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1. 发明申请

US20140065009A1 ULTRAPURE MAGNESIUM ALLOY WITH ADJUSTABLE DEGRADATION RATE 有权
标题翻译：超微镁合金具有可调节的降解率
公开(公告)号：US20140065009A1
公开(公告)日：2014-03-06
申请号：US13827008
申请日：2013-03-14
申请人： Thomas Imwinkelried , Stefan Beck , Peter Uggowitzer
发明人： Thomas Imwinkelried , Stefan Beck , Peter Uggowitzer
IPC分类号： C22C23/04
CPC分类号： A61L27/047 , A61B17/84 , A61F2/82 , A61L27/58 , A61L31/022 , A61L31/148 , A61L2400/12 , B21C23/002 , C22C23/00 , C22C23/04 , C22F1/06
摘要： An alloy and an implant having a three-dimensional structure based on such alloy. The alloy comprises a monophasic MgZn alloy containing from 2.0 wt. % Zn to 6 wt. % Zn, having less than 0.001 wt. % of one or more other elements with the remainder being Mg. In some embodiments, the alloy is substantially free of microgalvanic elements. In some embodiments, the alloy includes a MgZnCa alloy containing nanosized precipitates being less noble than the Mg matrix alloy and having a Zn content ranging from 3.0 wt. % Zn to 6 wt. % Zn and a calcium content ranging from 0.0005 wt. % to 1.0 wt. %, having less than 0.001 wt. % of one or more other elements with the remainder being Mg. In other embodiments, the alloy includes a MgZnCa alloy containing nanosized precipitates being less noble than the Mg matrix alloy, a plurality of nanosized precipitates being more noble than the Mg matrix and having a Zn content ranging from 3.0 wt. % Zn to 6 wt. % Zn, a calcium content ranging from 0.0005 wt. % to 1.0 wt. %, having less than 0.001 wt. % of one or more other elements with the remainder being Mg.
摘要翻译：一种具有基于这种合金的三维结构的合金和植入物。该合金包含单相MgZn合金，其含有2.0wt。％Zn至6wt。％Zn，小于0.001wt。％的一种或多种其它元素，其余为Mg。在一些实施方案中，该合金基本上不含微量元素。在一些实施方案中，合金包括MgZnCa合金，其含有比Mg基合金更贵的纳米沉淀物，并且Zn含量范围为3.0wt。％Zn至6wt。％Zn，钙含量为0.0005wt。％〜1.0wt ％，小于0.001wt。％的一种或多种其它元素，其余为Mg。在其它实施方案中，合金包括MgZnCa合金，其含有比Mg基质合金更贵的纳米沉淀物，多个纳米沉淀物比Mg基体更贵，Zn含量范围为3.0wt。％Zn至6wt。％Zn，钙含量为0.0005wt。％〜1.0wt ％，小于0.001wt。％的一种或多种其它元素，其余为Mg。

2. 发明申请

US20110192500A1 RESORBABLE MAGNESIUM ALLOY 审中-公开
标题翻译：可再生镁合金
公开(公告)号：US20110192500A1
公开(公告)日：2011-08-11
申请号：US12995767
申请日：2009-05-21
申请人： Peter Uggowitzer , Petra Gunde , Joerg Loeffler , Thomas Imwinkelried , Stefan Beck , Andrea Montali
发明人： Peter Uggowitzer , Petra Gunde , Joerg Loeffler , Thomas Imwinkelried , Stefan Beck , Andrea Montali
IPC分类号： C22C23/06 , C22C23/04 , C22C23/00 , C22C23/02
CPC分类号： C22C23/04 , A61L27/047 , A61L31/022 , C22C23/06
摘要： A magnesium alloy shown includes magnesium as a principal ingredient, and 0.5 to 8.0 percent ytterbium; 0.1 to 2.0 percent calcium; and 0.2 to 6.0 percent zinc, percentages calculated by weight. The magnesium alloy may be employed as an implant. Examples of implants include a plate, specifically a bone plate, a screw, a nail, a bone nail, a stent, a rod. Implants made of the specified alloy are suitable for implantation in animal or human body.
摘要翻译：所示的镁合金包括镁作为主要成分，和0.5-8.0％的镱; 0.1〜2.0％的钙; 和0.2〜6.0％的锌，按重量计算。镁合金可以用作植入物。植入物的实例包括板，特别是骨板，螺钉，钉子，骨钉，支架，杆。由特定合金制成的植入物适合植入动物或人体。

