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1. 发明授权

US5925736A Collagen-based methods and formulations for the treatment of arthritis 失效
标题翻译：基于胶原的治疗关节炎的方法和制剂
公开(公告)号：US5925736A
公开(公告)日：1999-07-20
申请号：US85363
申请日：1998-05-27
申请人： Thomas Neff , George Martin , Karl A. Piez , Taina Pihlajaniemi , Kari I. Kivirikko
发明人： Thomas Neff , George Martin , Karl A. Piez , Taina Pihlajaniemi , Kari I. Kivirikko
IPC分类号： A61K38/00 , C07K14/78 , A61K38/17
CPC分类号： C07K14/78 , A61K38/00 , Y10S530/868
摘要： The invention provides novel methods and compositions for the treatment of immune system-mediated arthritis, including rheumatoid arthritis. The subject compositions comprise one or more different types of collagen or collagen derivatives and a mucosa binding structure. Specific combinations of collagen and/or collagen derivatives may be used to treat specific types of arthritis. The collagen(s) and/or collagen(s) derivatives used in the subject compositions may be either obtained from natural sources or produced by recombinant genetic engineering techniques by chemical modification. Another aspect of the invention is to provide methods for treating various types of arthritis by administering an effective amount of the subject collagen-containing compositions. The methods of the invention involve the oral administration of a collagen or collagens found in a specific tissue, e.g., cartilage, so as to induce the suppression (immunological tolerance) of inflammation against the tissue from which the collagen is found to occur in nature. The methods of the invention include the administration of the subject collagen(s) and/or collagen derivative(s) containing compositions into the intestines so as to induce immune tolerance, e.g., oral administration.
摘要翻译：本发明提供了用于治疗免疫系统介导的关节炎（包括类风湿性关节炎）的新颖方法和组合物。主题组合物包含一种或多种不同类型的胶原或胶原衍生物和粘膜结合结构。胶原和/或胶原衍生物的具体组合可用于治疗特定类型的关节炎。用于本发明组合物中的胶原和/或胶原衍生物可以从天然来源获得或通过重组基因工程技术通过化学修饰产生。本发明的另一方面是提供通过施用有效量的含有受试者的含胶原的组合物来治疗各种类型的关节炎的方法。本发明的方法涉及口服给予在特定组织例如软骨中发现的胶原蛋白或胶原蛋白，从而诱导针对自然界发现胶原的组织的炎症的抑制（免疫耐受性）。本发明的方法包括将含有组合物的受试者胶原和/或胶原衍生物施用于肠内以引起免疫耐受性，例如口服给药。

2. 发明授权

US4774227A Collagen compositions for bone repair containing autogeneic marrow 失效
标题翻译：含有自体骨髓的骨修复胶原组合物
公开(公告)号：US4774227A
公开(公告)日：1988-09-27
申请号：US829809
申请日：1986-02-14
申请人： Karl A. Piez , Shlomo Weintraub
发明人： Karl A. Piez , Shlomo Weintraub
IPC分类号： A61L27/00 , A61L27/36 , C08L89/06 , A61K37/02 , A61K35/28 , A61F2/28
CPC分类号： A61L27/3608 , A61L27/24 , A61L27/365 , Y10S128/08 , Y10S514/801
摘要： A composition which combines autogenic bone marrow with a suspension of purified atelopeptide reconstituted collagen is used to repair bone defects in mammals.
摘要翻译：将自体骨髓与纯化的atelopeptide重构胶原的悬浮液组合的组合物用于修复哺乳动物的骨缺损。

3. 发明授权

US5246457A Xenogeneic collagen/mineral preparations in bone repair 失效
标题翻译：骨修复中的异种胶原蛋白/矿物质制剂
公开(公告)号：US5246457A
公开(公告)日：1993-09-21
申请号：US629074
申请日：1990-12-17
申请人： Karl A. Piez , Bruce B. Pharriss , George H. Chu , Thomas L. Smestad , Diana Hendricks
发明人： Karl A. Piez , Bruce B. Pharriss , George H. Chu , Thomas L. Smestad , Diana Hendricks
IPC分类号： A61F2/28 , A61L27/46
CPC分类号： A61L27/46 , A61F2002/2835 , A61L2430/02 , Y10S128/08 , Y10S623/923
摘要： A composition for use in bone repair, in particular, in only procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new bone growth through the implant. Additional processes for curing the implant to improve its compressive strength include heat curing, maturation, and cross-linking.
摘要翻译：公开了一种用于骨修复的组合物，特别是在仅包含磷酸钙矿物颗粒与阿替肽重构纤维状胶原蛋白制剂混合的方法中。该组合物是非免疫原性的，并且通过植入物促进宿主骨与新骨生长的融合。用于固化植入物以提高其抗压强度的其它方法包括热固化，成熟和交联。

4. 发明授权

US4992226A Method of making molds with xenogeneic collagen/mineral preparations for bone repair 失效
标题翻译：用于骨修复的异种胶原蛋白/矿物质制剂的制备方法
公开(公告)号：US4992226A
公开(公告)日：1991-02-12
申请号：US245449
申请日：1988-09-16
申请人： Karl A. Piez , Bruce B. Pharriss , George H. Chu , Thomas L. Smestad , Diana Hendricks
发明人： Karl A. Piez , Bruce B. Pharriss , George H. Chu , Thomas L. Smestad , Diana Hendricks
IPC分类号： A61F2/28 , A61L27/46
CPC分类号： A61L27/46 , A61F2002/2835 , A61L2430/02 , Y10S623/901 , Y10S623/923
摘要： A process for coating the pores of a mineral matrix with collagen by pumping collagen through the molded matrix is disclosed. The resulting coated matrix can be used as a prosthesis in bone repair.
摘要翻译：公开了一种通过将胶原蛋白泵送通过模塑基质来涂覆矿物基质的孔的方法。所得涂层基质可用作骨修复中的假体。

