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1. 发明申请

US20090004153A1 MUSCLE DERIVED CELLS FOR THE TREATMENT OF URINARY TRACT PATHOLOGIES AND METHODS OF MAKING AND USING SAME 有权
标题翻译：用于治疗尿道性病变的肌肉衍生细胞及其制备和使用方法
公开(公告)号：US20090004153A1
公开(公告)日：2009-01-01
申请号：US12013076
申请日：2008-01-11
申请人： Michael B. Chancellor , Ronald Jankowski , Ryan Pruchnic , Johnny Huard
发明人： Michael B. Chancellor , Ronald Jankowski , Ryan Pruchnic , Johnny Huard
IPC分类号： A61K35/12 , A61P13/00
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , C12N2500/38 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/39 , C12N2501/91
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for urinary incontinence and other urinary tract pathologies.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明还提供使用包含肌肉来源的祖细胞的组合物的方法，用于在治疗包括畸形，损伤，无力，疾病或功能障碍的各种功能状况的哺乳动物包括人类软组织的增加和膨胀中。特别地，本发明提供了治疗和改善尿失禁和其他尿路病变。

2. 发明授权

US08961954B2 Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using the same 有权
标题翻译：肌肉衍生细胞用于治疗尿道病变及其使用方法
公开(公告)号：US08961954B2
公开(公告)日：2015-02-24
申请号：US13336332
申请日：2011-12-23
申请人： Michael B. Chancellor , Ronald Jankowski , Ryan Pruchnic , Johnny Huard
发明人： Michael B. Chancellor , Ronald Jankowski , Ryan Pruchnic , Johnny Huard
IPC分类号： A61K35/34 , A61M5/178
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , C12N2500/38 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/39 , C12N2501/91
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for urinary incontinence and other urinary tract pathologies.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明还提供使用包含肌肉来源的祖细胞的组合物的方法，用于在治疗包括畸形，损伤，无力，疾病或功能障碍的各种功能状况的哺乳动物包括人类软组织的增加和膨胀中。特别地，本发明提供了治疗和改善尿失禁和其他尿路病变。

3. 发明申请

US20120109107A1 Muscle Derived Cells for the Treatment of Urinary Tract Pathologies and Methods of Making and Using the Same 有权
标题翻译：用于治疗尿道病理学的肌肉来源细胞及其制备和使用方法
公开(公告)号：US20120109107A1
公开(公告)日：2012-05-03
申请号：US13336332
申请日：2011-12-23
申请人： Michael B. Chancellor , Ronald Jankowski , Ryan Pruchnic , Johnny Huard
发明人： Michael B. Chancellor , Ronald Jankowski , Ryan Pruchnic , Johnny Huard
IPC分类号： A61M37/00 , A61P13/02 , C12N5/071 , A61K35/34
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , C12N2500/38 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/39 , C12N2501/91
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for urinary incontinence and other urinary tract pathologies.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明还提供使用包含肌肉来源的祖细胞的组合物的方法，用于在治疗包括畸形，损伤，无力，疾病或功能障碍的各种功能状况的哺乳动物包括人类软组织的增加和膨胀中。特别地，本发明提供了治疗和改善尿失禁和其他尿路病变。

4. 发明授权

US08105834B2 Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using same 有权
标题翻译：肌肉衍生细胞用于治疗尿道病理及其制作和使用方法
公开(公告)号：US08105834B2
公开(公告)日：2012-01-31
申请号：US12013076
申请日：2008-01-11
申请人： Michael B. Chancellor , Ronald Jankowski , Ryan Pruchnic , Johnny Huard
发明人： Michael B. Chancellor , Ronald Jankowski , Ryan Pruchnic , Johnny Huard
IPC分类号： C12N5/02 , C12N5/071
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , C12N2500/38 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/39 , C12N2501/91
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for urinary incontinence and other urinary tract pathologies.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明还提供使用包含肌肉来源的祖细胞的组合物的方法，用于在治疗包括畸形，损伤，无力，疾病或功能障碍的各种功能状况的哺乳动物包括人类软组织的增加和膨胀中。特别地，本发明提供了治疗和改善尿失禁和其他尿路病变。

5. 发明申请

US20100158875A1 MUSCLE DERIVED CELLS FOR THE TREATMENT OF GASTRO-ESOPHAGEAL PATHOLOGIES AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：用于治疗胃肠道病理学的肌肉衍生细胞及其制备和使用方法
公开(公告)号：US20100158875A1
公开(公告)日：2010-06-24
申请号：US12547149
申请日：2009-08-25
申请人： Michael B. Chancellor , Jay Pasricha , Ronald Jankowski , Ryan Pruchnic
发明人： Michael B. Chancellor , Jay Pasricha , Ronald Jankowski , Ryan Pruchnic
IPC分类号： A61K35/12 , A61P1/04
CPC分类号： A61K35/34 , A61F2/04 , A61F2/08 , A61F2002/044 , A61K35/12 , C12N5/0658 , C12N2500/38 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/39 , C12N2501/91 , C12N2509/00 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration of symptoms for gastro-esophageal pathologies like gastro-esophageal reflux.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明进一步提供使用包含肌肉来源的祖细胞的组合物的方法，用于增加和膨胀哺乳动物，包括人类软组织，以治疗各种美容或功能状况，包括畸形，损伤，无力，疾病或功能障碍。特别地，本发明提供了治疗和改善诸如胃食管反流的胃食管病理学症状。

