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1. 发明授权

US06506379B1 Intramuscular delivery of recombinant AAV 有权
标题翻译：肌内递送重组AAV
公开(公告)号：US06506379B1
公开(公告)日：2003-01-14
申请号：US09481620
申请日：2000-01-12
申请人： Timothy P. Clackson , Michael Gilman , Dennis Holt
发明人： Timothy P. Clackson , Michael Gilman , Dennis Holt
IPC分类号： A61K4800
CPC分类号： C12N9/1205 , A61K48/00 , C07K14/715 , C07K2319/00 , C12N15/1055 , C12N15/85 , C12N2830/002 , C12N2840/203
摘要： This invention concerns new configurations for biological switches and provides new methods and materials useful for regulating biological events in animal cells. The invention involves recombinant DNA constructs comprising DNA sequences derived from sequences encoding the proteins FRAP, Tor1, Tor2 and other proteins capable of binding to FKBP:rapamycin, other recombinant DNA constructs comprising DNA sequences encoding part or all of an FKBP protein, the proteins encoded by those constructs, cells (especially animal cells) transformed with one or more of the constructs, small molecules (multivalent multimerizing agents) which bind to and are capable of inducing multimerization of the chimeric proteins, and methods for preparing and using the foregoing, including methods involving the intramuscular delivery of such recombinant DNA constructs in AAV virus particles.
摘要翻译：本发明涉及用于生物开关的新配置，并且提供了用于调节动物细胞中的生物学事件的新方法和材料。本发明涉及包含衍生自编码蛋白质FRAP，Tor1，Tor2和能够结合FKBP：雷帕霉素的其他蛋白质的序列的DNA序列的重组DNA构建体，包含编码部分或全部FKBP蛋白的DNA序列的其他重组DNA构建体，编码通过这些构建体，用一种或多种构建体转化的细胞（特别是动物细胞），结合并能够诱导嵌合蛋白多聚化的小分子（多价多聚化剂），以及制备和使用前述物质的方法，包括涉及在AAV病毒颗粒中肌内递送这些重组DNA构建体的方法。

2. 发明申请

US20080184864A1 Electric guitar including a connection for a digital music player 审中-公开
标题翻译：电吉他包括数字音乐播放器的连接
公开(公告)号：US20080184864A1
公开(公告)日：2008-08-07
申请号：US11542485
申请日：2006-10-03
申请人： Dennis Holt , Lavere Lund
发明人： Dennis Holt , Lavere Lund
IPC分类号： G10H3/18
CPC分类号： G10H3/186 , G10H2220/505
摘要： A stringed instrument including a housing defining an interior space, at least one string on the housing, an amplifier positioned in the interior space and attached to the housing and a pick-up on the housing and positioned adjacent to the string where the pick-up converts vibrations from the string into electrical signals and transmits the electrical signals to the amplifier. The stringed instrument includes an audio input on the housing and coupled to the amplifier, where the audio input is coupled to a digital music player and sound stored by the digital music player is coupled to the amplifier. At least one speaker is mounted in the housing and coupled to the amplifier. The amplifier converts electrical signals from the pick-up into live music and the speaker emits both the live music and the sound from the digital music player to enable a player to play along with the sound.
摘要翻译：一种弦乐器，包括限定内部空间的壳体，壳体上的至少一个弦线，放置在内部空间中并连接到壳体上的放大器和位于壳体上的拾音器，并且位于拾音器附近将弦中的振动转换为电信号，并将电信号传输到放大器。弦乐器包括在外壳上的音频输入并耦合到放大器，其中音频输入耦合到数字音乐播放器，并且由数字音乐播放器存储的声音耦合到放大器。至少一个扬声器安装在壳体中并且耦合到放大器。该放大器将来自拾音器的电信号转换成现场音乐，扬声器从数字音乐播放器发出现场音乐和声音，使播放器能够与声音一起播放。

3. 发明授权

US09833652B2 Resistance band systems 有权
公开(公告)号：US09833652B2
公开(公告)日：2017-12-05
申请号：US15147388
申请日：2016-05-05
申请人： Dennis Holt , Shane Pilcher
发明人： Dennis Holt , Shane Pilcher
IPC分类号： A63B21/04 , A63B21/055 , A63B21/045 , A63B21/00 , A63B22/00
CPC分类号： A63B21/04 , A63B21/00061 , A63B21/0442 , A63B21/045 , A63B21/0555 , A63B21/0557 , A63B21/1609 , A63B21/4035 , A63B22/0002 , A63B2071/027 , A63B2208/0233 , A63B2209/10 , A63B2210/50 , A63B2225/09 , A63B2225/093
摘要： A resistance band system including a frame-assembly, a plurality of linear-straps, and a plurality of removable-D-rings. The frame-assembly, the plurality of linear-straps and plurality of removable-D-rings of the resistance band system are structured and arranged in combination to allow a user to affix a linear-resistance-band to the resistance band system to provide an overall exercise system which provides the user with a plurality of locations to affix the linear-resistance-band to the resistance band system to allow a highly flexible and diverse exercise system to the user. The frame-assembly includes an upper-frame, a lower-frame, and a u-member. The upper-frame includes two primary-members, two inbars, two forward-bars, and a crown-bar. The lower-frame includes two first-members, two downbars, and down-cross-member. The u-member comp includes rises a body, two legs, and two t-couplers, with u-member rotatably coupled to the lower-frame via the two t-couplers.

4. 发明申请

US20060025356A1 28-epirapalogs 有权
标题翻译： 28表皮拉胶
公开(公告)号：US20060025356A1
公开(公告)日：2006-02-02
申请号：US11229992
申请日：2005-09-19
申请人： Wu Yang , Cheryl Digits , Leonard Rozamus , Dennis Holt
发明人： Wu Yang , Cheryl Digits , Leonard Rozamus , Dennis Holt
IPC分类号： A61K31/4745 , C07D491/14
CPC分类号： C07D498/18 , A61K48/00 , C07K2319/00 , C12N9/1205
摘要： Methods and materials involving 28-epirapamycin analogs are disclosed.
摘要翻译：公开了涉及28-表拉拉霉素类似物的方法和材料。

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