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1. 发明申请

US20100254939A1 GRAFT COPOLYMERS AS DRUG DELIVERY SYSTEMS 有权
标题翻译： GRAFT共聚物作为药物递送系统
公开(公告)号：US20100254939A1
公开(公告)日：2010-10-07
申请号：US12677602
申请日：2008-09-08
申请人： Thomas Kissel , Xiaoying Wang
发明人： Thomas Kissel , Xiaoying Wang
IPC分类号： A61K38/20 , A61P11/00 , A61K38/21 , A61K38/19 , A61K38/09 , A61K38/22 , A61K38/18 , A61K38/28 , A61K38/31 , A61K38/26 , A61K38/23 , A61K38/48 , A61K38/12 , A61K31/137 , A61K31/4704 , A61K31/167 , A61K31/439 , A61K31/46 , C08F273/00 , B32B27/00 , C08F263/04
CPC分类号： C08F263/04 , A61K9/006 , A61K9/0073 , A61K9/5138 , C08F273/00 , C08G63/08 , C08G81/027 , C08J3/14 , C08J2367/04
摘要： The present invention relates to graft copolymers of polyvinyl sulfonic-co-vinyl alcohol)-g-poly(lactide-co-glycolide) (P(VS-VA)-g-PLGA) with negatively charged electrolyte properties, their method of preparation and their use. These negatively charged graft copolymers are suitable for effective loading and sustained-release of especially positively charged drugs, proteins and peptides, and drug-loaded particles from these grafted co-polymers are especially useful as parenteral or mucosal drug delivery systems for pharmaceutical applications.
摘要翻译：本发明涉及聚乙烯基磺酸 - 共 - 乙烯醇）-g-聚（丙交酯 - 共 - 乙交酯）（P（VS-VA）-g-PLGA）与带负电荷的电解质的接枝共聚物，它们的制备方法和他们的使用。这些带负电荷的接枝共聚物适用于特别是带正电荷的药物，蛋白质和肽的有效负载和持续释放，并且来自这些接枝的共聚物的药物负载的颗粒特别可用作药物应用的肠胃外或粘膜药物递送系统。

2. 发明授权

US08518444B2 Graft copolymers as drug delivery systems 有权
标题翻译：接枝共聚物作为药物递送系统
公开(公告)号：US08518444B2
公开(公告)日：2013-08-27
申请号：US12677602
申请日：2008-09-08
申请人： Thomas Kissel , Xiaoying Wang
发明人： Thomas Kissel , Xiaoying Wang
IPC分类号： A61K9/14
CPC分类号： C08F263/04 , A61K9/006 , A61K9/0073 , A61K9/5138 , C08F273/00 , C08G63/08 , C08G81/027 , C08J3/14 , C08J2367/04
摘要： The present invention relates to graft copolymers of polyvinyl sulfonic-co-vinyl alcohol)-g-poly(lactide-co-glycolide) (P(VS-VA)-g-PLGA) with negatively charged electrolyte properties, their method of preparation and their use. These negatively charged graft copolymers are suitable for effective loading and sustained-release of especially positively charged drugs, proteins and peptides, and drug-loaded particles from these grafted co-polymers are especially useful as parenteral or mucosal drug delivery systems for pharmaceutical applications.
摘要翻译：本发明涉及聚乙烯基磺酸 - 共 - 乙烯醇）-g-聚（丙交酯 - 共 - 乙交酯）（P（VS-VA）-g-PLGA）与带负电荷的电解质的接枝共聚物，它们的制备方法和他们的使用。这些带负电荷的接枝共聚物适用于特别是带正电荷的药物，蛋白质和肽的有效负载和持续释放，并且来自这些接枝的共聚物的药物负载的颗粒特别可用作药物应用的肠胃外或粘膜药物递送系统。

