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1. 发明授权

US4614740A 5H-2,3-benzodiazepine derivatives and pharmaceutical compositions containing the same 失效
标题翻译： 5H-2,3-苯并二氮杂衍生物和含有它们的药物组合物
公开(公告)号：US4614740A
公开(公告)日：1986-09-30
申请号：US759169
申请日：1985-07-26
申请人： Tibor Lang , Jeno Korosi , Ferenc Andrasi , Peter Botka , Tamas Hamori , Pal Berzsenyi , Katalin Goldschmidt , Gabor Zolyomi , Istvan Elekes , Zsuzsanna Lang nee Rihmer
发明人： Tibor Lang , Jeno Korosi , Ferenc Andrasi , Peter Botka , Tamas Hamori , Pal Berzsenyi , Katalin Goldschmidt , Gabor Zolyomi , Istvan Elekes , Zsuzsanna Lang nee Rihmer
IPC分类号： A61K31/55 , A61P21/02 , A61P25/20 , C07D243/02 , C07D243/04 , C07D243/10 , C07D491/04 , C07D491/056 , A61K31/35 , C07D243/00
CPC分类号： C07D491/04 , C07D243/02
摘要： The invention relates to new 5H-2,3-benzodiazepine derivatives and a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same.The new 5H-2,3-benzodiazepine derivatives of the invention possess valuable central nervous effect and in particular exert antiaggressive, anxiolytic, narcosis potentiating and soporific properties.
摘要翻译：本发明涉及新的5H-2,3-苯并二氮杂衍生物及其制备方法，此外涉及含有它们的药物组合物。本发明的新的5H-2,3-苯并二氮杂衍生物具有有价值的中枢神经效应，特别是具有抗刺激，抗焦虑，麻醉增效和口服特性。

2. 发明授权

US4835152A 1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-b enzodiazepine and acid addition salts thereof same 失效
标题翻译： 1-（4-氨基苯基）-4-甲基-7,8-亚甲二氧基-3,4-二氢-5H-2,3-苯并二氮杂及其酸加成盐
公开(公告)号：US4835152A
公开(公告)日：1989-05-30
申请号：US87341
申请日：1987-08-20
申请人： Jeno Korosi , Tibor Lang , Ferenc Andrasi , Pal Berzsenyi , Peter Botka , Tamas Hamori , Katalin G. Horvath , Jozsef Borsi , Istvan Elekes , Zsuzsanna L. Rihmer
发明人： Jeno Korosi , Tibor Lang , Ferenc Andrasi , Pal Berzsenyi , Peter Botka , Tamas Hamori , Katalin G. Horvath , Jozsef Borsi , Istvan Elekes , Zsuzsanna L. Rihmer
IPC分类号： C07D405/10 , A61K31/55 , A61K31/551 , A61P25/26 , C07D491/04 , C07D491/056
CPC分类号： C07D491/04
摘要： The invention relates to new 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepi ne of formula (1), optically active isomers and acid addition salts thereof as well as to pharmaceutical compositions containing these compounds. ##STR1## The new compounds of formula (I) can be prepared by reducing 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine of formula (II) with an inorganic or organic-inorganic and/or complex metal hydride and, if desired, separating the optically active forms of the compound of formula (I) thus-obtained and, if desired, converting the base or bases into acid addition salts or converting the salts into the free bases(s). ##STR2## The new compound of formula (I) possesses significant central nervous effects and can advantageously be used in the therapy.
摘要翻译：本发明涉及式（1）的新的1-（4-氨基苯基）-4-甲基-7,8-亚甲二氧基-3,4-二氢-5H-2,3-苯并二氮杂，旋光异构体和酸加成其盐以及含有这些化合物的药物组合物。（I）式（I）的新化合物可以通过将式（II）的1-（4-氨基苯基）-4-甲基-7,8-亚甲二氧基-5H-2,3-苯并二氮杂与无机或有机 - 无机和/或络合金属氢化物，如果需要，分离由此获得的式（I）化合物的光学活性形式，如果需要，将碱或碱转化为酸加成盐或将盐进入游离碱。（II）式（I）的新化合物具有显着的中枢神经作用，可有利地用于治疗。

