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1. 发明申请

US20070275033A9 Biodegradable polyurethane and polyurethane ureas 有权
标题翻译：生物降解聚氨酯和聚氨酯脲
公开(公告)号：US20070275033A9
公开(公告)日：2007-11-29
申请号：US11087561
申请日：2005-03-24
申请人： Timothy Moore , Raju Adhikari , Pathiraja Gunatillake
发明人： Timothy Moore , Raju Adhikari , Pathiraja Gunatillake
IPC分类号： A61F2/00 , C08G18/08
CPC分类号： C08G18/348 , A61K31/785 , A61L27/18 , A61L27/3804 , A61L27/54 , A61L31/10 , A61L2300/412 , A61L2300/414 , C08G18/3206 , C08G18/3221 , C08G18/4277 , C08G18/6607 , C08G18/771 , C08G2230/00 , C09D175/06 , C08L75/04
摘要： This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender having a hydrolysable linking group and their use in tissue engineering and repair applications, particularly as stents and stent coating.
摘要翻译：本发明涉及包含异氰酸酯，多元醇和具有可水解连接基团的常规扩链剂和/或扩链剂的生物相容性，可生物降解的热塑性聚氨酯或聚氨酯/脲，以及其在组织工程和修复应用中的用途，特别是作为支架和支架涂层。

2. 发明申请

US20090081270A9 Biodegradable polyurethane and polyurethane ureas 有权
标题翻译：生物降解聚氨酯和聚氨酯脲
公开(公告)号：US20090081270A9
公开(公告)日：2009-03-26
申请号：US11087561
申请日：2005-03-24
申请人： Timothy Moore , Raju Adhikari , Pathiraja Gunatillake
发明人： Timothy Moore , Raju Adhikari , Pathiraja Gunatillake
IPC分类号： A61F2/00 , C08G18/08
CPC分类号： C08G18/348 , A61K31/785 , A61L27/18 , A61L27/3804 , A61L27/54 , A61L31/10 , A61L2300/412 , A61L2300/414 , C08G18/3206 , C08G18/3221 , C08G18/4277 , C08G18/6607 , C08G18/771 , C08G2230/00 , C09D175/06 , C08L75/04
摘要： This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender having a hydrolysable linking group and their use in tissue engineering and repair applications, particularly as stents and stent coating.
摘要翻译：本发明涉及包含异氰酸酯，多元醇和具有可水解连接基团的常规扩链剂和/或扩链剂的生物相容性，可生物降解的热塑性聚氨酯或聚氨酯/脲，以及其在组织工程和修复应用中的用途，特别是作为支架和支架涂层。

3. 发明申请

US20060051394A1 Biodegradable polyurethane and polyurethane ureas 有权
公开(公告)号：US20060051394A1
公开(公告)日：2006-03-09
申请号：US11087561
申请日：2005-03-24
申请人： Timothy Moore , Raju Adhikari , Pathiraja Gunatillake
发明人： Timothy Moore , Raju Adhikari , Pathiraja Gunatillake
IPC分类号： A61F2/00 , C08G18/08
CPC分类号： C08G18/348 , A61K31/785 , A61L27/18 , A61L27/3804 , A61L27/54 , A61L31/10 , A61L2300/412 , A61L2300/414 , C08G18/3206 , C08G18/3221 , C08G18/4277 , C08G18/6607 , C08G18/771 , C08G2230/00 , C09D175/06 , C08L75/04
摘要： This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender having a hydrolysable linking group and their use in tissue engineering and repair applications, particularly as stents and stent coating.

4. 发明申请

US20070027285A1 Polyurethanes 审中-公开
标题翻译：聚氨酯
公开(公告)号：US20070027285A1
公开(公告)日：2007-02-01
申请号：US11440575
申请日：2006-05-25
申请人： Pathiraja Gunatillake , Ajay Padsalgikar , Raju Adhikari , Ian Griffiths , Mark Bown
发明人： Pathiraja Gunatillake , Ajay Padsalgikar , Raju Adhikari , Ian Griffiths , Mark Bown
IPC分类号： C08L83/10 , C08G77/60
CPC分类号： C08G18/12 , C08G18/3893 , C08G18/4854 , C08G18/61 , C08G18/6674 , C08G18/3206
摘要： The present invention relates to cross linked polyurethanes or polyurethane ureas and processes for their preparation. The polyurethanes are biostable and creep resistant which makes them useful in the manufacture of biomaterials and medical devices, articles or implants, in particular orthopaedic implants such as spinal disc prostheses.
摘要翻译：本发明涉及交联聚氨酯或聚氨酯脲及其制备方法。聚氨酯是生物稳定和抗蠕变性的，这使得它们可用于制造生物材料和医疗装置，制品或植入物，特别是矫形植入物，例如脊椎假体修复体。

