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1. 发明授权

US08808364B2 Local delivery of therapeutic agent to heart valves 有权
标题翻译：局部向心脏瓣膜递送治疗剂
公开(公告)号：US08808364B2
公开(公告)日：2014-08-19
申请号：US13240792
申请日：2011-09-22
申请人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
发明人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
IPC分类号： A61F2/06 , A61M29/00
CPC分类号： A61M31/002 , A61F2/24 , A61F2250/0067
摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.
摘要翻译：本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。在一个实施例中，提供了包括身体的医疗装置。身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。然后释放的治疗剂可以被递送到心脏瓣膜。

2. 发明授权

US07892205B2 Device and method for delivering micronized therapeutic agents in the body 失效
标题翻译：在体内递送微粉治疗剂的装置和方法
公开(公告)号：US07892205B2
公开(公告)日：2011-02-22
申请号：US10455298
申请日：2003-06-06
申请人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
发明人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
IPC分类号： A61M37/00
CPC分类号： A61M11/06 , A61M25/0054 , A61M2025/0057
摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.
摘要翻译：本发明提供一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。微粉化治疗剂以气溶胶形式或干粉形式递送。本发明还提供了一种通过将治疗剂放置在导管中将微粉化治疗剂递送到体内的靶位点的方法，将导管定位在靶位点，并将治疗剂暴露于足以产生超音速流动的激励机制将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。

3. 发明授权

US07517338B2 Delivery of therapeutic through multiple delivery members 有权
标题翻译：通过多个递送成员递送治疗
公开(公告)号：US07517338B2
公开(公告)日：2009-04-14
申请号：US11038241
申请日：2005-01-21
申请人： Toby Freyman , Maria Palasis , Wendy Naimark , William J. Shaw
发明人： Toby Freyman , Maria Palasis , Wendy Naimark , William J. Shaw
IPC分类号： A61M25/00 , A61M29/00
CPC分类号： A61M25/0068 , A61B2017/00247 , A61B2018/00392 , A61M25/0071 , A61M25/0074 , A61M25/0084 , A61M25/10 , A61M2025/0058 , A61M2025/0076 , A61M2025/0079 , A61M2025/0085 , A61M2025/0681
摘要： Embodiments of the present invention regard the delivery of therapeutic. One such apparatus may comprise multiple, independently-activated, injection devices for the delivery of therapeutic or other substances. This apparatus may include a first catheter; a second catheter in the first catheter and a multiple delivery member injection device. This multiple delivery member may include an expandable member and a plurality of injection elements. A third catheter may be positioned in the second catheter. This third catheter may have a distal end connected to a wall of the expandable member and a plurality of filling tubes connected to an distal end of the third catheter. In some of the embodiments each of the injection elements may hold a pressurized therapeutic prior to release of the therapeutic.
摘要翻译：本发明的实施方案涉及治疗的递送。一种这样的装置可以包括用于递送治疗剂或其它物质的多个独立激活的注射装置。该装置可以包括第一导管; 第一导管中的第二导管和多个递送部件注射装置。该多个传送构件可以包括可扩张构件和多个注射元件。第三导管可以定位在第二导管中。该第三导管可以具有连接到可扩张构件的壁的远端和连接到第三导管的远端的多个填充管。在一些实施方案中，每个注射元件可以在释放治疗剂之前保持加压治疗。

4. 发明申请

US20070065414A1 Enhanced delivery of cells 审中-公开
标题翻译：增强细胞的传递
公开(公告)号：US20070065414A1
公开(公告)日：2007-03-22
申请号：US11227278
申请日：2005-09-16
申请人： Toby Freyman , Maria Palasis , Wendy Naimark
发明人： Toby Freyman , Maria Palasis , Wendy Naimark
IPC分类号： A61K35/14 , C12N5/08 , A61K38/20
CPC分类号： A61M25/10 , A61K31/28 , A61K31/7076 , A61K35/28 , A61K45/00 , A61K45/06 , A61K2300/00 , A61M5/1407 , A61M2025/1052 , A61M2210/125
摘要： The present invention provides a method comprising administering cells by infusion through a blood vessel and administering a vasodilator, a vascular enhancer, or both. In accordance with one embodiment, the delivery of stem cells to the myocardium by intracoronary infusion is improved by administration of one or more vasodilators and/or vascular permeability enhancers prior to or at the time of cell therapy.
摘要翻译：本发明提供了一种方法，其包括通过血管输注施用细胞并施用血管扩张剂，血管增强剂或两者。根据一个实施方案，通过在细胞治疗之前或期间通过施用一种或多种血管扩张剂和/或血管通透性增强剂来改善通过冠状动脉内输注将干细胞递送至心肌。

