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1. 发明授权

US06210937B1 Development of genetically engineered bacteria for production of selected aromatic compounds 失效
标题翻译：开发用于生产选择的芳族化合物的转基因细菌
公开(公告)号：US06210937B1
公开(公告)日：2001-04-03
申请号：US09064693
申请日：1998-04-22
申请人： Thomas E. Ward , Carolyn S. Watkins , Deborah K. Bulmer , Bruce F. Johnson , Mohan Amaratunga
发明人： Thomas E. Ward , Carolyn S. Watkins , Deborah K. Bulmer , Bruce F. Johnson , Mohan Amaratunga
IPC分类号： C12P742
CPC分类号： C12P7/42 , C12N15/52
摘要： The cloning and expression of genes in the common aromatic pathway of E. coli are described. A compound for which chorismate, the final product of the common aromatic pathway, is an anabolic intermediate can be produced by cloning and expressing selected genes of the common aromatic pathway and the genes coding for enzymes necessary to convert chorismate to the selected compound. Plasmids carrying selected genes of the common aromatic pathway are also described.
摘要翻译：描述了大肠杆菌共同芳香途径中基因的克隆和表达。可以通过克隆和表达常见芳香途径的选定基因和编码将选择性化合物转化佐丹酸所必需的酶的基因来制备共振芳香途径的最终产物是合成代谢中间体的化合物。还描述了携带选定的共同芳香途径基因的质粒。

2. 发明授权

US6114157A Method for increasing total production of 4-hydroxybenzoic acid by biofermentation 失效
标题翻译：通过生物发酵增加4-羟基苯甲酸的总产量的方法
公开(公告)号：US6114157A
公开(公告)日：2000-09-05
申请号：US161129
申请日：1998-09-25
申请人： Bruce Fletcher Johnson , Mohan Amaratunga , John Henry Lobos
发明人： Bruce Fletcher Johnson , Mohan Amaratunga , John Henry Lobos
IPC分类号： C12P7/42 , C12N1/20
CPC分类号： C12P7/42 , Y10S435/849
摘要： This invention pertains to a method of production of 4-hydroxybenzoic acid, with purification and recovery of 4-hydroxybenzoic acid directly from the fermentation medium of a cultured organism, in the presence of other chemical species. Ion exchange resin is used during the fermentation process to recover the chemical product without the necessity of separating the biomass from the fermentation supernatant by filtration after fermentation is complete and then treating the filtrate to recover the product. This reduces or eliminates the need for filtration steps and eliminates the need for energy-intensive water removal processes. Furthermore, the removal of the product during the fermentation dramatically increases the production of the product during the fermentation process. This method therefore can both increase the amount of product produced in a single fermentation run and reduce the per unit cost of its biocatalytic production.
摘要翻译：本发明涉及一种生产4-羟基苯甲酸的方法，在其它化学物质存在下，直接从培养的生物体的发酵培养基中纯化和回收4-羟基苯甲酸。在发酵过程中使用离子交换树脂来回收化学产品，而不需要在发酵完成后通过过滤从发酵上清液分离生物质，然后处理滤液以回收产物。这减少或消除了对过滤步骤的需要，并且消除了对能量密集型除水过程的需要。此外，在发酵期间除去产物显着增加了发酵过程中产物的产生。因此，该方法可以增加在单次发酵运行中产生的产物的量并降低其生物催化生产的单位成本。

3. 发明申请

US20060140869A1 Polymeric contrast agents for use in medical imaging 审中-公开
标题翻译：用于医学成像的聚合物造影剂
公开(公告)号：US20060140869A1
公开(公告)日：2006-06-29
申请号：US11022984
申请日：2004-12-23
申请人： Egidijus Uzgiris , Mohan Amaratunga , Brian Grimmond , Daniel Meyer , Joanne Smith
发明人： Egidijus Uzgiris , Mohan Amaratunga , Brian Grimmond , Daniel Meyer , Joanne Smith
IPC分类号： A61K49/14
CPC分类号： A61K49/085 , A61K49/146
摘要： A contrast agent comprising a polypeptide is provided. The polypeptide contains lysine residues and optionally, one or more types of amino acid residues selected from the group consisting of glutamic acid residues and aspartic acid residues, wherein the lysine residues are substituted with a group derived from a steric hindrance molecule; and an image producing entity is present in a range between about 100 units and about 2000 units. Methods for administering the aforementioned contrast agent are also provided.
摘要翻译：提供了包含多肽的造影剂。多肽含有赖氨酸残基和任选的一种或多种选自谷氨酸残基和天冬氨酸残基的氨基酸残基，其中赖氨酸残基被衍生自空间位阻分子的基团取代; 并且图像产生实体存在于大约100单位和大约2000单位之间的范围内。还提供了施用前述造影剂的方法。

