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1. 发明授权

US07977065B2 Yeast strains autonomously producing steroids 有权
标题翻译：酵母菌自主生产类固醇
公开(公告)号：US07977065B2
公开(公告)日：2011-07-12
申请号：US12683642
申请日：2010-01-07
申请人： Roberto Spagnoli , Tilman Achstetter , Gilles Cauet , Eric Degryse , Bruno Dumas , Denis Pompon , Jacques Winter
发明人： Roberto Spagnoli , Tilman Achstetter , Gilles Cauet , Eric Degryse , Bruno Dumas , Denis Pompon , Jacques Winter
IPC分类号： C12P33/00 , C12P33/18 , C12P33/06 , C12N15/00 , C12N1/15 , C12P21/00
CPC分类号： C12Y114/15004 , C12P33/005 , C12P33/08 , C12P33/18 , C12Y114/15006 , C12Y114/99009 , C12Y114/9901 , C12Y118/01002
摘要： The present invention relates to genetically modified yeast strains autonomously producing, from a simple carbon source, steroids. The invention also relates to a method for producing steroids from such yeast strains.
摘要翻译：本发明涉及从简单的碳源自主生产类固醇的转基因酵母菌株。本发明还涉及从这样的酵母菌株生产类固醇的方法。

2. 发明授权

US07670829B2 Yeast strains autonomously producing steroids 有权
标题翻译：酵母菌自主生产类固醇
公开(公告)号：US07670829B2
公开(公告)日：2010-03-02
申请号：US10470673
申请日：2002-01-29
申请人： Roberto Spagnoli , Tilman Achstetter , Gilles Cauet , Eric Degryse , Bruno Dumas , Denis Pompon , Jacques Winter
发明人： Roberto Spagnoli , Tilman Achstetter , Gilles Cauet , Eric Degryse , Bruno Dumas , Denis Pompon , Jacques Winter
IPC分类号： C12N1/19 , C12N1/18 , C12P21/00 , C12P33/00 , C12P33/12 , C12P33/18 , C12P33/08 , C12N15/00 , C07H21/00
CPC分类号： C12Y114/15004 , C12P33/005 , C12P33/08 , C12P33/18 , C12Y114/15006 , C12Y114/99009 , C12Y114/9901 , C12Y118/01002
摘要： The present invention relates to genetically modified yeast strains autonomously producing, from a simple carbon source, steroids. The invention also relates to a method for producing steroids from such yeast strains.
摘要翻译：本发明涉及从简单的碳源自主生产类固醇的转基因酵母菌株。本发明还涉及从这样的酵母菌株生产类固醇的方法。

3. 发明申请

US20090239837A1 CHOLESTEROL-PRODUCING YEAST STRAINS AND USES THEREOF 有权
标题翻译：生产天竺葵油的菌株及其用途
公开(公告)号：US20090239837A1
公开(公告)日：2009-09-24
申请号：US11568572
申请日：2005-05-02
申请人： Denis Pompon , Bruno Dumas , Roberto Spagnoli
发明人： Denis Pompon , Bruno Dumas , Roberto Spagnoli
IPC分类号： A61K31/56 , C12N1/00 , C12N1/16 , C12P7/02 , A61P43/00
CPC分类号： A61K51/0493 , C07B2200/05 , C12P33/00
摘要： The invention concerns the production of cholesterol in organisms of the Fungi kingdom. More particularly, the invention concerns genetically modified Fungus independently producing cholesterol from a simple carbon source. The invention also concerns the use of the inventive Fungus for producing non-marked and marked cholesterol.
摘要翻译：本发明涉及真菌王国生物体内胆固醇的产生。更具体地说，本发明涉及从简单碳源独立生产胆固醇的转基因真菌。本发明还涉及本发明的真菌用于产生未标记和显着的胆固醇的用途。

4. 发明授权

US08685705B2 Desmosterol-producing yeast strains and uses thereof 有权
标题翻译：产生赖氨酸的酵母菌株及其用途
公开(公告)号：US08685705B2
公开(公告)日：2014-04-01
申请号：US13479355
申请日：2012-05-24
申请人： Denis Pompon , Bruno Dumas , Roberto Spagnoli
发明人： Denis Pompon , Bruno Dumas , Roberto Spagnoli
IPC分类号： C12P7/02 , C12N9/00 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： A61K51/0493 , C07B2200/05 , C12P33/00
摘要： The invention concerns the production of cholesterol of the Fungi kingdom. More particularly, the invention concerns genetically modified Fungus independently producing cholesterol from a simple carbon source. The invention also concerns the use of the inventive Fungus for producing non-marked and marked cholesterol.
摘要翻译：本发明涉及真菌王国的胆固醇生产。更具体地说，本发明涉及从简单碳源独立生产胆固醇的转基因真菌。本发明还涉及本发明的真菌用于产生未标记和显着的胆固醇的用途。

