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1. 发明授权

US08211463B2 Use of glycolipids as adjuvants 有权
标题翻译：使用糖脂作为佐剂
公开(公告)号：US08211463B2
公开(公告)日：2012-07-03
申请号：US12440315
申请日：2007-09-06
申请人： Thomas Ebensen , Michael Morr , Carlos Guzman , Goetz Milkereit
发明人： Thomas Ebensen , Michael Morr , Carlos Guzman , Goetz Milkereit
IPC分类号： A61K9/127
CPC分类号： A61K39/39 , A61K2039/55511
摘要： The present invention relates to adjuvants of the glycolipid type and their uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new uses of compounds useful as adjuvants for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumors and allergies. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants.
摘要翻译：本发明涉及糖脂类型的佐剂及其在药物组合物中的用途，如疫苗中。特别地，本发明提供了用作治疗感染性疾病，炎性疾病，自身免疫性疾病，肿瘤和过敏症中的预防和/或治疗性疫苗的辅助剂的新用途。所述化合物不仅特别适用于全身，而且优选作为粘膜佐剂。

2. 发明授权

US08119689B2 Adjuvants on the basis of bisacyloxypropylcystene conjugates and derivatives and their uses in pharmaceutical compositions 有权
标题翻译：基于双酰氧基丙基胱氨酸共轭物和衍生物的佐剂及其在药物组合物中的用途
公开(公告)号：US08119689B2
公开(公告)日：2012-02-21
申请号：US12093865
申请日：2006-11-22
申请人： Thomas Ebensen , Michael Morr , Carlos Guzman
发明人： Thomas Ebensen , Michael Morr , Carlos Guzman
IPC分类号： A01N37/02 , A01N37/06 , A61K31/225 , A61K51/00 , A61K45/00 , C07C321/00 , C07C323/00 , C07C381/00 , A61M36/14
CPC分类号： A61K47/60
摘要： Bisacyloxycysteine type conjugates have been found to be useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumors, and allergies, as well as in the control of fertility in human or animal populations. The compounds can be administered by system or mucosal routes and are particularly useful as mucosal adjuvants. These compounds can function as active ingredients in pharmaceutical compositions.
摘要翻译：已经发现双酰氧基半胱氨酸型缀合物可用作治疗感染性疾病，炎症性疾病，自身免疫性疾病，肿瘤和过敏以及在人类的生育能力的控制中用于预防和/或治疗性接种的佐剂和/或免疫调节剂或动物种群。化合物可以通过系统或粘膜途径施用，并且特别可用作粘膜佐剂。这些化合物可以用作药物组合物中的活性成分。

3. 发明授权

US08053417B2 Hexosylceramides as adjuvants and their uses in pharmaceutical compositions 有权
标题翻译：二十二烷酰胆碱作为佐剂及其在药物组合物中的用途
公开(公告)号：US08053417B2
公开(公告)日：2011-11-08
申请号：US12090279
申请日：2006-10-19
申请人： Thomas Ebensen , Michael Morr , Carlos Guzman
发明人： Thomas Ebensen , Michael Morr , Carlos Guzman
IPC分类号： A61K31/70 , A61K31/7028 , C07H15/04
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/0043 , A61K39/39 , A61K2039/55511 , C07H15/04 , C07H15/08 , Y02A50/412
摘要： The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.
摘要翻译：本发明涉及新的佐剂和药物组合物中的用途，如疫苗。特别地，本发明提供了新的化合物，其可用作治疗感染性疾病，炎性疾病，自身免疫性疾病，肿瘤，过敏症以及用于控制人或动物群体中的生育力的预防和/或治疗性疫苗的佐剂。所述化合物不仅特别适用于全身，而且优选作为粘膜佐剂。此外，本发明涉及其作为药物组合物中的活性成分的用途。

