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    • 2. 发明申请
    • APPARATUS AND METHODS OF FLOW TESTING FORMATION ZONES
    • 流量测试形成区域的装置和方法
    • US20080190605A1
    • 2008-08-14
    • US12030154
    • 2008-02-12
    • Timothy Dale ClappRobert MurphyPaul James WilsonMark Rogers
    • Timothy Dale ClappRobert MurphyPaul James WilsonMark Rogers
    • E21B47/00
    • E21B49/00E21B33/12E21B33/1246E21B49/087
    • Embodiments of the present invention provide a method and apparatus for flow testing multiple zones in a single trip. In one embodiment, a method of flow testing multiple zones in a wellbore includes lowering a tool string into the wellbore. The tool string includes an inflatable packer or plug and an electric pump. The method further includes operating the pump, thereby inflating the packer or plug and isolating a first zone from one or more other zones; monitoring flow from the first zone; deflating the packer or plug; moving the tool string in the wellbore; and operating the pump, thereby inflating the packer or plug and isolating a second zone from one or more other zones; and monitoring flow from the second zone. The zones are monitored in one trip.
    • 本发明的实施例提供了用于在单次行程中流动测试多个区域的方法和装置。 在一个实施例中,在井眼中测试多个区域的流动方法包括将工具串降低到井筒中。 工具串包括充气封隔器或塞子和电动泵。 该方法还包括操作泵,从而使封隔器或塞子充气并将第一区域与一个或多个其它区域隔离; 监测来自第一区的流量; 放气包装机或插头; 将工具柱移动到井眼中; 并且操作泵,从而使封隔器或塞子膨胀并将第二区域与一个或多个其它区域隔离; 并监测来自第二区域的流量。 在一个行程中监控区域。
    • 4. 发明申请
    • Scoring Function Penalizing Compounds Which Desolvate Charged Protein Side Chains Structure
    • 评分功能处罚化合物,其中脱蛋白带电蛋白质侧链结构
    • US20120252687A1
    • 2012-10-04
    • US13079489
    • 2011-04-04
    • Richard A. FriesnerRobert Murphy
    • Richard A. FriesnerRobert Murphy
    • C40B30/04
    • G16C20/50G16B15/00
    • A method of scoring binding affinity of a proposed ligand molecule for a receptor molecule using a computer and computer data bases, which accounts for the increase in energy required where docking disrupts water molecules that are localized or localized. The method uses computer-stored data representing a predicted ligand-receptor structure (preferably one that is validated) as well as computer-stored data representing a library of compounds to be tested. Data representing members of the compound library is analyzed by computerized operations which determine whether the receptor in the predicted ligand-receptor structure includes a) determining whether the receptor in the predicted ligand-receptor structure includes solvating water molecule(s) whose desolvation into the surrounding environment requires substantial energy, b) determining whether a docking configuration for a member of the compound library with the receptor requires desolvation of one or more of the desolvating water molecule(s), and, if so, assigning a desolvation penalty to the member of the compound library.
    • 使用计算机和计算机数据库评估所提出的配体分子对受体分子的结合亲和力的方法,其考虑到对接破坏定位或定位的水分子所需的能量的增加。 该方法使用表示预测的配体 - 受体结构(优选经过验证的)的计算机存储的数据以及表示待测化合物文库的计算机存储的数据。 通过计算机操作来分析表示化合物文库的成员的数据,其确定预测的配体 - 受体结构中的受体是否包括a)确定预测的配体 - 受体结构中的受体是否包含溶解到周围的溶剂化水分子 环境需要大量的能量,b)确定化合物文库与受体的成员的对接构型是否需要脱溶剂中的一种或多种去溶质水分子,如果是,则将脱溶剂处罚分配给 复合库。
    • 5. 发明授权
    • Binding affinity scoring function including factor for environs of ring or bulky rigid group
    • 结合亲和力评分函数包括环或笨重刚性组的环境因子
    • US08160820B2
    • 2012-04-17
    • US12152067
    • 2008-05-12
    • Richard A. FriesnerRobert Murphy
    • Richard A. FriesnerRobert Murphy
    • G06F19/10
    • G06F19/706G06F19/16G06F19/707
    • Scoring functions can be markedly improved by taking into account the status environs of ligand rings (or indeed other bulky rigid ligand structures) on the ligand when the ligand is complexed with the receptor. In its most general form, the invention features, quantifying a particular component of binding affinity between a ligand and a receptor molecule. Specifically, the component in question takes into account the spatial relationship between ligand ring structure(s) (or bulky rigid ligand structures) and their ambient surroundings when the ligand is bound to the receptor molecule. The method steps may be used when quantifying a component that reflects these particular ligand features alone, or the steps may be part of a comprehensive method of quantifying binding affinity which includes numerous other factors that relate to binding affinity in addition to the component. For example, one may calculate an initial binding affinity and then adjust the initial binding affinity by a factor obtained at least in part based on the classification of the ring structure.
