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1. 发明授权

US5606974A Catheter having ultrasonic device 失效
标题翻译：导管具有超声波装置
公开(公告)号：US5606974A
公开(公告)日：1997-03-04
申请号：US434004
申请日：1995-05-02
申请人： Thomas M. Castellano , Robert C. Hayzelden , Tracy D. Maahs
发明人： Thomas M. Castellano , Robert C. Hayzelden , Tracy D. Maahs
IPC分类号： A61B17/00 , A61B17/22 , A61B8/12
CPC分类号： A61B17/2202 , A61B2017/00084 , A61B2017/00092 , A61B2017/00243
摘要： A catheter includes a piezoelectric transducer mounted to the distal end of a catheter. In one embodiment, the piezoelectric transducer has the shape of a cylinder and in another embodiment, a convex shape with a mounting flange. In the cylindrical shape, a plurality of surface mounted temperature sensors are disposed within the piezoelectric transducer. The sensors are electrically insulated and a sealing technique prevents the leakage of body fluids from penetrating the interior of the catheter through the sensor bores. The cylindrical transducer is supported on mounting members so that it is accurately mounted and sealed while at the same time, the material used does not significantly dampen the transducer. The convex shape includes a temperature sensor at its tip.
摘要翻译：导管包括安装到导管的远端的压电换能器。在一个实施例中，压电换能器具有圆筒的形状，在另一实施例中，具有安装凸缘的凸形。在圆筒形状中，多个表面安装温度传感器设置在压电换能器内。传感器是电绝缘的，并且密封技术防止体液泄漏通过传感器孔穿透导管内部。圆柱形换能器支撑在安装构件上，使其精确安装和密封，同时所使用的材料不会显着损坏换能器。凸形包括其顶端的温度传感器。

2. 发明授权

US08486063B2 Ablation catheter 有权
标题翻译：消融导管
公开(公告)号：US08486063B2
公开(公告)日：2013-07-16
申请号：US12245625
申请日：2008-10-03
申请人： Randell L. Werneth , Marshall L. Sherman , Thomas M. Castellano , J. Christopher Flaherty , Gary Edward Currie
发明人： Randell L. Werneth , Marshall L. Sherman , Thomas M. Castellano , J. Christopher Flaherty , Gary Edward Currie
IPC分类号： A61B18/18
CPC分类号： A61B18/16 , A61B18/1492 , A61B18/18 , A61B2017/00482 , A61B2018/0016 , A61B2018/00214 , A61B2018/00291 , A61B2018/00351 , A61B2018/1467
摘要： Devices, systems and methods are disclosed for the ablation of tissue. Embodiments include an ablation catheter which has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be constrained within the lumen of a catheter, and deployed to take on an expanded condition.
摘要翻译：公开了用于组织消融的装置，系统和方法。实施例包括消融导管，其具有附接到可展开的载体组件的消融元件阵列。载体组件可以被限制在导管的内腔中，并且被部署以展开扩张状态。

3. 发明授权

US06558378B2 RF ablation system and method having automatic temperature control 有权
公开(公告)号：US06558378B2
公开(公告)日：2003-05-06
申请号：US09738032
申请日：2000-12-13
申请人： Marshall L. Sherman , Kathryn E. Lockwood , Thomas M. Castellano
发明人： Marshall L. Sherman , Kathryn E. Lockwood , Thomas M. Castellano
IPC分类号： A61B1818
CPC分类号： A61B18/1206 , A61B18/1492 , A61B2018/0016 , A61B2018/00351 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00714 , A61B2018/00726 , A61B2018/00738 , A61B2018/0075 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00875 , A61B2018/124 , A61B2018/126 , A61B2018/1273 , A61B2018/1467
摘要： A plurality of electrodes are positioned at the distal end of a catheter such that the electrodes may be positioned proximal biological tissue. A select number of the electrodes have a temperature sensing device associated with them for providing a temperature signal indicative of the temperature at the interface between the electrode and the tissue. A generator operates under the control of a processor to apply power to each of the electrodes. The power has an associated phase angle and, within a time duration, a plurality of alternating on periods and off periods, one set of adjacent on and off periods defining a duty cycle. The processor is programmed to determine the temperature at the electrode/tissue interface based on the temperature signals, compare the temperature to a target temperature and to adjust the power to the electrode accordingly. Such adjustments may comprise an increase or decrease in the duty cycle, a setting of the duty cycle to zero followed by an incremental increase in the duty cycle or a power interrupt.

