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1. 发明授权

US07360893B2 Systems and methods for shaping wavefronts in polychromatic light using phase shifting elements 有权
标题翻译：使用相移元件在多色光中整形波前的系统和方法
公开(公告)号：US07360893B2
公开(公告)日：2008-04-22
申请号：US10930730
申请日：2004-08-31
申请人： Tobias Kuhn , Ulrich von Pape
发明人： Tobias Kuhn , Ulrich von Pape
IPC分类号： A61B3/10
CPC分类号： G02B26/06 , G01J9/00
摘要： A system for producing polychromatic light having selectively shaped wavefronts includes a source for generating light beams of at least two wavelengths (λ1, λ2). The beams are made up of a plurality of contiguous sub-beams that establish λ1 and λ2 wavefronts. From the source, the light is directed toward an optical phase shifting device which can include one or more arrays, with each array having a plurality of elements. Functionally, within a particular array, each element is independently adjustable to selectively alter the optical pathlength of a corresponding sub-beam. For light having two wavelengths (λ1, λ2), a first array configuration is used to reshape the λ1 wavelength light and a second array configuration is used to reshape the λ2 wavelength light. After wavefront reshaping, the λ1 and λ2 wavelength light is directed onto a common beam path where it can be viewed, imaged or further processed.
摘要翻译：用于产生具有选择性地形成波前的多色光的系统包括用于产生至少两个波长（λ1λ2，λ2 2）的光束的光源。这些光束由多个连续的子光束组成，它们建立λ1和λ2波前。从光源开始，光被引导到可以包括一个或多个阵列的光学相移装置，每个阵列具有多个元件。在功能上，在特定阵列内，每个元件可独立调节以选择性地改变相应子光束的光程长度。对于具有两个波长（λ1，λ2，λ2）的光，使用第一阵列配置来重新形成λ1λ波长的光，并且使用第二阵列阵列配置用于重新形成λ<2>波长的光。在波前整形之后，λ1和λ2波长光被引导到共同的光束路径上，在那里可以观察，成像或进一步处理它们。

2. 发明申请

US20070173796A1 Device and method for calibrating a laser system 审中-公开
标题翻译：用于校准激光系统的装置和方法
公开(公告)号：US20070173796A1
公开(公告)日：2007-07-26
申请号：US11339309
申请日：2006-01-25
申请人： Ralf Kessler , Marcel Martin , Stefan Wuhl , Tobias Kuhn , Ulrich von Pape
发明人： Ralf Kessler , Marcel Martin , Stefan Wuhl , Tobias Kuhn , Ulrich von Pape
IPC分类号： A61B18/18
CPC分类号： A61F9/008 , A61B2017/00712 , A61F9/00825 , A61F9/0084 , A61F2009/00855 , A61F2009/00872
摘要： A device for calibrating a laser beam system includes a calibration member having a surface positioned at a predetermined distance from the base datum of the unit. Further, the system includes a mechanism for focusing the beam to a focal point and for moving the focal point relative to the surface of the calibration member. When the focal point reaches the surface of the calibration member, Laser Induced Optical Breakdown (LIOB) is induced. Thereafter, the position of the location of LIOB may be measured relative to the base datum to calibrate the laser beam. Further, patterns may be applied to the calibration member using LIOB to calibrate tilt/decenter of the beam and to determine the energy density and uniformity in the focal spot of the laser beam.
摘要翻译：用于校准激光束系统的装置包括校准构件，其具有位于与单元的基准原点预定距离的表面。此外，该系统包括用于将光束聚焦到焦点并用于相对于校准部件的表面移动焦点的机构。当焦点到达校准构件的表面时，引起激光诱导光击穿（LIOB）。此后，可以相对于基准面测量LIOB的位置的位置，以校准激光束。此外，可以使用LIOB将图案应用于校准构件，以校准光束的倾斜/偏心，并且确定激光束的焦斑中的能量密度和均匀性。

