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1. 发明申请

US20140072659A1 DIETARY SUPPLEMENTS CONTAINING EXTRACTS OF NELUMBO AND METHODS OF USING SAME 审中-公开
标题翻译：含有NELUMBO提取物的膳食补充剂及其使用方法
公开(公告)号：US20140072659A1
公开(公告)日：2014-03-13
申请号：US14077720
申请日：2013-11-12
申请人： Tim Romero , Peter J. Miller , Bolin Qin
发明人： Tim Romero , Peter J. Miller , Bolin Qin
IPC分类号： A61K36/185 , A61K31/155
CPC分类号： A61K36/185 , A61K31/155 , A61K36/62
摘要： Materials derived from Nelumbo are administered orally to humans or animals for the purpose of enhancing creatine transport into skeletal tissue and for purposes of enhancing lean body mass. Enhancing creatine transport through improved insulin signaling is a new method of depositing creatine and enhancing lean body mass. Such administration is also used for enhancing athletic performance and controlling bodyweight and body fat levels. More specifically, such administration is used for the purpose of enhancing creatine transport into excitable tissues such as skeletal muscle. The material is administered as extracts of Nelumbo and administered in a variety of ways including capsules, tablets, powdered beverages, bars, gels or drinks.
摘要翻译：来自Nelumbo的材料经口施用于人或动物，目的是增强肌酸转运到骨骼组织中并用于增强瘦体重的目的。通过改善胰岛素信号增强肌酸运输是沉积肌酸和增强瘦体重的新方法。这种管理也用于增强运动表现和控制体重和体脂肪水平。更具体地，这种施用用于增强肌酸转运到可兴奋组织如骨骼肌中的目的。该物质作为Nelumbo的提取物施用，并以各种方式施用，包括胶囊，片剂，粉末饮料，酒吧，凝胶或饮料。

2. 发明申请

US20100204121A1 DIETARY SUPPLEMENTS CONTAINING TERPENOID ACIDS OF MASLINIC ACID OR OLEANOLIC ACID AND PROCESS FOR ENHANCING MUSCLE MASS IN MAMMALS 审中-公开
标题翻译：含有马来酸或油酸的三烯酸的膳食补充剂和用于增强肌肉中的肌肉质量的方法
公开(公告)号：US20100204121A1
公开(公告)日：2010-08-12
申请号：US12702726
申请日：2010-02-09
申请人： Augustin T. Romero , Tim Romero , Peter Miller
发明人： Augustin T. Romero , Tim Romero , Peter Miller
IPC分类号： A61K38/00 , A61K31/19
CPC分类号： A61K45/06 , A23L33/10 , A23L33/175 , A23L33/185 , A23L33/19 , A61K31/192 , A61K2300/00
摘要： A process for increasing lean body mass in a mammalian subject is provided that includes administering to the subject a purified quantity of maslinic acid, oleanolic acid, or a combination thereof. The administration can be orally and benefits from ingestion of an amino acid source such as dietary protein, oligopeptides, or amino acids. Administration within 2 hours of muscle-degrading exercise or on a daily basis for a period of time increases lean body mass.
摘要翻译：提供了一种用于增加哺乳动物受试者的瘦体重的方法，其包括向受试者施用纯化量的马斯酸，齐墩果酸或其组合。给药可以是口服的，并且有益于摄取氨基酸来源，例如膳食蛋白质，寡肽或氨基酸。在肌肉退化运动的2小时内或每天进行一段时间的管理会增加瘦体重。