4. 发明申请

US20090030411A1 ABLATION CATHETER 有权
标题翻译：橡胶导管
公开(公告)号：US20090030411A1
公开(公告)日：2009-01-29
申请号：US12245625
申请日：2008-10-03
申请人： Randell L. Werneth , Marshall L. Sherman , Thomas M. Castellano , J. Christopher Flaherty , Gary Edward Currie
发明人： Randell L. Werneth , Marshall L. Sherman , Thomas M. Castellano , J. Christopher Flaherty , Gary Edward Currie
IPC分类号： A61B18/18 , A61B18/14
CPC分类号： A61B18/16 , A61B18/1492 , A61B18/18 , A61B2017/00482 , A61B2018/0016 , A61B2018/00214 , A61B2018/00291 , A61B2018/00351 , A61B2018/1467
摘要： Devices, systems and methods are disclosed for the ablation of tissue. Embodiments include an ablation catheter which has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be constrained within the lumen of a catheter, and deployed to take on an expanded condition.
摘要翻译：公开了用于组织消融的装置，系统和方法。实施例包括消融导管，其具有附接到可展开的载体组件的消融元件阵列。载体组件可以被限制在导管的内腔中，并且被部署以展开扩张状态。

5. 发明申请

US20080275443A1 ATRIAL ABLATION CATHETER ADAPTED FOR TREATMENT OF SEPTAL WALL ARRHYTHMOGENIC FOCI AND METHOD OF USE 有权
标题翻译：适用于治疗宫颈癌发生骨髓的ATRIAL ABLATION CATHETER及其使用方法
公开(公告)号：US20080275443A1
公开(公告)日：2008-11-06
申请号：US12176115
申请日：2008-07-18
申请人： Hakan Oral , Randell L. Werneth , Thomas M. Castellano , Christopher G. Kunis
发明人： Hakan Oral , Randell L. Werneth , Thomas M. Castellano , Christopher G. Kunis
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/0016 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/1475
摘要： An atrial ablation catheter with an electrode array particularly adapted to locate and ablate foci of arrhythmia which are required for sustained atrial fibrillation is provided. The array is easily deployed and retracted from the catheter, and presents a proximally oriented electrode array that can be pulled against the septal wall of the left atrium to engage the septal wall.
摘要翻译：提供了具有特别适于定位和消融持续性房颤所需的心律失常灶的电极阵列的心房消融导管。该阵列容易地从导管展开和缩回，并且呈现近端定向的电极阵列，其可以被拉到左心房的隔壁以接合隔膜。

6. 发明申请

US20120271341A1 Method and Apparatus for Treating a Mitral Valve Prolapse and Providing Embolic Protection 审中-公开
标题翻译：用于治疗二尖瓣止痛和提供栓塞保护的方法和装置
公开(公告)号：US20120271341A1
公开(公告)日：2012-10-25
申请号：US13093233
申请日：2011-04-25
申请人： Alexander J. Hill , Thomas M. Castellano , H. Toby Markowitz
发明人： Alexander J. Hill , Thomas M. Castellano , H. Toby Markowitz
IPC分类号： A61F2/01 , A61N1/00
CPC分类号： A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/0065 , A61N1/39
摘要： A method and apparatus for treating a mitral valve prolapse and providing embolic protection in a patient is disclosed. An embolic protection filter is delivered to the left atrium and placed in the blood flow exiting the left atrium of the heart. The filter is secured in the heart of a patient. A shaping member is delivered to the mitral valve of the heart and secured in the heart.
摘要翻译：公开了一种用于治疗二尖瓣脱垂并在患者中提供栓塞保护的方法和装置。栓塞保护过滤器被输送到左心房并且放置在离开心脏左心房的血流中。过滤器固定在患者的心脏中。成形构件被递送到心脏的二尖瓣并固定在心脏中。

7. 发明授权

US07468062B2 Atrial ablation catheter adapted for treatment of septal wall arrhythmogenic foci and method of use 有权
标题翻译：适用于治疗隔膜致心律失常灶的心房消融导管及其使用方法
公开(公告)号：US07468062B2
公开(公告)日：2008-12-23
申请号：US10997713
申请日：2004-11-24
申请人： Hakan Oral , Randell L. Werneth , Thomas M. Castellano , Christopher G. Kunis
发明人： Hakan Oral , Randell L. Werneth , Thomas M. Castellano , Christopher G. Kunis
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/0016 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/1475
摘要： An atrial ablation catheter with an electrode array particularly adapted to locate and ablate foci of arrhythmia which are required for sustained atrial fibrillation is provided. The array is easily deployed and retracted from the catheter, and presents a proximally oriented electrode array that can be pulled against the septal wall of the left atrium to engage the septal wall.
摘要翻译：提供了具有特别适于定位和消融持续性房颤所需的心律失常灶的电极阵列的心房消融导管。该阵列容易地从导管展开和缩回，并且呈现近端定向的电极阵列，其可以被拉到左心房的隔壁以接合隔膜。

