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1. 发明授权

US06649595B2 Regulation of biological events using novel compounds 有权
公开(公告)号：US06649595B2
公开(公告)日：2003-11-18
申请号：US09781804
申请日：2001-02-12
申请人： Timothy P. Clackson , Michael Z. Gilman , Dennis A. Holt , Terence P. Keenan , Leonard Rozamus , Wu Yang
发明人： Timothy P. Clackson , Michael Z. Gilman , Dennis A. Holt , Terence P. Keenan , Leonard Rozamus , Wu Yang
IPC分类号： C12N510
CPC分类号： C07K14/715 , A61K48/00 , C07D498/18 , C07K14/005 , C07K14/395 , C07K14/47 , C07K14/7051 , C07K14/70578 , C07K2319/00 , C12N9/1205 , C12N15/1055 , C12N15/85 , C12N2710/16622 , C12N2830/002 , C12N2840/203
摘要： Materials and methods are disclosed for regulation of biological events such as target gene transcription and growth, proliferation or differentiation of engineered cells.

2. 发明授权

US06693189B2 Materials and method for treating or preventing pathogenic fungal infection 有权
标题翻译：用于治疗或预防致病性真菌感染的材料和方法
公开(公告)号：US06693189B2
公开(公告)日：2004-02-17
申请号：US09902180
申请日：2001-07-10
申请人： Dennis A. Holt , Terence P. Keenan , Timothy P. Clackson , Leonard Rozamus , Wu Yang , Michael Z. Gilman
发明人： Dennis A. Holt , Terence P. Keenan , Timothy P. Clackson , Leonard Rozamus , Wu Yang , Michael Z. Gilman
IPC分类号： C07D48700
CPC分类号： C07D498/16
摘要： This invention concerns derivatives of rapamycin and their antifungal uses. Also disclosed are materials and methods relevant to the identification of non-immunosuppressive anti-fungal rapamycin derivatives. Use of compounds, among others, of the formula is disclosed, where the various substitutents are as defined.
摘要翻译：本发明涉及雷帕霉素的衍生物及其抗真菌用途。还公开了与非免疫抑制性抗真菌雷帕霉素衍生物的鉴定相关的材料和方法。使用所公开的化合物，其中各种取代基如所定义。

3. 发明授权

US06258823B1 Materials and method for treating or preventing pathogenic fungal infection 有权
标题翻译：用于治疗或预防致病性真菌感染的材料和方法
公开(公告)号：US06258823B1
公开(公告)日：2001-07-10
申请号：US09101616
申请日：1998-11-02
申请人： Dennis A. Holt , Terence P. Keenan , Timothy P. Clackson , Leonard Rozamus , Wu Yang , Michael Z. Gilman
发明人： Dennis A. Holt , Terence P. Keenan , Timothy P. Clackson , Leonard Rozamus , Wu Yang , Michael Z. Gilman
IPC分类号： A61K3144
CPC分类号： C07D498/16
摘要： This invention concerns derivatives of rapamycin and their antifungal uses. Also disclosed are materials and methods relevant to the identification of non-immunosuppressive antifungal rapamycin derivatives.
摘要翻译：本发明涉及雷帕霉素的衍生物及其抗真菌用途。还公开了与非免疫抑制性抗真菌雷帕霉素衍生物的鉴定相关的材料和方法。

4. 发明授权

US06187757B1 Regulation of biological events using novel compounds 失效
标题翻译：使用新化合物调节生物活性
公开(公告)号：US06187757B1
公开(公告)日：2001-02-13
申请号：US09012097
申请日：1998-01-22
申请人： Timothy P. Clackson , Michael Z. Gilman , Dennis A. Holt , Terence P. Keenan , Leonard Rozamus , Wu Yang
发明人： Timothy P. Clackson , Michael Z. Gilman , Dennis A. Holt , Terence P. Keenan , Leonard Rozamus , Wu Yang
IPC分类号： A61K3170
CPC分类号： C07K14/715 , A61K48/00 , C07D498/18 , C07K14/005 , C07K14/395 , C07K14/47 , C07K14/7051 , C07K14/70578 , C07K2319/00 , C12N9/1205 , C12N15/1055 , C12N15/85 , C12N2710/16622 , C12N2830/002 , C12N2840/203
摘要： Materials and methods are disclosed for regulation of biological events such as target gene transcription and growth, proliferation or differentiation of engineered cells.
摘要翻译：公开了用于调节生物事件的材料和方法，例如靶基因转录和工程细胞的生长，增殖或分化。