    • 当配体与受体复合时,通过考虑配体环(或实际上其它体积大的刚性配体结构)在配体上的状态环境,可以显着改善评分功能。 在其最通用形式中,本发明的特征在于定量配体和受体分子之间的结合亲和力的特定组分。 具体来说,当配体与受体分子结合时,所讨论的组分考虑了配体环结构(或体积大的刚性配体结构)及其周围环境之间的空间关系。 当量化单独反映这些特定配体特征的组分时,可以使用方法步骤,或者步骤可以是量化结合亲和力的全面方法的一部分,其包括与组分相关的结合亲和力相关的许多其它因子。 例如,可以计算初始结合亲和力,然后基于环结构的分类至少部分获得的因子来调整初始结合亲和力。
    • 7. 发明授权
    • Right angle driving tool
    • 直角驱动工具
    • US07484438B2
    • 2009-02-03
    • US11637323
    • 2006-12-12
    • Robert Murphy
    • Robert Murphy
    • B25B17/00
    • E21B4/006B23Q5/045B25B13/481B25B17/00B25B17/02E21B19/081E21B19/083
    • A right angle driving apparatus capable of operable attachment to a powered rotational drive device such as a drill, the driving apparatus being generally comprised of a worm gear drive encased within a unique block-shaped housing. The subject driving apparatus may be employed to transmit power at high velocity ratios between a shaft that is driven by the drill to a wheel having an axis of rotation perpendicular to that of the shaft. The worm gear drive may be used as a speed increaser but is preferably used as a speed reducer in which the worm is the driver and the wheel is the driven member. The worm wheel is slidably mounted on a cylindrical hub adapted to receive in either end a variety of driving tools such as sockets and screwdriver blades used to rotate fasteners. The worm wheel is driven by a worm attached to a drive shaft the journaled end of which may be adapted to receive driving tools as well to permit direct driving of tools in addition to right angle driving.
    • 一种能够可操作地附接到诸如钻头的动力旋转驱动装置的直角驱动装置,所述驱动装置通常包括封装在独特的块形壳体内的蜗轮传动装置。 主体驱动装置可以用于在由钻头驱动的轴与具有垂直于轴的旋转轴线的轮之间以高速比传递动力。 蜗轮传动装置可以用作增速器,但优选用作减速器,其中蜗杆是驱动器,而车轮是从动件。 蜗轮可滑动地安装在圆柱形毂上,适于在任一端接收各种驱动工具,例如用于旋转紧固件的插座和螺丝刀。 蜗轮由附接到驱动轴的蜗杆驱动,驱动轴的轴颈可适用于接收驱动工具,并允许除了直角驱动之外直接驱动工具。
    • 8. 发明申请
    • Diagnostic test reader with locking mechanism
    • 具有锁定机构的诊断测试读卡器
    • US20070141696A1
    • 2007-06-21
    • US11313091
    • 2005-12-19
    • Brenton BaughRobert Murphy
    • Brenton BaughRobert Murphy
    • C12M3/00G01N33/558
    • G01N21/01
    • A diagnostic test reader includes an assay interface, a locking mechanism, and a test unit. The assay interface is configured to receive a diagnostic assay. The locking mechanism is configured to lock the diagnostic assay within the assay interface in response to one of the diagnostic assay and the diagnostic test reader being given a first push in a first direction toward the other of the diagnostic assay and the diagnostic test reader. The locking mechanism is also configured to unlock the diagnostic assay within the assay interface in response to the one of the diagnostic assay and the diagnostic test reader being given a second push in the first direction. The test unit is configured to analyze the diagnostic assay.
