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1. 发明申请

US20130315996A1 BIO-FUNCTIONALIZED STIMULUS-RESPONSIVE DISSOLVABLE PEG-HYDROGELS 有权
标题翻译：生物功能化刺激性溶解性PEG-氢化物
公开(公告)号：US20130315996A1
公开(公告)日：2013-11-28
申请号：US13988252
申请日：2011-11-18
申请人： Thorsten Steinberg , Wilfried Weber , Raphael Guebeli , Pascal Tomakidi , Dougal Laird
发明人： Thorsten Steinberg , Wilfried Weber , Raphael Guebeli , Pascal Tomakidi , Dougal Laird
IPC分类号： A61K47/48 , A61K38/16
CPC分类号： A61K47/48215 , A61K9/0014 , A61K9/0043 , A61K9/0046 , A61K9/0048 , A61K9/006 , A61K9/0063 , A61K9/0085 , A61K9/06 , A61K38/16 , A61K38/18 , A61K47/10 , A61K47/60 , A61K47/6903 , C07K2319/20 , C07K2319/30 , C07K2319/33 , Y02A50/473 , Y10S514/801
摘要： The present invention is directed to a bio-functionalized stimulus-responsive dissolvable PEG-hydrogel. This inventive stimulus-responsive dissolvable PEG-hydrogel comprises a matrix of PEG-polymers, which are modified to contain at least one multifunctional fusion protein, the multifunctional fusion protein preferably comprising as components a substrate binding peptide (SBP), preferably a repetitive RGD-binding peptide and/or a ZZ-binding domain, preferably a tag for purification, and at least one N- and/or C-terminal linker. The present invention is furthermore directed to the use of such inventive stimulus-responsive dissolvable PEG-hydrogels in the treatment of lesions, in surgical dressings, for wound treating, for soft and hard tissue regeneration, for the treatment of wounds in the oral cavity, in the field of ophthalmology, in the field of periodontal defects, etc. The invention also describes a method of treatment for such diseases. Additionally, the present invention provides a kit comprising the inventive stimulus-responsive dissolvable PEG-hydrogel and optionally further components.
摘要翻译：本发明涉及生物功能化的刺激响应的可溶性PEG-水凝胶。本发明的刺激响应性可溶性PEG-水凝胶包含PEG-聚合物基质，其被修饰为含有至少一种多功能融合蛋白，所述多功能融合蛋白优选包含作为底物结合肽（SBP）的组分，优选地包含重复的RGD- 结合肽和/或ZZ结合结构域，优选用于纯化的标签，以及至少一个N-和/或C-末端连接体。本发明还涉及这种本发明的刺激响应性可溶性PEG-水凝胶在治疗病变中，在外科敷料中的用途，用于伤口治疗，用于软组织和硬组织再生，用于治疗口腔中的伤口，在眼科领域，在牙周缺损等领域。本发明还描述了一种治疗这种疾病的方法。另外，本发明提供了一种试剂盒，其包含本发明的刺激响应性可溶性PEG-水凝胶和任选的其它组分。

2. 发明授权

US08980278B2 Bio-functionalized stimulus-responsive dissolvable PEG-hydrogels 有权
标题翻译：生物功能化的刺激反应可溶性PEG-水凝胶
公开(公告)号：US08980278B2
公开(公告)日：2015-03-17
申请号：US13988252
申请日：2011-11-18
申请人： Thorsten Steinberg , Wilfried Weber , Raphael Guebeli , Pascal Tomakidi , Dougal Laird
发明人： Thorsten Steinberg , Wilfried Weber , Raphael Guebeli , Pascal Tomakidi , Dougal Laird
IPC分类号： A61K6/00 , A61K38/00 , C08L101/02 , A61K47/48 , A61K47/10 , A61K38/16 , A61K38/18 , A61K9/00 , A61K9/06
CPC分类号： A61K47/48215 , A61K9/0014 , A61K9/0043 , A61K9/0046 , A61K9/0048 , A61K9/006 , A61K9/0063 , A61K9/0085 , A61K9/06 , A61K38/16 , A61K38/18 , A61K47/10 , A61K47/60 , A61K47/6903 , C07K2319/20 , C07K2319/30 , C07K2319/33 , Y02A50/473 , Y10S514/801
摘要： The present invention is directed to a bio-functionalized stimulus-responsive dissolvable PEG-hydrogel. This inventive stimulus-responsive dissolvable PEG-hydrogel comprises a matrix of PEG-polymers, which are modified to contain at least one multifunctional fusion protein, the multifunctional fusion protein preferably comprising as components a substrate binding peptide (SBP), preferably a repetitive RGD-binding peptide and/or a ZZ-binding domain, preferably a tag for purification, and at least one N- and/or C-terminal linker. The present invention is furthermore directed to the use of such inventive stimulus-responsive dissolvable PEG-hydrogels in the treatment of lesions, in surgical dressings, for wound treating, for soft and hard tissue regeneration, for the treatment of wounds in the oral cavity, in the field of ophthalmology, in the field of periodontal defects, etc. The invention also describes a method of treatment for such diseases. Additionally, the present invention provides a kit comprising the inventive stimulus-responsive dissolvable PEG-hydrogel and optionally further components.
摘要翻译：本发明涉及生物功能化的刺激响应的可溶性PEG-水凝胶。本发明的刺激响应性可溶性PEG-水凝胶包含PEG-聚合物基质，其被修饰为含有至少一种多功能融合蛋白，所述多功能融合蛋白优选包含作为底物结合肽（SBP）的组分，优选地包含重复的RGD- 结合肽和/或ZZ结合结构域，优选用于纯化的标签，以及至少一个N-和/或C-末端连接体。本发明还涉及这种本发明的刺激响应性可溶性PEG-水凝胶在治疗病变中，在外科敷料中的用途，用于伤口治疗，用于软组织和硬组织再生，用于治疗口腔中的伤口，在眼科领域，在牙周缺损等领域。本发明还描述了一种治疗这种疾病的方法。另外，本发明提供了一种试剂盒，其包含本发明的刺激响应性可溶性PEG-水凝胶和任选的其它组分。