5. 发明授权

US08211676B2 Cholesterol-producing yeast strains and uses thereof 有权
标题翻译：产生胆固醇的酵母菌株及其用途
公开(公告)号：US08211676B2
公开(公告)日：2012-07-03
申请号：US11568572
申请日：2005-05-02
申请人： Denis Pompon , Bruno Dumas , Roberto Spagnoli
发明人： Denis Pompon , Bruno Dumas , Roberto Spagnoli
IPC分类号： C12P7/02 , C12N9/00 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： A61K51/0493 , C07B2200/05 , C12P33/00
摘要： The invention concerns the production of cholesterol in organisms of the Fungi kingdom. More particularly, the invention concerns genetically modified Fungus independently producing cholesterol from a simple carbon source. The invention also concerns the use of the inventive Fungus for producing non-marked and marked cholesterol.
摘要翻译：本发明涉及真菌王国生物体内胆固醇的产生。更具体地说，本发明涉及从简单碳源独立生产胆固醇的转基因真菌。本发明还涉及本发明的真菌用于产生未标记和显着的胆固醇的用途。

6. 发明申请

US20120231495A1 PRODUCTION OF NON-YEAST STEROLS BY YEAST 有权
标题翻译： YEAST生产非YEAST STEROLS
公开(公告)号：US20120231495A1
公开(公告)日：2012-09-13
申请号：US13510636
申请日：2010-11-24
申请人： Hans-Peter Hohmann , Martin Lehmann , Muriel Merkamm , Denis Pompon
发明人： Hans-Peter Hohmann , Martin Lehmann , Muriel Merkamm , Denis Pompon
IPC分类号： C12P33/06 , C12N15/53 , C12N15/81 , C12N1/19
CPC分类号： C12P33/00 , C12N9/001 , C12N9/0067 , C12N9/0071 , C12N9/0083 , C12N9/1007 , C12P33/06
摘要： This invention relates to the production of 7-dehydrocholesterol, 25-hydroxy-7-dehydrocholesterol, and 25-hydroxy ergosterol in yeast such as Saccharomyces cerevisiae. It also related to various enzymes catalyzing the reduction of the double bond at position 24 of lanosterol, dimethyl zymosterol, methyl zymosterol, zymosterol, cholesta-7, 24-dienol, or cholesta-5,7,24-trienol; or the hydroxylation at position 25 of ergosterol, 7-dehydrocholesterol, cholesta-8-enol, and cholesta-7-enol. It also relates to various nucleic acids encoding cholesterol C25-hydroxylases and sterol Δ24-reductases and their use to produce and hydroxylate 7-dehydrocholesterol or ergosterol. It also relates to the yeast strains so produced, and methods of making these sterols comprising the steps of cultivation a transformed yeast cell, and harvesting the resulting sterol(s).
摘要翻译：本发明涉及酵母如酿酒酵母中7-脱氢胆固醇，25-羟基-7-脱氢胆固醇和25-羟基麦角甾醇的生产。它还涉及催化羊毛甾醇，二甲基十八烷醇，甲基十八醇，十八酮，胆甾烯-7,24-二烯醇或胆石酯-5,7,24-三烯酚在位置24处双键还原的各种酶。或麦角甾醇，7-脱氢胆固醇，胆甾烯-8-烯醇和胆甾烯-7-烯醇在25位的羟基化。它还涉及编码胆固醇C25-羟化酶和甾醇和Dgr; 24-还原酶的各种核酸，以及它们用于产生7-羟基胆固醇或麦角固醇羟基化的用途。它还涉及如此制备的酵母菌株，以及制备这些甾醇的方法包括培养转化的酵母细胞的步骤，并收获所得的甾醇。

