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1. 发明申请

US20130136754A1 REGULATORY B CELLS AND THEIR USES 审中-公开
标题翻译：调节B细胞及其用途
公开(公告)号：US20130136754A1
公开(公告)日：2013-05-30
申请号：US13814165
申请日：2011-08-04
申请人： Thomas F. Tedder , Takashi Matsushita , Yohei Iwata , Koichi Yanaba , Jean-David Bouaziz
发明人： Thomas F. Tedder , Takashi Matsushita , Yohei Iwata , Koichi Yanaba , Jean-David Bouaziz
IPC分类号： C12N5/0781 , A61K39/00 , A61K35/14
CPC分类号： C12N5/0635 , A61K35/17 , A61K2039/505 , C07K16/2803 , G01N33/5052 , G01N33/6893 , G01N2800/7095 , Y02A50/388 , Y02A50/463 , Y02A50/471 , Y02A50/484
摘要： The present invention relates to a distinct B cell subset, B10 cells, that regulate T cell mediated inflammatory responses through the secretion of interleukin-10 (IL-10). The invention also relates to the use of B10 cells in the manipulation of immune and inflammatory responses, and in the treatment of disease. Therapeutic approaches involving adoptive transfer of B10 cells, or expansion of their endogenous levels for controlling autoimmune or inflammatory diseases and conditions are described. Ablation of B10 cells, or inhibition of their IL-10 production can be used to upregulate immunodeficient conditions, ameliorate infectious diseases and/or to treat tumors/cancer. Diagnostic applications are also encompassed.
摘要翻译：本发明涉及通过分泌白细胞介素-10（IL-10）调节T细胞介导的炎性反应的不同B细胞亚群B10细胞。本发明还涉及B10细胞在免疫和炎症反应的操作中的用途以及疾病的治疗。描述了涉及B10细胞的过继转移或其内源性水平的扩增用于控制自身免疫性或炎性疾病和病症的治疗方法。 B10细胞的消融或其IL-10产生的抑制可用于上调免疫缺陷状况，改善感染性疾病和/或治疗肿瘤/癌症。还包括诊断应用程序。

2. 发明授权

US10131875B2 Regulatory B cells and their uses 有权
公开(公告)号：US10131875B2
公开(公告)日：2018-11-20
申请号：US13814165
申请日：2011-08-04
申请人： Thomas F. Tedder , Takashi Matsushita , Yohei Iwata , Koichi Yanaba , Jean-David Bouaziz
发明人： Thomas F. Tedder , Takashi Matsushita , Yohei Iwata , Koichi Yanaba , Jean-David Bouaziz
IPC分类号： C12N5/00 , C12N5/02 , C12N5/0781 , C07K16/28 , A61K35/17 , G01N33/50 , G01N33/68 , A61K39/00
摘要： The present invention relates to a distinct B cell subset, B10 cells, that regulate T cell mediated inflammatory responses through the secretion of interleukin-10 (IL-10). The invention also relates to the use of B10 cells in the manipulation of immune and inflammatory responses, and in the treatment of disease. Therapeutic approaches involving adoptive transfer of B10 cells, or expansion of their endogenous levels for controlling autoimmune or inflammatory diseases and conditions are described. Ablation of B10 cells, or inhibition of their IL-10 production can be used to upregulate immunodeficient conditions, ameliorate infectious diseases and/or to treat tumors/cancer. Diagnostic applications are also encompassed.