3. 发明申请

US20060061731A1 Systems and methods for shaping wavefronts in polychromatic light using phase shifting elements 有权
标题翻译：使用相移元件在多色光中整形波前的系统和方法
公开(公告)号：US20060061731A1
公开(公告)日：2006-03-23
申请号：US10930730
申请日：2004-08-31
申请人： Tobias Kuhn , Ulrich Pape
发明人： Tobias Kuhn , Ulrich Pape
IPC分类号： A61B3/10
CPC分类号： G02B26/06 , G01J9/00
摘要： A system for producing polychromatic light having selectively shaped wavefronts includes a source for generating light beams of at least two wavelengths (λ1, λ2). The beams are made up of a plurality of contiguous sub-beams that establish λ1 and λ2 wavefronts. From the source, the light is directed toward an optical phase shifting device which can include one or more arrays, with each array having a plurality of elements. Functionally, within a particular array, each element is independently adjustable to selectively alter the optical pathlength of a corresponding sub-beam. For light having two wavelengths (λ1, λ2), a first array configuration is used to reshape the λ1 wavelength light and a second array configuration is used to reshape the λ2 wavelength light. After wavefront reshaping, the λ1 and λ2 wavelength light is directed onto a common beam path where it can be viewed, imaged or further processed.
摘要翻译：用于产生具有选择性地形成波前的多色光的系统包括用于产生至少两个波长（λ1λ2，λ2 2）的光束的光源。这些光束由多个连续的子光束组成，它们建立λ1和λ2波前。从光源开始，光被引导到可以包括一个或多个阵列的光学相移装置，每个阵列具有多个元件。在功能上，在特定阵列内，每个元件可独立调节以选择性地改变相应子光束的光程长度。对于具有两个波长（λ1，λ2，λ2）的光，使用第一阵列配置来重新形成λ1λ波长的光，并且使用第二阵列阵列配置用于重新形成λ<2>波长的光。在波前整形之后，λ1和λ2波长光被引导到共同的光束路径上，在那里可以观察，成像或进一步处理它们。

4. 发明授权

US07717905B2 Time-resolved scanning patterns for intrastromal surgery 有权
标题翻译：时间分辨扫描模式进行胸腔内手术
公开(公告)号：US07717905B2
公开(公告)日：2010-05-18
申请号：US10978613
申请日：2004-11-01
申请人： Frieder Loesel , Tobias Kuhn
发明人： Frieder Loesel , Tobias Kuhn
IPC分类号： A61F9/008
CPC分类号： A61F9/008 , A61F9/00825 , A61F2009/00872 , A61F2009/00897
摘要： A system and method for performing laser induced optical breakdown (LIOB) in corneal tissue of an eye requires calculating a pattern of focal spots. LIOB is then induced at a first focal spot, and is continued at a plurality of interim focal spots within a time period τ. Each focal spot has a diameter “d1” and generates a temporal cavitation bubble of diameter “d2”. It then collapses within time “τ” to a substantially stationary diameter “d3”, with (d1≦d3≦d2). Importantly, each focal spot is located more than “d2” from every other interim focal spot within the time period of “τ”. At the time “τ”, a second focal spot in the pattern can be generated at a distance “d3” from the first focal spot. This process is then continued with another plurality of interim focal spots being generated within another time period “τ”.
摘要翻译：用于在眼睛的角膜组织中进行激光诱导光学击穿（LIOB）的系统和方法需要计算焦点的图案。然后在第一焦点处诱导LIOB，并且在时间段τ内在多个临时焦斑处继续。每个焦斑具有直径“d1”，并产生直径“d2”的时间空化气泡。然后在时间“τ”内崩溃到基本上静止的直径“d3”，其中（d1＆nlE; d3＆nlE; d2）。重要的是，在“τ”的时间段内，每个焦斑位于距离每个其他中间焦点的“d2”以上。在时间“τ”，可以在与第一焦点相距“d3”的距离处产生图案中的第二焦点。然后继续在另一个时间段“τ”内产生另外多个临时焦斑的过程。

5. 发明申请

US20070244472A1 SYSTEM AND METHOD FOR CREATING SUTURE CHANNELS 审中-公开
标题翻译：创建通道的系统和方法
公开(公告)号：US20070244472A1
公开(公告)日：2007-10-18
申请号：US11279959
申请日：2006-04-17
申请人： Tobias Kuhn , Julian Stevens
发明人： Tobias Kuhn , Julian Stevens
IPC分类号： A61B18/18
CPC分类号： A61F9/008 , A61B2017/00969 , A61F2/142 , A61F9/00831 , A61F2009/00872
摘要： A device and method are provided for grafting a donor component onto a recipient member. In the method, a void in the recipient member is defined by a boundary with predetermined dimensions. Similarly, the donor component is specified as having a boundary with predetermined dimensions that are substantially compatible with the void. Thereafter, suture paths are created in the donor component and the recipient member. When the donor component has been positioned in the void of the recipient member, the suture paths are aligned. Then, a suture is passed through the suture path and across the respective boundaries to secure the donor component to the recipient member.
摘要翻译：提供了一种用于将供体组件接枝到受体构件上的装置和方法。在该方法中，受体构件中的空隙由具有预定尺寸的边界限定。类似地，供体部件被指定为具有与空隙基本相容的预定尺寸的边界。此后，在供体部件和受体部件中产生缝线路径。当供体部件已经定位在受体构件的空隙中时，缝线路径被对准。然后，将缝合线穿过缝线路径并穿过相应的边界，以将供体组件固定到受体构件。

