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1. 发明申请

US20120213857A1 Method for Producing Pancreatin Pellets 有权
标题翻译：生产胰岛素颗粒的方法
公开(公告)号：US20120213857A1
公开(公告)日：2012-08-23
申请号：US13368415
申请日：2012-02-08
申请人： Thomas Moest , Walter Doleschal , Manfred Kurfürst
发明人： Thomas Moest , Walter Doleschal , Manfred Kurfürst
IPC分类号： A61K9/14 , A61P1/18 , B29B9/00 , A61K38/54
CPC分类号： A61K9/1688 , A61K9/5021 , A61K9/5073 , A61K9/5089 , A61K35/39 , A61K38/00 , A61K38/48 , C12N9/94
摘要： In order to avoid compromising the pharmacological effect of pancreatin caused by the addition of auxiliary materials or binding agents, a pancreatin pellet having a 100% pancreatin content consists exclusively of pancreatin with a residual moisture content of less than 3% by weight, preferably less than 1% by weight or less than 0.5% by weight.
摘要翻译：为了避免由于添加辅助材料或粘合剂而导致的胰酶的药理作用的损害，具有100％胰酶含量的胰酶颗粒仅由胰酶组成，残留水分含量小于3重量％，优选小于 1重量％或小于0.5重量％。

2. 发明申请

US20110052706A1 Pancreatine pellets and method of producing same 有权
标题翻译：胰岛素颗粒及其制备方法
公开(公告)号：US20110052706A1
公开(公告)日：2011-03-03
申请号：US12806942
申请日：2010-08-24
申请人： Thomas Moest , Manfred Kurfürst , Walter Doleschal
发明人： Thomas Moest , Manfred Kurfürst , Walter Doleschal
IPC分类号： A61K9/14 , A61K38/54 , A61P1/00 , A61P5/48 , C12N9/94
CPC分类号： A61K9/14 , A61K9/5031 , A61K9/5047 , A61K9/5073 , A61K9/5089 , A61K38/465 , A61K38/47 , A61K38/48 , A61K2300/00
摘要： In order to prevent impairment of the pharmacological effect of pancreatine through added auxiliary substances or binding agents a pancreatine pellet consists exclusively of pancreatine.
摘要翻译：为了防止胰腺通过添加的辅助物质或粘合剂的药理作用受损，胰腺丸粒仅由胰腺组成。

3. 发明授权

US08999394B2 Pancreatine pellets and method of producing same 有权
标题翻译：胰岛素颗粒及其制备方法
公开(公告)号：US08999394B2
公开(公告)日：2015-04-07
申请号：US12806942
申请日：2010-08-24
申请人： Thomas Moest , Manfred Kurfürst , Walter Doleschal
发明人： Thomas Moest , Manfred Kurfürst , Walter Doleschal
IPC分类号： A61K9/16 , C12N9/94 , A61K9/14 , A61K9/50 , A61K38/46 , A61K38/47 , A61K38/48
CPC分类号： A61K9/14 , A61K9/5031 , A61K9/5047 , A61K9/5073 , A61K9/5089 , A61K38/465 , A61K38/47 , A61K38/48 , A61K2300/00
摘要： In order to prevent impairment of the pharmacological effect of pancreatine through added auxiliary substances or binding agents a pancreatine pellet consists exclusively of pancreatine.
摘要翻译：为了防止胰腺通过添加的辅助物质或粘合剂的药理作用受损，胰腺丸粒仅由胰腺组成。

4. 发明授权

US08691282B2 Method for producing pancreatin pellets 有权
标题翻译：胰蛋白酶颗粒的制备方法
公开(公告)号：US08691282B2
公开(公告)日：2014-04-08
申请号：US13368415
申请日：2012-02-08
申请人： Thomas Moest , Walter Doleschal , Manfred Kurfürst
发明人： Thomas Moest , Walter Doleschal , Manfred Kurfürst
IPC分类号： A61K9/16 , A61K9/50
CPC分类号： A61K9/1688 , A61K9/5021 , A61K9/5073 , A61K9/5089 , A61K35/39 , A61K38/00 , A61K38/48 , C12N9/94
摘要： In order to avoid compromising the pharmacological effect of pancreatin caused by the addition of auxiliary materials or binding agents, a pancreatin pellet having a 100% pancreatin content consists exclusively of pancreatin with a residual moisture content of less than 3% by weight, preferably less than 1% by weight or less than 0.5% by weight.
摘要翻译：为了避免由于添加辅助材料或粘合剂而导致的胰酶的药理作用的损害，具有100％胰酶含量的胰酶颗粒仅由胰酶组成，残留水分含量小于3重量％，优选小于 1重量％或小于0.5重量％。