5. 发明申请

US20060195059A1 Delivery of therapeutic through multiple delivery members 有权
公开(公告)号：US20060195059A1
公开(公告)日：2006-08-31
申请号：US11038241
申请日：2005-01-21
申请人： Toby Freyman , Maria Palasis , Wendy Naimark , William Shaw
发明人： Toby Freyman , Maria Palasis , Wendy Naimark , William Shaw
IPC分类号： A61M29/00
CPC分类号： A61M25/0068 , A61B2017/00247 , A61B2018/00392 , A61M25/0071 , A61M25/0074 , A61M25/0084 , A61M25/10 , A61M2025/0058 , A61M2025/0076 , A61M2025/0079 , A61M2025/0085 , A61M2025/0681
摘要： Embodiments of the present invention regard the delivery of therapeutic. One such apparatus may comprise multiple, independently-activated, injection devices for the delivery of therapeutic or other substances. This apparatus may include a first catheter; a second catheter in the first catheter and a multiple delivery member injection device. This multiple delivery member may include an expandable member and a plurality of injection elements. A third catheter may be positioned in the second catheter. This third catheter may have a distal end connected to a wall of the expandable member and a plurality of filling tubes connected to an distal end of the third catheter. In some of the embodiments each of the injection elements may hold a pressurized therapeutic prior to release of the therapeutic.

6. 发明申请

US20060029720A1 Methods and apparatus for injection coating a medical device 审中-公开
标题翻译：用于注射涂覆医疗装置的方法和装置
公开(公告)号：US20060029720A1
公开(公告)日：2006-02-09
申请号：US10909408
申请日：2004-08-03
申请人： Anastasia Panos , Wendy Naimark , Maria Palasis , Toby Freyman , Samuel Epstein
发明人： Anastasia Panos , Wendy Naimark , Maria Palasis , Toby Freyman , Samuel Epstein
IPC分类号： A61L33/00 , B05C5/00
CPC分类号： B05C5/0208 , A61F2/86 , A61F2002/072 , A61L31/08 , A61L31/10 , A61L2420/02 , B05C13/025 , B05D1/002 , B05D1/26 , B05D1/30
摘要： Methods and apparatus for coating at least a portion of the surface of medical devices using an injection coating device are disclosed. In one embodiment, the invention includes a coating method wherein an orifice of the injection coating device is placed adjacent a vertically positioned medical device, coating material is ejected from the orifice onto the medical device, and the coating material gravitationally flows downward coating the medical device. In another embodiment, an orifice of an injection coating device is positioned adjacent a horizontally positioned medical device to gravitationally flow and deposit coating material onto the medical device. These methods may be used to apply one or more coating materials, simultaneously or in sequence. In another embodiment, multiple injection coating devices may be utilized. In certain embodiments of the invention, the coating materials include therapeutic or biologically active agents.
摘要翻译：公开了使用注射涂覆装置涂覆医疗装置的表面的至少一部分的方法和装置。在一个实施方案中，本发明包括一种涂覆方法，其中注射涂覆装置的孔口邻近垂直定位的医疗装置放置，涂层材料从孔口喷射到医疗装置上，并且涂覆材料重力地向下流动涂覆医疗装置。在另一个实施例中，注射涂覆装置的孔口邻近水平定位的医疗装置定位以重力地流动并将涂层材料沉积到医疗装置上。这些方法可以同时或按顺序施用一种或多种涂料。在另一个实施例中，可以使用多个注射涂覆装置。在本发明的某些实施方案中，涂层材料包括治疗或生物活性剂。