3. 发明授权

US6075018A 1-[2-(substituted vinyl)]-3,4-dihydro-4-dihydro-5H-2,3-benzodiazepine derivatives 失效
标题翻译： 1- [2-（取代的乙烯基）] -3,4-二氢-4-二氢-5 + E，H + EE -2,3-苯并二氮杂衍生物
公开(公告)号：US6075018A
公开(公告)日：2000-06-13
申请号：US599235
申请日：1996-02-09
申请人： Pal Vago , Jozsef Reiter , Istvan Gyertyan , Gabor Gigler , Ferenc Andrasi , Anna Bakonyi , Pal Berzsenyi , Peter Botka, deceased , Erszebet Birkas , Tamas Hamori , Edit Horvath , Katalin Horvath , Jeno Korosi, deceased , Gyorgyne Mate , Imre Moravcsik , Gyorgy Somogyi , Eszter Szentkuti , Gabor Zolyomi
发明人： Pal Vago , Jozsef Reiter , Istvan Gyertyan , Gabor Gigler , Ferenc Andrasi , Anna Bakonyi , Pal Berzsenyi , Peter Botka, deceased , Erszebet Birkas , Tamas Hamori , Edit Horvath , Katalin Horvath , Jeno Korosi, deceased , Gyorgyne Mate , Imre Moravcsik , Gyorgy Somogyi , Eszter Szentkuti , Gabor Zolyomi
IPC分类号： A61K31/55 , A61K31/551 , A61P25/00 , C07D243/02 , C07D243/04 , C07D405/06 , C07D491/04 , C07D491/056 , C07D493/04 , A61K31/395
CPC分类号： C07D405/06 , C07D243/02 , C07D491/04 , C07D493/04
摘要： The invention relates to new 1-[2-(substituted vinyl)]-3,4-dihydro-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof and pharmaceutical compositions comprising them. The new 1-[2-(substituted vinyl)]-3,4-dihidro-5H-2,3-benzodiazepine derivatives according to the invention correspond to the general formula (I), ##STR1## wherein the variables are hereinbelow defined: The new compounds according to the invention affect the central nervous system and can be used to advantage in the therapy.
摘要翻译：本发明涉及新的1- [2-（取代的乙烯基）] -3,4-二氢-5 + E，非H + EE-2,3-苯并二氮杂衍生物，其制备方法和包含它们的药物组合物。根据本发明的新的1- [2-（取代的乙烯基）] -3,4-二阴离子-5 + E，非H + EE -2,3-苯并二氮杂衍生物对应于通式（I），其中变量在下文中定义：根据本发明的新化合物影响中枢神经系统并且可以在治疗中有利地使用。

