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1. 发明授权

US06558378B2 RF ablation system and method having automatic temperature control 有权
公开(公告)号：US06558378B2
公开(公告)日：2003-05-06
申请号：US09738032
申请日：2000-12-13
申请人： Marshall L. Sherman , Kathryn E. Lockwood , Thomas M. Castellano
发明人： Marshall L. Sherman , Kathryn E. Lockwood , Thomas M. Castellano
IPC分类号： A61B1818
CPC分类号： A61B18/1206 , A61B18/1492 , A61B2018/0016 , A61B2018/00351 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00714 , A61B2018/00726 , A61B2018/00738 , A61B2018/0075 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00875 , A61B2018/124 , A61B2018/126 , A61B2018/1273 , A61B2018/1467
摘要： A plurality of electrodes are positioned at the distal end of a catheter such that the electrodes may be positioned proximal biological tissue. A select number of the electrodes have a temperature sensing device associated with them for providing a temperature signal indicative of the temperature at the interface between the electrode and the tissue. A generator operates under the control of a processor to apply power to each of the electrodes. The power has an associated phase angle and, within a time duration, a plurality of alternating on periods and off periods, one set of adjacent on and off periods defining a duty cycle. The processor is programmed to determine the temperature at the electrode/tissue interface based on the temperature signals, compare the temperature to a target temperature and to adjust the power to the electrode accordingly. Such adjustments may comprise an increase or decrease in the duty cycle, a setting of the duty cycle to zero followed by an incremental increase in the duty cycle or a power interrupt.

2. 发明授权

US06391024B1 RF ablation apparatus and method having electrode/tissue contact assessment scheme and electrocardiogram filtering 有权
标题翻译： RF消融装置和方法，其具有电极/组织接触评估方案和心电图滤波
公开(公告)号：US06391024B1
公开(公告)日：2002-05-21
申请号：US09335200
申请日：1999-06-17
申请人： Weimin Sun , Thomas M. Castellano , Russ E. Anderson , Wade A. Bowe , John A. Simpson , Marshall L. Sherman , Kathryn E. Lockwood
发明人： Weimin Sun , Thomas M. Castellano , Russ E. Anderson , Wade A. Bowe , John A. Simpson , Marshall L. Sherman , Kathryn E. Lockwood
IPC分类号： A61B1804
CPC分类号： A61B18/1206 , A61B18/1492 , A61B2018/0066 , A61B2090/065
摘要： A method of assessing the adequacy of contact between an ablation electrode and biological tissue within a biological organ having biological fluid therein includes the steps of positioning the ablation electrode proximal the biological tissue; positioning a reference electrode a distance from the ablation electrode; measuring the impedance between the ablation electrode and the reference electrode at a first frequency and measuring the impedance between the ablation electrode and the reference electrode at a second frequency. The percentage difference between the first-frequency impedance and the second-frequency impedance provides an indication of the state of electrode/tissue contact. In general, a percentage difference of at least approximately 10% serves as an indication of substantially complete electrode/tissue contact. A percentage difference in the approximate range between 5% and 10% serves as an indication of partial electrode/tissue contact. A percentage difference less than approximately 5% serves as an indication of no electrode/tissue contact. Ratiometric measurements may also be used to assess the state of electrode/tissue contact.
摘要翻译：一种评估消融电极与生物体内具有生物流体的生物组织之间接触的充分性的方法包括以下步骤：将消融电极定位在生物组织附近; 将参考电极定位到距离消融电极的距离; 以第一频率测量消融电极和参考电极之间的阻抗，并以第二频率测量消融电极和参考电极之间的阻抗。第一频率阻抗和第二频率阻抗之间的百分比差异提供了电极/组织接触状态的指示。通常，至少约10％的百分比差异用作基本上完整的电极/组织接触的指示。在5％和10％之间的近似范围内的百分比差异用作部分电极/组织接触的指示。小于约5％的百分比差异表示没有电极/组织接触。比例测量也可用于评估电极/组织接触的状态。