4. 发明申请

US20090017106A1 ADJUVANTS ON THE BASIS OF BISACYLOXYPROPYLCYSTENE CONJUGATES AND DERIVATIVES AND THEIR USES IN PHARMACEUTICAL COMPOSITIONS 有权
标题翻译：基于双歧杆菌脂蛋白结合物和衍生物的研究进展及其在药物组合物中的应用
公开(公告)号：US20090017106A1
公开(公告)日：2009-01-15
申请号：US12093865
申请日：2006-11-22
申请人： Thomas Ebensen , Michael Morr , Carlos Guzman
发明人： Thomas Ebensen , Michael Morr , Carlos Guzman
IPC分类号： A61K31/225 , A61K9/127 , A61K9/14 , A61K47/20 , A61K39/00 , A61P31/00 , A61P37/00 , A61P35/00 , A61K39/395 , C07C321/04 , C12N5/06
CPC分类号： A61K47/60
摘要： The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new conjugates of the bisacyloxycysteine type useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.
摘要翻译：本发明涉及新的佐剂和药物组合物中的用途，如疫苗。特别地，本发明提供了用作治疗感染性疾病，炎症性疾病，自身免疫性疾病，肿瘤，过敏症以及用于治疗性疾病的预防和/或治疗性接种疫苗的辅助剂和/或免疫调节剂的双酰氧基半胱氨酸类型的新缀合物人或动物种群的生育力。所述化合物不仅特别适用于全身，而且优选作为粘膜佐剂。此外，本发明涉及其作为药物组合物中的活性成分的用途。

5. 发明授权

US08069236B2 Flow control of events based on threshold, grace period, and event signature 失效
标题翻译：基于阈值，宽限期和事件签名的事件流控制
公开(公告)号：US08069236B2
公开(公告)日：2011-11-29
申请号：US12333939
申请日：2008-12-12
申请人： Sanjay Agraharam , Savitha Iyer , Carlos Guzman
发明人： Sanjay Agraharam , Savitha Iyer , Carlos Guzman
IPC分类号： G06F15/173
CPC分类号： G06F9/542 , G06F2209/544
摘要： A method for controlling sender events arriving at a recipient system is provided. An event transmitted from a sender is received at recipient system, and an event signature is determined. An elapse time between received event and a previous event is calculated. If elapse time is less than or equal to a critical time, it is determined if a counter is equal to or greater than a maximum value. If yes, event is rejected. If not, counter is incremented and the event is processed. If elapse time is greater than critical time, it is determined if elapse time is less than or equal to a grace period and if counter is greater than zero. If yes, counter is decremented and the event is processed. If not, counter is set to zero and event is processed. The critical time, maximum value, and increment/decrement factor are set based on the event signature.
摘要翻译：提供了一种用于控制到达接收方系统的发送方事件的方法。从收件人系统接收从发送者发送的事件，并确定事件签名。计算接收事件与先前事件之间的时间。如果经过时间小于或等于临界时间，则确定计数器是否等于或大于最大值。如果是，事件被拒绝。如果不是，则递增计数器并处理事件。如果经过时间大于临界时间，则确定经过时间是否小于或等于宽限期，如果计数器大于零。如果是，计数器递减，事件被处理。如果不是，计数器被设置为零并且事件被处理。关键时间，最大值和增量/减量因子是基于事件签名设置的。