3. 发明申请

US20120003514A1 NON-AQUEOUS ELECTROLYTE BATTERY 审中-公开
标题翻译：非水电解电池
公开(公告)号：US20120003514A1
公开(公告)日：2012-01-05
申请号：US13061180
申请日：2010-03-03
申请人： Tomonobu Tsujikawa , Toshio Matsushima , Masahiro Ichimura , Tsutomu Ogata , Masayasu Arakawa , Kahou Yabuta , Takashi Matsushita , Kenji Kurita , Masayuki Terada , Koji Hayashi , Youhei Itoh , Yuki Ishizaki
发明人： Tomonobu Tsujikawa , Toshio Matsushima , Masahiro Ichimura , Tsutomu Ogata , Masayasu Arakawa , Kahou Yabuta , Takashi Matsushita , Kenji Kurita , Masayuki Terada , Koji Hayashi , Youhei Itoh , Yuki Ishizaki
IPC分类号： H01M10/42
CPC分类号： H01M4/131 , H01M2/1673 , H01M2/1686 , H01M4/13 , H01M4/133 , H01M4/62 , H01M10/0525 , H01M10/0566 , H01M10/4235 , H01M2200/10
摘要： A non-aqueous electrolyte battery capable of making behavior of the battery calm at a time of battery abnormality to secure safety is provided. In a lithium-ion secondary battery 20, an electrode group 6 is accommodated in a cylindrical battery container 7 having a bottom. A positive electrode plate and a negative electrode plate are wound via separators W5 to form the electrode group 6. The positive electrode plate has an aluminum foil W1 as a positive electrode collector. A positive electrode mixture including a lithium transition metal complex oxide as a positive electrode active material is applied to both surfaces of the aluminum foil W1 to form a positive electrode mixture layer W2. A flame retardant layer W6 containing a flame retardant is formed at a surface of the positive electrode mixture layer W2. The negative electrode plate has a rolled copper foil W3 as a negative electrode collector. A negative electrode mixture including a carbon material as a negative electrode active material is applied to both surfaces of the rolled copper foil W3 to form a negative electrode mixture layer W4. The flame retardant decomposes under a high temperature environment such as battery abnormality or the like.
摘要翻译：提供能够使电池在电池异常时平静以确保安全性的非水电解质电池。在锂离子二次电池20中，电极组6容纳在具有底部的圆筒形电池容器7中。正极板和负极板通过隔板W5缠绕以形成电极组6.正极板具有铝箔W1作为正极集电体。将包含锂过渡金属复合氧化物作为正极活性物质的正极合剂涂布在铝箔W1的两面上，形成正极合剂层W2。在正极合剂层W2的表面形成含有阻燃剂的阻燃层W6。负极板具有作为负极集电体的卷绕铜箔W3。将包含碳材料作为负极活性物质的负极混合物施加到轧制的铜箔W3的两个表面上以形成负极混合物层W4。阻燃剂在诸如电池异常等的高温环境下分解。

4. 发明申请

US20100148595A1 LINEAR SYNCHRONOUS MOTOR 有权
标题翻译：线性同步电机
公开(公告)号：US20100148595A1
公开(公告)日：2010-06-17
申请号：US12635981
申请日：2009-12-11
申请人： Yuqi Tang , Takashi Matsushita , Satoshi Sugita
发明人： Yuqi Tang , Takashi Matsushita , Satoshi Sugita
IPC分类号： H02K41/03
CPC分类号： H02K41/03
摘要： A linear synchronous motor, in which one or more intermediate annular magnetic pole portions and yoke assemblies can be connected easily while positioning the intermediate annular magnetic pole portions. A fitting concave portion that is opened in an axial direction and a direction away from a direct drive shaft is formed in each connected portion of the intermediate annular magnetic pole portions. A plurality of fitting grooves are formed on an outer peripheral surface of a pair of magnetic cylindrical members at a plurality of portions facing the plurality of intermediate annular magnetic pole portions. The intermediate annular magnetic pole portions are fixedly positioned between the pair of magnetic cylindrical members by fitting a peripheral portion defining the fitting concave portion of the intermediate annular magnetic pole portion into the corresponding fitting groove of the magnetic cylindrical member.
摘要翻译：一种线性同步电动机，其中一个或多个中间环形磁极部分和轭组件可以容易地连接，同时定位中间环形磁极部分。在中间环形磁极部分的每个连接部分中形成有在轴向上开放并且远离直接驱动轴的方向的嵌合凹部。在面对多个中间环形磁极部的多个部分的一对磁性圆柱形部件的外周面上形成有多个嵌合槽。通过将限定中间环形磁极部分的嵌合凹部的周边部分嵌合到磁性圆柱形部件的相应的装配槽中，中间环形磁极部分固定地位于一对磁性圆柱形部件之间。