7. 发明授权

US5635369A Yeast strains with stable integration of heterologous genes 失效
标题翻译：具有稳定整合异源基因的酵母菌株
公开(公告)号：US5635369A
公开(公告)日：1997-06-03
申请号：US182127
申请日：1994-01-13
申请人： Denis Pompon , Christophe Cullin , Gilles Truan , Philippe Urban , Piotr Slonimski
发明人： Denis Pompon , Christophe Cullin , Gilles Truan , Philippe Urban , Piotr Slonimski
IPC分类号： C07K14/80 , C12N1/18 , C12N1/19 , C12N9/02 , C12N9/16 , C12N15/09 , C12N15/81 , C12P21/02 , C12N1/15
CPC分类号： C12N9/0042 , C07K14/80 , C12N1/18 , C12N15/81 , C12N9/0004 , C12N9/16
摘要： Yeast strains and a method of expression in yeast of the monooxygenase activity of heterologous cytochromes P450 are disclosed. Within the genome of the yeast strain, genes for NADPH-cytochrome P450 reductase and cytochrome b5 are stably integrated and coexpressed. The genome is transformed with a plasmid carrying a cassette for the expression of a heterologous P450 gene.
摘要翻译： PCT No.PCT / FR92 / 00682 Sec。 371日期1994年1月13日 102（e）日期1994年1月13日PCT提交1992年7月15日PCT公布。出版物WO93 / 02200 日期：1993年2月4日公开了异源细胞色素P450的单加氧酶活性的酵母菌株和酵母表达方法。在酵母菌株的基因组中，NADPH-细胞色素P450还原酶和细胞色素b5的基因稳定整合并共表达。用携带用于表达异源P450基因的盒的质粒转化基因组。

8. 发明申请

US20060110728A1 Supported double layer structure for displaying a nucleic acid associated with a protein 失效
标题翻译：用于显示与蛋白质相关的核酸的支持的双层结构
公开(公告)号：US20060110728A1
公开(公告)日：2006-05-25
申请号：US10474299
申请日：2002-04-03
申请人： Denis Pompon , Wilfried Boireau , Marie-Agnes Sari , Sophie Bombard
发明人： Denis Pompon , Wilfried Boireau , Marie-Agnes Sari , Sophie Bombard
IPC分类号： C12Q1/68 , C12M1/34 , C12N5/00
CPC分类号： G01N33/543 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C40B40/06 , C40B40/10 , C12Q2565/607
摘要： The invention concerns novel biosensors, in particular a support for displaying nucleic acids and for detecting both the presence of nucleic acids in a sample and the linkage between proteins and nucleic acids, as well as the linkage between a ligand and a protein linked to a nucleic acid.
摘要翻译：本发明涉及新型生物传感器，特别是显示核酸的支持物，以及检测样品中核酸的存在以及蛋白质和核酸之间的连接以及配体与与核酸连接的蛋白质之间的连接酸。

9. 发明授权

US5989881A Nucleic acid molecules encoding delta-5,7-sterol, delta-7 reductase from arabidopsis thaliana 失效
标题翻译：编码来自拟南芥的Δ-5,7-甾醇，δ-7还原酶的核酸分子
公开(公告)号：US5989881A
公开(公告)日：1999-11-23
申请号：US783202
申请日：1997-01-14
申请人： Xavier Chenivesse , Catherine Duport , Eric Lecain , Denis Pompon
发明人： Xavier Chenivesse , Catherine Duport , Eric Lecain , Denis Pompon
IPC分类号： C12N1/19 , C07H21/04 , C07K14/415 , C07K16/00 , C07K16/16 , C12N9/02 , C12N15/09 , C12N15/29 , C12N15/31 , C12N15/52 , C12N15/53 , C12N15/81 , C12N15/82 , C12P33/00 , C12P33/02 , C12Q1/68 , C12R1/645 , G01N33/53 , G01N33/573 , C12N1/16 , C12N15/00
CPC分类号： C12N9/001 , C12P33/02
摘要： A nucleic acid sequence containing a sequence coding for a protein having a delta-5,7 sterol, delta-7 reductase activity, said nucleic acid being a DNA or an RNA, production process, strains of transformed yeasts and uses thereof.
摘要翻译：含有编码具有δ-5,7固醇，δ-7还原酶活性的蛋白质的序列的核酸序列，所述核酸是DNA或RNA，生产方法，转化的酵母菌株及其用途。

10. 发明授权

US07294460B2 Supported double layer structure for displaying a nucleic acid associated with a protein 失效
标题翻译：用于显示与蛋白质相关的核酸的支持的双层结构
公开(公告)号：US07294460B2
公开(公告)日：2007-11-13
申请号：US10474299
申请日：2002-04-03
申请人： Denis Pompon , Wilfrid Boireau , Marie-Agnès Sari , Sophie Bombard
发明人： Denis Pompon , Wilfrid Boireau , Marie-Agnès Sari , Sophie Bombard
IPC分类号： C12Q1/68 , C12M1/00
CPC分类号： G01N33/543 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C40B40/06 , C40B40/10 , C12Q2565/607
摘要： The invention concerns novel biosensors, in particular a support for displaying nucleic acids and for detecting both the presence of nucleic acids in a sample and the linkage between proteins and nucleic acids, as well as the linkage between a ligand and a protein linked to a nucleic acid.
摘要翻译：本发明涉及新型生物传感器，特别是显示核酸的支持物，以及检测样品中核酸的存在以及蛋白质和核酸之间的连接以及配体与与核酸连接的蛋白质之间的连接酸。

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