5. 发明授权

US08283147B2 Pancreatin and method for reducing the viral and microbial contamination of pancreatin 有权
标题翻译：胰蛋白酶和减少胰腺炎病毒和微生物污染的方法
公开(公告)号：US08283147B2
公开(公告)日：2012-10-09
申请号：US12403697
申请日：2009-03-13
申请人： Manfred Kurfürst , Christian Rämsch , Thomas Schräder , Thomas Moest
发明人： Manfred Kurfürst , Christian Rämsch , Thomas Schräder , Thomas Moest
IPC分类号： C12N9/94
CPC分类号： C12N9/94 , A61L2/0023
摘要： The invention relates to a method for producing pancreatin with reduced viral and microbial contamination, comprising the steps of (a) providing the pancreatin in solid form with a residual moisture of 0.5 weight % or less, down to almost zero, based on the pancreatin provided; (b) subjecting the pancreatin provided in step (a) to a heat treatment at a temperature of 84° C., preferably 80° C. and below; wherein, the biological activity of the pancreatin obtained in step (b) corresponds to at least 50% of the biological activity of the pancreatin provided in step (a); and the viral infectiousness of the pancreatin obtained in step (b) has been reduced by a factor of more than 1 log10 in comparison with the viral infectiousness of the pancreatin provided in step (a), as well as a pancreatin produced according to this method and its use for producing a medicine or a nutritional supplement.
摘要翻译：本发明涉及一种生产具有减少的病毒和微生物污染的胰酶的方法，其包括以下步骤：（a）基于所提供的胰酶，提供固体形式的胰酶，残留水分为0.5重量％或更少，至少几乎为零 ; （b）使步骤（a）中提供的胰酶在84℃，优选80℃及以下的温度下进行热处理; 其中，步骤（b）中获得的胰酶的生物活性对应于步骤（a）中提供的胰酶的生物活性的至少50％。与步骤（a）中提供的胰酶的病毒感染性相比，步骤（b）中获得的胰酶的病毒感染性已经降低了大于1log10的因子，以及根据该方法制备的胰酶及其用于生产药物或营养补充剂的用途。

6. 发明授权

US09107966B2 Method for reducing the viral and microbial load of biological extracts containing solids 有权
标题翻译：减少包含固体的生物提取物的病毒和微生物负荷的方法
公开(公告)号：US09107966B2
公开(公告)日：2015-08-18
申请号：US13060712
申请日：2009-08-27
申请人： Christian Rämsch , Thomas Schräder , Thomas Moest , Manfred Kurfürst
发明人： Christian Rämsch , Thomas Schräder , Thomas Moest , Manfred Kurfürst
IPC分类号： C12N9/00 , A23L1/305 , A23L1/28 , A61L2/00 , C12N9/94 , A61K38/00
CPC分类号： A61L2/0011 , A61K38/00 , C12N9/94
摘要： The invention is a method for reducing the viral and microbial content of biological extracts which contain solids. The method comprises the steps of, (1), providing a biological extract which contains solids that comprise a biologically active substance, selected from enzymes, proteins and peptides, or a mixture of such substances; and (2) subjecting the biological extract to a high-pressure treatment; wherein the biological activity of the biological extract after the high-pressure treatment is at least 50% of the biological activity of the biological extract before the high-pressure treatment.
摘要翻译：本发明是减少含有固体的生物提取物的病毒和微生物含量的方法。该方法包括以下步骤：（1）提供含有选自酶，蛋白质和肽或这些物质的混合物的生物活性物质的固体的生物提取物; 和（2）对生物提取物进行高压处理; 其中，高压处理后的生物提取物的生物活性为高压处理前生物提取物的生物活性的至少50％。

7. 发明申请

US20110268844A1 METHOD FOR REDUCING THE VIRAL AND MICROBIAL LOAD OF BIOLOGICAL EXTRACTS CONTAINING SOLIDS 有权
标题翻译：减少含有固体的生物提取物的病毒和微生物负荷的方法
公开(公告)号：US20110268844A1
公开(公告)日：2011-11-03
申请号：US13060712
申请日：2009-08-27
申请人： Christian Rämsch , Thomas Schräder , Thomas Moest , Manfred Kurfürst
发明人： Christian Rämsch , Thomas Schräder , Thomas Moest , Manfred Kurfürst
IPC分类号： C12N9/00 , A23L1/305 , A23L1/28
CPC分类号： A61L2/0011 , A61K38/00 , C12N9/94
摘要： The invention relates to a method for reducing the viral and microbial content of biological extracts which contain solids. It is provided that the method comprises the steps (a) provision of the biological extract which contains solids, comprising a biologically active substance, selected from enzymes, proteins and peptides, or a mixture of such substances; and (b) subjecting the biological extract provided in step (a) to a high-pressure treatment; wherein the biological activity of the biological extract which contains solids after the high-pressure treatment is at least 50% of the biological activity of the biological extract which contains solids before the high-pressure treatment.
摘要翻译：本发明涉及一种减少含有固体的生物提取物的病毒和微生物含量的方法。提供的方法包括步骤（a）提供含有选自酶，蛋白质和肽的生物活性物质或这些物质的混合物的固体的生物提取物; 和（b）对步骤（a）中提供的生物提取物进行高压处理; 其中在高压处理后含有固体的生物提取物的生物活性是在高压处理前含有固体的生物提取物的生物活性的至少50％。