4. 发明授权

US5519019A N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same 失效
标题翻译： N-酰基-2,3-苯并吖庚因衍生物，含有它们的药物组合物及其制备方法
公开(公告)号：US5519019A
公开(公告)日：1996-05-21
申请号：US472454
申请日：1995-06-07
申请人： Ferenc Andrasi , Pal Berzsenyi , Peter Botka , Sandor Farkas , Katalin Goldschmidt , Tamas Hamori , Jeno Korosi , Imre Moravcsik , Istvan Tarnawa
发明人： Ferenc Andrasi , Pal Berzsenyi , Peter Botka , Sandor Farkas , Katalin Goldschmidt , Tamas Hamori , Jeno Korosi , Imre Moravcsik , Istvan Tarnawa
IPC分类号： C07D491/04 , A61K31/55 , C07D243/02
CPC分类号： C07D491/04
摘要： The invention relates to novel N-acyl-2,3-benzodiezapine derivatives of the general formula (I), their stereoisomers and acid-addition salts, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I)R stands for a C.sub.1-6 alkanoyl group optionally substituted by a methoxy, cyano, carboxyl, amino, C.sub.1-4 alkylamino, di(C.sub.1-4 alkyl)amino, pyrrolidino, phthalimido or phenyl group, or by one or more halogen(s); or R is a benzoyl, cyclopropanecarbonyl, C.sub.1-5 alkylcarbamoyl or phenylcarbamoyl group; or R is absent when a double bond exists between the N(3) and C(4) atoms;R.sup.1 means hydrogen; or R.sup.1 is absent when a double bond exists between the N(3) and C(4) atoms;R.sup.2 means a C.sub.1-3 alkyl group; orR.sup.1 and R.sup.2 together stand for a methylene group and no double bond is present between the N(3) and C(4) atoms;R.sup.3 means hydrogen or a C.sub.1-4 alkanoyl group;R.sup.4 represents hydrogen; a C.sub.1-6 alkanoyl group optionally substituted by a methoxy, cyano, carboxyl, amino, C.sub.1-4 alkylamino, di(C.sub.1-4 alkyl)amino, pyrrolidino, phthalimido or phenyl group or by one or more halogen(s); as well as a benzoyl, palmitoyl, cyclopropane-carbonyl, C.sub.1-5 alkylcarbamoyl or phenylcarbamoyl group; andthe dotted lines represent valence bonds optionally being present, with the proviso that no double bond exists between the N(3) and C(4) atoms when both R.sup.3 and R.sup.4 stand for hydrogen.The compounds of the general formula (I) possess valuable central nervous system effects, particularly muscle-relaxant, anticonvulsive and neuroprotective action. Thus, they may be useful for the treatment of various diseases of central nervous system origin.
摘要翻译：本发明涉及通式（I）的新型N-酰基-2,3-苯并二氮杂萘衍生物，其立体异构体和酸加成盐，含有它们的药物组合物及其制备方法。在通式（I）中，R代表任选被甲氧基，氰基，羧基，氨基，C 1-4烷基氨基，二（C 1-4烷基）氨基，吡咯烷子基，邻苯二甲酰亚胺基或苯基取代的C 1-6烷酰基，或通过一个或多个卤素; 或R是苯甲酰基，环丙烷羰基，C 1-5烷基氨基甲酰基或苯基氨基甲酰基; 或者当N（3）和C（4）原子之间存在双键时，R不存在; R1表示氢; 当N（3）和C（4）原子之间存在双键时，R1不存在; R2表示C1-3烷基; 或者R 1和R 2一起代表亚甲基，N（3）和C（4）原子之间不存在双键; R3表示氢或C1-4烷酰基; R4代表氢; 任选被甲氧基，氰基，羧基，氨基，C1-4烷基氨基，二（C1-4烷基）氨基，吡咯烷子基，苯二甲酰亚氨基或苯基或一个或多个卤素取代的C 1-6烷酰基; 以及苯甲酰基，棕榈酰基，环丙烷 - 羰基，C 1-5烷基氨基甲酰基或苯基氨基甲酰基; 并且虚线表示任选存在的价键，条件是当R3和R4均代表氢时，N（3）和C（4）原子之间不存在双键。通式（I）的化合物具有有价值的中枢神经系统作用，特别是肌肉松弛剂，抗惊厥和神经保护作用。因此，它们可用于治疗中枢神经系统起源的各种疾病。

