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1. 发明申请

US20050276813A1 Use of a lipopeptide or lipoprotein as an adjuvant in therapeutic or prophylactic vaccinations 审中-公开
标题翻译：在治疗性或预防性接种中使用脂肽或脂蛋白作为佐剂
公开(公告)号：US20050276813A1
公开(公告)日：2005-12-15
申请号：US10509917
申请日：2003-04-03
申请人： Peter Muhlradt , Carlos Guzman
发明人： Peter Muhlradt , Carlos Guzman
IPC分类号： A61K39/39 , A61P31/00 , A61K39/00
CPC分类号： A61K39/39 , A61K2039/541 , A61K2039/55516
摘要： Disclosed is the use of lipopeptides and lipoproteins as mucosal adjuvants for various vaccinations via mucous membranes, particularly intranasally. Said lipopeptides represent peptides or proteins substituted with 2,3-diacyloxy(2R)-propyl at the amino-terminal cystein of a peptide or protein, preferably S-(2,3-bispalmitoyloxy-(2R)-propyl)cysteinyl peptides derived from mycoplasmas. Said peptides are highly effective even in small doses, produce good immunization results, and increase the IgA level, among others.
摘要翻译：公开了使用脂肽和脂蛋白作为粘膜佐剂，用于通过粘膜，特别是鼻内的各种疫苗接种。所述脂肽代表肽或蛋白质的氨基末端半胱氨酸上的2,3-二酰氧基（2R） - 丙基取代的肽或蛋白质，优选衍生自S-或2,3-二氨基甲酰氧基 - （2R） - 丙基）的S- 支原体所述肽即使在小剂量下也是非常有效的，产生良好的免疫结果，并且增加IgA水平等。

2. 发明申请

US20050192217A1 Utilization of lipopeptides or lipoproteins in wound treatment and infection prophylaxis 审中-公开
标题翻译：脂多糖或脂蛋白在伤口治疗和感染预防中的应用
公开(公告)号：US20050192217A1
公开(公告)日：2005-09-01
申请号：US10748033
申请日：2003-12-30
申请人： Peter Muhlradt , Ursula Deiters
发明人： Peter Muhlradt , Ursula Deiters
IPC分类号： A61K9/00 , A61K9/127 , A61K35/74 , A61K38/00 , A61K38/16 , A61P17/02 , A61K38/17 , C07K14/775
CPC分类号： A61K38/164
摘要： The invention concerns a pharmaceutical preparation for the treatment of wounds in animals or humans containing or consisting of a lipopeptide or lipoprotein which carries at the N-terminals a dihydroxypropyl-cysteine group with two, optionally long-chain, fatty acids bonded via ester bonds.
摘要翻译：本发明涉及一种药物制剂，用于治疗动物或人体中含有脂质肽或脂蛋白或由其组成的伤口，所述脂肽或脂蛋白在N-末端携带二羟丙基半胱氨酸基团，其具有通过酯键键合的两个任选的长链脂肪酸。

3. 发明授权

US07316996B2 Bisacyloxypropylcysteine conjugates and the use thereof 有权
标题翻译：双丙酰氧基丙基半胱氨酸共轭物及其用途
公开(公告)号：US07316996B2
公开(公告)日：2008-01-08
申请号：US10521013
申请日：2003-07-18
申请人： Peter Muhlradt , Michael Morr
发明人： Peter Muhlradt , Michael Morr
IPC分类号： A61K38/00 , A61K38/02 , C07K5/00 , C07K5/06 , C07K5/08 , C07K7/00
CPC分类号： A61K47/60
摘要： The invention provides lipopeptide conjugates in which a cysteine that is double-substituted by a fatty acid is bonded by means of the carboxyl group to a highly soluble, physiologically compatible and non-immunogenic, polymeric conjugate group. The conjugates exhibit an excellent macrophage stimulant action and do not require addition solutizing. They can be used in a wide range of applications, in particular for stimulating macrophages, for stimulating antibody synthesis, for combating infection, as an immunostimulant, in particular in relation to tumors, for preventing and treating septicaemic shock, for would healing and as an adjuvant for vaccines.
摘要翻译：本发明提供了脂肽共轭物，其中被脂肪酸双取代的半胱氨酸通过羧基键合到高度可溶的，生理上相容的和非免疫原性的聚合共轭基团。缀合物表现出优异的巨噬细胞兴奋剂作用，不需要添加溶解。它们可用于广泛的应用，特别是用于刺激巨噬细胞，用于刺激抗体合成，抗感染，免疫刺激剂，特别是与肿瘤相关，用于预防和治疗败血性休克，用于治愈和作为疫苗佐剂。