5. 发明申请

US20090215812A1 BIOMARKERS FOR EVALUATING LIKELIHOOD OF TUMOR SENSITIVITY TO AN MTOR INHIBITOR 审中-公开
标题翻译：用于评估肿瘤抑制剂的肿瘤敏感性的生物标志物
公开(公告)号：US20090215812A1
公开(公告)日：2009-08-27
申请号：US11913964
申请日：2006-05-08
申请人： Camille L. Bedrosian , Timothy P. Clackson , Victor Rivera
发明人： Camille L. Bedrosian , Timothy P. Clackson , Victor Rivera
IPC分类号： A61K31/436 , C12Q1/00 , C12Q1/68 , G01N33/53
CPC分类号： C12N5/0607 , C12N5/0676 , C12N2501/117 , C12N2506/03
摘要： The present invention provides compositions and methods for evaluating the likelihood that a tumor is sensitive to an mTOR inhibitor, e.g., rapamycin or a rapamycin analog. The invention provides FKBP proteins as biomarkers for predicting the likelihood that a tumor is sensitive to an mTOR inhibitor. The methods include assessing the expression or activity of an FKBP protein, e.g., FKBP 12, in a subject with a tumor or in a sample derived from a tumor. Additional biomarkers and biomarker combinations are also provided. The invention also provides kits containing, e.g., a validated antibody or ligand for assessing the expression or activity of an FKBP protein.
摘要翻译：本发明提供用于评价肿瘤对mTOR抑制剂例如雷帕霉素或雷帕霉素类似物敏感的可能性的组合物和方法。本发明提供FKBP蛋白作为生物标志物，用于预测肿瘤对mTOR抑制剂敏感的可能性。所述方法包括在具有肿瘤的受试者或衍生自肿瘤的样品中评估FKBP蛋白（例如FKBP 12）的表达或活性。还提供了额外的生物标志物和生物标志物组合。本发明还提供了包含例如用于评估FKBP蛋白的表达或活性的经验证的抗体或配体的试剂盒。

6. 发明申请

US20120316137A1 Methods and Compositions for Treating Cancer 审中-公开
标题翻译：治疗癌症的方法和组成
公开(公告)号：US20120316137A1
公开(公告)日：2012-12-13
申请号：US13504251
申请日：2010-11-01
申请人： Wei-Sheng Huang , Victor M. Rivera , Timothy P. Clackson , William C. Shakespeare , Rachel M. Squillace , Joseph M. Gozgit
发明人： Wei-Sheng Huang , Victor M. Rivera , Timothy P. Clackson , William C. Shakespeare , Rachel M. Squillace , Joseph M. Gozgit
IPC分类号： A61K31/5025 , A61P35/02 , A61K31/553 , A61K31/5377 , A61K31/519 , A61K31/53 , A61P35/00 , A61K31/675
CPC分类号： C07D487/04 , A61K31/5025
摘要： The invention features methods, kits, and pharmaceutical compositions for treating cancer using 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)-methyl)-3-(trifluoromethyl)phenyl)benzamide.
摘要翻译：本发明的特征在于使用3-（咪唑并[1,2-b]哒嗪-3-基乙炔基）-4-甲基-N-（4 - （（4-甲基哌嗪-1-基）） - 甲基）-3-（三氟甲基）苯基）苯甲酰胺。

7. 发明授权

US06506379B1 Intramuscular delivery of recombinant AAV 有权
标题翻译：肌内递送重组AAV
公开(公告)号：US06506379B1
公开(公告)日：2003-01-14
申请号：US09481620
申请日：2000-01-12
申请人： Timothy P. Clackson , Michael Gilman , Dennis Holt
发明人： Timothy P. Clackson , Michael Gilman , Dennis Holt
IPC分类号： A61K4800
CPC分类号： C12N9/1205 , A61K48/00 , C07K14/715 , C07K2319/00 , C12N15/1055 , C12N15/85 , C12N2830/002 , C12N2840/203
摘要： This invention concerns new configurations for biological switches and provides new methods and materials useful for regulating biological events in animal cells. The invention involves recombinant DNA constructs comprising DNA sequences derived from sequences encoding the proteins FRAP, Tor1, Tor2 and other proteins capable of binding to FKBP:rapamycin, other recombinant DNA constructs comprising DNA sequences encoding part or all of an FKBP protein, the proteins encoded by those constructs, cells (especially animal cells) transformed with one or more of the constructs, small molecules (multivalent multimerizing agents) which bind to and are capable of inducing multimerization of the chimeric proteins, and methods for preparing and using the foregoing, including methods involving the intramuscular delivery of such recombinant DNA constructs in AAV virus particles.
摘要翻译：本发明涉及用于生物开关的新配置，并且提供了用于调节动物细胞中的生物学事件的新方法和材料。本发明涉及包含衍生自编码蛋白质FRAP，Tor1，Tor2和能够结合FKBP：雷帕霉素的其他蛋白质的序列的DNA序列的重组DNA构建体，包含编码部分或全部FKBP蛋白的DNA序列的其他重组DNA构建体，编码通过这些构建体，用一种或多种构建体转化的细胞（特别是动物细胞），结合并能够诱导嵌合蛋白多聚化的小分子（多价多聚化剂），以及制备和使用前述物质的方法，包括涉及在AAV病毒颗粒中肌内递送这些重组DNA构建体的方法。

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