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1. 发明申请

US20090312955A1 METHOD AND APPARATUS FOR CALIBRATING FILTERS DURING SPECIMEN COLLECTION 有权
标题翻译：在样本采集过程中校准过滤器的方法和装置
公开(公告)号：US20090312955A1
公开(公告)日：2009-12-17
申请号：US12482731
申请日：2009-06-11
申请人： Timothy Hutchins , Steven A. Scampini , Eric Baur
发明人： Timothy Hutchins , Steven A. Scampini , Eric Baur
IPC分类号： G06F19/00 , G01N1/28 , G01N15/08
CPC分类号： G01N1/36
摘要： A bubble point of a combination of a filter and a liquid is calibrated by applying an initial back pressure through the filter toward the liquid; taking a first plurality of measurements of the level of the liquid in the container; calculating a first variance of the first plurality of measurements; and comparing the first calculated variance with a known threshold variance. Then a second plurality of measurements of the level of the liquid in the container is taken; a second variance of the second plurality of measurements is calculated; and the second calculated variance is compared with a known threshold variance. The above described steps are repeated at incrementally increased back pressures until the first and second calculated variances are each greater than or equal to the known threshold variance, which is about 0.01. The bubble point is determined to be the back pressure at that point. If the determined bubble point is less than or equal to the known threshold bubble point, which is about 0.8 pounds per square inch, the filter is identified as unsuitable for use in cell block formation.
摘要翻译：过滤器和液体的组合的起泡点通过将初始的背压通过过滤器朝向液体进行校准; 对容器中液体的水平进行第一次多次测量; 计算所述第一多个测量的第一方差; 以及将第一计算的方差与已知的阈值方差进行比较。然后取出容器中的液体水平的第二多个测量值; 计算第二多个测量的第二方差; 并将第二计算方差与已知的阈值方差进行比较。上述步骤以逐渐增加的背压重复，直到第一和第二计算的方差各自大于或等于已知阈值方差，其为约0.01。泡点确定为此时的背压。如果确定的气泡点小于或等于已知的阈值气泡点（约0.8磅/平方英寸），则过滤器被识别为不适合用于细胞块形成。

2. 发明授权

US07914738B2 Cell block cassette and filter assembly 有权
标题翻译：电池盒和过滤器组件
公开(公告)号：US07914738B2
公开(公告)日：2011-03-29
申请号：US11839533
申请日：2007-08-15
申请人： Timothy Hutchins , Hal Watts , Steven A. Scampini , Eric Grimes
发明人： Timothy Hutchins , Hal Watts , Steven A. Scampini , Eric Grimes
IPC分类号： G01N21/00
CPC分类号： C12M47/00 , G01N1/36 , Y10T436/25 , Y10T436/2575
摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.
摘要翻译：用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中，至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。

3. 发明申请

US20100330660A1 CELL BLOCK PROCESSING STATION 有权
标题翻译：电池块处理站
公开(公告)号：US20100330660A1
公开(公告)日：2010-12-30
申请号：US12876879
申请日：2010-09-07
申请人： Timothy Hutchins , Hal Watts , Steven A. Scampini , Eric Grimes , Andrew H. Fischer
发明人： Timothy Hutchins , Hal Watts , Steven A. Scampini , Eric Grimes , Andrew H. Fischer
IPC分类号： C12M1/36
CPC分类号： C12M47/00 , G01N1/36 , Y10T436/25 , Y10T436/2575
摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.
摘要翻译：用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中，至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。

4. 发明授权

US08118962B2 Method and apparatus for spacing cellular matter in a cell block 有权
标题翻译：用于在细胞块中间隔细胞物质的方法和装置
公开(公告)号：US08118962B2
公开(公告)日：2012-02-21
申请号：US12268298
申请日：2008-11-10
申请人： Eric Baur , Steven A. Scampini
发明人： Eric Baur , Steven A. Scampini
IPC分类号： G01N1/30 , B29C47/00
CPC分类号： G01N1/36
摘要： Methods and apparatus for bonding block of paraffin having cellular material embedded at one end thereof with an additional amount of paraffin are disclosed, including a method comprising placing the paraffin block in a well of a mold with the paraffin-embedded cellular material positioned on a support structure that elevates the cellular matter from a bottom surface of the well; heating the mold to thereby soften and at least partially melt and blend together the embedding paraffin and additional paraffin located in the well, the support structure sized such that some of the additional paraffin flows on the bottom surface of the well at least partially surrounding the support structure; and cooling the mold to thereby bond the additional paraffin to the embedding paraffin and re-solidify the paraffin block, wherein the retained cellular matter is spaced apart from an end of the re-solidified paraffin block defined by the bottom surface of the well.
摘要翻译：公开了用于将其一端嵌入细胞材料的石蜡块与另外的石蜡粘合的方法和装置，包括将石蜡块放置在模具的孔中，将石蜡包埋的细胞材料置于载体上从井下表面升高细胞物质的结构; 加热模具从而软化并且至少部分地熔化并将包埋石蜡和位于孔中的另外的链烷烃混合在一起，所述支撑结构的尺寸使得一些额外的石蜡在井的底部表面上至少部分地围绕支撑件结构体; 并冷却模具，从而将另外的石蜡粘合到包埋石蜡上并重新固化石蜡块，其中保留的细胞物质与由井的底部表面限定的再固化石蜡块的端部间隔开。

