专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20160303169A9 SKELETAL MUSCLE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS, AND TREATMENTS THEREOF 有权
公开(公告)号：US20160303169A9
公开(公告)日：2016-10-20
申请号：US12245379
申请日：2008-10-03
申请人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic , Michael Chancellor
发明人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic , Michael Chancellor
IPC分类号： A61K35/34
CPC分类号： A61K35/34 , A61K9/0019 , A61K35/12 , C12N5/0658 , C12N5/0659 , C12N2500/84 , C12N2501/70 , C12N2510/00 , C12N2510/02 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. The invention also relates to novel uses of muscle-derived progenitor cells for the treatment of cosmetic or functional conditions, including, but not limited to skeletal muscle weakness, muscular dystrophy, muscle atrophy, spasticity, myoclonus and myalgia. The invention also relates to the novel use of MDCs for the increase of skeletal muscle mass in athletes or other organisms in need of greater than average skeletal muscle mass.

2. 发明授权

US09499791B2 Skeletal muscle augmentation utilizing muscle-derived progenitor compositions, and treatments thereof 有权
标题翻译：使用肌肉来源的祖细胞组合物的骨骼肌增强及其治疗
公开(公告)号：US09499791B2
公开(公告)日：2016-11-22
申请号：US12245379
申请日：2008-10-03
申请人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic , Michael Chancellor
发明人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic , Michael Chancellor
IPC分类号： A61K35/34 , C12N5/077 , A61K35/12
CPC分类号： A61K35/34 , A61K9/0019 , A61K35/12 , C12N5/0658 , C12N5/0659 , C12N2500/84 , C12N2501/70 , C12N2510/00 , C12N2510/02 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells (MDCs) that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction into a site of soft tissue. Also provided are methods of isolating MDCs. The invention further provides methods of using compositions comprising MDCs for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. The invention also relates to uses of MDCs for the treatment of cosmetic or functional conditions, including, but not limited to skeletal muscle weakness, muscular dystrophy, muscle atrophy, spasticity, myoclonus and myalgia. The invention also relates to the use of MDCs for the increase of skeletal muscle.
摘要翻译：本发明提供了肌肉衍生的祖细胞（MDCs），其在移植到身体组织中后显示出长期存活，并且可以在引入软组织部位后增加软组织。还提供了隔离MDC的方法。本发明还提供了使用包含MDC的组合物的方法，用于在治疗各种美容或功能状况（包括畸形，损伤，无力，疾病或功能障碍）的哺乳动物包括人类软组织的增加和膨胀中。本发明还涉及MDC用于治疗化妆品或功能状况的用途，包括但不限于骨骼肌无力，肌营养不良，肌肉萎缩，痉挛状态，肌阵挛和肌痛。本发明还涉及MDCs用于增加骨骼肌的用途。

3. 发明申请

US20090098094A1 SKELETAL MUSCLE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS, AND TREATMENTS THEREOF 有权
标题翻译：使用肌肉衍生的孕激素组合物的骨骼肌肉康复治疗及其治疗
公开(公告)号：US20090098094A1
公开(公告)日：2009-04-16
申请号：US12245379
申请日：2008-10-03
申请人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic , Michael Chancellor
发明人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic , Michael Chancellor
IPC分类号： A61K35/34
CPC分类号： A61K35/34 , A61K9/0019 , A61K35/12 , C12N5/0658 , C12N5/0659 , C12N2500/84 , C12N2501/70 , C12N2510/00 , C12N2510/02 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. The invention also relates to novel uses of muscle-derived progenitor cells for the treatment of cosmetic or functional conditions, including, but not limited to skeletal muscle weakness, muscular dystrophy, muscle atrophy, spasticity, myoclonus and myalgia. The invention also relates to the novel use of MDCs for the increase of skeletal muscle mass in athletes or other organisms in need of greater than average skeletal muscle mass.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明进一步提供使用包含肌肉来源的祖细胞的组合物的方法，用于增加和膨胀哺乳动物，包括人类软组织，以治疗各种美容或功能状况，包括畸形，损伤，无力，疾病或功能障碍。本发明还涉及肌肉衍生的祖细胞用于治疗化妆品或功能状况的新用途，包括但不限于骨骼肌无力，肌营养不良，肌肉萎缩，痉挛状态，肌阵挛和肌痛。本发明还涉及MDC在需要大于平均骨骼肌质量的运动员或其他生物体中增加骨骼肌质量的新用途。

