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1. 发明授权

US07463791B2 Method for automatic alignment of tilt series in an electron microscope 有权
标题翻译：在电子显微镜中自动对准倾斜系列的方法
公开(公告)号：US07463791B2
公开(公告)日：2008-12-09
申请号：US10733741
申请日：2003-12-10
申请人： Thomas Koehler , Thomas Netsch , Kerstin Stockmeier
发明人： Thomas Koehler , Thomas Netsch , Kerstin Stockmeier
IPC分类号： G06K9/32 , G06K9/62 , G06K9/00
CPC分类号： G06K9/00134 , G06K2209/403 , H01J37/26 , H01J2237/2611
摘要： It may be desirable to obtain three-dimensional information on a sample 2 to be studied in an electron microscope. Such information can be derived from a tilt series 2-i of the sample and a subsequent reconstruction of the three-dimensional structure by means of a computer algorithm. For a proper reconstruction of the structure in the volume of the sample it is important that the measurement geometry be known; therefore it is important that the images be properly aligned. Therefore markers 8-i (e.g. gold particles) are applied to the sample, which markers yield straight lines 10-i as the sample is rotated and projections of that rotated sample are made onto one image plane. According to the invention the straight lines are recognized, which gives the possibility to identify the individual markers in the images of the tilt series, and to align those images on the basis of the information thus obtained.
摘要翻译：可能需要在电子显微镜中获得待研究的样品2上的三维信息。这样的信息可以从样本的倾斜系列2-i和借助于计算机算法对三维结构的后续重建得出。对于样品体积中的结构的适当重建，重要的是测量几何是已知的; 因此，重要的是图像被正确对齐。因此，标本8-i（例如金颗粒）被施加到样品上，随着样品旋转，这些标记产生直线10-i，旋转的样品的投影被制成在一个图像平面上。根据本发明，识别出直线，其给出了识别倾斜系列的图像中的各个标记的可能性，并且基于由此获得的信息对准这些图像。

2. 发明申请

US20100061632A1 METHOD, AN APPARATUS AND A COMPUTER PROGRAM FOR DATA PROCESSING 有权
标题翻译：方法，数据处理的装置和计算机程序
公开(公告)号：US20100061632A1
公开(公告)日：2010-03-11
申请号：US12516357
申请日：2007-11-26
申请人： Stewart Young , Daniel Bystrov , Thomas Netsch , Michael Kaus , Vladimir Pekar
发明人： Stewart Young , Daniel Bystrov , Thomas Netsch , Michael Kaus , Vladimir Pekar
IPC分类号： G06K9/34 , G06K9/46
CPC分类号： G06T7/149 , G06T7/12 , G06T7/70 , G06T2207/30016
摘要： The invention relates to a method for data processing. At stage 3 the position of the reference object in the reference image and its relation to a set of reference landmarks in the reference image is established at step 6. In order to enable this, the reference imaging of learning examples may be performed at step 2 and each reference image may be analyzed at step 4, the results may be stored in a suitably arranged database. In order to process the image under consideration, the image is accessed at step 11, the suitable landmark corresponding to the reference landmark in the reference image is identified at step 13 and the spatial relationship established at step 6 is applied to the landmark thereby providing the initial position of the object in the actual image. In case when for the object an imaging volume is selected, the method 1 according to the invention follows to step 7, whereby the scanning 17 is performed within the boundaries given by the thus established scanning volume. In case when for the object a model representative of the target is selected, the method 1 follows to the image segmentation step 19, whereby a suitable segmentation is performed. In case when for the model a deformable model is selected, the segmentation is performed by deforming the model thereby providing spatial boundaries of the target area. The invention further relates to an apparatus and a computer program for image processing.
摘要翻译：本发明涉及一种数据处理方法。在阶段3，在步骤6中建立参考图像中的参考对象的位置及其与参考图像中的一组参考标记的关系。为了实现这一点，可以在步骤2执行学习示例的参考成像并且可以在步骤4分析每个参考图像，结果可以存储在适当布置的数据库中。为了处理所考虑的图像，在步骤11访问图像，在步骤13识别与参考图像中的参考标记相对应的合适地标，并将在步骤6建立的空间关系应用于地标，从而提供物体在实际图像中的初始位置。在对于物体选择成像体积的情况下，根据本发明的方法1遵循步骤7，由此在由这样建立的扫描体积给出的边界内执行扫描17。在针对对象的情况下，选择了表示目标的模型，则对图像分割步骤19进行方法1，由此执行适当的分割。在为模型选择可变形模型的情况下，通过使模型变形从而提供目标区域的空间边界来执行分割。本发明还涉及一种用于图像处理的装置和计算机程序。