6. 发明申请

US20080152627A1 Muscle Derived Cells For The Treatment Of Gastro-Esophageal Pathologies And Methods Of Making And Using The Same 有权
标题翻译：用于治疗胃食管病理学的肌肉来源细胞及其制备和使用方法
公开(公告)号：US20080152627A1
公开(公告)日：2008-06-26
申请号：US11959054
申请日：2007-12-18
申请人： Michael B. Chancellor , Jay Pasricha , Ronald Jankowski , Ryan Pruchnic
发明人： Michael B. Chancellor , Jay Pasricha , Ronald Jankowski , Ryan Pruchnic
IPC分类号： A61K35/00 , C12N5/06 , A61P1/00
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , C12N2509/00 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration of symptoms for gastro-esophageal pathologies like gastro-esophageal reflux.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明进一步提供使用包含肌肉来源的祖细胞的组合物的方法，用于增加和膨胀哺乳动物，包括人类软组织，以治疗各种美容或功能状况，包括畸形，损伤，无力，疾病或功能障碍。特别地，本发明提供了治疗和改善诸如胃食管反流的胃食管病理学症状。

7. 发明授权

US09121009B2 Muscle derived cells for the treatment of gastro-esophageal pathologies and methods of making and using the same 有权
标题翻译：肌肉衍生细胞用于治疗胃食管病变及其制备和使用方法
公开(公告)号：US09121009B2
公开(公告)日：2015-09-01
申请号：US11959054
申请日：2007-12-18
申请人： Michael B. Chancellor , Jay Pasricha , Ronald Jankowski , Ryan Pruchnic
发明人： Michael B. Chancellor , Jay Pasricha , Ronald Jankowski , Ryan Pruchnic
IPC分类号： C12N5/077 , A61K35/34 , A61K35/12
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , C12N2509/00 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration of symptoms for gastro-esophageal pathologies like gastro-esophageal reflux.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明进一步提供使用包含肌肉来源的祖细胞的组合物的方法，用于增加和膨胀哺乳动物，包括人类软组织，以治疗各种美容或功能状况，包括畸形，损伤，无力，疾病或功能障碍。特别地，本发明提供了治疗和改善诸如胃食管反流的胃食管病理学症状。

8. 发明申请

US20090010897A1 Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same 有权
标题翻译：用于治疗心脏病理学的肌源性细胞及其制备和使用方法
公开(公告)号：US20090010897A1
公开(公告)日：2009-01-08
申请号：US11998330
申请日：2007-11-28
申请人： Michael B. Chancellor , Thomas Payne , Ronald Jankowski , Ryan Pruchnic
发明人： Michael B. Chancellor , Thomas Payne , Ronald Jankowski , Ryan Pruchnic
IPC分类号： A61K35/12 , C12N5/00 , C12N5/08 , A61P9/00
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0658
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明进一步提供使用包含肌肉来源的祖细胞的组合物的方法，用于增加和膨胀哺乳动物，包括人类软组织，以治疗各种美容或功能状况，包括畸形，损伤，无力，疾病或功能障碍。特别地，本发明提供了用于皮肤病学，胃食管反流，膀胱输尿管反流，尿失禁，大便失禁，心力衰竭和心肌梗死的治疗和改善。

9. 发明授权

US08211423B2 Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same 有权
标题翻译：用于治疗心脏病理学的肌源性细胞及其制备和使用方法
公开(公告)号：US08211423B2
公开(公告)日：2012-07-03
申请号：US11998330
申请日：2007-11-28
申请人： Michael B. Chancellor , Thomas Payne , Ronald Jankowski , Ryan Pruchnic
发明人： Michael B. Chancellor , Thomas Payne , Ronald Jankowski , Ryan Pruchnic
IPC分类号： A01N63/00 , C12N5/07
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0658
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明进一步提供使用包含肌肉来源的祖细胞的组合物的方法，用于在治疗各种美容或功能状况（包括畸形，损伤，无力，疾病或功能障碍）的哺乳动物（包括人）软组织的增加和膨胀中。特别地，本发明提供了用于皮肤病学，胃食管反流，膀胱输尿管反流，尿失禁，大便失禁，心力衰竭和心肌梗死的治疗和改善。

10. 发明申请

US20160303169A9 SKELETAL MUSCLE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS, AND TREATMENTS THEREOF 有权
公开(公告)号：US20160303169A9
公开(公告)日：2016-10-20
申请号：US12245379
申请日：2008-10-03
申请人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic , Michael Chancellor
发明人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic , Michael Chancellor
IPC分类号： A61K35/34
CPC分类号： A61K35/34 , A61K9/0019 , A61K35/12 , C12N5/0658 , C12N5/0659 , C12N2500/84 , C12N2501/70 , C12N2510/00 , C12N2510/02 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. The invention also relates to novel uses of muscle-derived progenitor cells for the treatment of cosmetic or functional conditions, including, but not limited to skeletal muscle weakness, muscular dystrophy, muscle atrophy, spasticity, myoclonus and myalgia. The invention also relates to the novel use of MDCs for the increase of skeletal muscle mass in athletes or other organisms in need of greater than average skeletal muscle mass.

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