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1. 发明申请

US20050214833A1 Cyanine dyes 有权
标题翻译：花青染料
公开(公告)号：US20050214833A1
公开(公告)日：2005-09-29
申请号：US11051666
申请日：2005-02-04
申请人： Tim Carter , Mark Reddington
发明人： Tim Carter , Mark Reddington
IPC分类号： C12Q1/37 , C12Q1/68 , G01N33/542 , C07D43/02
CPC分类号： G01N33/542 , C12Q1/37 , C12Q2337/00 , G01N2333/95
摘要： The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.
摘要翻译：本发明提供了一种新颖的花青染料，其可以通过促进它们与其它物质共轭的连接体部分官能化。还提供了染料的缀合物，使用染料及其缀合物的方法和试剂盒，包括染料及其缀合物。

2. 发明授权

US07705150B2 Cyanine dyes 有权
标题翻译：花青染料
公开(公告)号：US07705150B2
公开(公告)日：2010-04-27
申请号：US11051666
申请日：2005-02-04
申请人： Tim Carter , Mark Reddington
发明人： Tim Carter , Mark Reddington
IPC分类号： C09B23/06 , C09B23/08
CPC分类号： G01N33/542 , C12Q1/37 , C12Q2337/00 , G01N2333/95
摘要： The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.
摘要翻译：本发明提供了一种新颖的花青染料，其可以通过促进它们与其它物质共轭的连接体部分官能化。还提供了染料的缀合物，使用染料及其缀合物的方法和试剂盒，包括染料及其缀合物。

3. 发明授权

US08436153B2 Cyanine dyes 有权
标题翻译：花青染料
公开(公告)号：US08436153B2
公开(公告)日：2013-05-07
申请号：US12652625
申请日：2010-01-05
申请人： Tim Carter , Mark Reddington
发明人： Tim Carter , Mark Reddington
IPC分类号： C09B23/02 , C09B23/06 , C09B23/08 , C07H19/00 , C12Q1/68
CPC分类号： G01N33/542 , C12Q1/37 , C12Q2337/00 , G01N2333/95
摘要： The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.
摘要翻译：本发明提供了一种新颖的花青染料，其可以通过促进它们与其它物质共轭的连接体部分官能化。还提供了染料的缀合物，使用染料及其缀合物的方法和试剂盒，包括染料及其缀合物。

4. 发明申请

US20120115133A1 CYANINE DYES 有权
公开(公告)号：US20120115133A1
公开(公告)日：2012-05-10
申请号：US13179345
申请日：2011-07-08
申请人： Tim Carter , Mark Reddington
发明人： Tim Carter , Mark Reddington
IPC分类号： C12Q1/68
CPC分类号： G01N33/542 , C12Q1/37 , C12Q2337/00 , G01N2333/95
摘要： The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.
摘要翻译：本发明提供了一种新颖的花青染料，其可以通过促进它们与其它物质共轭的连接体部分官能化。还提供了染料的缀合物，使用染料及其缀合物的方法和试剂盒，包括染料及其缀合物。

5. 发明授权

US09435796B2 Cyanine dyes 有权
公开(公告)号：US09435796B2
公开(公告)日：2016-09-06
申请号：US13179345
申请日：2011-07-08
申请人： Tim Carter , Mark Reddington
发明人： Tim Carter , Mark Reddington
IPC分类号： C12Q1/68 , G01N33/542 , C12Q1/37
CPC分类号： G01N33/542 , C12Q1/37 , C12Q2337/00 , G01N2333/95
摘要： The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.

6. 发明申请

US20100136567A1 CYANINE DYES 有权
公开(公告)号：US20100136567A1
公开(公告)日：2010-06-03
申请号：US12652625
申请日：2010-01-05
申请人： Tim Carter , Mark Reddington
发明人： Tim Carter , Mark Reddington
IPC分类号： C12Q1/68 , C07D209/02 , C07F9/02 , C07K2/00 , C07H21/00 , C12Q1/37
CPC分类号： G01N33/542 , C12Q1/37 , C12Q2337/00 , G01N2333/95
摘要： The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.
摘要翻译：本发明提供了一种新颖的花青染料，其可以通过促进它们与其它物质共轭的连接体部分官能化。还提供了染料的缀合物，使用染料及其缀合物的方法和试剂盒，包括染料及其缀合物。

