专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120128647A1 DELIVERY OF COMPOUNDS WITH REHYDRATED BLOOD CELLS 有权
标题翻译：递送化合物与再生血液细胞
公开(公告)号：US20120128647A1
公开(公告)日：2012-05-24
申请号：US11863462
申请日：2007-09-28
申请人： Timothy C. Nichols , Thomas Fischer , Marjorie S. Read
发明人： Timothy C. Nichols , Thomas Fischer , Marjorie S. Read
IPC分类号： A61K35/14 , A61P7/02 , A61P7/04 , C12N5/078 , A61P31/12
CPC分类号： A61K38/02 , A01N1/02 , A01N1/0215 , A61K31/00 , A61K31/7088 , A61K35/18 , A61K35/19 , A61K45/06 , A61K47/6901 , Y10S977/905 , A61K2300/00
摘要： Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the same. The blood cells are preferably blood platelets.
摘要翻译：描述了携带活性剂的固定干细胞及其制备方法，以及使用它们的方法，以及含有它们的组合物。血细胞优选为血小板。

2. 发明授权

US07294455B2 Fixed-dried platelets cross-linked to protein 有权
标题翻译：固定干燥的血小板与蛋白质交联
公开(公告)号：US07294455B2
公开(公告)日：2007-11-13
申请号：US10845045
申请日：2004-05-13
申请人： Timothy C. Nichols , Thomas Fischer , Marjorie S. Read
发明人： Timothy C. Nichols , Thomas Fischer , Marjorie S. Read
IPC分类号： A01N1/02 , A01N63/00
CPC分类号： A61K38/02 , A01N1/02 , A01N1/0215 , A61K31/00 , A61K31/7088 , A61K35/18 , A61K35/19 , A61K45/06 , A61K47/6901 , Y10S977/905 , A61K2300/00
摘要： Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the same. The blood cells may be red blood cells or blood platelets.
摘要翻译：描述了携带活性剂的固定干细胞及其制备方法，以及使用它们的方法，以及含有它们的组合物。血细胞可能是红细胞或血小板。

3. 发明授权

US08492081B2 Aldehyde-fixed, dried platelets with covalently attached exogenous active agent and method of making thereof 有权
标题翻译：具有共价连接的外源活性剂的醛固定的干燥血小板及其制备方法
公开(公告)号：US08492081B2
公开(公告)日：2013-07-23
申请号：US11863462
申请日：2007-09-28
申请人： Timothy C. Nichols , Thomas Fischer , Marjorie S. Read
发明人： Timothy C. Nichols , Thomas Fischer , Marjorie S. Read
IPC分类号： A01N1/02 , A01N63/00
CPC分类号： A61K38/02 , A01N1/02 , A01N1/0215 , A61K31/00 , A61K31/7088 , A61K35/18 , A61K35/19 , A61K45/06 , A61K47/6901 , Y10S977/905 , A61K2300/00
摘要： Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the same. The blood cells are preferably blood platelets.
摘要翻译：描述了携带活性剂的固定干细胞及其制备方法，以及使用它们的方法，以及含有它们的组合物。血细胞优选为血小板。

4. 发明授权

US07901674B2 Aldehyde-fixed platelets with internalized paramagnetic or magnetic nanoparticles 有权
标题翻译：具有内在顺磁性或磁性纳米粒子的醛固定血小板
公开(公告)号：US07901674B2
公开(公告)日：2011-03-08
申请号：US11751295
申请日：2007-05-21
申请人： Timothy C. Nichols , Thomas Fischer , Marjorie S. Read
发明人： Timothy C. Nichols , Thomas Fischer , Marjorie S. Read
IPC分类号： A61B5/055 , A01N63/00
CPC分类号： A61K38/02 , A01N1/02 , A01N1/0215 , A61K31/00 , A61K31/7088 , A61K35/18 , A61K35/19 , A61K45/06 , A61K47/6901 , Y10S977/905 , A61K2300/00
摘要： Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the sane. The blood cells may be red blood cells or blood platelets.
摘要翻译：描述了携带活性剂的固定干细胞，以及制备它们的方法，使用它们的方法，以及包含理智的组合物。血细胞可能是红细胞或血小板。