6. 发明申请

US20050276813A1 Use of a lipopeptide or lipoprotein as an adjuvant in therapeutic or prophylactic vaccinations 审中-公开
标题翻译：在治疗性或预防性接种中使用脂肽或脂蛋白作为佐剂
公开(公告)号：US20050276813A1
公开(公告)日：2005-12-15
申请号：US10509917
申请日：2003-04-03
申请人： Peter Muhlradt , Carlos Guzman
发明人： Peter Muhlradt , Carlos Guzman
IPC分类号： A61K39/39 , A61P31/00 , A61K39/00
CPC分类号： A61K39/39 , A61K2039/541 , A61K2039/55516
摘要： Disclosed is the use of lipopeptides and lipoproteins as mucosal adjuvants for various vaccinations via mucous membranes, particularly intranasally. Said lipopeptides represent peptides or proteins substituted with 2,3-diacyloxy(2R)-propyl at the amino-terminal cystein of a peptide or protein, preferably S-(2,3-bispalmitoyloxy-(2R)-propyl)cysteinyl peptides derived from mycoplasmas. Said peptides are highly effective even in small doses, produce good immunization results, and increase the IgA level, among others.
摘要翻译：公开了使用脂肽和脂蛋白作为粘膜佐剂，用于通过粘膜，特别是鼻内的各种疫苗接种。所述脂肽代表肽或蛋白质的氨基末端半胱氨酸上的2,3-二酰氧基（2R） - 丙基取代的肽或蛋白质，优选衍生自S-或2,3-二氨基甲酰氧基 - （2R） - 丙基）的S- 支原体所述肽即使在小剂量下也是非常有效的，产生良好的免疫结果，并且增加IgA水平等。

7. 发明申请

US20120066139A1 Methods, Systems, and Processes for Identifying Affected and Related Individuals During a Crisis 审中-公开
标题翻译：在危机期间识别受影响人和相关个人的方法，制度和过程
公开(公告)号：US20120066139A1
公开(公告)日：2012-03-15
申请号：US12878099
申请日：2010-09-09
申请人： Carlos Guzman , Sanjay Agraharam , Joseph Robinson
发明人： Carlos Guzman , Sanjay Agraharam , Joseph Robinson
IPC分类号： G06Q99/00 , G06F15/16
CPC分类号： G06Q50/01 , G06Q10/10
摘要： A crisis management system may retrieve and analyze data from the social network system to identify, find, and/or locate individuals affected by a crisis. For example, when a crisis occurs, the crisis management system may retrieve data from a social network system regarding individuals that may be affected by the crisis. Crisis management system may then analyze the retrieved data to determine whether the individuals may have been located within the crisis area. Additionally, crisis management system may analyze the retrieved data to determine related individuals, such as co-workers, friends, family, relatives, or other individuals that may act as emergency contacts for the affected individuals.
摘要翻译：危机管理系统可以从社会网络系统检索和分析数据，以识别，查找和/或定位受危机影响的个人。例如，当发生危机时，危机管理系统可以从社会网络系统检索可能受危机影响的个人的数据。然后，危机管理系统可以分析检索的数据，以确定个人是否可能位于危机区域内。此外，危机管理系统可以分析检索到的数据，以确定相关个人，如同事，朋友，家人，亲戚或可能作为受影响人员紧急联系的其他个人。

8. 发明授权

US08468253B2 Method and apparatus for multimedia collaboration using a social network system 有权
标题翻译：使用社交网络系统进行多媒体协作的方法和装置
公开(公告)号：US08468253B2
公开(公告)日：2013-06-18
申请号：US12326563
申请日：2008-12-02
申请人： Carlos Guzman , Sanjay Agraharam
发明人： Carlos Guzman , Sanjay Agraharam
IPC分类号： G06F15/16 , G06F3/00 , H04L12/16
CPC分类号： H04L67/18 , H04L12/1818 , H04L12/185
摘要： In one embodiment, the present invention is a method and apparatus for multimedia collaboration using a social network system. In one embodiment, a method for using a social network to establish a collaborative multimedia interaction includes receiving a request from a user to establish the collaborative multimedia interaction, where the user has established the social network, and notifying one or more members of the social network of the collaborative multimedia interaction using, in some embodiments, information about the members' current or last known digital presence and a customizable set of notification rules.
摘要翻译：在一个实施例中，本发明是一种使用社交网络系统进行多媒体协作的方法和装置。在一个实施例中，使用社交网络来建立协作多媒体交互的方法包括从用户接收建立协作多媒体交互的请求，用户建立了社交网络，并通知社交网络的一个或多个成员在一些实施例中，使用关于成员的当前或最后已知数字存在的信息以及可定制的一组通知规则来进行协作多媒体交互。