5. 发明申请

US20100015379A1 NEAR INFRARED LIGHT SHIELDING FILM 审中-公开
标题翻译：近红外光屏蔽膜
公开(公告)号：US20100015379A1
公开(公告)日：2010-01-21
申请号：US12449569
申请日：2008-02-19
申请人： Takashi Matsushita
发明人： Takashi Matsushita
IPC分类号： B32B27/30 , B32B27/18 , C09J7/02 , B32B33/00
CPC分类号： C09J7/29 , C08K3/22 , C08K2003/2258 , C09J2205/106 , C09J2433/006 , Y10T428/1462 , Y10T428/266 , Y10T428/2809 , Y10T428/2848
摘要： A near infrared light shielding film which comprise a hard coat layer which is formed by using a material for forming a hard coat layer comprising an agent for absorbing near infrared light and a compound curable with active energy ray and is disposed on one face of a substrate film and a pressure sensitive adhesive layer which is disposed on the other face of the substrate film, wherein the compound curable with active energy ray comprises a polyfunctional acrylate-based monomer having a functionality of five or greater as the main component. The film exhibits excellent near infrared light shielding property and transmission of visible light, excellent scratch resistance and weatherability and, moreover, excellent workability in lamination to glass having a curved surface since curling of the film is suppressed and is advantageously used for attaching to window panes of buildings and windshield glasses of automobiles and, in particular, to windshield glasses of automobiles.
摘要翻译：一种近红外光屏蔽膜，其包括通过使用用于形成包含用于吸收近红外光的试剂的硬涂层的材料和可用活性能量射线固化的化合物形成的硬涂层，并且设置在基板的一个面上膜和压敏粘合剂层，其设置在基材膜的另一面上，其中可用活性能量射线固化的化合物包含官能度为五以上的多官能丙烯酸酯类单体作为主要成分。该薄膜表现出优异的近红外光屏蔽性能和可见光透射性，优异的耐划伤性和耐候性，此外，由于膜的卷曲被抑制，因此具有弯曲表面的玻璃的层压加工性优异，并且有利地用于附接到窗玻璃的建筑物和挡风玻璃眼镜的汽车，特别是汽车的挡风玻璃。

6. 发明授权

US5108394A Bone fixing device 失效
标题翻译：骨固定装置
公开(公告)号：US5108394A
公开(公告)日：1992-04-28
申请号：US578564
申请日：1990-09-06
申请人： Takahide Kurokawa , Takashi Matsushita , Isao Ohnishi , Shigemitsu Ogawa , Tsuneo Yokotsuka , Akio Nakazawa
发明人： Takahide Kurokawa , Takashi Matsushita , Isao Ohnishi , Shigemitsu Ogawa , Tsuneo Yokotsuka , Akio Nakazawa
IPC分类号： A61B17/64 , A61B17/66
CPC分类号： A61B17/66 , A61B17/6458
摘要： A bone fixing device is disclosed in which a single rod member is arranged in a longitudinal direction of a bone, and at least two block members are mounted on the rod member so that the block members may be fixed to any desired positions in the axial direction and around the axis of the rod member. Pin holding mechanisms for holding a plurality of pins to be inserted into the bone are mounted on the block members, respectively. By the pin holding mechanisms, the pins are positionally adjustable around axes in the first and second directions which are preferably perpendicular to the axial direction. Also, an actuator is fixed to the rod member. One of the block members slidable relative to the rod member is moved in the axial direction relative to the rod member to thereby impart elongation/contraction force to the bone. A detector is fixed to the other member and is brought into contact with a contact located at an end of the rod member to thereby detect the repulsive force from the bone.