3. 发明申请

US20090010505A1 Method, a System and a Computer Program for Segmenting a Structure in a Dataset 有权
标题翻译：方法，系统和用于分割数据集中的结构的计算机程序
公开(公告)号：US20090010505A1
公开(公告)日：2009-01-08
申请号：US11909165
申请日：2006-03-21
申请人： Christian Adrian Cocosco , Thomas Netsch
发明人： Christian Adrian Cocosco , Thomas Netsch
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/12 , G06T7/149 , G06T2207/10072 , G06T2207/30048
摘要： The method (1) according to the invention may be schematically divided into three major phases. Phase (2) comprises step (3) of acquiring a suitable dataset, which is then subjected to a suitable binary segmentation at step (4) results of which are being accessed at step (5). The results comprise temporally sequenced binary coded images, whereby image portions corresponding to blood are labeled as unity, the rest is set to zero. The subsequent phase (12) of the method according to the invention is directed to performing the image processing for segmenting a structure. At step (8) a computation is performed whereby a preceding binary coded image (8a) corresponding to a phase from the temporal sequence is subtracted from a subsequent binary coded image 8b corresponding to a phase yielding a multi-dimensional temporal feature map (8c). At step (9) spatial positions corresponding to a certain voxel value are derived and are used to segment the structure. A pre-defined deformable shape model is accessed at step (11), which is then deformed at step (14) in accordance with spatial coordinates, derived at step (9). Preferably, the segmentation result is stored at step (16). Finally, during a further phase (22) of the method according to the invention, the segmentation results are displayed at step (18) using suitable display means. Preferably, the segmented surface is overlaid on the original data using a two, three or four-dimensional visualization technique. Still preferable, to ease comprehension of the result, the segmented surface is presented as a color-code in a suitable transparency mode. The invention further relates to an apparatus and a computer program for segmenting a structure in a dataset.
摘要翻译：根据本发明的方法（1）可以示意性地分为三个主要阶段。阶段（2）包括步骤（3），获取合适的数据集，然后在步骤（4）对其结果进行适当的二进制分段，结果在步骤（5）被访问。结果包括时间排序的二进制编码图像，由此对应于血液的图像部分被标记为一体，其余部分被设置为零。根据本发明的方法的后续阶段（12）涉及执行用于分割结构的图像处理。在步骤（8），进行计算，由此从对应于产生多维时间特征图（8c）的相位的后续二进制编码图像8b中减去对应于来自时间序列的相位的先前二进制编码图像（8a）。在步骤（9），导出与某个体素值对应的空间位置，并用于分割结构。在步骤（11）访问预定义的可变形形状模型，然后在步骤（14）根据在步骤（9）导出的空间坐标变形。优选地，在步骤（16）存储分割结果。最后，在根据本发明的方法的另一阶段（22）期间，使用合适的显示装置在步骤（18）显示分割结果。优选地，使用二，三或四维可视化技术将分割的表面覆盖在原始数据上。仍然优选的是，为了简化对结果的理解，分段表面以适当的透明度模式呈现为颜色代码。本发明还涉及用于分割数据集中的结构的装置和计算机程序。