5. 发明申请

US20050238683A1 Biodegradable polyurethane/urea compositions 有权
标题翻译：生物降解聚氨酯/尿素组合物
公开(公告)号：US20050238683A1
公开(公告)日：2005-10-27
申请号：US10520414
申请日：2003-07-23
申请人： Raju Adhikari , Pathiraja Gunatillake
发明人： Raju Adhikari , Pathiraja Gunatillake
IPC分类号： A61F2/00 , A61K31/74 , A61L27/18 , A61L27/58 , A61L31/06 , B01J20060101 , C08G18/10 , C08G18/32 , C08G18/77 , C08G18/80 , C08K3/32 , C08K5/00
CPC分类号： A61K47/482 , A61F2/30 , A61F2/30756 , A61K31/74 , A61L27/18 , A61L27/3817 , A61L27/3834 , A61L27/50 , A61L27/58 , C08G18/3206 , C08G18/8022 , C08L75/04
摘要： The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
摘要翻译：本发明涉及生物相容的，可生物降解的聚氨酯/尿素聚合物组合物，其能够在低发热下体内固化以形成适用于组织工程应用如骨和软骨修复中的支架的材料。聚合物理想地是可流动和可注射的，并且可以支持活的生物组分以帮助愈合过程。它们可以用于侵入性外科手术修复方法离体固化，或者替代地用于相对非侵入性的手术修复方法，例如通过关节镜。本发明还涉及可用于制备聚合物组合物的预聚物，以及使用本发明的聚合物处理受损组织的方法。

6. 发明申请

US20050197422A1 Biocompatible polymer compositions for dual or multi staged curing 有权
标题翻译：用于双阶段或多阶段固化的生物相容性聚合物组合物
公开(公告)号：US20050197422A1
公开(公告)日：2005-09-08
申请号：US11070217
申请日：2005-03-03
申请人： Roshan Mayadunne , Raju Adhikari , Pathiraja Gunatillake
发明人： Roshan Mayadunne , Raju Adhikari , Pathiraja Gunatillake
IPC分类号： A61K6/00 , A61K6/087 , A61L24/04 , A61L27/18 , A61L31/06 , C08G18/10 , C09J167/07 , C09J175/16
CPC分类号： C08G18/10 , C08G18/3206 , C08G18/4277 , C08G18/428 , C08G18/4854 , C08G18/7671 , C08G18/771 , C08G18/8116 , C08L75/16 , C08L101/16
摘要： The present invention provides a biocompatible polymer composition for use in biomedical applications comprising a base molecule, a linker molecule and at least one initiator compound, said base molecule having at least two differing functionalities, and said linker molecule having a functionality reactive with at least one functionality of said base molecule, the first of said at least two functionalities of said base molecule enabling a first curing stage of said polymer composition by reaction with said linker molecule, and the second and any further functionality of said base molecule enabling second and further curing stages of said polymer composition, said first, second and any further curing stages being capable of activation simultaneously or independently of each other as required. The invention further provides uses of the polymer compositions of the invention in biomedical applications such as tissue engineering, dry delivery, as a bioadhesive in wound healing, as bone substitutes or scaffolds, as cements in dental and periodontal applications and as anti-adhesives or protective barriers.
摘要翻译：本发明提供了用于生物医学应用的生物相容性聚合物组合物，其包含基础分子，连接分子和至少一种引发剂化合物，所述碱基分子具有至少两个不同的官能团，并且所述连接分子具有与至少一个所述碱基分子的功能性，所述碱基分子的所述至少两个官能团中的第一个能够通过与所述连接分子的反应来实现所述聚合物组合物的第一固化阶段，并且所述碱基分子的第二和任何其它官能团能够进行第二次和进一步固化所述聚合物组合物的阶段，所述第一，第二和任何其它固化阶段能够根据需要同时或彼此独立地活化。本发明进一步提供本发明的聚合物组合物在生物医学应用中的用途，例如组织工程，干燥递送，作为伤口愈合中的生物粘合剂，作为骨替代物或支架，用作牙科和牙周应用中的水泥，以及作为抗粘合剂或保护性障碍

