状构件和安装在管状构件之间的支撑构件，以向柔性导管提供刚性。支撑构件包括高抗拉强度的线编织物，并且在优选实施例中包括已经回火或硬化的不锈钢丝编织物。这种较高的拉伸强度使柔性导管具有显着更大的扭结抗性。一根丝编织物的拉伸强度范围为300至425kpsi，编织密度约为40pi。高抗拉强度丝编织物的缺点在于它的自由端有倾向。因此，提供了用于在制造管组件期间防止线编织物的扩口的装置。一种方法包括在自由端施加的粘合剂。另一种装置包括施加在自由端上的限制套筒。

10. 发明授权

US5762637A Insert molded catheter tip 失效
标题翻译：插入模制导管尖端
公开(公告)号：US5762637A
公开(公告)日：1998-06-09
申请号：US703641
申请日：1996-08-27
申请人： Todd A. Berg , Bruce Ebner
发明人： Todd A. Berg , Bruce Ebner
IPC分类号： A61M25/00 , A61M25/16 , A61M5/00
CPC分类号： A61M25/001 , A61M25/0069 , A61M2025/0081 , A61M25/008 , B29L2031/7542
摘要： A catheter incorporating an insert molded tip and an improved method of manufacture that is simple, efficient, and significantly reduces current scrap rates for soft tip attachment to catheters. One catheter shaft embodiment includes a counterbored distal portion having anchor holes through the wall of the catheter body in this distal portion. In another embodiment, the catheter shaft has a reduced diameter portion including anchor holes. In yet another embodiment the catheter shaft has external longitudinal and external grooves. The tip is injection molded onto the body with tip material filling the counterbore, reduced diameter portion, anchor holes, and grooves to form integral anchors to secure the tip.
摘要翻译：包括插入模制尖端的导管和改进的制造方法，其简单，有效并且显着降低软尖端附着于导管的当前废品率。一个导管轴实施例包括一个沉积的远端部分，该远端部分在该远侧部分中具有穿过导管主体的壁的锚定孔。在另一个实施例中，导管轴具有包括锚孔的直径减小的部分。在另一个实施例中，导管轴具有外部纵向和外部凹槽。尖端注射成型到主体上，其尖端材料填充沉孔，减径部分，锚定孔和凹槽以形成一体的锚固件以固定尖端。

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