4. 发明申请

US20080069418A1 User Interface for Motion Analysis in Kinematic Mr Studies 有权
标题翻译：运动分析用户界面
公开(公告)号：US20080069418A1
公开(公告)日：2008-03-20
申请号：US11814406
申请日：2006-01-05
申请人： Daniel Bystrov , Vladimir Pekar , Kirsten Meetz , Thomas Netsch , Stewart Young
发明人： Daniel Bystrov , Vladimir Pekar , Kirsten Meetz , Thomas Netsch , Stewart Young
IPC分类号： G06K9/00
CPC分类号： G06T13/20 , G06T7/246 , G06T2207/10076 , G06T2207/10088 , G06T2207/30048
摘要： In a diagnostic imaging system (10), a user interface (82) facilitates viewing of 4D kinematic data sets. A set of reference points is selected in a first 3D image to designate an anatomical component. An algorithm (104) calculates a propagation of the selected reference points from the first 3D image into other 3D images. Transforms which describe the propagation of the reference points between 3D images are defined. An aligning algorithm (112) applies inverse of the transforms to the 3D images to define a series of frames for the video processor (120) to display, in which frames the designated anatomical component defined by the reference points in each of the 3D images remains fixed while the other portions of the anatomical region of interest move relative to the fixed designated anatomical component.
摘要翻译：在诊断成像系统（10）中，用户界面（82）便于观看4D运动数据集。在第一3D图像中选择一组参考点以指定解剖组件。算法（104）计算所选择的参考点从第一3D图像到其他3D图像的传播。定义描述3D图像之间参考点传播的变换。对准算法（112）将变换的逆向应用于3D图像以定义用于视频处理器（120）显示的一系列帧，其中由每个3D图像中的参考点定义的指定解剖组件保留固定，而感兴趣的解剖区域的其他部分相对于固定的指定解剖部件移动。

5. 发明申请

US20070195923A1 Cone beam ct apparatus using truncated projections and a previously acquired 3d ct image 有权
标题翻译：锥形束ct装置使用截断的投影和以前获得的3d ct图像
公开(公告)号：US20070195923A1
公开(公告)日：2007-08-23
申请号：US11568115
申请日：2005-03-31
申请人： Thomas Netsch , Georg Rose , Hermann Schomberg
发明人： Thomas Netsch , Georg Rose , Hermann Schomberg
IPC分类号： H05G1/60 , A61B6/00 , G01N23/00 , G21K1/12
CPC分类号： G06T11/005 , A61B6/027 , G06T2211/432 , Y10S378/901
摘要： A 3D image of a region of an object is computed from truncated cone beam projection data acquired with an x-ray device and a prior CT image representing a larger region of the object. The truncated projection data are extrapolated to derive pseudoprojection data associated with projection directions outside the detector, and an intermediate CT image is reconstructed based on the truncated projection data completed with the pseudoprojection data. The prior CT image is then registered with the intermediate CT image. Forward projection data associated with projection directions outside the detector are computed from the truncated projection data and the registered prior CT image. The 3D image is finally reconstructed based on the truncated projection data completed with the forward projection data.
摘要翻译：使用由X射线装置获得的截头圆锥束投影数据和表示对象的较大区域的先前CT图像计算物体区域的3D图像。外推截断的投影数据以导出与检测器外部的投影方向相关联的伪投影数据，并且基于用伪投影数据完成的截断的投影数据来重建中间CT图像。然后将先前的CT图像与中间CT图像对准。从截断的投影数据和注册的先前CT图像计算与检测器外部的投影方向相关联的前向投影数据。基于用前向投影数据完成的截断的投影数据，最终重建3D图像。

6. 发明申请

US20070133849A1 Method and apparatus for visualisation of a tubular structure 审中-公开
标题翻译：用于可视化管状结构的方法和装置
公开(公告)号：US20070133849A1
公开(公告)日：2007-06-14
申请号：US10595694
申请日：2004-11-02
申请人： Stewart Young , Thomas Netsch
发明人： Stewart Young , Thomas Netsch
IPC分类号： G06K9/00
CPC分类号： G06T15/20 , G06T15/08 , G06T19/00 , G06T2210/41 , G06T2215/06
摘要： The present invention relates to a method and a corresponding apparatus for visualization of a tubular structure of an object by use of a 3D image data set of said object. In order to provide a more efficient and illustrative visualization a method is proposed comprising the steps of: —generating and visualising a curved planar reformation view (C) from a symbolic pathway view (B) of said tubular structure, said symbolic pathway view (B) representing said tubular structure and the pathway points of said symbolic pathway being assigned with their 3D spatial position data, and —generating and visualising at least one planar view (O) of said object (1) through a viewing point (V) of said tubular structure selected in said curved planar reformation view (C) or said symbolic pathway view (B).
摘要翻译：本发明涉及一种通过使用所述对象的3D图像数据集可视化对象的管状结构的方法和相应的装置。为了提供更有效和说明性的可视化，提出了一种方法，其包括以下步骤： - 从所述管状结构的符号通路图（B）产生和可视化曲面平面重构视图（C），所述符号通路视图（B ），并且所述符号路径的路径点被分配有它们的3D空间位置数据，并且通过所述管状结构的观察点（V）生成和可视化所述物体（1）的至少一个平面视图（O）在所述弯曲平面重构视图（C）或所述符号通路视图（B）中选择的管状结构。