7. 发明授权

US4951794A Electromagnetic clutch with a structure which is simple in assembly 失效
标题翻译：具有组装简单结构的电磁离合器
公开(公告)号：US4951794A
公开(公告)日：1990-08-28
申请号：US323810
申请日：1989-03-15
申请人： Takashi Matsushita
发明人： Takashi Matsushita
IPC分类号： F16D27/10 , F16D27/112
CPC分类号： F16D27/112 , F16D2027/008
摘要： In an electromagnetic clutch for selectively transmitting rotation of a pulley to a drive shaft having an armature by magnetic force attracting the armature to the pulley, the pulley is mounted by a bearing on a tubular support projecting from a side wall of a mount and an electromagnetic device is mounted through a supporting plate on the mount for generating a magnetic force to attract the armature to the pulley. In order to make assembly of the clutch easy, the supporting plate supports the electromagnetic device at an outer peripheral region on one surface and comprises a central boss projecting from the surface and extending around the tubular support to have a projecting end, an annular surface region in contact with the side surface of the mount, and a radial inner flange radially inwardly extending from the projecting end to form a central hole through which the tubular support extends. The bearing has an axial end in press contact with the radial inner flange and an opposite axial end engaging a snap ring fitted in a snap ring receiving groove of the tubular support, to thereby prevent the bearing and the supporting plate from moving in an axial direction on the tubular support between the side wall of the mount and the snap ring.
摘要翻译：在用于选择性地将滑轮的旋转传递到具有将电枢吸引到滑轮的磁力的具有电枢的驱动轴的电磁离合器中，滑轮由轴承安装在从安装件的侧壁突出的管状支撑件和电磁装置通过安装件上的支撑板安装以产生磁力以将电枢吸引到滑轮。为了使离合器的组装容易，支撑板在一个表面的外周区域上支撑电磁装置，并且包括从表面突出并且围绕管状支撑件延伸的中心凸台以具有突出端，环形表面区域与安装件的侧表面接触，以及从突出端径向向内延伸的径向内凸缘，以形成管状支撑件延伸穿过的中心孔。该轴承具有与径向内凸缘压接的轴向端，并且相对的轴向端接合安装在管状支撑件的卡环接收槽中的卡环，从而防止轴承和支撑板沿轴向移动在支架的侧壁和卡环之间的管状支撑件上。

8. 发明授权

US4828090A Electromagnetic clutch 失效
标题翻译：电磁离合器
公开(公告)号：US4828090A
公开(公告)日：1989-05-09
申请号：US31705
申请日：1987-03-30
申请人： Takashi Matsushita
发明人： Takashi Matsushita
IPC分类号： F16D27/112 , F16D27/14
CPC分类号： F16D27/14 , F16D27/112 , F16D2027/008
摘要： An electromagnetic clutch is disclosed that includes a pulley and an electromagnetic mechanism. A hub is secured on a drive shaft and has a radially extending flange portion. An armature plate is concentrically disposed on the hub and faces the axial end surface of the pulley with an axial air gap therebetween. A holder plate is fixed on an outer axial end surface of the armature plate and is formed with a triangularly axially extending flange. The radial flange portion of the hub is also formed with a second axially extending flange corresponding to the first flange. The first and second axially extending flanges are formed of a similar configuration and face one another with a radial gap. An elastic member is disposed in the radial gap to ease the impact force created when the clutch is engaged.