    • 诊断测试读取器包括测定界面,锁定机构和测试单元。 测定界面被配置为接收诊断测定。 锁定机构被配置为响应于诊断测定中的一个和诊断测试读取器中的一个,在第一方向上向诊断测定和诊断测试读取器中的另一个进行第一推动来将诊断测定锁定在测定界面内。 锁定机构还被配置为响应于诊断测试和诊断测试读取器中的一个在第一方向被给予第二推动而在测定界面内解锁诊断测定。 测试单元被配置为分析诊断测定。
    • 9. 发明申请
    • Predictive scoring function for estimating binding affinity
    • 用于估计结合亲和力的预测评分函数
    • US20070061118A1
    • 2007-03-15
    • US11373684
    • 2006-03-10
    • Richard FriesnerRobert Murphy
    • Richard FriesnerRobert Murphy
    • G06G7/48G06G7/58
    • G06F19/706C40B30/02G06F19/16G06F19/18G06F19/26
    • A computer-implemented method for calculating a value representative of interaction (VRI) of a proposed ligand with a specified receptor. Hydrophobic interactions between one or more ligand atoms and one or more receptor atoms are scored by a method that awards a bonus for the presence of hydrophobic enclosure of one or more ligand atoms by the receptor. Also, charge-charge hydrogen bonds between a ligand and a receptor are scored by setting a default value for a charge-charge hydrogen bond and awarding a bonus above the default value when one or more specialized predetermined charge-charge hydrogen bond criteria is satisfied. Various charge-charge hydrogen bond criteria are used. Zwitterions, charge, salvation, geometry and electrostatic energy are accounted for.
    • 一种计算机实现的方法,用于计算代表所提及的配体与指定受体的相互作用(VRI)的值。 通过一种方法来评估一个或多个配体原子和一个或多个受体原子之间的疏水相互作用,所述方法为受体的一个或多个配体原子的疏水封闭的存在赋予奖励。 此外,通过设定充电氢氢键的默认值,并且当满足一个或多个专门的预定充电氢键标准时,将奖金高于默认值来评分配体和受体之间的充电氢键。 使用各种充电氢键标准。 两性离子,电荷,溶剂化,几何形状和静电能量。
    • 10. 发明申请
    • BAG TOSS GAME TARGET ASSEMBLIES
    • BAG游戏目标组合
    • US20060125186A1
    • 2006-06-15
    • US11306934
    • 2006-01-17
    • Randolph DiggesRobert Murphy
    • Randolph DiggesRobert Murphy
    • A63B63/00
    • A63B67/06A63B63/00A63B2024/0046
    • Bag toss game target assemblies that include a deck and a base unit. The deck includes at least one through-aperture dimensioned to allow a bag to pass entirely therethrough. The base unit has a bottom portion that is configured to rest on a generally horizontal surface and a top portion that is configured to support the deck during game play. In one preferred embodiment, the base unit further includes an open-top storage receptacle that is covered by the deck during game play, but can be accessed by moving the deck independent of the base unit. In another preferred embodiment, the deck from at least target assembly can be removed from its corresponding base unit, and the corresponding base unit can be nested beneath and partially within the base unit of another target assembly.
    • 袋子折腾包括甲板和基本单元的游戏目标组件。 甲板包括至少一个通孔,其尺寸设计成允许袋子完全通过。 基座单元具有构造成搁置在大致水平的表面上的底部部分和被配置为在游戏过程中支撑甲板的顶部部分。 在一个优选实施例中,基座单元还包括在游戏过程中由甲板覆盖的敞开顶部存储容器,但是可以通过独立于基座单元移动甲板来访问。 在另一个优选实施例中,来自至少目标组件的甲板可以从其对应的基座单元移除,并且相应的基座单元可以嵌套在另一个目标组件的基座单元的下面和部分内。