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    • 9. 发明授权
    • Mutated 5-enolpyruvylshikimate-3-phosphate synthase, gene coding for said protein and transformed plants containing said gene
    • 突变的5-烯醇丙酮酸莽草酸-3-磷酸合酶,编码所述蛋白质的基因和含有所述基因的转化植物
    • US06566587B1
    • 2003-05-20
    • US08945144
    • 1998-01-20
    • Michel LebrunAlain SaillandGeorges FreyssinetEric Degryse
    • Michel LebrunAlain SaillandGeorges FreyssinetEric Degryse
    • C12N1582
    • C12N9/1092C12N15/8275
    • The present invention relates to DNA molecules of plant origin encoding a modified 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) enzyme wherein the a first EPSPS coding sequence that normally encodes a threonine residue of a mature EPSPS sequence is modified to encode isoleucine of the mature EPSPS sequence, and a second EPSPS coding sequence that normally encodes a proline residue of a mature EPSPS sequence is modified to encode serine of the mature EPSPS sequence, wherein the first and second residues are respectively located at relatively positions 102 and 106 of a mature EPSPS sequence encoded by said DNA molecule; and the production of a transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The mutated enzyme, which substantially maintains the catalytic activity of the wild-type enzyme, allows for increased tolerance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells.
    • 本发明涉及编码经修饰的5-烯醇丙酮酸莽草酸-3-磷酸合成酶(EPSPS)酶的植物来源的DNA分子,其中通常将编码成熟EPSPS序列的苏氨酸残基的第一EPSPS编码序列修饰为编码 修饰成熟的EPSPS序列,并且通常编码成熟EPSPS序列的脯氨酸残基的第二EPSPS编码序列被修饰以编码成熟EPSPS序列的丝氨酸,其中第一和第二残基分别位于成熟的EPSPS序列的相对位置102和106 由所述DNA分子编码的EPSPS序列; 以及产生对膦酰基甲基甘氨酸家族例如草甘膦的除草剂具有抗性或耐受性的转基因植物。 基本上保持野生型酶的催化活性的突变酶允许植物对膦酰基甲基甘氨酸家族的除草剂的耐受性或耐受性增加,并允许植物,其器官的基本正常生长或发育, 组织或细胞。