5. 发明授权

US5204343A 5H-benzodiazepin derivative 失效
标题翻译： 5H-苯并咪唑衍生物
公开(公告)号：US5204343A
公开(公告)日：1993-04-20
申请号：US776771
申请日：1991-10-17
申请人： Ferenc Andrasi , Peter Botka , Katalin Goldschmidt nee Horvath , Tamas Hamori , Gyula Horvath , Jeno Korosi , Imre Moravcsik , Marta Rusz nee Patfalusi , Eva Tomori nee Joszt , Gabor Zolyomi
发明人： Ferenc Andrasi , Peter Botka , Katalin Goldschmidt nee Horvath , Tamas Hamori , Gyula Horvath , Jeno Korosi , Imre Moravcsik , Marta Rusz nee Patfalusi , Eva Tomori nee Joszt , Gabor Zolyomi
IPC分类号： A61K31/55 , A61P25/20 , A61P25/24 , A61P25/26 , C07D243/02 , C07D243/04
CPC分类号： C07D243/02
摘要： The invention relates to the new 1-(3-chlorophenyl)-4-hydroxymethyl-7,8-dimethoxy-5H-2,3-benzodiazepine of formula (I) ##STR1## and pharmaceutically acceptable acid addition salts thereof, furthermore to a process for preparing these compounds.The compounds according to the invention possess valuable anxiolytic, antiaggressive and antidepressant effects and have at the same time favorable acute toxicity values, so they can be used to advantage in therapy.
摘要翻译：本发明涉及式（I）的新的1-（3-氯苯基）-4-羟甲基-7,8-二甲氧基-5H-2,3-苯并二氮杂及其药学上可接受的酸加成盐，此外涉及制备这些化合物的方法。根据本发明的化合物具有有价值的抗焦虑，抗侵袭和抗抑郁作用，同时具有有利的急性毒性值，因此它们可用于治疗中的优势。

6. 发明授权

US5639751A N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders 失效
标题翻译：用于治疗急性和慢性神经变性疾病的N-酰基-2,3-苯并二氮杂衍生物
公开(公告)号：US5639751A
公开(公告)日：1997-06-17
申请号：US477801
申请日：1995-06-07
申请人： Ferenc Andrasi , Pal Berzsenyi , Peter Botka , Sandor Farkas , Katalin Goldschmidt , Tamas Hamori , Jeno Korosi , Imre Moravcsik , Istvan Tarnawa
发明人： Ferenc Andrasi , Pal Berzsenyi , Peter Botka , Sandor Farkas , Katalin Goldschmidt , Tamas Hamori , Jeno Korosi , Imre Moravcsik , Istvan Tarnawa
IPC分类号： C07D491/04 , A61K31/55 , A61K31/44
CPC分类号： C07D491/04
摘要： The invention relates to novel N-acyl-2,3-benzodiezapine derivatives of the general formula (I), their stereoisomers and acid-addition salts, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I)R stands for a C.sub.1-6 alkanoyl group optionally substituted by a methoxy, cyano, carboxyl, amino, C.sub.1-4 alkylamino, di(C.sub.1-4 alkyl)amino, pyrrolidino, phthalimido or phenyl group, or by one or more halogen(s); or R is a benzoyl, cyclopropanecarbonyl, C.sub.1-5 alkylcarbamoyl or phenylcarbamoyl group; or R is absent when a double bond exists between the N(3) and C(4) atoms;R.sup.1 means hydrogen; or R.sup.1 is absent when a double bond exists between the N(3) and C(4) atoms;R.sup.2 means a C.sub.1-3 alkyl group; orR.sup.1 and R.sup.2 together stand for a methylene group and no double bond is present between the N(3) and C(4) atoms;R.sup.3 means hydrogen or a C.sub.1-4 alkanoyl group;R.sup.4 represents hydrogen; a C.sub.1-6 alkanoyl group optionally substituted by a methoxy, cyano, carboxyl, amino, C.sub.1-4 alkylamino, di(C.sub.1-4 alkyl)amino, pyrrolidino, phthalimido or phenyl group or by one or more halogen(s); as well as a benzoyl, palmitoyl, cyclopropanecarbonyl, C.sub.1-5 alkylcarbamoyl or phenylcarbamoyl group; andthe dotted lines represent valence bonds optionally being present, with the proviso that no double bond exists between the N(3) and C(4) atoms when both R.sup.3 and R.sup.4 stand for hydrogen.The compounds of the general formula (I) possess valuable central nervous system effects, particularly muscle-relaxant, anticonvulsive and neuroprotective action. Thus, they may be useful for the treatment of various diseases of central nervous system origin.
摘要翻译：本发明涉及通式（I）的新型N-酰基-2,3-苯并二氮杂萘衍生物，其立体异构体和酸加成盐，含有它们的药物组合物及其制备方法。在通式（I）中，R代表任选被甲氧基，氰基，羧基，氨基，C 1-4烷基氨基，二（C 1-4烷基）氨基，吡咯烷子基，邻苯二甲酰亚胺基或苯基取代的C 1-6烷酰基，或通过一个或多个卤素; 或R是苯甲酰基，环丙烷羰基，C 1-5烷基氨基甲酰基或苯基氨基甲酰基; 或者当N（3）和C（4）原子之间存在双键时，R不存在; R1表示氢; 当N（3）和C（4）原子之间存在双键时，R1不存在; R2表示C1-3烷基; 或者R 1和R 2一起代表亚甲基，N（3）和C（4）原子之间不存在双键; R3表示氢或C1-4烷酰基; R4代表氢; 任选被甲氧基，氰基，羧基，氨基，C1-4烷基氨基，二（C1-4烷基）氨基，吡咯烷子基，苯二甲酰亚氨基或苯基或一个或多个卤素取代的C 1-6烷酰基; 以及苯甲酰基，棕榈酰基，环丙烷羰基，C 1-5烷基氨基甲酰基或苯基氨基甲酰基; 并且虚线表示任选存在的价键，条件是当R3和R4均代表氢时，N（3）和C（4）原子之间不存在双键。通式（I）的化合物具有有价值的中枢神经系统作用，特别是肌肉松弛剂，抗惊厥和神经保护作用。因此，它们可用于治疗中枢神经系统起源的各种疾病。