7. 发明申请

US20060111630A1 Method of tomographic imaging 审中-公开
标题翻译：断层成像方法
公开(公告)号：US20060111630A1
公开(公告)日：2006-05-25
申请号：US10538448
申请日：2003-12-04
申请人： Thomas Netsch , Hans Barschdorf
发明人： Thomas Netsch , Hans Barschdorf
IPC分类号： A61B5/05
CPC分类号： A61B6/08
摘要： The invention relates to a method of tomographic imaging, and in particular a CT or MR method, for the repetitive production of diagnostic slice images of a part of a patient's body. To allow a geometrical transformation (2) to be determined, current reference slice images (1) of the part of the body, which are brought into agreement with earlier reference slice images (3) of the part of the body are first made in this case. Current imaging parameters (5) are then calculated for a current diagnostic slice image (6) by transforming earlier imaging parameters by the geometrical transformation (2) previously determined. To give greater accuracy and, at the same time, a short image-making time, the image proposes that at least two current reference slice images (1, 1′) be made, whose image planes are preset in such a way that their relative positions and orientations in three dimensions agree with the relative positions and orientations in three dimensions of the earlier reference slice images (3, 3′), the geometrical transformation (2) being determined in such a way that it brings all the current reference slice images (1, 1′) in agreement with the corresponding earlier reference slice images (3, 3′) simultaneously.
摘要翻译：本发明涉及用于重复生产患者身体的一部分的诊断切片图像的断层成像方法，特别是CT或MR方法。为了允许确定几何变换（2），首先在身体的一部分与先前的参考切片图像（3）一致的身体部分的当前参考切片图像（1）案件。然后通过先前确定的几何变换（2）将较早的成像参数进行变换，计算当前诊断切片图像（6）的当前成像参数（5）。为了提供更高的准确度，并且同时缩短了图像制作时间，图像提出了至少两个当前的参考切片图像（1,1'），其图像平面被预设为使得它们的相对三维中的位置和取向与早期参考切片图像（3,3'）的三维的相对位置和取向一致，几何变换（2）被确定为使得所有当前参考切片图像（1,1'）与相应的早期参考切片图像（3,3'）同时地一致。

8. 发明授权

US06555379B1 Device for monitoring a processing liquid 失效
标题翻译：用于监测处理液体的装置
公开(公告)号：US06555379B1
公开(公告)日：2003-04-29
申请号：US09581421
申请日：2000-09-08
申请人： Karl-Guenter Bremer , Thomas Hoefler , Peter Holzhauer , Thomas Netsch , Eckehard Walitza
发明人： Karl-Guenter Bremer , Thomas Hoefler , Peter Holzhauer , Thomas Netsch , Eckehard Walitza
IPC分类号： G01N3508
CPC分类号： G01N33/1833 , B23Q11/10 , G01N33/28 , Y02A20/206 , Y10T436/12 , Y10T436/209163
摘要： A device for monitoring a processing liquid comprising at least one sensor for generating at least one monitoring signal, and a device for processing the monitoring signal and for generating a control signal for directly or indirectly influencing the composition or condition of the processing liquid. A device is also provided for detecting, storing, and maintaining the reliability of performance of the sensor. In addition, actuators are provided for converting given criteria or specified values.
摘要翻译：一种用于监测处理液体的装置，包括用于产生至少一个监测信号的至少一个传感器，以及用于处理监测信号并产生用于直接或间接影响处理液体的组成或状况的控制信号的装置。还提供了用于检测，存储和维持传感器的性能的可靠性的装置。另外，提供用于转换给定标准或指定值的致动器。