3. 发明授权

US08802178B2 Method of making a heat stable chocolate confectionery product 有权
标题翻译：制作热稳定巧克力糖果产品的方法
公开(公告)号：US08802178B2
公开(公告)日：2014-08-12
申请号：US13422101
申请日：2012-03-16
申请人： Xiaoying Wang , Julie Hickey
发明人： Xiaoying Wang , Julie Hickey
IPC分类号： A23G1/00
CPC分类号： A23G1/32 , A23G1/0016 , A23G1/36 , A23G1/38
摘要： A method of producing a heat resistant chocolate confectionery product is disclosed. The method provides for such products to be made without the addition of water and which can be made with traditional chocolate making ingredients to yield a dough. The dough retains its shape above the melting point of fats in the product, while the product still retains a flavor and mouthfeel comparable with chocolate made by traditional methods.
摘要翻译：公开了一种生产耐热巧克力糖果产品的方法。该方法提供这样的产品，而不需要添加水，并且可以用传统的巧克力制成成分制成面团。面团保持其形状高于产品中脂肪的熔点，而产品仍然保留与传统方法制成的巧克力相当的风味和口感。

4. 发明申请

US20110129526A1 COMPOSITIONS AND METHODS FOR TREATING VASCULAR DISEASE 审中-公开
标题翻译：用于治疗血管疾病的组合物和方法
公开(公告)号：US20110129526A1
公开(公告)日：2011-06-02
申请号：US12918726
申请日：2009-02-19
申请人： Xiaoying Wang , Eng Lo
发明人： Xiaoying Wang , Eng Lo
IPC分类号： A61K38/49 , A61K9/127 , A61P9/00
CPC分类号： A61K38/17 , A61K38/00 , A61K38/1709 , A61K38/49 , A61K2300/00
摘要： The use of tPA to treat hemorrhagic transformation, neurotoxicity has been limited to short treatment time windows because a high dose of tPA required to generate sufficient amounts of the enzyme plasmin for clot lysis. The present invention combines tPA with recombinant Annexin A2 resulting in thrombolysis without hemorrhagic transformation at delayed times after stroke. This embodiment allows the administration of a lower, non-neurotoxic, tPA dose. Our results suggest this novel combination for stroke therapy may greatly improve both efficacy and safety, and prolong tPA therapeutic time window.
摘要翻译：使用tPA治疗出血性转化，神经毒性已经被限制在短的治疗时间窗口，因为需要高剂量的tPA以产生足够量的用于凝块溶解的酶纤溶酶。本发明将tPA与重组膜联蛋白A2组合，导致中风后延迟时间溶栓而不出血性转化。该实施方案允许施用较低的非神经毒性的tPA剂量。我们的研究结果表明，这种中风治疗的新型组合可以大大提高功效和安全性，并延长tPA治疗时间窗口。

5. 发明申请

US20120295996A1 Fire Retardant Composition 审中-公开
标题翻译：阻燃组合物
公开(公告)号：US20120295996A1
公开(公告)日：2012-11-22
申请号：US13441977
申请日：2012-04-09
申请人： Minji Wang , Xiaoying Wang
发明人： Minji Wang , Xiaoying Wang
IPC分类号： C09D133/08 , C08K13/02
CPC分类号： C09D5/18 , C08K3/016 , C09D5/185 , C09D7/63
摘要： A fire retardant composition comprising the following amounts by weight: blowing type fire-retardant coat base ingredients in an amount of 8-15%, a fire-retardant smoke suppression agent fire retardant agent in an amount of 10-14%, the fire-retardant smoke suppression agent including Antimony (Sb), Boron (B), Zinc (Zn), Magnesium (Mg), Calcium Carbonate (CaCO3) and Phosphorus (P), a dehydration char formation promoting agent in an amount of 8-12%, a fire-retardant smoke suppression curing agent in an amount of 6-8%, a fire-retardant heat absorb expanding agent in an amount of 3-3.5%, a fire and heat resistance base agent in an amount of 11-23.5%, dispersant in an amount of 0.2-0.6%; a defoaming agent in an amount of 0.1-0.2%, a wetting agent in an amount of 0.1-0.2%, a film-forming additive in an amount of 0.1-0.5%;, pigments in an amount of 11-15%; and water in an amount of 22-31%.
摘要翻译：一种阻燃剂组合物，其包含以下重量份数：8-15％的吹塑型阻燃涂料基础成分，10-14％的阻燃防烟剂阻燃剂，包括锑（Sb），硼（B），锌（Zn），镁（Mg），碳酸钙（CaCO3）和磷（P））的阻燃烟抑制剂，8-12％的脱水焦化促进剂，6-8％的阻燃防烟固化剂，3-3.5％的阻燃吸热发泡剂，11-23.5％的耐火基础剂，，分散剂的量为0.2-0.6％; 0.1-0.2％的消泡剂，0.1-0.2％的润湿剂，0.1-0.5％的成膜添加剂，11-15％的颜料; 水量为22-31％。