5. 发明授权

US06884573B2 Fixed dried red blood cells and method of use 失效
标题翻译：固定干红细胞和使用方法
公开(公告)号：US06884573B2
公开(公告)日：2005-04-26
申请号：US10231635
申请日：2002-08-30
申请人： Thomas H. Fischer , Marjorie S. Read , Arthur P. Bode , Timothy C. Nichols
发明人： Thomas H. Fischer , Marjorie S. Read , Arthur P. Bode , Timothy C. Nichols
IPC分类号： A01N1/02 , A61K35/18 , A01N63/00
CPC分类号： A01N1/0226 , A01N1/02 , A01N1/0284 , A01N1/0289 , A61K35/18
摘要： Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenicity to platelets, and have oblated blood group antigens. The RBCs are preferably fixed by means of cross-linkers with aldehyde functions such as paraformaldehyde or glutaraldehyde either alone or in combination. Native oxygen kinetics are achieved by preparing the red blood cells with 1,6-diphosphofructose. Blood group antigens and chemical functions that render the lyophilized RBCs thrombogenic are occluded by chemically attaching polyoxyethylene glycol polymers to the surface membrane of the red blood cells. The cross-linked red blood cells are preferably died by lyophilization.
摘要翻译：公开了固定干红细胞（RBC）及其制备方法。红细胞在用蒸馏水或适当的缓冲液重构后，与氧化天然亲和力结合，具有部分变形能力，对血小板具有最小的血栓形成，并且具有扁平的血型抗原。 RBCs优选通过具有醛官能团的交联剂例如多聚甲醛或戊二醛单独或组合固定。通过制备具有1,6-二磷酸果糖的红细胞来实现天然氧动力学。通过将聚氧乙烯二醇聚合物化学连接到红细胞的表面膜上，使冻干的RBC血栓形成的血型抗原和化学功能被阻断。交联的红细胞优选通过冻干死亡。

6. 发明授权

US07358039B2 Fixed-dried red blood cells 失效
标题翻译：固定干红细胞
公开(公告)号：US07358039B2
公开(公告)日：2008-04-15
申请号：US11041560
申请日：2005-01-24
申请人： Thomas H. Fischer , Marjorie S. Read , Arthur P. Bode , Timothy C. Nichols
发明人： Thomas H. Fischer , Marjorie S. Read , Arthur P. Bode , Timothy C. Nichols
IPC分类号： A01N1/02 , A01N63/00
CPC分类号： A01N1/0226 , A01N1/02 , A01N1/0284 , A01N1/0289 , A61K35/18
摘要： Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenicity to platelets, and have oblated blood group antigens. The RBCs are preferably fixed by means of cross-linkers with aldehyde functions such as paraformaldehyde or glutaraldehyde either alone or in combination. Native oxygen kinetics are achieved by preparing the red blood cells with 1,6-diphosphofructose. Blood group antigens and chemical functions that render the lyophilized RBCs thrombogenic are occluded by chemically attaching polyoxyethylene glycol polymers to the surface membrane of the red blood cells. The cross-linked red blood cells are preferably died by lyophilization.
摘要翻译：公开了固定干红细胞（RBC）及其制备方法。红细胞在用蒸馏水或适当的缓冲液重构后，与氧化天然亲和力结合，具有部分变形能力，对血小板具有最小的血栓形成，并且具有扁平的血型抗原。 RBCs优选通过具有醛官能团的交联剂例如多聚甲醛或戊二醛单独或组合固定。通过制备具有1,6-二磷酸果糖的红细胞来实现天然氧动力学。通过将聚氧乙烯二醇聚合物化学连接到红细胞的表面膜上，使冻干的RBC血栓形成的血型抗原和化学功能被阻断。交联的红细胞优选通过冻干死亡。

7. 发明授权

US5902608A Surgical aids containing pharmaceutically acceptable fixed-dried human blood platelets 失效
标题翻译：包含药学上可接受的固定干燥人血小板的外科辅助设备
公开(公告)号：US5902608A
公开(公告)日：1999-05-11
申请号：US775287
申请日：1996-12-31
申请人： Marjorie S. Read , Robert L. Reddick , Arthur P. Bode
发明人： Marjorie S. Read , Robert L. Reddick , Arthur P. Bode
IPC分类号： A01N1/02 , A61K35/14 , A61K35/19 , A61K38/18 , A61L15/40 , A61L17/00 , A61L26/00 , A61L27/22 , A61L27/50 , A61L27/60 , A61L31/00 , A61L33/00 , C12N5/08 , A61K35/18
CPC分类号： A61L27/50 , A01N1/0221 , A01N1/0231 , A61K35/19 , A61K38/1858 , A61L15/40 , A61L17/005 , A61L26/0047 , A61L26/0057 , A61L26/0066 , A61L27/227 , A61L27/3804 , A61L27/60 , A61L2300/414 , A61L2300/418 , A61L2300/602 , A61L2300/64 , A61L2400/04
摘要： Fixed-dried human blood platelets and processes for preparing them are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Surgical aids containing such platelets are also disclosed. The platelets are preferably fixed by a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by a permanganate fixate. The platelets are preferably dried by lyophilization.
摘要翻译：公开了固定的人血小板及其制备方法。重建后的血小板：粘附于血栓形成的表面; 不粘附于非血栓形成的表面; 在粘附于血栓形成的表面时经历形状变化（扩散）; 彼此粘附以在粘附于血栓形成表面时形成止血塞; 并释放其颗粒内容。还公开了含有这种血小板的外科手术辅助剂。血小板优选由固定剂如甲醛，多聚甲醛或戊二醛固定，或通过高锰酸盐固定物固定。血小板优选通过冻干干燥。