3. 发明授权

US07850997B2 Dietary compositions and methods of enhancing lean body mass and exercise performance 有权
标题翻译：膳食组合物和增强瘦体重和锻炼性能的方法
公开(公告)号：US07850997B2
公开(公告)日：2010-12-14
申请号：US12052940
申请日：2008-03-21
申请人： Tim Romero , Peter Miller
发明人： Tim Romero , Peter Miller
IPC分类号： A61K33/00 , A61K9/68 , A01N37/12
CPC分类号： A61K36/87 , A23L33/175 , A23L33/30 , A23V2002/00 , A61K31/198 , C07C279/14 , A23V2200/332 , A23V2250/06 , A23V2250/21
摘要： Various compounds can be administered orally to humans or animals for the purpose of enhancing nitric oxide production. Enhancing nitric oxide production is beneficial for those looking to increase lean body mass or enhance exercise performance. Such administration can also be used for the purpose of enhancing nutrient transport for purposes of athletic performance and controlling bodyweight and body fat levels. L-Arginine and alpha amino n-Butryate work synergistically to enhance nitric oxide production and may further be coupled with either and/or a) an inhibitor of nitric oxide breakdown or b) a nitric oxide potentiators or other precursor and serve to accomplish this goal of enhance nitric oxide. The composition may be administered in a variety of ways including capsules, tablets, powdered beverages, bars, gels or drinks.
摘要翻译：为了增加一氧化氮产生的目的，各种化合物可以口服给予人或动物。增强一氧化氮的生产对于那些希望增加瘦体重或增强运动性能的人来说是有益的。这种施用也可以用于增强运动性能的营养物质运输，并且控制体重和体脂肪水平。 L-精氨酸和α氨基正丁醇协同作用以增强一氧化氮的产生，并且可以进一步与二氧化氮分解和/或a）一氧化氮分解抑制剂或b）一氧化氮增效剂或其它前体偶联，并用于实现该目标增强一氧化氮。组合物可以以各种方式施用，包括胶囊，片剂，粉末饮料，酒吧，凝胶或饮料。

4. 发明申请

US20100227007A1 DIETARY SUPPLEMENTS CONTAINING EXTRACTS OF NELUMBO AND PROCESSES OF USING SAME 有权
标题翻译：含有NELUMBO提取物的食物补充剂及其使用方法
公开(公告)号：US20100227007A1
公开(公告)日：2010-09-09
申请号：US12702753
申请日：2010-02-09
申请人： Tim Romero , Peter Miller , Bolin Qin
发明人： Tim Romero , Peter Miller , Bolin Qin
IPC分类号： A61K36/62 , A61P43/00
CPC分类号： A61K36/185 , A61K31/155 , A61K36/62
摘要： Materials derived from Nelumbo are administered orally to humans or animals for the purpose of enhancing creatine transport into skeletal tissue and for purposes of enhancing lean body mass. Enhancing creatine transport through improved insulin signaling is a new method of depositing creatine and enhancing lean body mass. Such administration is also used for enhancing athletic performance and controlling bodyweight and body fat levels. More specifically, such administration is used for the purpose of enhancing creatine transport into excitable tissues such as skeletal muscle. The material is administered as extracts of Nelumbo and administered in a variety of ways including capsules, tablets, powdered beverages, bars, gels or drinks.
摘要翻译：来自Nelumbo的材料经口施用于人或动物，目的是增强肌酸转运到骨骼组织中并用于增强瘦体重的目的。通过改善胰岛素信号增强肌酸运输是沉积肌酸和增强瘦体重的新方法。这种管理也用于增强运动表现和控制体重和体脂肪水平。更具体地，这种施用用于增强肌酸转运到可兴奋组织如骨骼肌中的目的。该物质作为Nelumbo的提取物施用，并以各种方式施用，包括胶囊，片剂，粉末饮料，酒吧，凝胶或饮料。