3. 发明申请

US20130338326A1 COVALENTLY ATTACHED ANTIMICROBIAL POLYMERS 有权
标题翻译：共同附着的抗微生物聚合物
公开(公告)号：US20130338326A1
公开(公告)日：2013-12-19
申请号：US13997444
申请日：2011-12-22
申请人： Thorsten Steinberg , Karen Lienkamp , Pascal Tomakidi , Ali AL-Ahmad
发明人： Thorsten Steinberg , Karen Lienkamp , Pascal Tomakidi , Ali AL-Ahmad
IPC分类号： A01N43/08
CPC分类号： A01N43/08 , A01N25/10 , A01N25/34 , C08F8/00 , C08F291/18 , C08F292/00 , A01N33/12
摘要： The present invention relates to substrates comprising covalently attached antimicrobial polymers, which act as synthetic mimics of antimicrobial peptides (SMAMPs) and are preferably obtained by ring opening metathesis polymerization (ROMP). The inventive antimicrobial polymers exhibit a molecular weight of more than 100,000 g mol−1 and are preferably covalently attached to the surface of a substrate, e.g. an implant, a medical device, medical equipment or a (tissue-supporting) biomaterial, etc. Covalent bonding may be carried out using a photoreactive crosslinker but also by “grafting onto” or “grafting from”. The present invention is also directed to uses of the inventive antimicrobial polymers as defined herein, e.g. for antimicrobially coating a surface of such a substrate with a layer of the inventive antimicrobial polymer.
摘要翻译：本发明涉及包含共价连接的抗微生物聚合物的底物，其作为抗微生物肽（SMAMP）的合成模拟物，并且优选通过开环易位聚合（ROMP）获得。本发明的抗微生物聚合物显示出超过100,000g mol -1的分子量，并且优选共价连接到底物的表面，例如，植入物，医疗装置，医疗设备或（组织支撑）生物材料等。共价键可以使用光反应性交联剂进行，而且可以通过“接枝”或“接枝”进行。本发明还涉及本文定义的本发明的抗微生物聚合物的用途，例如，用本发明的抗微生物聚合物的一层抗微生物涂覆这种基材的表面。

4. 发明授权

US09332755B2 Covalently attached antimicrobial polymers 有权
标题翻译：共价附着的抗菌聚合物
公开(公告)号：US09332755B2
公开(公告)日：2016-05-10
申请号：US13997444
申请日：2011-12-22
申请人： Thorsten Steinberg , Karen Lienkamp , Pascal Tomakidi , Ali Al-Ahmad
发明人： Thorsten Steinberg , Karen Lienkamp , Pascal Tomakidi , Ali Al-Ahmad
IPC分类号： A01N43/08 , A01N25/10 , C08F8/00 , C08F291/18 , C08F292/00 , A01N25/34
CPC分类号： A01N43/08 , A01N25/10 , A01N25/34 , C08F8/00 , C08F291/18 , C08F292/00 , A01N33/12
摘要： The present invention relates to substrates comprising covalently attached antimicrobial polymers, which act as synthetic mimics of antimicrobial peptides (SMAMPs) and are preferably obtained by ring opening metathesis polymerization (ROMP). The inventive antimicrobial polymers exhibit a molecular weight of more than 100,000 g mol−1 and are preferably covalently attached to the surface of a substrate, e.g. an implant, a medical device, medical equipment or a (tissue-supporting) biomaterial, etc. Covalent bonding may be carried out using a photoreactive crosslinker but also by “grafting onto” or “grafting from”. The present invention is also directed to uses of the inventive antimicrobial polymers as defined herein, e.g. for antimicrobially coating a surface of such a substrate with a layer of the inventive antimicrobial polymer.
摘要翻译：本发明涉及包含共价连接的抗微生物聚合物的底物，其作为抗微生物肽（SMAMP）的合成模拟物，并且优选通过开环易位聚合（ROMP）获得。本发明的抗微生物聚合物显示出超过100,000g mol -1的分子量，并且优选共价连接到底物的表面，例如，植入物，医疗装置，医疗设备或（组织支撑）生物材料等。共价键可以使用光反应性交联剂进行，而且可以通过“接枝”或“接枝”进行。本发明还涉及本文定义的本发明的抗微生物聚合物的用途，例如，用本发明的抗微生物聚合物的一层抗微生物涂覆这种基材的表面。