3. 发明授权

US08486063B2 Ablation catheter 有权
标题翻译：消融导管
公开(公告)号：US08486063B2
公开(公告)日：2013-07-16
申请号：US12245625
申请日：2008-10-03
申请人： Randell L. Werneth , Marshall L. Sherman , Thomas M. Castellano , J. Christopher Flaherty , Gary Edward Currie
发明人： Randell L. Werneth , Marshall L. Sherman , Thomas M. Castellano , J. Christopher Flaherty , Gary Edward Currie
IPC分类号： A61B18/18
CPC分类号： A61B18/16 , A61B18/1492 , A61B18/18 , A61B2017/00482 , A61B2018/0016 , A61B2018/00214 , A61B2018/00291 , A61B2018/00351 , A61B2018/1467
摘要： Devices, systems and methods are disclosed for the ablation of tissue. Embodiments include an ablation catheter which has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be constrained within the lumen of a catheter, and deployed to take on an expanded condition.
摘要翻译：公开了用于组织消融的装置，系统和方法。实施例包括消融导管，其具有附接到可展开的载体组件的消融元件阵列。载体组件可以被限制在导管的内腔中，并且被部署以展开扩张状态。

4. 发明授权

US08273084B2 Atrial ablation catheter and method of use 有权
标题翻译：心房消融导管及使用方法
公开(公告)号：US08273084B2
公开(公告)日：2012-09-25
申请号：US12197425
申请日：2008-08-25
申请人： Christopher G. Kunis , Thomas M. Castellano , Marshall L. Sherman , Randell L. Werneth
发明人： Christopher G. Kunis , Thomas M. Castellano , Marshall L. Sherman , Randell L. Werneth
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/0016 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/1475
摘要： An atrial ablation catheter and methods for its use. The endocardial catheter includes an electrode array particularly adapted to locate and ablate foci of arrhythmia which are required for sustained atrial fibrillation is provided. The array is easily deployed and retracted from the catheter, and presents a distally oriented electrode array that can be pressed against the wall of the atrium.
摘要翻译：心房消融导管及其使用方法。心内膜导管包括特别适于定位和消融提供持续性心房颤动所需的心律失常灶的电极阵列。阵列容易地从导管展开和缩回，并且呈现可以压靠在心房的壁上的远侧取向的电极阵列。

5. 发明申请

US20090030411A1 ABLATION CATHETER 有权
标题翻译：橡胶导管
公开(公告)号：US20090030411A1
公开(公告)日：2009-01-29
申请号：US12245625
申请日：2008-10-03
申请人： Randell L. Werneth , Marshall L. Sherman , Thomas M. Castellano , J. Christopher Flaherty , Gary Edward Currie
发明人： Randell L. Werneth , Marshall L. Sherman , Thomas M. Castellano , J. Christopher Flaherty , Gary Edward Currie
IPC分类号： A61B18/18 , A61B18/14
CPC分类号： A61B18/16 , A61B18/1492 , A61B18/18 , A61B2017/00482 , A61B2018/0016 , A61B2018/00214 , A61B2018/00291 , A61B2018/00351 , A61B2018/1467
摘要： Devices, systems and methods are disclosed for the ablation of tissue. Embodiments include an ablation catheter which has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be constrained within the lumen of a catheter, and deployed to take on an expanded condition.
摘要翻译：公开了用于组织消融的装置，系统和方法。实施例包括消融导管，其具有附接到可展开的载体组件的消融元件阵列。载体组件可以被限制在导管的内腔中，并且被部署以展开扩张状态。