7. 发明授权

US5393858A Polyurethane or polyurethane-urea elastomeric compositions 失效
标题翻译：聚氨酯或聚氨酯 - 脲弹性体组合物
公开(公告)号：US5393858A
公开(公告)日：1995-02-28
申请号：US962799
申请日：1993-02-23
申请人： Gordon F. Meijs , Ezio Rizzardo , Arthur Brandwood , Pathiraja Gunatillake , Klaus H. Schindhelm
发明人： Gordon F. Meijs , Ezio Rizzardo , Arthur Brandwood , Pathiraja Gunatillake , Klaus H. Schindhelm
IPC分类号： A61L27/00 , A61L17/04 , A61L27/18 , A61L29/00 , A61L29/06 , A61L31/00 , C08G18/10 , C08G18/48 , C08G18/65 , C08G18/66 , C08G18/76 , C08G18/30
CPC分类号： C08G18/765 , A61L17/04 , A61L27/18 , A61L29/06 , C08G18/10 , C08G18/4858
摘要： A polyurethane or polyurethane-urea elastomeric composition, characterized in that the composition is a reaction product of:(A) a soft segment macrodiol which is either:(i) a homopolymer represented by formula I,HO--[(CH.sub.2).sub.n O].sub.m --H Iwherein n represents an integer greater than 5 and less than 13, m is a number such that the number average molecular weight of the compound of formula I falls in the range from 218 to 5000 and optionally at least one hydrogen atom represented in formula I is substituted by a C.sub.1 to C.sub.3 alkyl group or a halogen atom;(ii) a copolymer containing at least 25% by mass of repeating units --(CH.sub.2).sub.n O-- wherein n is as defined in formula I above; or(iii) mixture of macrodiols comprising greater than 10% of a macrodiol as defined in formula I above;(B ) an aliphatic or aromatic diisocyanate known in the art of polyurethane manufacture; and(C) optionally a chain extender.A biomaterial and a medical device which are composed wholly or partly of the polyurethane or polyurethane-urea elastomeric composition are also described.
摘要翻译： PCT No.PCT / AU91 / 00270 Sec。 371日期：1993年2月23日 102（e）1993年2月23日PCT PCT 1991年6月26日PCT公布。出版物WO92 / 日本1992年1月9日。一种聚氨酯或聚氨酯 - 脲弹性体组合物，其特征在于所述组合物是以下物质的反应产物：（A）软段大分子二醇，其为：（i）由式I表示的均聚物，HO- [（CH 2）n O] m-HI其中n表示大于5且小于13的整数，m是使式I化合物的数均分子量在218至5000的范围内的数，式I中表示的至少一个氢原子被C1至C3烷基或卤素原子取代; （ii）含有至少25质量％的重复单元 - （CH 2）n O-的共聚物，其中n如上述式I中所定义; 或（iii）包含大于10％上述式I定义的大分子二醇的大分子二醇的混合物; （B）聚氨酯制造领域已知的脂族或芳族二异氰酸酯; 和（C）任选的扩链剂。还描述了全部或部分由聚氨酯或聚氨酯 - 脲弹性体组合物组成的生物材料和医疗装置。

8. 发明申请

US20070225387A1 Polymer Compositions for Dual or Multi Staged Curing 审中-公开
标题翻译：双组分或多分段固化的聚合物组合物
公开(公告)号：US20070225387A1
公开(公告)日：2007-09-27
申请号：US10591606
申请日：2005-03-03
申请人： Roshan Mayadunne , Pathiraja Gunatillake , Raju Adhkari
发明人： Roshan Mayadunne , Pathiraja Gunatillake , Raju Adhkari
IPC分类号： C08G18/10 , C09D167/07 , C09D175/16 , C09J167/07 , C09J175/16
CPC分类号： C08G18/10 , C08G18/3206 , C08G18/4277 , C08G18/428 , C08G18/4854 , C08G18/7664 , C08G18/771 , C08G18/775 , C08G18/8025 , C08G18/8116 , C08G18/42
摘要： The present invention provides a polymer composition for use at least in surface coating applications and in fabrication of rigid foams with load bearing capacity comprising a base molecule, a linker molecule and at least one initiator compound, said base molecule having at least two differing functionalities, and said linker molecule having a functionality reactive with at least one functionality of said base molecule, the first of said at least two functionalities of said base molecule enabling a first curing stage of said polymer composition by reaction with said linker molecule, and the second and any further functionality of said base molecule enabling second and further curing stages of said polymer composition, said first, second and any further curing stages being capable of activation simultaneously or independently of each other as required. A further provides uses of the polymer compositions of the invention in surface coating and adhesives applications and in the preparation of rigid foams with load bearing capacity.
摘要翻译：本发明提供一种聚合物组合物，其用于至少在表面涂覆应用中并用于制造具有承载能力的刚性泡沫体，其具有包含基础分子，连接分子和至少一种引发剂化合物，所述碱基分子具有至少两个不同的官能团，并且所述连接分子具有与所述碱基分子的至少一个官能度反应的官能度，所述碱基分子的所述至少两个官能团中的第一个能够通过与所述连接分子的反应来实现所述聚合物组合物的第一固化阶段，所述基础分子的任何另外的功能使得所述聚合物组合物的第二和进一步固化阶段，所述第一，第二和任何其它固化阶段能够根据需要同时或彼此独立地活化。本发明的聚合物组合物进一步提供了表面涂层和粘合剂应用以及制备具有承载能力的刚性泡沫的用途。

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