4. 发明授权

US6030819A Genetically engineered microorganisms and method for producing 4-hydroxybenzoic acid 失效
标题翻译：遗传工程微生物和生产4-羟基苯甲酸的方法
公开(公告)号：US6030819A
公开(公告)日：2000-02-29
申请号：US161364
申请日：1998-09-28
申请人： Mohan Amaratunga , John Henry Lobos , Bruce Fletcher Johnson , Eric Douglas Williams
发明人： Mohan Amaratunga , John Henry Lobos , Bruce Fletcher Johnson , Eric Douglas Williams
IPC分类号： C12N9/88 , C12P7/42 , C12P7/00 , C12P7/02 , C12P7/22 , C12P7/40
CPC分类号： C12N9/88 , C12P7/42 , Y10S435/849
摘要： The present invention pertains to a method for economical biofermentative production of 4-hydroxybenzoic acid (PHB) using genetically engineered E. coli. According to the invention, a plasmid is provided which controls the overexpression of chorismate pyruvate lyase, the bacterial enzyme which catalyzes the production of PHB from chorismate. Mutant E. coli selected with a unique two-step screening assay to overproduce chorismate have been transformed with this plasmid, providing a biocatalyst that efficiently converts glucose to PHB.
摘要翻译：本发明涉及使用遗传工程改造的大肠杆菌经济生物发酵生产4-羟基苯甲酸（PHB）的方法。根据本发明，提供了控制佐剂酸丙酮酸裂解酶的过度表达的质粒，其是催化从酸性磷酸盐生产PHB的细菌酶。用该质粒转化了用独特的两步筛选分析方法筛选突变型大肠杆菌以过度产生酸碱，提供了有效地将葡萄糖转化为PHB的生物催化剂。

5. 发明申请

US20050260131A1 Pharmaceuticals for enhanced delivery to disease targets 审中-公开
标题翻译：用于增强输送到疾病目标的药物
公开(公告)号：US20050260131A1
公开(公告)日：2005-11-24
申请号：US10851359
申请日：2004-05-20
申请人： Mohan Amaratunga , Bahram Moasser , Faisal Syud , John Brogan , Daniel Kramer
发明人： Mohan Amaratunga , Bahram Moasser , Faisal Syud , John Brogan , Daniel Kramer
IPC分类号： C07H21/00 , C07K14/00 , A61K51/00 , A61K48/00 , A61K49/00 , C07K14/52 , C07K16/46
CPC分类号： C07H21/00
摘要： Pharmaceuticals for enhanced delivery to a disease target comprises a pair of compounds. The first compound comprises a first oligopeptide conjugated to a first moiety for coupling with a diagnostic or therapeutic active agent. The second compound comprises a second oligopeptide conjugated to a targeting species having a targeting moiety capable of binding to a target. The second oligopeptide has a sequence that is complementary to a sequence of the first oligopeptide. The first and second oligopeptides can be complementary PNA sequences. The pharmaceuticals are administered into a subject in methods for diagnosing or treating a disease condition, or assessing the effectiveness of a treatment of the disease condition.
摘要翻译：用于增强递送至疾病靶标的药物包含一对化合物。第一化合物包含与第一部分缀合的第一寡肽，用于与诊断或治疗活性剂偶联。第二化合物包含与具有能与靶标结合的靶向部分的靶向物质缀合的第二寡肽。第二寡肽具有与第一寡肽的序列互补的序列。第一和第二寡肽可以是互补的PNA序列。药物在用于诊断或治疗疾病状况的方法或评估治疗疾病状况的有效性的方法中施用于受试者。

6. 发明授权

US6143858A Polyestercarbonate comprising residues of branched diacids 失效
标题翻译：包含支链二酸残基的聚酯碳酸酯
公开(公告)号：US6143858A
公开(公告)日：2000-11-07
申请号：US363222
申请日：1999-07-30
申请人： David Paul Mobley , Mohan Amaratunga , Gary Charles Davis , Peter David Phelps
发明人： David Paul Mobley , Mohan Amaratunga , Gary Charles Davis , Peter David Phelps
IPC分类号： C08J5/00 , C08G63/64 , C08G63/02
CPC分类号： C08G63/64
摘要： This invention relates to polyestercarbonates comprising residues of at least one branched aliphatic dicarboxylic acid, and methods for preparation of polyestercarbonates comprising residues of at least one branched aliphatic dicarboxylic acid. This invention further relates to articles and methods of making articles from the polyestercarbonates.
摘要翻译：本发明涉及包含至少一种支链脂族二羧酸残基的聚酯碳酸酯，以及包含至少一种支链脂族二羧酸残基的聚酯碳酸酯的制备方法。本发明还涉及从聚酯碳酸酯制造制品的制品和方法。

7. 发明申请

US20050271585A1 Extended conjugated polymers 审中-公开
标题翻译：扩展共轭聚合物
公开(公告)号：US20050271585A1
公开(公告)日：2005-12-08
申请号：US10861879
申请日：2004-06-07
申请人： Egidijus Uzgiris , Mohan Amaratunga
发明人： Egidijus Uzgiris , Mohan Amaratunga
IPC分类号： A61K49/00 , A61K51/00 , A61K51/06
CPC分类号： A61K49/0002 , A61K51/065
摘要： A polymer is conjugated to a plurality of molecules having at least a functionality and further comprises an active agent, such as a diagnostic agent or a therapeutic agent. The diagnostic agent is capable of generating a signal detectable by a medical imaging technique. The conjugated polymer has an extended conformation and provides enhanced contrast of images of diseased tissues or enhanced delivery of therapeutic agents to these tissues.
摘要翻译：聚合物与至少具有官能团的多个分子缀合，并且还包含活性剂，例如诊断剂或治疗剂。诊断剂能够产生可由医学成像技术检测的信号。共轭聚合物具有延伸的构象，并且提供患病组织的图像的增强的对比度或增强了对这些组织的治疗剂的递送。