7. 发明授权

US5536832A N-acyl-2,3-benzodiazepine derivatives pharmaceutical compositions containing them and process for preparing same 失效
标题翻译： N-酰基-2,3-苯并二氮杂衍生物含有它们的药物组合物及其制备方法
公开(公告)号：US5536832A
公开(公告)日：1996-07-16
申请号：US423153
申请日：1995-04-17
申请人： Ferenc Andrasi , Pal Berzsenyi , Peter Botka , Sandor Farkas , Katalin Goldschmidt , Tamas Hamori , Jeno Korosi , Imre Moravcsik , Istvan Tarnawa
发明人： Ferenc Andrasi , Pal Berzsenyi , Peter Botka , Sandor Farkas , Katalin Goldschmidt , Tamas Hamori , Jeno Korosi , Imre Moravcsik , Istvan Tarnawa
IPC分类号： A61K31/55 , A61K20060101 , A61K31/00 , A61K31/335 , A61K31/395 , A61K31/551 , A61P9/08 , A61P9/10 , A61P21/02 , A61P25/00 , A61P25/08 , A61P25/28 , C07D20060101 , C07D243/00 , C07D243/02 , C07D247/00 , C07D317/00 , C07D317/08 , C07D317/44 , C07D491/00 , C07D491/04 , C07D491/056 , C07D493/04
CPC分类号： C07D491/04
摘要： The invention relates to novel N-acyl-2,3-benzodiezapine derivatives of the general formula (I), their stereoisomers and acid-addition salts, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I)R stands for a C.sub.1-6 alkanoyl group optionally substituted by a methoxy, cyano, carboxyl, amino, C.sub.1-4 alkylamino, di(C.sub.1-4 alkyl)amino, pyrrolidino, phthalimido or phenyl group, or by one or more halogen(s); or R is a benzoyl, cyclopropanecarbonyl, C.sub.1-5 alkylcarbamoyl or phenylcarbamoyl group; or R is absent when a double bond exists between the N(3) and C(4) atoms;R.sup.1 means hydrogen; or R.sup.1 is absent when a double bond exists between the N(3) and C(4) atoms;R.sup.2 means a C.sub.1-3 alkyl group; orR.sup.1 and R.sup.2 together stand for a methylene group and no double bond is present between the N(3) and C(4) atoms;R.sup.3 means hydrogen or a C.sub.1-4 alkanoyl group;R.sup.4 represents hydrogen; a C.sub.1-6 alkanoyl group optionally substituted by a methoxy, cyano, carboxyl, amino, C.sub.1-4 alkylamino, di(C.sub.1-4 alkyl)amino, pyrrolidino, phthalimido or phenyl group or by one or more halogen(s); as well as a benzoyl, palmitoyl, cyclopropane-carbonyl, C.sub.1-5 alkylcarbamoyl or phenylcarbamoyl group; andthe dotted lines represent valence bonds optionally being