5. 发明授权

US09278104B2 Methods and materials for reducing multiple risk factors associated with the metabolic syndrome 有权
标题翻译：减少与代谢综合征相关的多种危险因素的方法和材料
公开(公告)号：US09278104B2
公开(公告)日：2016-03-08
申请号：US13882006
申请日：2011-10-26
申请人： Tim Romero
发明人： Tim Romero
IPC分类号： A61K36/54 , A61K36/00 , A61K31/575 , A23L1/30 , A23L1/302 , A23L1/305 , A61K9/00 , A61K9/14 , A61K36/62 , A61K31/045
CPC分类号： A61K36/185 , A23L33/10 , A23L33/105 , A23L33/11 , A23L33/15 , A23L33/175 , A23V2002/00 , A61K9/0019 , A61K9/145 , A61K31/045 , A61K31/575 , A61K36/54 , A61K36/62 , A23V2200/328 , A23V2250/21 , A23V2250/21368 , A23V2250/306
摘要： A composition containing nelumbo extract reduces and/or eliminates one or more risk factors associated with Metabolic syndrome. The composition also includes optionally one of more components selected from the group consisting of vitamins, cholesterol lowering agents, lipid lowering agents, and glucose lowering agent. Also described is a method of reducing and/or eliminating risk factors associated with Metabolic syndrome in a subject through the administration of the nelumbo extract. The nelumbo extract supplement is administered orally, intravenously, or subcutaneously. In one embodiment, a daily dose of 10-1,000 mg of the extract supplement is administered to the subject for a period of 6 weeks to 6 months.
摘要翻译：含有尼罗布提取物的组合物降低和/或消除与代谢综合征相关的一种或多种危险因素。所述组合物还包括选自维生素，降胆固醇剂，降脂剂和葡萄糖降低剂中的更多组分之一。还描述了通过施用尼罗布提取物来减少和/或消除与受试者中的代谢综合征相关的危险因素的方法。尼罗布提取物补充剂经口，静脉内或皮下给药。在一个实施方案中，将10-1,000mg的提取物补充剂的日剂量施用于受试者6周至6个月的时间。

6. 发明申请

US20130224317A1 METHODS AND MATERIALS FOR REDUCING MULTIPLE RISK FACTORS ASSOCIATED WITH THE METABOLIC SYNDROME 有权
标题翻译：减少与代谢综合征相关的多种风险因素的方法和材料
公开(公告)号：US20130224317A1
公开(公告)日：2013-08-29
申请号：US13882006
申请日：2011-10-26
申请人： Tim Romero
发明人： Tim Romero
IPC分类号： A61K31/575 , A61K36/54 , A61K31/045
CPC分类号： A61K36/185 , A23L33/10 , A23L33/105 , A23L33/11 , A23L33/15 , A23L33/175 , A23V2002/00 , A61K9/0019 , A61K9/145 , A61K31/045 , A61K31/575 , A61K36/54 , A61K36/62 , A23V2200/328 , A23V2250/21 , A23V2250/21368 , A23V2250/306
摘要： A composition containing nelumbo extract reduces and/or eliminates one or more risk factors associated with Metabolic syndrome. The composition also includes optionally one of more components selected from the group consisting of vitamins, cholesterol lowering agents, lipid lowering agents, and glucose lowering agent. Also described is a method of reducing and/or eliminating risk factors associated with Metabolic syndrome in a subject through the administration of the nelumbo extract. The nelumbo extract supplement is administered orally, intravenously, or subcutaneously. In one embodiment, a daily dose of 10-1,000 mg of the extract supplement is administered to the subject for a period of 6 weeks to 6 months.
摘要翻译：含有尼罗布提取物的组合物降低和/或消除与代谢综合征相关的一种或多种危险因素。所述组合物还包括选自维生素，降胆固醇剂，降脂剂和葡萄糖降低剂中的更多组分之一。还描述了通过施用尼罗布提取物来减少和/或消除与受试者中的代谢综合征相关的危险因素的方法。尼罗布提取物补充剂经口，静脉内或皮下给药。在一个实施方案中，将10-1,000mg的提取物补充剂的日剂量施用于受试者6周至6个月的时间。