8. 发明申请

US20050036947A1 Target-specific activatable polymeric imaging agents 审中-公开
标题翻译：靶向特异性可激活聚合成像剂
公开(公告)号：US20050036947A1
公开(公告)日：2005-02-17
申请号：US10638888
申请日：2003-08-12
申请人： Egidijus Uzgiris , Mohan Amaratunga
发明人： Egidijus Uzgiris , Mohan Amaratunga
IPC分类号： A61K49/10 , A61K49/00
CPC分类号： A61K49/085 , A61K49/0056 , A61K49/14 , A61K49/146
摘要： A target-specific image-enhancing agent for medical imaging comprises an extended poly(amino acid), wherein at least 90 percent of the amino acid residues are conjugated to signal-generating moieties attached to signal-controlling moieties via bonds that are cleavable by a physiological substance produced by the target. The image-enhancing agent becomes activated when the bonds is cleaved by the physiological substance. The image-enhancing agent is used in detecting and/or diagnosing a disease that is characterized by an overproduction of the substance.
摘要翻译：用于医学成像的靶特异性图像增强剂包括延伸的聚（氨基酸），其中至少90％的氨基酸残基通过可以被一个或多个氨基酸可切割的键经由键连接到与信号控制部分连接的信号产生部分上目标产生的生理物质。当键被生理物质切割时，图像增强剂变得活化。图像增强剂用于检测和/或诊断以物质过量产生为特征的疾病。

9. 发明申请

US20070238088A1 Hydrophilic functionalized colloidal silica compositions, methods of making, and uses therefor 审中-公开
标题翻译：亲水官能化胶体二氧化硅组合物，制备方法和用途
公开(公告)号：US20070238088A1
公开(公告)日：2007-10-11
申请号：US11392133
申请日：2006-03-29
申请人： Slawomir Rubinsztajn , David Demoulpied , Omayra de Jesus , Gregory Goddard , James Van Alstine , Jan Larsson , Mohan Amaratunga , Nicolas Thevenin
发明人： Slawomir Rubinsztajn , David Demoulpied , Omayra de Jesus , Gregory Goddard , James Van Alstine , Jan Larsson , Mohan Amaratunga , Nicolas Thevenin
IPC分类号： C12N5/08 , C12Q1/00 , C04B14/04
CPC分类号： C09C1/3081 , B01D2221/10 , B01J13/003 , B01J13/0034 , B01J13/0047 , B82Y30/00 , C01P2004/62 , C01P2004/64
摘要： Disclosed are hydrophilic functionalized silica compositions that are stable and do not show significant pH increases upon heat sterilization. Also provided are methods to make hydrophilic functionalized silica compositions by reacting acidic silica particles with hydrophilic organosilanes. Further provided are methods of separating components in a mixture using hydrophilic functionalized silica compositions.
摘要翻译：公开了稳定的并且在加热灭菌时不显示显着的pH增加的亲水性官能化二氧化硅组合物。还提供了通过使酸性二氧化硅颗粒与亲水性有机硅烷反应来制备亲水性官能化二氧化硅组合物的方法。还提供了使用亲水性官能化二氧化硅组合物分离混合物中的组分的方法。

10. 发明申请

US20070140967A1 Agents and methods for analyzing protein interactions 审中-公开
标题翻译：用于分析蛋白质相互作用的试剂和方法
公开(公告)号：US20070140967A1
公开(公告)日：2007-06-21
申请号：US11305970
申请日：2005-12-19
申请人： Nichole Wood , Mohan Amaratunga , Hans Grade , Faisal Syud , Anup Sood , Reginald Smith , Ayse Dinc , Amy Williams , Anthony Murray , Gregory Goddard
发明人： Nichole Wood , Mohan Amaratunga , Hans Grade , Faisal Syud , Anup Sood , Reginald Smith , Ayse Dinc , Amy Williams , Anthony Murray , Gregory Goddard
IPC分类号： A61K51/00
CPC分类号： G01N33/6845 , G01N33/6848
摘要： Agents and methods for qualitative and quantitative analysis a protein complex or protein complexes using isotope-labeled symmetrical bifunctional crosslinkers and mass spectrometry are provided. Targeting moieties, cell permeability moieties, or affinity moieties, may be appended to the bifunctional crosslinkers. The isotope-labeled symmetrical bifunctional crosslinkers may be used in a kit or as a library.
摘要翻译：提供了使用同位素标记的对称双功能交联剂和质谱定性和定量分析蛋白质复合物或蛋白质复合物的试剂和方法。靶向部分，细胞渗透性部分或亲和部分可附加到双功能交联剂上。同位素标记的对称双功能交联剂可用于试剂盒或文库。

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