3. 发明申请

US20120156477A1 Medical Implant Comprising A Biodegradable Magnesium-Based Alloy And Method For Its Manufacture 有权
标题翻译：包括可生物降解的镁基合金的医疗植入物及其制造方法
公开(公告)号：US20120156477A1
公开(公告)日：2012-06-21
申请号：US13331683
申请日：2011-12-20
申请人： Peter Kurze , Thomas Imwinkelried , Stefan Beck , Dora Banerjee , Tamara Schwarz
发明人： Peter Kurze , Thomas Imwinkelried , Stefan Beck , Dora Banerjee , Tamara Schwarz
IPC分类号： B32B3/00 , B05D3/10
CPC分类号： A61L27/047 , A61B17/80 , A61B17/864 , A61F2310/00425 , A61L27/303 , A61L27/306 , A61L27/58 , A61L31/022 , A61L31/082 , A61L31/148 , A61L2400/18 , A61L2430/02 , C01F5/24 , Y10T428/265 , Y10T428/31678
摘要： A medical implant comprises a biodegradable magnesium-based alloy of which at least a part of its surface layer comprises a magnesium carbonate. A method for the manufacture of a biocompatible, corrosion-inhibiting protective surface layer on a medical implant comprising a magnesium-based alloy, comprises: providing an implant comprising a magnesium-based alloy to be coated; placing the implant into a reactor chamber; exposing at least part of the surface of said implant to an atmosphere comprising humid carbon dioxide to produce a coating on the surface of the implant comprising a magnesium carbonate of the formula x MgCO3·y Mg (OH)2, whereby x+y=1; removing the implant from the reactor chamber; and drying the surface of the implant.
摘要翻译：医疗植入物包括其表面层的至少一部分包含碳酸镁的可生物降解的镁基合金。一种用于在包括镁基合金的医用植入物上制造生物相容性腐蚀抑制保护性表面层的方法，包括：提供包含待涂覆的镁基合金的植入物; 将植入物置于反应室中; 将所述植入物的表面的至少一部分暴露于包含潮湿二氧化碳的气氛中，以在植入物表面上产生包含式x MgCO 3·y Mg（OH）2的碳酸镁的涂层，由此x + y = 1 ; 从反应器室移除植入物; 并干燥植入物的表面。

4. 发明授权

US09050389B2 Medical implant comprising a biodegradable magnesium-based alloy and method for its manufacture 有权
标题翻译：包括可生物降解的镁基合金的医用植入物及其制造方法
公开(公告)号：US09050389B2
公开(公告)日：2015-06-09
申请号：US13331683
申请日：2011-12-20
申请人： Peter Kurze , Thomas Imwinkelried , Stefan Beck , Dora Banerjee , Tamara Schwarz
发明人： Peter Kurze , Thomas Imwinkelried , Stefan Beck , Dora Banerjee , Tamara Schwarz
IPC分类号： C01F5/24 , A61L27/30 , B05D3/02 , A61L27/04 , A61L27/58 , A61L31/02 , A61L31/08 , A61L31/14
CPC分类号： A61L27/047 , A61B17/80 , A61B17/864 , A61F2310/00425 , A61L27/303 , A61L27/306 , A61L27/58 , A61L31/022 , A61L31/082 , A61L31/148 , A61L2400/18 , A61L2430/02 , C01F5/24 , Y10T428/265 , Y10T428/31678
摘要： A medical implant comprises a biodegradable magnesium-based alloy of which at least a part of its surface layer comprises a magnesium carbonate. A method for the manufacture of a biocompatible, corrosion-inhibiting protective surface layer on a medical implant comprising a magnesium-based alloy, comprises: providing an implant comprising a magnesium-based alloy to be coated; placing the implant into a reactor chamber; exposing at least part of the surface of said implant to an atmosphere comprising humid carbon dioxide to produce a coating on the surface of the implant comprising a magnesium carbonate of the formula x MgCO3.y Mg (OH)2, whereby x+y=1; removing the implant from the reactor chamber; and drying the surface of the implant.
摘要翻译：医疗植入物包括其表面层的至少一部分包含碳酸镁的可生物降解的镁基合金。一种用于在包括镁基合金的医用植入物上制造生物相容性腐蚀抑制保护性表面层的方法，包括：提供包含待涂覆的镁基合金的植入物; 将植入物置于反应室中; 将所述植入物的表面的至少一部分暴露于包含潮湿二氧化碳的气氛中，以在植入物表面上产生包含式x MgCO 3 y Mg（OH）2的碳酸镁的涂层，由此x + y = 1 ; 从反应器室移除植入物; 并干燥植入物的表面。