7. 发明申请

US20130072574A1 DIETARY SUPPLEMENTS CONTAINING EXTRACTS OF CINNAMON AND METHODS OF USING SAME TO PROMOTE ENHANCED SIRTUIN, CELL AND TELOMERE INTEGRITY 审中-公开
标题翻译：含有CINNAMON提取物的膳食补充剂及其使用方法促进增强SIRTUIN，细胞和TELOMERE INTEGRITY
公开(公告)号：US20130072574A1
公开(公告)日：2013-03-21
申请号：US13699779
申请日：2011-05-26
申请人： Peter J. Miller , Tim Romero , Bolin Qin , Augustin T. Romero
发明人： Peter J. Miller , Tim Romero , Bolin Qin , Augustin T. Romero
IPC分类号： A61K38/06 , A61K36/54 , A61K31/05 , A61K31/08
CPC分类号： A61K36/54 , A23L33/105 , A23V2002/00 , A61K31/07 , A61K31/185 , A61K31/59 , A61K45/06 , A61K2300/00 , A23V2200/302 , A23V2250/21
摘要： A dietary supplement composition is provided for enhancing the expression of a sirtuin gene or protein. An inventive supplement composition includes at least one cinnamon extract containing at least 0.5% doubly linked Type-A polymers by dry weight. The cinnamon extract is derived from the Cinnamonum aromaticum, Cinnamonum verum or Cinnamonum burmannii plant. In some embodiments, the cinnamon extract is present at approximately 20%-50% of the dry weight of the composition. A vitamin, weight loss agent, or antioxidant is optionally provided in the composition. The dietary supplement composition is administered orally to promote expression or enhanced expression of a sirtuin gene or protein.
摘要翻译：提供膳食补充剂组合物用于增强沉默调节蛋白基因或蛋白质的表达。本发明的补充剂组合物包含至少一种含有至少0.5％双重A型聚合物的肉桂提取物。肉桂提取物衍生自Cinnamonum aromaticum，Cinnamonum verum或Cinnamonum burmannii植物。在一些实施方案中，肉桂提取物以组合物干重的约20％-50％存在。任选地在组合物中提供维生素，减肥剂或抗氧化剂。口服营养补充剂组合物以促进sirtuin基因或蛋白质的表达或增强的表达。

8. 发明申请

US20080233186A1 DIETARY COMPOSITIONS AND METHODS OF ENHANCING LEAN BODY MASS AND EXERCISE PERFORMANCE 有权
标题翻译：膳食组合物和增强身体质量和锻炼性能的方法
公开(公告)号：US20080233186A1
公开(公告)日：2008-09-25
申请号：US12052940
申请日：2008-03-21
申请人： Tim Romero , Peter Miller
发明人： Tim Romero , Peter Miller
IPC分类号： A61K9/48 , A61K31/198 , C07C279/14 , A61K36/87
CPC分类号： A61K36/87 , A23L33/175 , A23L33/30 , A23V2002/00 , A61K31/198 , C07C279/14 , A23V2200/332 , A23V2250/06 , A23V2250/21
摘要： Various compounds can be administered orally to humans or animals for the purpose of enhancing nitric oxide production. Enhancing nitric oxide production is beneficial for those looking to increase lean body mass or enhance exercise performance. Such administration can also be used for the purpose of enhancing nutrient transport for purposes of athletic performance and controlling bodyweight and body fat levels. L-Arginine and alpha amino n-Butryate work synergistically to enhance nitric oxide production and may further be coupled with either and/or a) an inhibitor of nitric oxide breakdown or b) a nitric oxide potentiators or other precursor and serve to accomplish this goal of enhance nitric oxide. The composition may be administered in a variety of ways including capsules, tablets, powdered beverages, bars, gels or drinks.
摘要翻译：为了增加一氧化氮产生的目的，各种化合物可以口服给予人或动物。增强一氧化氮的生产对于那些希望增加瘦体重或增强运动性能的人来说是有益的。这种施用也可以用于增强运动性能的营养物质运输，并且控制体重和体脂肪水平。 L-精氨酸和α氨基正丁醇协同作用以增强一氧化氮的产生，并且可以进一步与二氧化氮分解和/或a）一氧化氮分解抑制剂或b）一氧化氮增效剂或其它前体偶联，并用于实现该目标增强一氧化氮。组合物可以以各种方式施用，包括胶囊，片剂，粉末饮料，酒吧，凝胶或饮料。