5. 发明授权

US08088329B2 Cell block processing station 有权
标题翻译：单元块处理站
公开(公告)号：US08088329B2
公开(公告)日：2012-01-03
申请号：US12876879
申请日：2010-09-07
申请人： Timothy Hutchins , Hal Watts , Steven A. Scampini , Eric Grimes , Andrew H. Fischer
发明人： Timothy Hutchins , Hal Watts , Steven A. Scampini , Eric Grimes , Andrew H. Fischer
IPC分类号： G01N21/00
CPC分类号： C12M47/00 , G01N1/36 , Y10T436/25 , Y10T436/2575
摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.
摘要翻译：用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中，至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。

6. 发明申请

US20100112629A1 CELL BLOCK CASSETTE DEVICE 有权
标题翻译：电池盒CASSETTE设备
公开(公告)号：US20100112629A1
公开(公告)日：2010-05-06
申请号：US12684041
申请日：2010-01-07
申请人： Steven A. Scampini
发明人： Steven A. Scampini
IPC分类号： C12Q1/02 , C12N11/02
CPC分类号： G01N1/36 , Y10T436/25 , Y10T436/2575
摘要： A tissue cassette assembly includes a housing having a recess formed therein, and a compressible reservoir disposed partially or wholly inside of, or otherwise attached in fluid communication with, the housing recess, the compressible reservoir containing a tissue embedding material. The tissue cassette further includes a port disposed in the housing, the port in fluid communication with the compressible reservoir at one end and terminating in a sample cavity at another end. During operation, the compressible reservoir is compressed or squeezed to release the tissue embedding material into the sample cavity containing the biological sample.
摘要翻译：组织盒组件包括具有形成在其中的凹部的壳体和设置成部分地或全部地设置在壳体凹部内或以其它方式与流体连通的壳体凹部的可压缩储存器，该可压缩储存器包含组织嵌入材料。组织盒还包括设置在壳体中的端口，该端口在一端处与可压缩储存器流体连通，并且在另一端终止于样品腔。在操作期间，压缩或压缩可压缩储存器以将组织包埋材料释放到包含生物样品的样品腔中。

7. 发明申请

US20080262351A1 Microbeamforming Transducer Architecture 审中-公开
标题翻译：微波传感器架构
公开(公告)号：US20080262351A1
公开(公告)日：2008-10-23
申请号：US11576401
申请日：2005-09-22
申请人： Steven A. Scampini
发明人： Steven A. Scampini
IPC分类号： G01S15/89 , G01S7/521 , A61B8/14 , G06K9/36
CPC分类号： G01S15/8925 , A61B8/4483 , G01S7/52079 , G01S7/5208 , G01S15/8927
摘要： A method for ultrasound imaging utilizes microbeamforming within a transducer probe in electrical communication with a base ultrasound system. The transducer elements are arranged in sub-arrays or subsets, and the transducer includes a cross-point/summation switch in communication with each sub-array, and the base ultrasound system. In the microbeamforming operation, the signals received at the receiving elements comprising a sub-array are summed to generate a composite sub-array signal for same sub-array, and a set of composite sub-array signals corresponding to a particular receive beamforming pattern is defined using a signal controlling the output of the cross-point switch.
摘要翻译：一种用于超声成像的方法利用与基础超声系统电连通的换能器探头内的微波束形成。换能器元件被布置在子阵列或子集中，并且换能器包括与每个子阵列通信的交叉点/求和开关和基本超声系统。在微波形成操作中，在包括子阵列的接收元件处接收到的信号被相加以产生用于相同子阵列的复合子阵列信号，并且对应于特定接收波束成形模式的一组复合子阵列信号是使用控制交叉点开关输出的信号来定义。