6. 发明申请

US20080306477A1 ATRIAL ABLATION CATHETER AND METHOD OF USE 有权
标题翻译： ATRIAL ABLATION导管及其使用方法
公开(公告)号：US20080306477A1
公开(公告)日：2008-12-11
申请号：US12197425
申请日：2008-08-25
申请人： Christopher G. Kunis , Thomas M. Castellano , Marshall L. Sherman , Randell L. Werneth
发明人： Christopher G. Kunis , Thomas M. Castellano , Marshall L. Sherman , Randell L. Werneth
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/0016 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/1475
摘要： An atrial ablation catheter and methods for its use. The endocardial catheter includes an electrode array particularly adapted to locate and ablate foci of arrhythmia which are required for sustained atrial fibrillation is provided. The array is easily deployed and retracted from the catheter, and presents a distally oriented electrode array that can be pressed against the wall of the atrium.
摘要翻译：心房消融导管及其使用方法。心内膜导管包括特别适于定位和消融提供持续性心房颤动所需的心律失常灶的电极阵列。阵列容易地从导管展开和缩回，并且呈现可以压靠在心房的壁上的远侧取向的电极阵列。

7. 发明授权

US07429261B2 Atrial ablation catheter and method of use 有权
标题翻译：心房消融导管及使用方法
公开(公告)号：US07429261B2
公开(公告)日：2008-09-30
申请号：US10997172
申请日：2004-11-24
申请人： Christopher G. Kunis , Thomas M. Castellano , Marshall L. Sherman , Randell L. Werneth
发明人： Christopher G. Kunis , Thomas M. Castellano , Marshall L. Sherman , Randell L. Werneth
IPC分类号： A61B18/18 , A61N1/00
CPC分类号： A61B18/1492 , A61B2018/0016 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/1475
摘要： An atrial ablation catheter and methods for its use. The endocardial catheter includes an electrode array particularly adapted to locate and ablate foci of arrhythmia which are required for sustained atrial fibrillation is provided. The array is easily deployed and retracted from the catheter, and presents a distally oriented electrode array that can be pressed against the wall of the atrium.
摘要翻译：心房消融导管及其使用方法。心内膜导管包括特别适于定位和消融提供持续性心房颤动所需的心律失常灶的电极阵列。阵列容易地从导管展开和缩回，并且呈现可以压靠在心房的壁上的远侧取向的电极阵列。

8. 发明授权

US5596995A Biomedical device having a temperature sensing system 失效
标题翻译：具有温度感测系统的生物医学装置
公开(公告)号：US5596995A
公开(公告)日：1997-01-28
申请号：US432837
申请日：1995-05-02
申请人： Marshall L. Sherman , Thomas M. Castellano , Jose J. Moya
发明人： Marshall L. Sherman , Thomas M. Castellano , Jose J. Moya
IPC分类号： A61B5/00 , A61B5/01
CPC分类号： A61B5/01
摘要： A system for monitoring temperature comprising a first thermocouple temperature sensor mounted to a catheter, the catheter also having a connector with a plurality of connecting devices for making the thermocouple signals available to external equipment. The connecting devices are formed of a material dissimilar to at least one of the thermocouple leads such that a second thermocouple is created at the connection point. The second thermocouple produces a second temperature signal that combines with the signal from the first thermocouple. A reference temperature sensor is mounted at the connector to sense the temperature at the connector and provide a reference temperature signal for use by a processor in correcting the combined temperature signal to derive the first thermocouple signal received from the connector.
摘要翻译：一种用于监测温度的系统，包括安装到导管的第一热电偶温度传感器，所述导管还具有连接器，所述连接器具有用于使热电偶信号可用于外部设备的多个连接装置。连接装置由不同于至少一个热电偶引线的材料形成，使得在连接点处形成第二热电偶。第二个热电偶产生与第一个热电偶信号相结合的第二个温度信号。参考温度传感器安装在连接器处以感测连接器处的温度，并提供参考温度信号，供处理器用于校正组合温度信号以导出从连接器接收的第一热电偶信号。