4. 发明申请

US20060134061A1 Bisacyloxypropylcysteine conjugates and the use thereof 有权
标题翻译：双丙酰氧基丙基半胱氨酸共轭物及其用途
公开(公告)号：US20060134061A1
公开(公告)日：2006-06-22
申请号：US10521013
申请日：2003-07-18
申请人： Peter Muhlradt , Michael Morr
发明人： Peter Muhlradt , Michael Morr
IPC分类号： A61K38/17 , A61K31/737 , A61K38/16 , C07K14/47
CPC分类号： A61K47/60
摘要： The invention relates to novel lipopeptide conjugates, in which a cysteine that is double-substituted by a fatty acid is bonded by means of the carboxyl group to a highly soluble, physiologically compatible and non-immunogenic, polymeric conjugate group. The novel conjugates exhibit an excellent macrophage stimulant action and do not require additional solutizing. They can be used in a wide range of applications, in particular for stimulating macrophages, for stimulating antibody synthesis, for combating infection, as an immunostimulant, in particular in relation to tumours, for preventing and treating septicaemic shock, for wound healing and as an adjuvant for vaccines.
摘要翻译：本发明涉及新的脂肽缀合物，其中由脂肪酸双取代的半胱氨酸通过羧基键合到高度可溶的，生理上相容的和非免疫原性的聚合共轭基团。新型缀合物表现出优异的巨噬细胞兴奋剂作用，不需要额外的溶解。它们可用于广泛的应用，特别是用于刺激巨噬细胞，用于刺激抗体合成，抵抗感染，作为免疫刺激剂，特别是与肿瘤相关，用于预防和治疗败血性休克，用于伤口愈合和作为疫苗佐剂。

5. 发明申请

US20160256542A1 Use of a Lipopeptide or Lipoprotein as an Adjuvant in Therapeutic or Prophylactic Vaccinations 审中-公开
标题翻译：在治疗或预防接种中使用脂肽或脂蛋白作为佐剂
公开(公告)号：US20160256542A1
公开(公告)日：2016-09-08
申请号：US13848936
申请日：2013-03-22
申请人： Carlos Alberto Guzman , Peter Muhlradt
发明人： Carlos Alberto Guzman , Peter Muhlradt
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K2039/541 , A61K2039/55516
摘要： Disclosed is the use of lipopeptides and lipoproteins as mucosal adjuvants for various vaccinations via mucous membranes, particularly intranasally. Said lipopeptides represent peptides or proteins substituted with 2,3-diacyloxy(2R)-propyl at the amino-terminal cystein of a peptide or protein, preferably S-(2,3-bis-palmitoyloxy-(2R)-propyl)cysteinyl peptides derived from mycoplasmas. Said peptides are highly effective even in small doses, produce good immunization results, and increase the IgA level, among others.
摘要翻译：公开了使用脂肽和脂蛋白作为粘膜佐剂，用于通过粘膜，特别是鼻内的各种疫苗接种。所述脂肽代表在肽或蛋白质的氨基末端半胱氨酸上优选用2,3-二酰氧基（2R） - 丙基取代的肽或蛋白质，优选S-（2,3-双 - 棕榈酰氧基 - （2R） - 丙基）半胱氨酰肽源自支原体所述肽即使在小剂量下也是非常有效的，产生良好的免疫结果，并且增加IgA水平等。

6. 发明申请

US20070203185A1 Therapeutical Composition Containing Dentritic Cells And Use Thereof 审中-公开
标题翻译：含有牙粉质细胞的治疗组合及其用途
公开(公告)号：US20070203185A1
公开(公告)日：2007-08-30
申请号：US10559375
申请日：2004-06-03
申请人： Peter Muhlradt , Armin Braun , Norbert Krug , Henning Weigt
发明人： Peter Muhlradt , Armin Braun , Norbert Krug , Henning Weigt
IPC分类号： A61K31/445
CPC分类号： C12N5/0639 , A61K35/15 , A61K35/17 , A61K39/0003 , A61K2039/5158 , C12N5/064 , C12N2501/24 , A61K2300/00
摘要： The present invention relates to a method for the preparation of a therapeutical composition, in particular, the present invention relates to a method for treating dendritic cells with a combination of at least one interferon gamma receptor agonist and at least one toll like receptor 2 and/or TLR 6 agonist and using these pretreated dendritic cells for the preparation of a therapeutical composition. Moreover, the present invention relates to a therapeutical composition containing dendritic cells and the use thereof for the treatment of various diseases and disorders.
摘要翻译：本发明涉及一种治疗组合物的制备方法，特别是本发明涉及用至少一种干扰素γ受体激动剂和至少一种通道类似受体2的组合治疗树突细胞的方法和/ 或TLR 6激动剂，并使用这些预处理的树突状细胞制备治疗组合物。此外，本发明涉及含有树突状细胞的治疗组合物及其用于治疗各种疾病和病症的用途。

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