6. 外观设计

USD926361S1 Electronic cigarette case 有权
公开(公告)号：USD926361S1
公开(公告)日：2021-07-27
申请号：US29722504
申请日：2020-01-30
申请人： Xiaoying Wang
设计人： Xiaoying Wang

7. 发明授权

US08709524B2 Process for preparing red cocoa ingredients, red chocolate, and food products 有权
标题翻译：制备红可可成分，红巧克力和食品的方法
公开(公告)号：US08709524B2
公开(公告)日：2014-04-29
申请号：US12274080
申请日：2008-11-19
申请人： Kenneth B. Miller , Xiaoying Wang , David A. Stuart , Mark Holmgren
发明人： Kenneth B. Miller , Xiaoying Wang , David A. Stuart , Mark Holmgren
IPC分类号： A23G1/00
CPC分类号： A23G1/002 , A23G1/32 , A23G1/46 , A23G1/56 , A23L5/40
摘要： The invention provides acidified red cocoa products and ingredients, such as acidified red cocoa bean nibs, red cocoa liquor, and red cocoa powder. The acidified cocoa products and ingredients are generally made from under-fermented or unfermented cocoa beans that are treated with an acid composition. The methods include those of making food products and ingredients where the levels cocoa antioxidants are maintained by the use of an acid treatment and the avoidance of dutching, and the food products and ingredient have a distinctive red color. Cocoa nibs, chocolate or cocoa liquor and cocoa powders having a red hue or color and having high levels of cocoa antioxidants are disclosed, as well as food products made from them.
摘要翻译：本发明提供酸化的红可可制品和成分，例如酸化的红可可豆尖，红可可液和红可可粉。酸化的可可制品和成分通常由用酸组合物处理的未发酵或未发酵的可可豆制成。这些方法包括通过使用酸处理来维持可可抗氧化剂水平的食品和成分的方法，并且避免脱水，并且食品和成分具有鲜明的红色。公开了可可可可，巧克力或可可液以及具有红色调或颜色的高可可抗氧化剂的可可粉以及由它们制成的食品。

8. 发明授权

US08668950B2 Cocoa nuggets and method of making same 有权
标题翻译：可可块和其制作方法
公开(公告)号：US08668950B2
公开(公告)日：2014-03-11
申请号：US13457803
申请日：2012-04-27
申请人： Xiaoying Wang
发明人： Xiaoying Wang
IPC分类号： A23G1/00
CPC分类号： A23G1/0006 , A23G1/0016 , A23G1/0059 , A23G1/32 , A23G1/50 , A23G2220/00 , A23V2002/00 , A23V2200/02
摘要： Cocoa nuggets and methods for their manufacture are disclosed. The nuggets are formed by providing a dough including, on a dry basis, at least 30% by weight cocoa powder, the dough having a moisture content of at least 10% to about 52% by weight. The dough is processed into nuggets having a moisture content of not greater than about 15% by weight. The nuggets can be crunchy or chewy and can be used as an ingredient such as an inclusion or a topping for food products in order to increase antioxidant levels and the method of creating the nuggets results in minimal loss of antioxidant capacity as a result of processing.
摘要翻译：披露可可块及其制造方法。矿块通过提供一种面团形成，其包括基于干燥的至少30重量％的可可粉，面团的水分含量为至少10重量％至约52重量％。将面团加工成含水量不大于约15重量％的块。掘金可以是脆脆的或耐嚼的，并且可以用作食品的包合物或顶部成分，以增加抗氧化剂水平，并且创建掘金的方法导致加工结果的抗氧化能力的最小损失。