7. 发明授权

US10078079B2 Device for detecting an analyte 有权
公开(公告)号：US10078079B2
公开(公告)日：2018-09-18
申请号：US14110033
申请日：2012-04-05
申请人： Steve Ross , Julie Richards , Tim Carter
发明人： Steve Ross , Julie Richards , Tim Carter
IPC分类号： G01N33/543 , G01N21/17 , G01N29/02 , G01N33/542 , G01N33/53 , G01N21/64 , G01N33/58
CPC分类号： G01N33/54373 , G01N21/171 , G01N21/6428 , G01N29/022 , G01N33/5302 , G01N33/542 , G01N33/582 , G01N2021/6439 , G01N2201/062 , G01N2291/02433 , G01N2291/0255 , G01N2291/0256
摘要： This invention relates to a device for detecting an analyte in a sample comprising: a radiation source adapted to generate a series of pulses of electromagnetic radiation; a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing energy generated by non-radiative decay into an electrical signal; a detector which is capable of detecting the electrical signal generated by the transducer; a first reagent proximal to the transducer, the first reagent having a binding site which is capable of binding a labelled reagent proportionally to the concentration of the analyte in the sample, which labelled reagent being capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; a second reagent proximal to the transducer, the second reagent having a lower affinity for the labelled reagent under the conditions of the assay than the first reagent; and a third reagent proximal to the transducer, the third reagent having a binding site which is capable of binding the labelled reagent, wherein the third reagent has an affinity for the labelled reagent which is less influenced than the first reagent by the concentration of the analyte or the complex or derivative of the analyte.

8. 发明申请

US20140119995A1 DEVICE FOR DETECTING AN ANALYTE 审中-公开
标题翻译：用于检测分析仪的装置
公开(公告)号：US20140119995A1
公开(公告)日：2014-05-01
申请号：US14110033
申请日：2012-04-05
申请人： Steve Ross , Julie Richards , Tim Carter
发明人： Steve Ross , Julie Richards , Tim Carter
IPC分类号： G01N33/53
CPC分类号： G01N33/54373 , G01N21/171 , G01N21/6428 , G01N29/022 , G01N33/5302 , G01N33/542 , G01N33/582 , G01N2021/6439 , G01N2201/062 , G01N2291/02433 , G01N2291/0255 , G01N2291/0256
摘要： This invention relates to a device for detecting an analyte in a sample comprising: a radiation source adapted to generate a series of pulses of electromagnetic radiation; a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing energy generated by non-radiative decay into an electrical signal; a detector which is capable of detecting the electrical signal generated by the transducer; a first reagent proximal to the transducer, the first reagent having a binding site which is capable of binding a labelled reagent proportionally to the concentration of the analyte in the sample, which labelled reagent being capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; a second reagent proximal to the transducer, the second reagent having a lower affinity for the labelled reagent under the conditions of the assay than the first reagent; and a third reagent proximal to the transducer, the third reagent having a binding site which is capable of binding the labelled reagent, wherein the third reagent has an affinity for the labelled reagent which is less influenced than the first reagent by the concentration of the analyte or the complex or derivative of the analyte.
摘要翻译：本发明涉及一种用于检测样品中分析物的装置，包括：辐射源，适于产生一系列电磁辐射脉冲; 具有热电或压电元件的传感器和能够将由非辐射衰减产生的能量转换成电信号的电极; 检测器，其能够检测由换能器产生的电信号; 靠近换能器的第一试剂，第一试剂具有结合位点，其能够将标记的试剂与样品中分析物的浓度成比例地结合，该标记试剂能够吸收由辐射源产生的电磁辐射，通过非辐射衰减产生能量; 靠近换能器的第二试剂，所述第二试剂在所述测定条件下对所述标记试剂的亲和力低于所述第一试剂; 以及靠近所述换能器的第三试剂，所述第三试剂具有能够结合所述标记试剂的结合位点，其中所述第三试剂对所述标记试剂具有亲和性，所述试剂比所述第一试剂的浓度受到分析物的浓度影响小或分析物的复合物或衍生物。

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