8. 发明授权

US06811054B1 Dosing spoon for micro-tablets 有权
标题翻译：微量滴定汤匙
公开(公告)号：US06811054B1
公开(公告)日：2004-11-02
申请号：US10009061
申请日：2002-04-11
申请人： Thomas Moest , Ludwig Matz
发明人： Thomas Moest , Ludwig Matz
IPC分类号： G07F1156
CPC分类号： A61J7/0023 , A61J7/0053 , A61J7/02
摘要： A dosing spoon for microtablets is described for which the lower part (1) of the spoon consists of an even polygone which possesses a border (2) on all sides with exception of one side and whereby the polygone has a number of individual recesses (3) which are formed in such a way that an individual microtablet fits in each individual recess.
摘要翻译：描述了用于微片的计量匙，其中勺子的下部（1）由均匀的多边形组成，除了一侧之外，所有侧面都具有边界（2），并且由此多边形具有多个单独的凹部（3 ），其以这样的方式形成，使得各个微片安装在每个单独的凹部中。

9. 发明授权

US5320852A Antacid microtablets 失效
标题翻译：抗酸微片
公开(公告)号：US5320852A
公开(公告)日：1994-06-14
申请号：US987559
申请日：1992-12-08
申请人： Thomas Moest
发明人： Thomas Moest
IPC分类号： A61J3/10 , A61K9/20 , A61K33/06 , A61K33/10 , A61K45/08 , A61P1/00 , A61K33/08 , A61K33/12
CPC分类号： A61K33/06 , A61K9/2072 , Y10S514/819 , Y10S514/96
摘要： A biconvex tablet whose height and diameter are approximately equal and are from 1.5 to 4 mm and which, besides conventional pharmaceutical auxiliaries, contains an antacid as active substance is described.
摘要翻译：描述了其高度和直径近似相等并且为1.5至4mm的双凸片，并且除了常规药物助剂之外，还含有作为活性物质的抗酸剂。

10. 发明授权

US5453280A Production of pellets composed of an ephedrine derivative 失效
标题翻译：生产由麻黄碱衍生物组成的丸粒
公开(公告)号：US5453280A
公开(公告)日：1995-09-26
申请号：US117285
申请日：1993-09-07
申请人： Thomas Moest , Uwe Loeffler , Hans Waiblinger
发明人： Thomas Moest , Uwe Loeffler , Hans Waiblinger
IPC分类号： A61K9/16 , A61K31/135 , A61K31/137 , A61K9/54 , B29B9/08 , B29B9/16
CPC分类号： A61K31/135 , A61K9/1688
摘要： A process for producing pellets which are markedly spherical and have a particle size in the range from 0.1 to 4 mm and an apparent density above 0.5 g/cm.sup.3, and which are composed of 90-100% by weight of an ephedrine derivative and 0-10% by weight of a pharmaceutical aid, entails suspending ephedrine derivative powder with an average particle size of from 0.5 to 50 .mu.m at 0.degree.-90.degree. C. with stirring in a water-immiscible non solvent with a boiling point in the range from 60.degree. to 160.degree. C., adding 5-60% by weight, based on the ephedrine derivative, of an agglomerating liquid while continuing stirring, and, if there has been previous heating, cooling to from -5 to 25.degree. C. at 5-40K per hour, with the stirring speed being adjusted after the agglomeration of the powder particles to a value which is necessary for the required average particle size, and removing and drying the resulting pellets. A drug which contains the active ingredient in the form of such pellets, with or without slowing of release, is also described.
摘要翻译：一种制备显影球形，粒径为0.1〜4mm，表观密度为0.5g / cm 3以上的颗粒的方法，由90-100重量％的麻黄碱衍生物和0〜 10重量％的药物助剂，需要在0〜90℃下搅拌平均粒度为0.5〜50μm的麻黄碱衍生物粉末，在沸点范围内的不溶于水的非溶剂中搅拌从60℃升至160℃，在连续搅拌的同时加入约5-60重量％的基于麻黄碱衍生物的附聚液，如果先前加热，冷却至-5〜25℃ 以每小时5-40K的速度调整粉末颗粒附聚后的搅拌速度至所需的平均颗粒尺寸所需的值，并除去和干燥所得的颗粒。还描述了含有这种丸剂形式的活性成分的药物，其具有或没有减缓释放。

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