9. 发明授权

US09514575B2 Image and annotation display 有权
标题翻译：图像和注释显示
公开(公告)号：US09514575B2
公开(公告)日：2016-12-06
申请号：US13825824
申请日：2011-09-23
申请人： Sebastian Peter Michael Dries , Fabian Wenzel , Thomas Netsch
发明人： Sebastian Peter Michael Dries , Fabian Wenzel , Thomas Netsch
IPC分类号： G06T19/20 , G06T19/00
CPC分类号： G06T19/20 , G06T19/00 , G06T2219/004 , G06T2219/008
摘要： A system (100) for displaying a multi-dimensional image and an annotation located therein, the system comprising receiving means (110) for receiving: the multi-dimensional image, the annotation, and representation data associated with the annotation, the representation data being indicative of a preferred representation of the multi-dimensional image and the annotation located therein; display means (130) for displaying an initial representation (300) of the multi-dimensional image and the annotation located therein; input means (120) for enabling a user to provide a visualization request when the initial representation shows at least a first part (310) of the annotation; and the display means (130) being arranged for, after receiving the visualization request, displaying the preferred representation (400) of the multi-dimensional image and the annotation located therein in accordance with the representation data, the preferred representation showing at least a second part (410) of the annotation, the second part being different from the first part.
摘要翻译：一种用于显示位于其中的多维图像和注释的系统（100），所述系统包括接收装置（110），用于接收：所述多维图像，所述注释和与所述注释相关联的表示数据，所述表示数据是指示多维图像和位于其中的注释的优选表示; 显示装置（130），用于显示多维图像的初始表示（300）和位于其中的注释; 输入装置（120），用于当所述初始表示显示至少所述注释的第一部分（310）时，使用户能够提供可视化请求; 并且所述显示装置（130）被布置用于在接收到所述可视化请求之后，根据所述表示数据显示所述多维图像和位于其中的注释的优选表示（400），所述优选表示显示至少第二注释的部分（410），第二部分与第一部分不同。

10. 发明申请

US20130301893A1 CONTOUR DELINEATION FOR RADIATION THERAPY PLANNING WITH REAL-TIME CONTOUR SEGMENT IMPACT RENDERING 有权
标题翻译：用于辐射治疗计划的轮廓划分与实时轮廓分段冲击渲染
公开(公告)号：US20130301893A1
公开(公告)日：2013-11-14
申请号：US13821572
申请日：2011-09-05
申请人： Thomas Netsch , Daniel Bystrov
发明人： Thomas Netsch , Daniel Bystrov
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , A61N5/103 , G06T7/12 , G06T2207/10072 , G06T2207/30096
摘要： A contouring module (22, 24) iteratively adjusts contours delineating a radiation target region and risk regions in a planning image. An intensity modulation optimization module (30) generates a radiation therapy plan conforming with dosage or dosage constraints (26) for the radiation target region and the risk regions delineated by the contours. A differential analysis module (40) is configured to invoke the intensity modulation optimization module (30) to estimate partial derivatives of an output of the intensity modulation optimization respective to the contours. The contouring module (22, 24) is configured to invoke the differential analysis module (40) after each iterative contour adjustment to estimate the partial derivatives respective to the contour segments and to render the contour segments on a display of the planning image with the contour segments coded based on the estimated partial derivatives to indicate impact of the contour segments on the intensity modulation optimization.
摘要翻译：轮廓模块（22,24）迭代地调整描绘辐射目标区域的轮廓并且在规划图像中风险区域。强度调制优化模块（30）产生符合用于辐射目标区域的剂量或剂量约束（26）和由轮廓描绘的风险区域的放射治疗计划。差分分析模块（40）被配置为调用强度调制优化模块（30）以估计相应于轮廓的强度调制优化的输出的偏导数。轮廓模块（22,24）被配置为在每次迭代轮廓调整之后调用差分分析模块（40）以估计相应于轮廓段的偏导数，并且使轮廓段在具有轮廓的规划图像的显示器上呈现基于估计的偏导数编码的段，以指示轮廓段对强度调制优化的影响。

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