6. 发明申请

US20060106372A1 Systems and methods for intrastromal scanning patterns 有权
标题翻译：体内扫描模式的系统和方法
公开(公告)号：US20060106372A1
公开(公告)日：2006-05-18
申请号：US10987542
申请日：2004-11-12
申请人： Tobias Kuhn , Frieder Loesel
发明人： Tobias Kuhn , Frieder Loesel
IPC分类号： A61F9/008 , A61B18/18
CPC分类号： A61F9/008 , A61F9/00827 , A61F2009/00872 , A61F2009/00897
摘要： A method for photodisrupting a preselected subsurface volume of corneal tissue to alter a cornea's refractive properties is disclosed. Specifically, at least one stromal volume having a substantially conical shaped surface is photodisrupted. For this purpose, a laser device having a laser source, laser scanner and one or more optical elements is typically used. In one embodiment, a plurality of stromal volumes, with each stromal volume having a substantially conical shaped surface, is sequentially photodisrupted to form a contiguous stromal cavity. In a particular implementation, each conical shaped surface defines a cone axis that is aligned to be co-linear with a reference axis that passes through the anterior surface of the eye and may be aligned orthogonally to the anterior surface of the eye.
摘要翻译：公开了一种用于光破坏预选的地下体积的角膜组织以改变角膜的折射性质的方法。具体地说，具有基本圆锥形表面的至少一个基质体积被光破坏。为此，通常使用具有激光源，激光扫描器和一个或多个光学元件的激光装置。在一个实施方案中，具有每个基质体积具有基本上圆锥形表面的多个基质体积被顺序地光致破坏以形成连续的基质腔。在特定实施方案中，每个圆锥形表面限定锥形轴线，该锥形轴线对齐以与穿过眼睛前表面的参考轴线共线，并且可以与眼睛的前表面正交对齐。

7. 发明申请

US20060020259A1 System for performing a corneal transplantation 审中-公开
标题翻译：执行角膜移植的系统
公开(公告)号：US20060020259A1
公开(公告)日：2006-01-26
申请号：US10895276
申请日：2004-07-20
申请人： Klaus Baumeister , Tobias Kuhn , Frieder Loesel , Fritz Meisel
发明人： Klaus Baumeister , Tobias Kuhn , Frieder Loesel , Fritz Meisel
IPC分类号： A61F9/009 , A61B18/20 , A61F9/01
CPC分类号： A61F9/009 , A61B2017/00969 , A61F9/00831 , A61F2009/00846 , A61F2009/00872
摘要： A system for performing a corneal transplantation includes a laser source for generating a laser beam and a chair for positioning a patient relative to the laser source. A stabilizing element, engageable with the laser source, is fixated on the anterior surface of the patient's cornea to hold the cornea in alignment with the laser source. The laser source is then used to remove diseased tissue from the cornea of the patient, thereby creating a corneal cavity of known dimensions. In a subsequent step, a donor graft that was previously photoaltered to have substantially the same dimensions as the corneal cavity, is transplanted into the corneal cavity.
摘要翻译：用于进行角膜移植的系统包括用于产生激光束的激光源和用于相对于激光源定位患者的椅子。与激光源接合的稳定元件被固定在患者角膜的前表面上，以将角膜保持与激光源对准。然后将激光源用于从患者角膜去除病变组织，从而产生已知尺寸的角膜腔。在随后的步骤中，先前被光学变化以具有与角膜腔基本相同的尺寸的供体移植物移植到角膜腔中。