7. 发明申请

US20050181016A1 Decullularized extracellular matrix of conditioned body tissues and uses thereof 审中-公开
标题翻译：条状体组织的脱细胞细胞外基质及其用途
公开(公告)号：US20050181016A1
公开(公告)日：2005-08-18
申请号：US11076328
申请日：2005-03-10
申请人： Toby Freyman , Wendy Naimark , Maria Palasis
发明人： Toby Freyman , Wendy Naimark , Maria Palasis
IPC分类号： A61K35/12 , A61L27/36 , C12N5/071 , A61B17/58
CPC分类号： A61L27/3683 , A61K35/12 , A61L27/3633 , A61L2430/40 , C12N5/0679 , C12N2510/00
摘要： The invention is directed to an apparatus, such as a medical device, having a surface coated or covered with a decellularized extracellular matrix or having a component comprising the decellularized extracellular matrix for implantation into a subject, preferably a human. In one embodiment of the invention, a decellularized extracellular matrix is used to form a bodily implant such as a vein, an artery, an esophagus, or a ventricular restraining device. In some embodiments of the invention, the decellularized extracellular matrix is configured to be a time released therapeutic. In another embodiment of the invention, a decellularized extracellular matrix forms an aneurysm treatment device, such as an aneurysm coil, a seal, a pouch, or a filler. In a further embodiment of the invention, decellularized extracellular matrix is used to embolize lesions, tumors, or vessels. Methods for making the tissue regeneration scaffold and methods for manufacturing a coated or covered medical device having a component comprising decellularized extracellular matrix of body tissues are also provided.
摘要翻译：本发明涉及一种诸如医疗装置的装置，其具有被脱细胞的细胞外基质包被或覆盖的表面，或具有包含用于植入受试者，优选人的脱细胞的细胞外基质的组分。在本发明的一个实施方案中，使用脱细胞的细胞外基质形成诸如静脉，动脉，食管或心室抑制装置的身体植入物。在本发明的一些实施方案中，脱细胞的细胞外基质被配置为时间释放的治疗剂。在本发明的另一个实施方案中，脱细胞的细胞外基质形成动脉瘤治疗装置，例如动脉瘤线圈，密封件，小袋或填充物。在本发明的另一个实施方案中，脱细胞的细胞外基质用于栓塞病变，肿瘤或血管。还提供了用于制备组织再生支架的方法和用于制造具有包含身体组织的脱细胞的细胞外基质的组分的涂覆或覆盖的医疗装置的方法。

8. 发明授权

US08038709B2 Local delivery of therapeutic agent to heart valves 有权
标题翻译：局部向心脏瓣膜递送治疗剂
公开(公告)号：US08038709B2
公开(公告)日：2011-10-18
申请号：US12022413
申请日：2008-01-30
申请人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
发明人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
IPC分类号： A61F2/06 , A61M31/00
CPC分类号： A61M31/002 , A61F2/24 , A61F2250/0067
摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.
摘要翻译：本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。在一个实施例中，提供了包括身体的医疗装置。身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。然后释放的治疗剂可以被递送到心脏瓣膜。

9. 发明授权

US07674250B2 Methods of delivering therapeutic agents 失效
标题翻译：递送治疗剂的方法
公开(公告)号：US07674250B2
公开(公告)日：2010-03-09
申请号：US10211384
申请日：2002-08-05
申请人： Toby Freyman , Maria Palasis , Wendy Naimark
发明人： Toby Freyman , Maria Palasis , Wendy Naimark
IPC分类号： A61M31/00 , A61B17/32
CPC分类号： A61K9/0024 , A61K9/0019 , A61K47/42 , A61K47/46 , A61M37/00
摘要： Devices and methods of delivering therapeutic agents to tissue are provided, which provide reduced outflow of therapeutic agents from an injection site. The methods include delivering one or more clot-promoting substances, such as platelets, fibrin and/or thrombin, to the injection site to entrap the therapeutic agent in the injection site. Devices include devices that are suitable for use in the provided methods.
摘要翻译：提供将治疗剂递送至组织的装置和方法，其提供治疗剂从注射部位的流出减少。所述方法包括将一种或多种凝块促进物质（例如血小板，纤维蛋白和/或凝血酶）递送至注射部位以将治疗剂捕获到注射部位。设备包括适用于所提供方法的设备。

10. 发明授权

US07527604B2 Rotatable multi-port therapeutic delivery device 有权
标题翻译：可旋转多端口治疗输送装置
公开(公告)号：US07527604B2
公开(公告)日：2009-05-05
申请号：US11074850
申请日：2005-03-09
申请人： Wendy Naimark , Maria Palasis , Toby Freyman , William J. Shaw
发明人： Wendy Naimark , Maria Palasis , Toby Freyman , William J. Shaw
IPC分类号： A61M31/00 , A61M37/00
CPC分类号： A61M25/0069
摘要： A therapeutic delivery device is provided wherein a delivery body is supported by an elongate member such that the body may rotate as it delivers therapeutic to a target site. Therapeutic may be delivered by deploying delivery heads into a target site as well as by dispensing therapeutic from the delivery head. The delivery body may be cylindrically shaped, spherically shaped or shaped in various other configurations. In one embodiment the delivery body contains tracks that may roll back and forth over a target site to dispense therapeutic. In another embodiment, the delivery heads of the delivery body have internal valves that open and close in order to dispense therapeutic.
摘要翻译：提供了一种治疗性递送装置，其中递送体由细长构件支撑，使得主体在将治疗递送至目标部位时可旋转。可以通过将输送头部署到目标部位以及通过从输送头分配治疗剂来递送治疗剂。输送体可以是各种其他构型的圆柱形，球形或成形。在一个实施方案中，递送体包含可以在靶位点上来回滚动以分配治疗剂的轨迹。在另一个实施例中，输送体的输送头具有打开和关闭的内部阀，以便分配治疗剂。

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