4. 发明申请

US20090155221A1 BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS, AND TREATMENTS THEREOF 审中-公开
标题翻译：使用肌肉衍生的孕激素组合物的骨质康复及其治疗
公开(公告)号：US20090155221A1
公开(公告)日：2009-06-18
申请号：US12129272
申请日：2008-05-29
申请人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic
发明人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic
IPC分类号： A61K35/34 , A61P19/00 , C12N5/02
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0654 , C12N5/0658 , C12N5/0659 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/39 , C12N2501/91 , C12N2506/13 , C12N2510/00
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone). Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
摘要翻译：本发明提供肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如经由注射，移植或植入）之后增加非软组织到非软组织部位（例如，骨）。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明还提供了使用包含肌肉来源的祖细胞的组合物用于增加和膨胀哺乳动物（包括人类）骨组织以治疗各种功能状况的方法，包括骨质疏松症，佩吉特氏病，成骨不全，骨折，骨软化，减少在骨小梁强度，骨皮质强度下降和老年骨密度降低。

5. 发明申请

US20090010897A1 Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same 有权
标题翻译：用于治疗心脏病理学的肌源性细胞及其制备和使用方法
公开(公告)号：US20090010897A1
公开(公告)日：2009-01-08
申请号：US11998330
申请日：2007-11-28
申请人： Michael B. Chancellor , Thomas Payne , Ronald Jankowski , Ryan Pruchnic
发明人： Michael B. Chancellor , Thomas Payne , Ronald Jankowski , Ryan Pruchnic
IPC分类号： A61K35/12 , C12N5/00 , C12N5/08 , A61P9/00
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0658
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明进一步提供使用包含肌肉来源的祖细胞的组合物的方法，用于增加和膨胀哺乳动物，包括人类软组织，以治疗各种美容或功能状况，包括畸形，损伤，无力，疾病或功能障碍。特别地，本发明提供了用于皮肤病学，胃食管反流，膀胱输尿管反流，尿失禁，大便失禁，心力衰竭和心肌梗死的治疗和改善。

6. 发明授权

US08211423B2 Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same 有权
标题翻译：用于治疗心脏病理学的肌源性细胞及其制备和使用方法
公开(公告)号：US08211423B2
公开(公告)日：2012-07-03
申请号：US11998330
申请日：2007-11-28
申请人： Michael B. Chancellor , Thomas Payne , Ronald Jankowski , Ryan Pruchnic
发明人： Michael B. Chancellor , Thomas Payne , Ronald Jankowski , Ryan Pruchnic
IPC分类号： A01N63/00 , C12N5/07
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0658
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明进一步提供使用包含肌肉来源的祖细胞的组合物的方法，用于在治疗各种美容或功能状况（包括畸形，损伤，无力，疾病或功能障碍）的哺乳动物（包括人）软组织的增加和膨胀中。特别地，本发明提供了用于皮肤病学，胃食管反流，膀胱输尿管反流，尿失禁，大便失禁，心力衰竭和心肌梗死的治疗和改善。

7. 发明申请

US20100233138A1 Vocal Cord Augmentation Utilizing Muscle-Derived Progenitor Compositions, and Treatments Thereof 审中-公开
标题翻译：声带增强利用肌肉衍生的祖细胞组合物及其治疗方法
公开(公告)号：US20100233138A1
公开(公告)日：2010-09-16
申请号：US12614650
申请日：2009-11-09
申请人： Thomas Payne , Ryan Pruchnic , Ronald Jankowski
发明人： Thomas Payne , Ryan Pruchnic , Ronald Jankowski
IPC分类号： A61K35/34
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0658 , C12N5/0659
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment vocal cord tissue following introduction (e.g. via injection, transplantation, or implantation) into the vocal cords. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, vocal cords in the treatment of various cosmetic or functional conditions, including vocal cord tissue weakness, voice and swallowing disorders. The invention also relates to the novel use of MDCs for the increase of vocal cord tissue mass in speakers, singers or other people in need of greater than average vocal cord tissue mass.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）到声带中之后增加声带组织。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明进一步提供了使用包含肌肉来源的祖细胞的组合物的方法，用于增加和膨胀哺乳动物，包括人类的声带，以治疗各种美容或功能状况，包括声带组织虚弱，声音和吞咽障碍。本发明还涉及MDC用于增加需要大于平均声带组织块的说话者，歌手或其他人中的声带组织块的新颖应用。