9. 发明授权

US08397504B2 Method and apparatus to recover and convert waste heat to mechanical energy 失效
标题翻译：回收和将废热转化为机械能的方法和装置
公开(公告)号：US08397504B2
公开(公告)日：2013-03-19
申请号：US12701865
申请日：2010-02-08
申请人： Carlos Guzman , Larry Lee Walter
发明人： Carlos Guzman , Larry Lee Walter
IPC分类号： F02G3/00 , F02G5/04 , F02G5/02 , F01K25/10 , F01K23/10 , F01K23/02
CPC分类号： F01N5/02 , F01K15/02 , F01K23/065 , F28D21/0003 , Y02T10/16
摘要： A method and system for waste heat recovery for conversion to mechanical energy. Exhaust is received from an engine into a first heat exchanger where heat from the exhaust is transferred to a refrigerant. The exhaust is then transferred to a regenerator module in order to produce electricity which is provided to a power box. The hot refrigerant from the first heat exchanger is transferred to a kinetic energy recovery system to produce electricity which is also transferred to said power box. The power box provides electricity to a traction motor and the traction motor turns an axle. The refrigerant is then transferred to a refrigerant cooling unit and then to a second heat exchanger wherein ambient air from the regenerator module is cooled. The refrigerant and cooled ambient air can be then transferred to an engine cooling jacket to cool the engine.
摘要翻译：一种用于转换为机械能的余热回收方法和系统。排气从发动机被接收到第一热交换器中，其中来自排气的热量被传递到制冷剂。然后将废气转移到再生器模块，以产生提供给动力箱的电力。来自第一热交换器的热制冷剂被转移到动能回收系统以产生也转移到所述动力箱的电力。电源箱为牵引电动机提供电力，牵引电动机转动轴。然后将制冷剂转移到制冷剂冷却单元，然后转移到第二热交换器，其中来自再生器模块的环境空气被冷却。然后将制冷剂和冷却的环境空气转移到发动机冷却套中以冷却发动机。

10. 发明申请

US20110193346A1 METHOD AND APPARATUS TO RECOVER AND CONVERT WASTE HEAT TO MECHANICAL ENERGY 失效
标题翻译：回收和转化废气对机械能的方法和装置
公开(公告)号：US20110193346A1
公开(公告)日：2011-08-11
申请号：US12701865
申请日：2010-02-08
申请人： Carlos Guzman , Larry Lee Walter
发明人： Carlos Guzman , Larry Lee Walter
IPC分类号： H02K7/18 , F02B33/34 , F01N5/02 , F01N5/04 , H02P3/14
CPC分类号： F01N5/02 , F01K15/02 , F01K23/065 , F28D21/0003 , Y02T10/16
摘要： A method and system for waste heat recovery for conversion to mechanical energy. Exhaust is received from an engine into a first heat exchanger where heat from the exhaust is transferred to a refrigerant. The exhaust is then transferred to a regenerator module in order to produce electricity which is provided to a power box. The hot refrigerant from the first heat exchanger is transferred to a kinetic energy recovery system to produce electricity which is also transferred to said power box. The power box provides electricity to a traction motor and the traction motor turns an axle. The refrigerant is then transferred to a refrigerant cooling unit and then to a second heat exchanger wherein ambient air from the regenerator module is cooled. The refrigerant and cooled ambient air can be then transferred to an engine cooling jacket to cool the engine.
摘要翻译：一种用于转换为机械能的余热回收方法和系统。排气从发动机被接收到第一热交换器中，其中来自排气的热量被传递到制冷剂。然后将废气转移到再生器模块，以产生提供给动力箱的电力。来自第一热交换器的热制冷剂被转移到动能回收系统以产生也转移到所述动力箱的电力。电源箱为牵引电动机提供电力，牵引电动机转动轴。然后将制冷剂转移到制冷剂冷却单元，然后转移到第二热交换器，其中来自再生器模块的环境空气被冷却。然后将制冷剂和冷却的环境空气转移到发动机冷却套中以冷却发动机。

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