5. 发明授权

US4816442A Method of inhibiting tumor growth sensitive to CIF-.beta.treatment 失效
标题翻译：抑制对CIF-β治疗敏感的肿瘤生长的方法
公开(公告)号：US4816442A
公开(公告)日：1989-03-28
申请号：US928760
申请日：1986-11-07
申请人： John M. McPherson , Danile R. Twardzik , George J. Todaro , Karl A. Piez , Jane E. Ranchalis
发明人： John M. McPherson , Danile R. Twardzik , George J. Todaro , Karl A. Piez , Jane E. Ranchalis
IPC分类号： A61K38/22 , A61K38/00 , A61K38/18 , A61P35/00 , A61K37/00
CPC分类号： A61K38/1841 , Y10S930/12
摘要： Polypeptides called cartilage-inducing factors (CIFs) that are found in bone and have heretofore been identified as having in vitro cartilage-inducing activity. TGF-.beta. activity, and anti-inflammatory activity have now been found to possess potent oncostatic activity. The CIFs showed oncostatic activity on human and animal tumors, including carcinomas, adenocarcinomas, lymphomas, and melanomas.
摘要翻译：称为软骨诱导因子（CIF）的多肽，其在骨中发现并且迄今已被鉴定为具有体外软骨诱导活性。现在已经发现TGF-β活性和抗炎活性具有强的抗静电活性。 CIFs对人和动物肿瘤（包括癌，腺癌，淋巴瘤和黑素瘤）表现出增强的活性。

6. 发明授权

US4789663A Methods of bone repair using collagen 失效
标题翻译：使用胶原的骨修复方法
公开(公告)号：US4789663A
公开(公告)日：1988-12-06
申请号：US752447
申请日：1985-07-05
申请人： Donald G. Wallace , Thomas L. Smestad , John M. McPherson , Karl A. Piez , Saeid Seyedin , Rosa Armstrong
发明人： Donald G. Wallace , Thomas L. Smestad , John M. McPherson , Karl A. Piez , Saeid Seyedin , Rosa Armstrong
IPC分类号： A61F2/00 , A61L27/24 , A61K37/12 , A61K35/32 , C07K15/20 , C12P21/00
CPC分类号： A61L27/24 , A61F2002/2835 , A61F2310/00365 , Y10S514/801
摘要： A method of repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or mixtures thereof is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen may also be lyophilized and used in the form of mats.
摘要翻译：公开了通过使用含有纯化的三肽，重组的，纤维状皮肤胶原或骨胶原粉末或其混合物的悬浮液来修复骨缺损的方法。悬浮液提供用于将骨导入生长缺损的基质。皮肤胶原蛋白也可以冻干，并以垫的形式使用。

7. 发明授权

US5425770A Calcium phosphate/atelopeptide collagen compositions for bone repair 失效
标题翻译：用于骨修复的磷酸钙/血管肽胶原组合物
公开(公告)号：US5425770A
公开(公告)日：1995-06-20
申请号：US99610
申请日：1993-07-30
申请人： Karl A. Piez , Bruce B. Pharriss , George H. Chu , Thomas L. Smestad , Diana Hendricks
发明人： Karl A. Piez , Bruce B. Pharriss , George H. Chu , Thomas L. Smestad , Diana Hendricks
IPC分类号： A61F2/28 , A61L27/46
CPC分类号： A61L27/46 , A61F2002/2835 , A61L2430/02 , Y10S128/08 , Y10S623/923
摘要： Processes for the preparation of compositions used in conductive bone repair are disclosed. The compositions contain a mixture consisting essentially of either a calcium phosphate particulate mineral component or particulate hydroxyapatite in admixture with atelopeptide reconstituted fibrillar collagen. The method is comprised of mixing a dispersion of the collagen and mineral, the latter which is present in dry particulate form, followed by molding and drying the composition in a mold to obtain a dried composition.
摘要翻译：公开了用于制备用于导电骨修复的组合物的方法。组合物含有基本上由磷酸钙颗粒状矿物组分或颗粒状羟基磷灰石组成的混合物，与磷酸腺苷重构的纤维状胶原混合。该方法包括混合胶原蛋白和矿物质的分散体，后者以干燥颗粒形式存在，然后在模具中成型和干燥组合物以获得干燥的组合物。

8. 发明授权

US4795467A Xenogeneic collagen/mineral preparations in bone repair 失效
标题翻译：骨修复中的异种胶原蛋白/矿物质制剂
公开(公告)号：US4795467A
公开(公告)日：1989-01-03
申请号：US848443
申请日：1986-04-04
申请人： Karl A. Piez , Bruce B. Pharriss , George H. Chu , Thomas L. Smestad , Diana Hendricks
发明人： Karl A. Piez , Bruce B. Pharriss , George H. Chu , Thomas L. Smestad , Diana Hendricks
IPC分类号： A61L27/00 , A61F2/28 , A61L27/46
CPC分类号： A61L27/46 , A61F2002/2835 , A61L2430/02 , Y10S514/801
摘要： A composition for use in bone repair, in particular, in onlay procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new bone growth through the implant. Additional processes for curing the implant to improve its compressive strength include heat curing, maturation, and cross-linking.
摘要翻译：公开了一种用于骨修复的组合物，特别是在包含磷灰石矿物颗粒与阿替肽复构的纤维状胶原蛋白制剂混合的敷贴方法中。该组合物是非免疫原性的，并且通过植入物促进宿主骨与新骨生长的融合。用于固化植入物以提高其抗压强度的其它方法包括热固化，成熟和交联。

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