8. 发明申请

US20090004153A1 MUSCLE DERIVED CELLS FOR THE TREATMENT OF URINARY TRACT PATHOLOGIES AND METHODS OF MAKING AND USING SAME 有权
标题翻译：用于治疗尿道性病变的肌肉衍生细胞及其制备和使用方法
公开(公告)号：US20090004153A1
公开(公告)日：2009-01-01
申请号：US12013076
申请日：2008-01-11
申请人： Michael B. Chancellor , Ronald Jankowski , Ryan Pruchnic , Johnny Huard
发明人： Michael B. Chancellor , Ronald Jankowski , Ryan Pruchnic , Johnny Huard
IPC分类号： A61K35/12 , A61P13/00
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , C12N2500/38 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/39 , C12N2501/91
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for urinary incontinence and other urinary tract pathologies.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明还提供使用包含肌肉来源的祖细胞的组合物的方法，用于在治疗包括畸形，损伤，无力，疾病或功能障碍的各种功能状况的哺乳动物包括人类软组织的增加和膨胀中。特别地，本发明提供了治疗和改善尿失禁和其他尿路病变。

9. 发明申请

US20100158875A1 MUSCLE DERIVED CELLS FOR THE TREATMENT OF GASTRO-ESOPHAGEAL PATHOLOGIES AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：用于治疗胃肠道病理学的肌肉衍生细胞及其制备和使用方法
公开(公告)号：US20100158875A1
公开(公告)日：2010-06-24
申请号：US12547149
申请日：2009-08-25
申请人： Michael B. Chancellor , Jay Pasricha , Ronald Jankowski , Ryan Pruchnic
发明人： Michael B. Chancellor , Jay Pasricha , Ronald Jankowski , Ryan Pruchnic
IPC分类号： A61K35/12 , A61P1/04
CPC分类号： A61K35/34 , A61F2/04 , A61F2/08 , A61F2002/044 , A61K35/12 , C12N5/0658 , C12N2500/38 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/39 , C12N2501/91 , C12N2509/00 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration of symptoms for gastro-esophageal pathologies like gastro-esophageal reflux.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明进一步提供使用包含肌肉来源的祖细胞的组合物的方法，用于增加和膨胀哺乳动物，包括人类软组织，以治疗各种美容或功能状况，包括畸形，损伤，无力，疾病或功能障碍。特别地，本发明提供了治疗和改善诸如胃食管反流的胃食管病理学症状。

10. 发明申请

US20080152627A1 Muscle Derived Cells For The Treatment Of Gastro-Esophageal Pathologies And Methods Of Making And Using The Same 有权
标题翻译：用于治疗胃食管病理学的肌肉来源细胞及其制备和使用方法
公开(公告)号：US20080152627A1
公开(公告)日：2008-06-26
申请号：US11959054
申请日：2007-12-18
申请人： Michael B. Chancellor , Jay Pasricha , Ronald Jankowski , Ryan Pruchnic
发明人： Michael B. Chancellor , Jay Pasricha , Ronald Jankowski , Ryan Pruchnic
IPC分类号： A61K35/00 , C12N5/06 , A61P1/00
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , C12N2509/00 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration of symptoms for gastro-esophageal pathologies like gastro-esophageal reflux.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明进一步提供使用包含肌肉来源的祖细胞的组合物的方法，用于增加和膨胀哺乳动物，包括人类软组织，以治疗各种美容或功能状况，包括畸形，损伤，无力，疾病或功能障碍。特别地，本发明提供了治疗和改善诸如胃食管反流的胃食管病理学症状。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式