8. 发明授权

US5651966A Pharmaceutically acceptable fixed-dried human blood platelets 失效
标题翻译：药学上可接受的固定干燥人血小板
公开(公告)号：US5651966A
公开(公告)日：1997-07-29
申请号：US325424
申请日：1994-11-28
申请人： Marjorie S. Read , Robert L. Reddick , Arthur P. Bode
发明人： Marjorie S. Read , Robert L. Reddick , Arthur P. Bode
IPC分类号： A01N1/02 , A61K35/14 , A61K35/19 , A61K38/18 , A61L15/40 , A61L17/00 , A61L26/00 , A61L27/22 , A61L27/50 , A61L27/60 , A61L31/00 , A61L33/00 , C12N5/08 , A61K35/18
CPC分类号： A61L27/50 , A01N1/0221 , A01N1/0231 , A61K35/19 , A61K38/1858 , A61L15/40 , A61L17/005 , A61L26/0047 , A61L26/0057 , A61L26/0066 , A61L27/227 , A61L27/3804 , A61L27/60 , A61L2300/414 , A61L2300/418 , A61L2300/602 , A61L2300/64 , A61L2400/04
摘要： Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Pharmaceutical formulations containing the same are also disclosed. The platelets are preferably fixed by means of a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by means of a permanganate fixate. The platelets are preferably dried by lyophilization.
摘要翻译： PCT No.PCT / US93 / 04142 Sec。 371日期：1994年11月28日 102（e）日期1994年11月28日PCT 1993年4月28日PCT公布。第WO93 / 23997号公报日本1993年12月9日公开了固定干燥的人血小板及其制备方法。重建后的血小板：粘附于血栓形成的表面; 不粘附于非血栓形成的表面; 在粘附于血栓形成的表面时经历形状变化（扩散）; 彼此粘附以在粘附于血栓形成表面时形成止血塞; 并释放其颗粒内容。还公开了含有该制剂的药物制剂。血小板优选通过固定剂如甲醛，多聚甲醛或戊二醛固定，或通过高锰酸盐固定物固定。血小板优选通过冻干干燥。

9. 发明授权

US5993804A Pharmaceutically acceptable fixed-dried human blood platelets 失效
标题翻译：药学上可接受的固定干燥人血小板
公开(公告)号：US5993804A
公开(公告)日：1999-11-30
申请号：US775413
申请日：1996-12-31
申请人： Marjorie S. Read , Robert L. Reddick , Arthur P. Bode
发明人： Marjorie S. Read , Robert L. Reddick , Arthur P. Bode
IPC分类号： A01N1/02 , A61K35/14 , A61K35/19 , A61K38/18 , A61L15/40 , A61L17/00 , A61L26/00 , A61L27/22 , A61L27/50 , A61L27/60 , A61L31/00 , A61L33/00 , C12N5/08 , A61K35/18
CPC分类号： A61L27/50 , A01N1/0221 , A01N1/0231 , A61K35/19 , A61K38/1858 , A61L15/40 , A61L17/005 , A61L26/0047 , A61L26/0057 , A61L26/0066 , A61L27/227 , A61L27/3804 , A61L27/60 , A61L2300/414 , A61L2300/418 , A61L2300/602 , A61L2300/64 , A61L2400/04
摘要： Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Pharmaceutical formulations containing the same are also disclosed. The platelets are preferably fixed by means of a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by means of a permanganate fixate. The platelets are preferably dried by lyophilization.
摘要翻译：公开了固定干燥的人血小板及其制备方法。重建后的血小板：粘附于血栓形成的表面; 不粘附于非血栓形成的表面; 在粘附于血栓形成的表面时经历形状变化（扩散）; 彼此粘附以在粘附于血栓形成表面时形成止血塞; 并释放其颗粒内容。还公开了含有该制剂的药物制剂。血小板优选通过固定剂例如甲醛，多聚甲醛或戊二醛固定，或通过高锰酸盐固定物固定。血小板优选通过冻干干燥。

10. 发明授权

US4145185A Reagents for screening tests and bioassay of von Willebrand's factor (platelet aggregating factor) in blood plasmas 失效
标题翻译：血液血浆中von Willebrand {3 s因子（血小板聚集因子）的筛选试验和生物测定试剂
公开(公告)号：US4145185A
公开(公告)日：1979-03-20
申请号：US772228
申请日：1977-02-25
申请人： Kenneth M. Brinkhous , Marjorie S. Read
发明人： Kenneth M. Brinkhous , Marjorie S. Read
IPC分类号： G01N33/50 , G01N33/16 , A61K35/38 , C09K3/00
CPC分类号： G01N33/5005
摘要： Screening tests and bioassay of von Willebrand's factor (platelet aggregating factor) in human and animal blood plasma are effected using a reagent of blood platelets and snake venom having a positive platelet aggregating cofactor effect. The reagent and tests may also suitably employ dried blood platelets. The reagent may comprise dried platelets and either ristocetin or active snake venom as the platelet aggregating cofactor.
摘要翻译：使用血小板试剂和具有积极的血小板聚集辅因子作用的蛇毒进行人和动物血浆中von Willebrand因子（血小板聚集因子）的筛选试验和生物测定。试剂和试验也可适当地使用干血小板。试剂可以包含干血小板和瑞斯托菌素或活性蛇毒作为血小板聚集辅因子。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式