9. 发明申请

US20070196520A1 METHODS AND MATERIALS FOR REDUCING OR ELIMINATING RISK FACTORS ASSOCIATED WITH SYNDROME X 审中-公开
标题翻译：减少或消除与症状相关的风险因素的方法和材料
公开(公告)号：US20070196520A1
公开(公告)日：2007-08-23
申请号：US11673063
申请日：2007-02-09
申请人： Jie Lin , Tim Romero
发明人： Jie Lin , Tim Romero
IPC分类号： A61K36/54
CPC分类号： A61K36/54
摘要： A composition containing cinnamon extract reduces and/or eliminates one or more risk factors associated with Syndrome X. The composition also includes optionally one of more components selected from the group consisting of vitamins, cholesterol lowering agents, lipid lowering agents, and glucose lowering agent. Also described is a method of reducing and/or eliminating risk factors associated with Syndrome X in a subject through the administration of the cinnamon extract. The cinnamon extract supplement is administered orally, intravenously, or subcutaneously. In one embodiment, a daily dose of 10-1,000 mg of the cinnamon extract supplement is administered to the subject for a period of 6 weeks to 6 months.
摘要翻译：包含肉桂提取物的组合物降低和/或消除与综合征X相关的一种或多种危险因素。组合物还包括选自维生素，降胆固醇，降脂药和葡萄糖降低剂的更多组分之一。还描述了通过施用肉桂提取物来减少和/或消除与受试者中的综合征X相关的危险因素的方法。肉桂提取物补充剂经口，静脉内或皮下给药。在一个实施方案中，将10-1000mg肉桂提取物补充剂的日剂量施用于受试者6周至6个月的时间。

10. 发明申请

US20080242727A1 DIETARY COMPOSITIONS CONTAINING ALPHA AMINO N-BUTYRATE AND METHODS OF ENHANCING LEAN BODY MASS 审中-公开
标题翻译：含有ALPHA氨基丁酸的食品组合物及其增强身体质量的方法
公开(公告)号：US20080242727A1
公开(公告)日：2008-10-02
申请号：US12056662
申请日：2008-03-27
申请人： Tim Romero , Peter Miller
发明人： Tim Romero , Peter Miller
IPC分类号： A61K31/164 , A61P21/00
CPC分类号： A61K45/06 , A61K31/164 , A61K31/198 , A61K2300/00
摘要： A composition that may include branched chain amino acids, alpha amino n-Butyrate and/or alpha amino-n-valerate works synergistically to enhance lean body mass and prevent body mass breakdown. The composition may also be coupled with other agents to a) provide an increased level of amino acids and/or protein in the body's total pool or b) increase markers for protein translation or decrease markers of protein turnover. The composition may be administered in a variety of ways including capsules, tablets, powdered beverages, bars, gels or drinks. Increasing lean body mass is import to athletes looking to enhance performance, in the event of certain muscle wasting diseases, and to the general population that loses muscle mass as it ages.
摘要翻译：可以包括支链氨基酸，α-氨基正丁酸盐和/或α-氨基正戊酸盐的组合物协同地起作用以增强瘦体重并防止体重下降。组合物还可以与其它试剂偶联以a）在体内总池中提供增加水平的氨基酸和/或蛋白质，或b）增加蛋白质翻译的标记或降低蛋白质周转的标志物。组合物可以以各种方式施用，包括胶囊，片剂，粉末饮料，酒吧，凝胶或饮料。越来越瘦的身体质量是进口到运动员，如果某些肌肉消瘦疾病，以及一般人群随着年龄增长而失去肌肉量，就会提高性能。

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