9. 发明申请

US20060263351A1 Methods and compositions for protection against thrombolysis associated reperfusion injury 审中-公开
标题翻译：用于保护溶栓相关再灌注损伤的方法和组合物
公开(公告)号：US20060263351A1
公开(公告)日：2006-11-23
申请号：US10540344
申请日：2003-12-22
申请人： Eng Lo , Xiaoying Wang , G. William Rebeck , Ken Arai
发明人： Eng Lo , Xiaoying Wang , G. William Rebeck , Ken Arai
IPC分类号： A61K39/395 , A61K38/54
CPC分类号： A61K38/49 , C12Q1/56 , G01N33/86 , G01N33/92 , G01N2500/00
摘要： The invention relates to products and methods for reducing cerebral hemorrhage and edema, which can be negative side-effects of thrombolytic therapies with tissue plasminogen activator (tPA) and/or urokinase plasminogen activator (uPA).
摘要翻译：本发明涉及减少脑出血和水肿的产物和方法，其可能是组织纤溶酶原激活剂（tPA）和/或尿激酶纤溶酶原激活物（uPA）的溶栓治疗的负面副作用。

10. 发明申请

US20070218113A1 Health bars and compositions for improving cardiovascular risk factors 审中-公开
标题翻译：用于改善心血管危险因素的健康酒吧和组合物
公开(公告)号：US20070218113A1
公开(公告)日：2007-09-20
申请号：US11711780
申请日：2007-02-28
申请人： Debra Miller , Xiaoying Wang , Julia Watterson , Philip Ward
发明人： Debra Miller , Xiaoying Wang , Julia Watterson , Philip Ward
IPC分类号： A61K47/00 , A61K36/48
CPC分类号： A61K31/20 , A23G1/32 , A23G1/48 , A23L7/126 , A23L11/05 , A23L33/11 , A23L33/12 , A23L33/185 , A23L33/22 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K9/0056 , A61K31/575 , A61K36/48 , A61K2300/00 , A23V2200/326 , A23V2250/187 , A23V2250/1868 , A23V2250/2136 , A23V2250/5034 , A23V2250/1882 , A23V2250/54252 , A23V2250/5488 , A23V2250/70 , A23V2250/1842
摘要： The invention provides, in one aspect, a method of administering a product comprising beta glucan, soy protein, phytosterols, and an omega-3 fatty acid, such as one or more of DHA and EPA, to improve cardiovascular risk factors, such as LDL levels or total cholesterol levels. The amount of each of beta glucan, soy protein, phytosterols, and omega-3 fatty acids is selected from the amount providing the beneficial health effects associated with the health claims for these compositions or ingredients. Methods of making nutritional health bars and food ingredients that comprise the same compositions and ingredients in effective amounts that are shelf-stable are also disclosed.
摘要翻译：本发明在一个方面提供一种施用包含β-葡聚糖，大豆蛋白，植物甾醇和ω-3脂肪酸的产物的方法，所述ω-3脂肪酸例如DHA和EPA中的一种或多种，以改善心血管危险因素，例如LDL 水平或总胆固醇水平。 β-葡聚糖，大豆蛋白，植物甾醇和ω-3脂肪酸各自的量选自提供与这些组合物或成分的健康权利要求相关的有益健康效果的量。还公开了制备营养健康酒吧和食品成分的方法，所述营养保健品和食品成分包含具有有效量的相同组成和成分，其是稳定的。

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