5. 发明申请

US20120053637A1 Controlling the Degradation of Bioresorbable Metal Implants 审中-公开
标题翻译：控制生物可吸收金属植入物的降解
公开(公告)号：US20120053637A1
公开(公告)日：2012-03-01
申请号：US13213213
申请日：2011-08-19
申请人： Thomas Imwinkelried , Elliott Gruskin , Andrea Montali , Stefan Beck
发明人： Thomas Imwinkelried , Elliott Gruskin , Andrea Montali , Stefan Beck
IPC分类号： A61B17/88 , A61B17/80
CPC分类号： A61B17/80 , A61B17/866
摘要： A degradation controlled metal implant and methods of controlling the degradation of the implant. In one embodiment, the implant includes a body, one or more apertures, and one or more fastener blanks fixed within one or more apertures. In another embodiment, the implant includes a body of a first material and a second material plated in various patterns over the first material.
摘要翻译：降解受控金属植入物和控制植入物降解的方法。在一个实施例中，植入物包括主体，一个或多个孔，以及固定在一个或多个孔内的一个或多个紧固件坯料。在另一个实施例中，植入物包括第一材料的主体和在第一材料上以各种图案电镀的第二材料。

6. 发明授权

US10039580B2 Controlling the degradation of bioresorbable metal implants 有权
公开(公告)号：US10039580B2
公开(公告)日：2018-08-07
申请号：US13213213
申请日：2011-08-19
申请人： Thomas Imwinkelried , Elliott Gruskin , Andrea Montali , Stefan Beck
发明人： Thomas Imwinkelried , Elliott Gruskin , Andrea Montali , Stefan Beck
IPC分类号： A61B17/80 , A61B17/86
摘要： A degradation controlled metal implant and methods of controlling the degradation of the implant. In one embodiment, the implant includes a body, one or more apertures, and one or more fastener blanks fixed within one or more apertures. In another embodiment, the implant includes a body of a first material and a second material plated in various patterns over the first material.

7. 发明授权

US06382302B1 Casting system for thixoforms 失效
标题翻译：触变型铸造系统
公开(公告)号：US06382302B1
公开(公告)日：2002-05-07
申请号：US09720703
申请日：2000-12-29
申请人： Thomas Imwinkelried
发明人： Thomas Imwinkelried
IPC分类号： B22D1710
CPC分类号： B22D17/007 , B22D17/2272 , Y10S164/90
摘要： Diecasting machine for production of mouldings from thixotropic metal billets, containing a sprue system which connects a cylindrical casting chamber cavity with a moulding cavity, where the sprue system has a cylindrical sprue cavity immediately adjacent to the casting chamber cavity and contains at least one sprue, and all sprues lead laterally away from the generated surface of the sprue cavity and each sprue has a concentric center line and at its end facing towards the moulding cavity has an inlet opening for introduction of the thixotropic metal alloy into the moulding cavity, and the sprue system is connected to the casting chamber cavity by a passage opening perpendicular in relation to a concentric longitudinal axis of the cylindrical casting chamber cavity, wherein each sprue has a circular or elliptical cross section with a substantially constant cross sectional area over its entire length.
摘要翻译：用于生产来自触变性金属坯料的模制品的压铸机，其包含将圆柱形浇注腔室与模制腔连接的浇口系统，其中浇口系统具有紧邻浇铸室腔体的圆柱形浇道腔，并且包含至少一个浇口，并且所有的浇道横向地远离浇口腔的所产生的表面，并且每个浇口具有同心的中心线，并且在其朝向模腔的面的端部具有用于将触变性金属合金引入模制腔的入口，并且浇口系统通过相对于圆柱形铸腔室的同心纵向轴线垂直的通道开口连接到铸造腔室腔，其中每个浇口具有在其整个长度上具有基本上恒定的横截面面积的圆形或椭圆形横截面。

8. 发明申请

US20080215098A1 POROUS IMPLANT 审中-公开
标题翻译：多孔植入
公开(公告)号：US20080215098A1
公开(公告)日：2008-09-04
申请号：US12027551
申请日：2008-02-07
申请人： Thomas Imwinkelried , Lukas Giger
发明人： Thomas Imwinkelried , Lukas Giger
IPC分类号： A61B17/86 , C04B33/32
CPC分类号： A61F2/28 , A61C8/0012 , A61C13/0022 , A61F2/44 , A61F2/4611 , A61F2002/30006 , A61F2002/30011 , A61F2002/30013 , A61F2002/30321 , A61F2250/0015 , A61F2250/0023 , A61F2250/0024 , A61F2250/0025 , A61F2310/00017 , A61F2310/00023 , A61F2310/00041 , A61F2310/00131 , A61F2310/00179
摘要： An implant comprising a shaped body having a first region with a mean porosity P2 and a second region with a mean porosity P3
摘要翻译：一种植入物，其包括具有平均孔隙率P 2 N 2的第一区域和平均孔隙率P 3 3 P <2的第二区域的成形体， ; 其中具有较低平均孔隙率P 3 3的第二区域对于植入物的处理和固定是有效的。

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