9. 发明申请

US20110159329A1 NON-AQUEOUS ELECTROLYTE BATTERY 审中-公开
标题翻译：非水电解电池
公开(公告)号：US20110159329A1
公开(公告)日：2011-06-30
申请号：US13061189
申请日：2010-03-03
申请人： Tomonobu Tsujikawa , Toshio Matsushima , Masahiro Ichimura , Tsutomu Ogata , Masayasu Arakawa , Kahou Yabuta , Takashi Matsushita , Koji Hayashi , Masayuki Terada , Youhei Itoh , Kenji Kurita , Yuki Ishizaki
发明人： Tomonobu Tsujikawa , Toshio Matsushima , Masahiro Ichimura , Tsutomu Ogata , Masayasu Arakawa , Kahou Yabuta , Takashi Matsushita , Koji Hayashi , Masayuki Terada , Youhei Itoh , Kenji Kurita , Yuki Ishizaki
IPC分类号： H01M10/36 , H01M2/02 , H01M4/64
CPC分类号： H01M10/0525 , H01M4/505 , H01M4/525 , H01M10/0567 , H01M10/0568 , H01M10/0587 , H01M10/4235 , Y02T10/7011
摘要： A manganese non-aqueous electrolyte battery having safety at a time of battery abnormality and having a long life span is provided. A battery 20 has a cylindrical container 7 having a bottom. An electrode group 6 where a positive electrode plate that a spinel-related lithium manganese complex oxide is used as a positive electrode active material and a negative electrode plate that a carbon material is used as a negative electrode active material are wound via separators W5, is accommodated in the container 7. The electrode group 6 is infiltrated by an electrolytic solution in which LiBF4 is added as an electrolyte to organic solvent. Further, a phosphazene flame retardant is added at 10 wt % to the electrolytic solution. The electrolytic solution hardly catches fire at a time of battery abnormality and manganese elution can be prevented.
摘要翻译：提供一种在电池异常时具有安全性且寿命长的锰非水电解质电池。电池20具有底部的圆筒形容器7。使用尖晶石相关的锂锰复合氧化物作为正极活性物质的正极板和碳材料用作负极活性物质的负极板的电极组6通过分离器W5卷绕，容纳在容器7中。电极组6被其中添加LiBF 4作为电解质的电解液渗透到有机溶剂中。此外，向电解液中添加10重量％的磷腈阻燃剂。电解液在电池异常时几乎不会起火，可以防止锰洗脱。

10. 发明申请

US20090175554A1 DISPLAY APPARATUS AND DISPLAY METHOD 有权
标题翻译：显示装置和显示方法
公开(公告)号：US20090175554A1
公开(公告)日：2009-07-09
申请号：US12348503
申请日：2009-01-05
申请人： Takashi Matsushita
发明人： Takashi Matsushita
IPC分类号： G06K9/40
CPC分类号： G03B17/18 , H04N1/0044 , H04N1/60 , H04N5/23212 , H04N5/23293 , H04N2101/00
摘要： A display apparatus able to perform appropriate and accurate focusing. An image displayed on a display unit is stored in a first storage unit, a focus position of the image is moved by a movement unit, and the image obtained after the focus position movement is stored in a second storage unit. The images stored in the first and second storage units are compared by a comparison unit on a pixel basis, and based on a result of the comparison, an image area where there is a change in pixel state is extracted by an extraction unit, a contrast value in the extracted image area is calculated by a calculation unit, and a change in the calculated contrast values is determined by a determination unit. Based on a result of the determination, the attribute of pixels in the extracted image area is changed by a change unit.
摘要翻译：能够进行适当且准确聚焦的显示装置。在显示单元上显示的图像被存储在第一存储单元中，图像的聚焦位置被移动单元移动，并且在聚焦位置移动之后获得的图像被存储在第二存储单元中。存储在第一和第二存储单元中的图像通过比较单元在像素的基础上进行比较，并且基于比较的结果，通过提取单元提取出像素状态改变的图像区域，对比度通过计算单元计算提取图像区域中的值，并且由确定单元确定计算出的对比度值的变化。基于确定的结果，通过改变单元改变提取的图像区域中的像素的属性。

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