present, with the proviso that no double bond exists between the N(3) and C(4) atoms when both R.sup.3 and R.sup.4 stand for hydrogen.The compounds of the general formula (I) possess valuable central nervous system effects, particularly muscle-relaxant, anticonvulsive and neuroprotective action. Thus, they may be useful for the treatment of various diseases of central nervous system origin.
摘要翻译：本发明涉及通式（I）的新型N-酰基-2,3-苯并二氮杂萘衍生物，其立体异构体和酸加成盐，含有它们的药物组合物及其制备方法。在通式（I）中，R代表任选被甲氧基，氰基，羧基，氨基，C 1-4烷基氨基，二（C 1-4烷基）氨基，吡咯烷子基，邻苯二甲酰亚胺基或苯基取代的C 1-6烷酰基，或通过一个或多个卤素; 或R是苯甲酰基，环丙烷羰基，C 1-5烷基氨基甲酰基或苯基氨基甲酰基; 或者当N（3）和C（4）原子之间存在双键时，R不存在; R1means氢; 当N（3）和C（4）原子之间存在双键时，R1不存在; R2表示C1-3烷基; 或者R 1和R 2一起代表亚甲基，N（3）和C（4）原子之间不存在双键; R3表示氢或C1-4烷酰基; R4表示氢; 任选被甲氧基，氰基，羧基，氨基，C 1-4烷基氨基，二（C 1-4烷基）氨基，吡咯烷子基，苯二甲酰亚氨基或苯基或被一个或多个卤素取代的C 1-6烷酰基; 以及苯甲酰基，棕榈酰基，环丙烷 - 羰基，C 1-5烷基氨基甲酰基或苯基氨基甲酰基; 并且虚线表示任选存在的价键，条件是当R3和R4均代表氢时，N（3）和C（4）原子之间不存在双键。通式（I）的化合物具有有价值的中枢神经系统作用，特别是肌肉松弛剂，抗惊厥和神经保护作用。因此，它们可用于治疗中枢神经系统起源的各种疾病。

8. 发明授权

US4322346A 5H-2,3-Benzodiazepine derivatives 失效
标题翻译： 5H-2,3-苯并二氮杂衍生物
公开(公告)号：US4322346A
公开(公告)日：1982-03-30
申请号：US191811
申请日：1980-09-26
申请人： Jeno Korosi , Tibor Lang , Jozsef Szekely , Ferenc Andrasi , Gabor Zolyomi , Jozsef Borsi , Katalin Goldschmidt nee Horvath , Tamas Hamori , Gabriella Szabo nee Czibula , Zsuzsanna Meszaros nee Dunai-Kovacs , Erzsebet Miglecz
发明人： Jeno Korosi , Tibor Lang , Jozsef Szekely , Ferenc Andrasi , Gabor Zolyomi , Jozsef Borsi , Katalin Goldschmidt nee Horvath , Tamas Hamori , Gabriella Szabo nee Czibula , Zsuzsanna Meszaros nee Dunai-Kovacs , Erzsebet Miglecz
IPC分类号： C07D253/02 , A61K31/55 , A61P25/00 , A61P25/20 , C07D243/02 , C07D243/04 , C07D311/76 , C07D405/04 , C07D409/04 , C07D491/056 , C07D243/00 , C07D407/04
CPC分类号： C07D243/02 , C07D311/76
摘要： New 5H-2,3-benzodiazepine derivatives of the formula ##STR1## wherein R is phenyl having a trifluoromethyl or halogen substituent,R.sup.1 is methyl,R.sup.2 is hydrogen,R.sup.3 is methoxy and R.sup.4 is methoxy, and the pharmaceutically acceptable acid addition salts thereof, are potent tranquilizers.
摘要翻译：式（I）的新的5H-2,3-苯并二氮杂衍生物，其中R是具有三氟甲基或卤素取代基的苯基，R 1是甲基，R 2是氢，R 3是甲氧基，R 4是甲氧基，其药学上可接受的酸加成盐它们是有力的镇定剂。