8. 发明授权

US07892225B2 Devices and methods for separating layers of materials having different ablation thresholds 有权
标题翻译：用于分离具有不同消融阈值的材料层的装置和方法
公开(公告)号：US07892225B2
公开(公告)日：2011-02-22
申请号：US11015338
申请日：2004-12-17
申请人： Martin Weinacht , Frieder Loesel , Tobias Kuhn
发明人： Martin Weinacht , Frieder Loesel , Tobias Kuhn
IPC分类号： A61B18/18
CPC分类号： A61F9/008 , A61F9/00836 , A61F9/0084 , A61F2009/00872
摘要： A method and device for photoablation is disclosed wherein photoablation occurs along the interface between a material having a lower energy ablation threshold and a material having a higher energy ablation threshold. The method and device utilize a laser beam having a beam energy density which is less than the higher energy ablation threshold and greater than or equal to the lower energy ablation threshold. By directing such a laser beam to the interface, the material having the lower energy threshold is photoablated while the material having the higher energy threshold is largely unaffected.
摘要翻译：公开了一种用于光消融的方法和装置，其中光消除沿着具有较低能量消融阈值的材料和具有较高能量消融阈值的材料之间的界面发生。该方法和装置利用具有小于较高能量消融阈值并且大于或等于较低能量消融阈值的光束能量密度的激光束。通过将这样的激光束引导到界面，具有较低能量阈值的材料被光照化，而具有较高能量阈值的材料在很大程度上不受影响。

9. 发明授权

US07662148B2 Systems and methods for intrastromal scanning patterns 有权
标题翻译：体内扫描模式的系统和方法
公开(公告)号：US07662148B2
公开(公告)日：2010-02-16
申请号：US10987542
申请日：2004-11-12
申请人： Tobias Kuhn , Frieder Loesel
发明人： Tobias Kuhn , Frieder Loesel
IPC分类号： A61F9/008
CPC分类号： A61F9/008 , A61F9/00827 , A61F2009/00872 , A61F2009/00897
摘要： A method for photodisrupting a preselected subsurface volume of corneal tissue to alter a cornea's refractive properties is disclosed. Specifically, at least one stromal volume having a substantially conical shaped surface is photodisrupted. For this purpose, a laser device having a laser source, laser scanner and one or more optical elements is typically used. In one embodiment, a plurality of stromal volumes, with each stromal volume having a substantially conical shaped surface, is sequentially photodisrupted to form a contiguous stromal cavity. In a particular implementation, each conical shaped surface defines a cone axis that is aligned to be co-linear with a reference axis that passes through the anterior surface of the eye and may be aligned orthogonally to the anterior surface of the eye.
摘要翻译：公开了一种用于光破坏预选的地下体积的角膜组织以改变角膜的折射性质的方法。具体地说，具有基本圆锥形表面的至少一个基质体积被光破坏。为此，通常使用具有激光源，激光扫描器和一个或多个光学元件的激光装置。在一个实施方案中，具有每个基质体积具有基本上圆锥形表面的多个基质体积被顺序地光致破坏以形成连续的基质腔。在特定实施方案中，每个圆锥形表面限定锥形轴线，该锥形轴线对齐以与穿过眼睛前表面的参考轴线共线，并且可以与眼睛的前表面正交对齐。

10. 发明授权

US07390089B2 Device and method for aligning an eye with a surgical laser 有权
标题翻译：用于使眼睛与手术激光器对准的装置和方法
公开(公告)号：US07390089B2
公开(公告)日：2008-06-24
申请号：US11066726
申请日：2005-02-25
申请人： Frieder Loesel , Fritz Meisel , Bernhard Gress , Tobias Kuhn
发明人： Frieder Loesel , Fritz Meisel , Bernhard Gress , Tobias Kuhn
IPC分类号： A61B3/00
CPC分类号： A61F9/009 , A61B2017/306 , A61F9/008
摘要： A device for establishing a desired alignment between a patient's eye and a laser system to facilitate an engagement therebetween includes a light source to illuminate the eye. A moveable platform is provided to move the patient relative to the laser system. To establish alignment between the eye and the laser system, a reference marker is based on the laser system. An image of the marker, along with reflections from the illuminated eye, is then transmitted to the system controller. There, the image and reflections are processed to determine a measured alignment that is then compared to the desired alignment. An error signal that is indicative of an alignment difference is then generated and used to incrementally move the platform, or the patient, in an appropriate direction.
摘要翻译：用于在患者的眼睛和激光系统之间建立期望的对准以便于其间的接合的装置包括照亮眼睛的光源。提供可移动平台以相对于激光系统移动患者。为了建立眼睛和激光系统之间的对准，参考标记基于激光系统。然后将标记的图像以及来自照明眼睛的反射传输到系统控制器。在那里，处理图像和反射以确定测量的对准，然后将其与期望的对准进行比较。然后产生指示对准差异的误差信号并用于沿适当的方向递增地移动平台或患者。

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