8. 发明授权

US07859667B2 Slide misload detection system and method 有权
标题翻译：滑动误动检测系统及方法
公开(公告)号：US07859667B2
公开(公告)日：2010-12-28
申请号：US11933889
申请日：2007-11-01
申请人： Steven A. Scampini
发明人： Steven A. Scampini
IPC分类号： G01B11/00 , G01N21/01 , G03B23/00
CPC分类号： G01N35/00029 , G01N2035/00089 , G01N2035/00138 , G02B21/34
摘要： A system and method for determining whether one or more slides are loaded properly within a cassette. Each slide includes one or more transparent regions and one or more non-transparent regions. The slides are between a light source and a sensor. The light source generates light that is directed towards the sensor through the slides. If the sensor is able to detect light from the light source, then the slides are properly loaded in the cassette. Slides are not properly loaded if the light is blocked by a non-transparent region before reaching the sensor. The sensor or a separate controller can generate a signal or data to provide an indication to a user or to processing equipment that the slides are or are not properly loaded. For example, a speaker or an indicator light can be used to provide an indication to the user. The signal or data can also be used for other functions, such as displaying a message on a screen indicating whether the slides are properly loaded.
摘要翻译：一种用于确定一个或多个幻灯片是否正确加载在盒内的系统和方法。每个幻灯片包括一个或多个透明区域和一个或多个不透明区域。幻灯片在光源和传感器之间。光源通过幻灯片产生指向传感器的光。如果传感器能够检测来自光源的光，则将幻灯片正确地装载到暗盒中。如果在到达传感器之前光被非透明区域阻挡，则幻灯片未正确加载。传感器或单独的控制器可以生成信号或数据，以向用户或处理设备提供指示或未正确加载幻灯片的指示。例如，扬声器或指示灯可以用于向用户提供指示。信号或数据也可用于其他功能，例如在屏幕上显示指示幻灯片是否正确加载的消息。

9. 发明授权

US07666358B2 Cell block cassette device 有权
标题翻译：电池盒装置
公开(公告)号：US07666358B2
公开(公告)日：2010-02-23
申请号：US11551623
申请日：2006-10-20
申请人： Steven A. Scampini
发明人： Steven A. Scampini
IPC分类号： B01L3/00
CPC分类号： G01N1/36 , Y10T436/25 , Y10T436/2575
摘要： A tissue cassette assembly includes a housing having a recess formed therein, and a compressible reservoir disposed partially or wholly inside of, or otherwise attached in fluid communication with, the housing recess, the compressible reservoir containing a tissue embedding material. The tissue cassette further includes a port disposed in the housing, the port in fluid communication with the compressible reservoir at one end and terminating in a sample cavity at another end. During operation, the compressible reservoir is compressed or squeezed to release the tissue embedding material into the sample cavity containing the biological sample.
摘要翻译：组织盒组件包括具有形成在其中的凹部的壳体和设置成部分地或全部地设置在壳体凹部内或以其它方式与流体连通的壳体凹部的可压缩储存器，该可压缩储存器包含组织嵌入材料。组织盒还包括设置在壳体中的端口，该端口在一端处与可压缩储存器流体连通，并且在另一端终止于样品腔。在操作期间，压缩或压缩可压缩储存器以将组织包埋材料释放到包含生物样品的样品腔中。

10. 发明授权

US07300163B2 Slide misload detection system and method 有权
标题翻译：滑动误动检测系统及方法
公开(公告)号：US07300163B2
公开(公告)日：2007-11-27
申请号：US11040958
申请日：2005-01-21
申请人： Steven A. Scampini
发明人： Steven A. Scampini
IPC分类号： G03B23/00 , G01B11/00
CPC分类号： G01N35/00029 , G01N2035/00089 , G01N2035/00138 , G02B21/34
摘要： A system and method for determining whether one or more slides are loaded properly within a cassette. Each slide includes one or more transparent regions and one or more non-transparent regions. The slides are between a light source and a sensor. The light source generates light that is directed towards the sensor through the slides. If the sensor is able to detect light from the light source, then the slides are properly loaded in the cassette. Slides are not properly loaded if the light is blocked by a non-transparent region before reaching the sensor. The sensor or a separate controller can generate a signal or data to provide an indication to a user or to processing equipment that the slides are or are not properly loaded. For example, a speaker or an indicator light can be used to provide an indication to the user. The signal or data can also be used for other functions, such as displaying a message on a screen indicating whether the slides are properly loaded.
摘要翻译：一种用于确定一个或多个幻灯片是否正确加载在盒内的系统和方法。每个幻灯片包括一个或多个透明区域和一个或多个不透明区域。幻灯片在光源和传感器之间。光源通过幻灯片产生指向传感器的光。如果传感器能够检测来自光源的光，则将幻灯片正确地装载到暗盒中。如果在到达传感器之前光被非透明区域阻挡，则幻灯片未正确加载。传感器或单独的控制器可以生成信号或数据，以向用户或处理设备提供指示或未正确加载幻灯片的指示。例如，扬声器或指示灯可以用于向用户提供指示。信号或数据也可用于其他功能，例如在屏幕上显示指示幻灯片是否正确加载的消息。

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