9. 发明授权

US5735280A Ultrasound energy delivery system and method 失效
标题翻译：超声能量输送系统及方法
公开(公告)号：US5735280A
公开(公告)日：1998-04-07
申请号：US708829
申请日：1996-09-09
申请人： Marshall L. Sherman , Thomas M. Castellano
发明人： Marshall L. Sherman , Thomas M. Castellano
IPC分类号： A61B18/00 , A61B17/00 , A61B17/22 , A61B8/00
CPC分类号： A61B17/2202 , A61B2017/00084 , A61B2017/00092 , A61B2017/00243
摘要： An energy delivery system and method controls the frequency of the power driving an ultrasonic device to achieve more efficient power delivery. During operation of the ultrasonic device to deliver power to a patient site, the system and method automatically sweeps the drive power through a frequency range, locates the series and parallel resonance frequencies, calculates the average of those frequencies and locks the power generator at that average frequency to drive the crystal. This frequency sweep procedure occurs automatically when the ultrasonic crystal is located at the patient site and the power generator operator presses the power-on switch to apply power. The method of tuning the power generator thus occurs when the crystal is at the site temperature and is transparent to the operator. The application of an external bio-layer to the crystal increases its bandwidth and its robustness. Mounting a temperature sensor or sensors at the crystal permits monitoring of the crystal temperature and allows drive level control over the power generator to control the temperature at the crystal.
摘要翻译：能量输送系统和方法控制驱动超声波装置的功率的频率以实现更有效的功率传递。在超声波设备运行期间向病人现场输送电力时，系统和方法会自动扫描驱动电源频率范围，定位串联和并联谐振频率，计算出这些频率的平均值，并将发电机锁定在该平均值频率驱动晶体。当超声波晶体位于患者现场时，该频率扫描过程自动发生，发电机操作者按下电源开关以施加电力。因此，当晶体处于现场温度并且对操作者是透明的时，调谐发电机的方法发生。外部生物层在晶体上的应用增加了其带宽和其鲁棒性。将温度传感器或传感器安装在晶体处可以监控晶体温度，并允许对发电机进行驱动电平控制，以控制晶体的温度。

10. 发明授权

US09265557B2 Multi frequency and multi polarity complex impedance measurements to assess ablation lesions 有权
标题翻译：多频和多极性复阻抗测量来评估消融病变
公开(公告)号：US09265557B2
公开(公告)日：2016-02-23
申请号：US13017122
申请日：2011-01-31
申请人： Marshall L. Sherman , Catherine R. Condie , Mark T. Stewart
发明人： Marshall L. Sherman , Catherine R. Condie , Mark T. Stewart
IPC分类号： A61B18/12 , A61B18/02 , A61B18/14 , A61B17/00 , A61B18/00
CPC分类号： A61B18/1492 , A61B5/4848 , A61B18/02 , A61B18/12 , A61B2017/00128 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00279 , A61B2018/00285 , A61B2018/00404 , A61B2018/00577 , A61B2018/00642 , A61B2018/00648 , A61B2018/00666 , A61B2018/00869 , A61B2018/00875 , A61B2018/0212
摘要： A method of assessing a tissue ablation treatment, including positioning a medical device adjacent a target tissue; measuring a first impedance magnitude a first frequency with the medical device; measuring a first impedance phase at a second frequency with the medical device; ablating at least a portion of the target tissue with the medical device; measuring at second impedance magnitude at a third frequency with the medical device; measuring a second impedance phase at a fourth frequency with the medical device; comparing at least one of (i) the first and second impedance magnitudes and (ii) the first and second impedance phases; and providing an indication of the efficacy of the ablation treatment based at least in part on the comparison.
摘要翻译：一种评估组织消融治疗的方法，包括定位邻近靶组织的医疗装置; 用所述医疗设备测量第一频率的第一阻抗幅度; 用所述医疗装置测量第二频率的第一阻抗相位; 用医疗装置切除目标组织的至少一部分; 以医疗装置在第三频率的第二阻抗幅度下测量; 用医疗装置测量第四频率的第二阻抗相位; 比较（i）第一和第二阻抗幅度和（ii）第一和第二阻抗相位中的至少一个; 以及至少部分地基于比较来提供消融治疗的功效的指示。

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