5. 发明授权

US09937278B2 Biocompatible and biodegradable gradient layer system for regenerative medicine and for tissue support 有权
公开(公告)号：US09937278B2
公开(公告)日：2018-04-10
申请号：US14110031
申请日：2012-04-04
申请人： Thorsten Steinberg , Pascal Tomakidi , Simon Schulz , Marco Angarano , Rolf Muelhaupt , Martin Fabritius
发明人： Thorsten Steinberg , Pascal Tomakidi , Simon Schulz , Marco Angarano , Rolf Muelhaupt , Martin Fabritius
IPC分类号： A61L26/00 , A61L27/34 , A61L27/38 , A61L27/50 , A61L27/58 , A61L31/12 , A61L31/16
CPC分类号： A61L26/0095 , A61L27/34 , A61L27/3804 , A61L27/50 , A61L27/58 , A61L31/125 , A61L31/16 , A61L2420/08 , C08L89/06
摘要： The present invention is directed to a biocompatible and preferably biodegradable gradient layer system comprising at least one set of layers comprising a biocompatible and preferably biodegradable cross-linked polymer and at least one biocompatible and preferably biodegradable support layer, wherein a gradient is preferably formed with respect to the mechanical and/or physical properties of one or more layers of the at least one set of layers comprising a biocompatible and biodegradable cross-linked polymer and/or the at least one biocompatible and preferably biodegradable support layer. The at least one support layer preferably comprises a biocompatible and preferably biodegradable meltable polymer and/or a biocompatible and incorporable material. This biocompatible and preferably biodegradable gradient layer system may be used as a biomaterial for regenerative medicine, particularly as a wound dressing or for tissue support. The present invention also provides means utilizing said inventive gradient layer system and methods for producing same.

6. 发明申请

US20140112973A1 BIOCOMPATIBLE AND BIODEGRADABLE GRADIENT LAYER SYSTEM FOR REGENERATIVE MEDICINE AND FOR TISSUE SUPPORT 有权
标题翻译：用于再生医学和组织支持的生物可降解和生物降解梯度系统
公开(公告)号：US20140112973A1
公开(公告)日：2014-04-24
申请号：US14110031
申请日：2012-04-04
申请人： Thorsten Steinberg , Pascal Tomakidi , Simon Schulz , Marco Angarano , Rolf Muelhaupt , Martin Fabritius
发明人： Thorsten Steinberg , Pascal Tomakidi , Simon Schulz , Marco Angarano , Rolf Muelhaupt , Martin Fabritius
IPC分类号： A61L26/00 , A61L31/16 , A61L31/12
CPC分类号： A61L26/0095 , A61L27/34 , A61L27/3804 , A61L27/50 , A61L27/58 , A61L31/125 , A61L31/16 , A61L2420/08 , C08L89/06
摘要： The present invention is directed to a biocompatible and preferably biodegradable gradient layer system comprising at least one set of layers comprising a biocompatible and preferably biodegradable cross-linked polymer and at least one biocompatible and preferably biodegradable support layer, wherein a gradient is preferably formed with respect to the mechanical and/or physical properties of one or more layers of the at least one set of layers comprising a biocompatible and biodegradable cross-linked polymer and/or the at least one biocompatible and preferably biodegradable support layer. The at least one support layer preferably comprises a biocompatible and preferably biodegradable meltable polymer and/or a biocompatible and incorporable material. This biocompatible and preferably biodegradable gradient layer system may be used as a biomaterial for regenerative medicine, particularly as a wound dressing or for tissue support. The present invention also provides means utilizing said inventive gradient layer system and methods for producing same.
摘要翻译：本发明涉及生物相容且优选可生物降解的梯度层系统，其包括至少一组包含生物相容性且优选可生物降解的交联聚合物和至少一种生物相容且优选可生物降解的支撑层的层，其中优选地形成梯度涉及包含生物相容性和可生物降解的交联聚合物的至少一组层的一层或多层的机械和/或物理性质和/或至少一种生物相容性并且优选可生物降解的支撑层。所述至少一个支撑层优选包含生物相容性且优选可生物降解的可熔融聚合物和/或生物相容性和可结合材料。该生物相容性优选可生物降解的梯度层系统可用作再生医学的生物材料，特别是作为伤口敷料或用于组织支持。本发明还提供利用本发明的梯度层系统及其制造方法的方法。

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