8. 发明授权

US07252663B2 Device and method for the creation of a circumferential cryogenic lesion in a pulmonary vein 有权
标题翻译：在肺静脉中产生圆周低温病变的装置和方法
公开(公告)号：US07252663B2
公开(公告)日：2007-08-07
申请号：US10847057
申请日：2004-05-17
申请人： Eugene Brian Reu , Thomas M. Castellano , Gregory M. Ayers
发明人： Eugene Brian Reu , Thomas M. Castellano , Gregory M. Ayers
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/00243 , A61B2017/003 , A61B2017/22067 , A61B2018/0212 , A61B2018/0262
摘要： A device and method for ablating tissue includes a sheath system with an occlusion structure. In certain embodiments, arrhythmias originating in pulmonary veins are treated cryogenically.
摘要翻译：用于消融组织的装置和方法包括具有闭塞结构的鞘系统。在某些实施方案中，源自肺静脉的心律失常被低温处理。

9. 发明授权

US5735280A Ultrasound energy delivery system and method 失效
标题翻译：超声能量输送系统及方法
公开(公告)号：US5735280A
公开(公告)日：1998-04-07
申请号：US708829
申请日：1996-09-09
申请人： Marshall L. Sherman , Thomas M. Castellano
发明人： Marshall L. Sherman , Thomas M. Castellano
IPC分类号： A61B18/00 , A61B17/00 , A61B17/22 , A61B8/00
CPC分类号： A61B17/2202 , A61B2017/00084 , A61B2017/00092 , A61B2017/00243
摘要： An energy delivery system and method controls the frequency of the power driving an ultrasonic device to achieve more efficient power delivery. During operation of the ultrasonic device to deliver power to a patient site, the system and method automatically sweeps the drive power through a frequency range, locates the series and parallel resonance frequencies, calculates the average of those frequencies and locks the power generator at that average frequency to drive the crystal. This frequency sweep procedure occurs automatically when the ultrasonic crystal is located at the patient site and the power generator operator presses the power-on switch to apply power. The method of tuning the power generator thus occurs when the crystal is at the site temperature and is transparent to the operator. The application of an external bio-layer to the crystal increases its bandwidth and its robustness. Mounting a temperature sensor or sensors at the crystal permits monitoring of the crystal temperature and allows drive level control over the power generator to control the temperature at the crystal.
摘要翻译：能量输送系统和方法控制驱动超声波装置的功率的频率以实现更有效的功率传递。在超声波设备运行期间向病人现场输送电力时，系统和方法会自动扫描驱动电源频率范围，定位串联和并联谐振频率，计算出这些频率的平均值，并将发电机锁定在该平均值频率驱动晶体。当超声波晶体位于患者现场时，该频率扫描过程自动发生，发电机操作者按下电源开关以施加电力。因此，当晶体处于现场温度并且对操作者是透明的时，调谐发电机的方法发生。外部生物层在晶体上的应用增加了其带宽和其鲁棒性。将温度传感器或传感器安装在晶体处可以监控晶体温度，并允许对发电机进行驱动电平控制，以控制晶体的温度。

10. 发明授权

US09005194B2 Atrial ablation catheter adapted for treatment of septal wall arrhythmogenic foci and method of use 有权
标题翻译：适用于治疗隔膜致心律失常灶的心房消融导管及其使用方法
公开(公告)号：US09005194B2
公开(公告)日：2015-04-14
申请号：US12176115
申请日：2008-07-18
申请人： Hakan Oral , Randell L. Werneth , Thomas M. Castellano , Christopher G. Kunis
发明人： Hakan Oral , Randell L. Werneth , Thomas M. Castellano , Christopher G. Kunis
IPC分类号： A61B18/14 , A61B18/00
CPC分类号： A61B18/1492 , A61B2018/0016 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/1475
摘要： An atrial ablation catheter with an electrode array particularly adapted to locate and ablate foci of arrhythmia which are required for sustained atrial fibrillation is provided. The array is easily deployed and retracted from the catheter, and presents a proximally oriented electrode array that can be pulled against the septal wall of the left atrium to engage the septal wall.
摘要翻译：提供了具有特别适于定位和消融持续性房颤所需的心律失常灶的电极阵列的心房消融导管。该阵列容易地从导管展开和缩回，并且呈现近端定向的电极阵列，其可以被拉到左心房的隔壁以接合隔膜。

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