9. 发明授权

US5521174A N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith 失效
标题翻译： N-酰基-2,3-苯并二氮杂衍生物和治疗骨骼肌肉痉挛的方法
公开(公告)号：US5521174A
公开(公告)日：1996-05-28
申请号：US477799
申请日：1995-06-07
申请人： Ferenc Andrasi , Pal Berzsenyi , Peter Botka , Sandor Farkas , Katalin Goldschmidt , Tamas Hamori , Jeno Korosi , Imre Moravcsik , Istvan Tarnawa
发明人： Ferenc Andrasi , Pal Berzsenyi , Peter Botka , Sandor Farkas , Katalin Goldschmidt , Tamas Hamori , Jeno Korosi , Imre Moravcsik , Istvan Tarnawa
IPC分类号： C07D491/04 , A61K31/55 , C07D243/02
CPC分类号： C07D491/04
摘要： The invention relates to novel N-acyl-2,3-benzodiezapine derivatives and a method of treating spasms of the skeletal musculature therewith.
摘要翻译：本发明涉及新型N-酰基-2,3-苯并二氮杂衍生物及其治疗骨骼肌肉痉挛的方法。

10. 发明授权

US5459137A N-acyl-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for preparing same 失效
标题翻译： N-酰基-2,3-苯并二氮杂衍生物，含有它们的药物组合物及其制备方法
公开(公告)号：US5459137A
公开(公告)日：1995-10-17
申请号：US80604
申请日：1993-06-21
申请人： Ferenc Andrasi , Pal Berzsenyi , Peter Botka , Sandor Farkas , Katalin Goldschmidt , Tamas Hamori , Jeno Korosi , Imre Moravcsik , Istvan Tarnawa
发明人： Ferenc Andrasi , Pal Berzsenyi , Peter Botka , Sandor Farkas , Katalin Goldschmidt , Tamas Hamori , Jeno Korosi , Imre Moravcsik , Istvan Tarnawa
IPC分类号： A61K31/55 , A61K20060101 , A61K31/00 , A61K31/335 , A61K31/395 , A61K31/551 , A61P9/08 , A61P9/10 , A61P21/02 , A61P25/00 , A61P25/08 , A61P25/28 , C07D20060101 , C07D243/00 , C07D243/02 , C07D247/00 , C07D317/00 , C07D317/08 , C07D317/44 , C07D491/00 , C07D491/04 , C07D491/056 , C07D493/04
CPC分类号： C07D491/04
摘要： The invention relates to novel N-acyl-2,3-benzodiezapine derivatives of the general formula (I), their stereoisomers and acid-addition salts, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I), defined in the specification, a more complete description of the compounds may be found.The compounds of the general formula (I) possess valuable central nervous system effects, particularly muscle-relaxant, anticonvulsive and neuroprotective action. Thus, they may be useful for the treatment of various diseases of central nervous system origin.
摘要翻译：本发明涉及通式（I）的新型N-酰基-2,3-苯并二氮杂萘衍生物，其立体异构体和酸加成盐，含有它们的药物组合物及其制备方法。在本说明书中定义的通式（I）中，可以找到更完整的化合物的描述。通式（I）的化合物具有有价值的中枢神经系统作用，特别是肌肉松弛剂，抗惊厥和神经保护作用。因此，它们可用于治疗中枢神经系统起源的各种疾病。

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