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1. 发明授权

US06846283B2 Methods and apparatus for loading radioactive seeds into brachytherapy needles 失效
公开(公告)号：US06846283B2
公开(公告)日：2005-01-25
申请号：US10134098
申请日：2002-04-25
申请人： Thomas C. Green , Ryan P. Boucher , Yuri Belman
发明人： Thomas C. Green , Ryan P. Boucher , Yuri Belman
IPC分类号： A61M5/32 , A61M36/04 , A61M36/12 , A61N5/10 , A61N5/00
CPC分类号： A61M37/0069 , A61M5/329 , A61M2210/166 , A61N5/1007 , A61N5/1027 , A61N2005/1009 , A61N2005/101 , A61N2005/1011
摘要： Methods and apparatus are provided for loading therapeutic materials into brachytherapy needles. The apparatus comprises an apparatus with chambers, and radioactive seed and spacer cartridges received therein. The apparatus may be used in conjunction with a standard brachytherapy needle coupled to the distal end of the apparatus. The plunger dislodges seeds and spacers from the cartridge chambers to load the needle with a predetermined packing arrangement.

2. 发明授权

US06695787B2 Prostate visualization device and methods of use 失效
标题翻译：前列腺可视化装置及使用方法
公开(公告)号：US06695787B2
公开(公告)日：2004-02-24
申请号：US10160341
申请日：2002-05-31
申请人： Michael Hogendijk , Thomas C. Green , Isidro M. Gandionco , Ryan P. Boucher , Yuri Belman
发明人： Michael Hogendijk , Thomas C. Green , Isidro M. Gandionco , Ryan P. Boucher , Yuri Belman
IPC分类号： A61B814
CPC分类号： A61B8/0841 , A61B8/0833 , A61B8/12 , A61B8/481 , A61M25/1002 , A61M25/1011 , A61M2210/1085 , A61N5/1001 , A61N5/1014 , A61N2005/1011
摘要： Methods and apparatus are provided for improved administration of brachytherapy in the treatment of prostate disease. More particularly, a prostate visualization device is provided comprising a catheter coupled to at least one deployable member at the distal end of the catheter. The deployable member is preferably manufactured from a shape memory alloy having a petal-shaped configuration suitable for engaging and defining the proximal region of a patient's bladder. The deployable member may comprise tubing filled with air or other radiopaque agents to facilitate ultrasonic imaging of the deployable members near the bladder/prostate junction.
摘要翻译：为治疗前列腺疾病提供近距离放射治疗的方法和装置。更具体地，提供了前列腺可视化装置，其包括在导管的远端处联接到至少一个可展开构件的导管。可展开构件优选地由具有适于接合和限定患者膀胱近端区域的花瓣状构型的形状记忆合金制成。可部署构件可以包括填充有空气或其它不透射线剂的管道，以促进膀胱/前列腺结合附近的可部署构件的超声成像。

3. 发明授权

US06709380B2 Brachytherapy needle with impedance measurement apparatus and methods of use 失效
公开(公告)号：US06709380B2
公开(公告)日：2004-03-23
申请号：US09873666
申请日：2001-05-31
申请人： Thomas C. Green , Michael Hogendijk , Keith Seiler , Larry DeSoto , Edo Ziring
发明人： Thomas C. Green , Michael Hogendijk , Keith Seiler , Larry DeSoto , Edo Ziring
IPC分类号： A61B505
CPC分类号： A61N5/1007 , A61N5/1027 , A61N2005/1011
摘要： Apparatus and methods for depositing radioactive seeds into a patient's prostate are provided that include impedance measuring circuitry for detecting whether the distal end of an elongated needle extends into a patient's bladder. The elongated needle includes two conductive traces and a lumen adapted to receive a column of radioactive seeds and spacers. The impedance measuring circuitry is coupled to the conductive traces of the elongated needle and provides a display indicative of the monitored impedance.

4. 发明授权

US06398711B1 Pivoting needle template apparatus for brachytherapy treatment of prostate disease and methods of use 失效
标题翻译：用于前列腺疾病的近距离放射治疗的旋转针模板装置和使用方法
公开(公告)号：US06398711B1
公开(公告)日：2002-06-04
申请号：US09648091
申请日：2000-08-25
申请人： Thomas C. Green , Michael J. Horzewski
发明人： Thomas C. Green , Michael J. Horzewski
IPC分类号： A61M3600
CPC分类号： A61N5/1007 , A61B2017/3411 , A61M5/427 , A61M25/01 , A61M2210/166 , A61N5/1027 , A61N2005/1012
摘要： Methods and apparatus are provided for improved brachytherapy treatment of prostate disease. The apparatus comprises a needle template mount for use with standard brachytherapy apparatus. The mount provides for angular reorientation of a needle template with respect to an ultrasound probe during brachytherapy administration. Angular reorientation is expected to beneficially overcome anatomical constraints, such as skeletal structures, that may limit a medical practitioner's ability to deliver radioactive brachytherapy seeds into a prostate in proper alignment. The mount comprises an arc slot in which the template may translate to achieve angular reorientation. A guide tube is also provided to ensure straight advancement of brachytherapy needles.
摘要翻译：提供了用于改善前列腺疾病近距离放射治疗的方法和装置。该装置包括用于与标准近距离放射治疗装置一起使用的针模座。在近距离放射治疗期间，该安装件提供针模板相对于超声探头的角度重新定向。预计角度重新定向将有利地克服诸如骨骼结构之类的解剖学限制，这可能限制医师将放射性近距离放射治疗种子递送到前列腺中以适当对准的能力。安装座包括弧槽，模板可以在其中平移以实现角度重定向。还提供导管以确保近距离放射治疗针的直线前进。

5. 发明授权

US06358195B1 Method and apparatus for loading radioactive seeds into brachytherapy needles 失效
标题翻译：将放射性种子装入近距离放射治疗针的方法和装置
公开(公告)号：US06358195B1
公开(公告)日：2002-03-19
申请号：US09522248
申请日：2000-03-09
申请人： Thomas C. Green , Michael J. Horzewski , Jason Klofstad
发明人： Thomas C. Green , Michael J. Horzewski , Jason Klofstad
IPC分类号： A61M3600
CPC分类号： A61M37/0069 , A61M5/329 , A61M2210/166 , A61N5/1007 , A61N5/1027 , A61N2005/1009 , A61N2005/101 , A61N2005/1011
摘要： Methods and apparatus are provided for loading therapeutic materials into brachytherapy needles. The apparatus comprises a loading tube with a lumen and two transverse slots, and radioactive seed and spacer cartridges slidably received within the transverse slots. The apparatus may be used in conjunction with a standard brachytherapy plunger and needle coupled to, respectively, the proximal and distal ends of the loading tube. The plunger dislodges seeds and spacers from the cartridge chambers to load the needle with a predetermined packing arrangement.
摘要翻译：提供了将治疗材料装入近距离放射治疗针的方法和装置。该装置包括具有内腔和两个横向槽的加载管，以及可滑动地容纳在横向狭槽内的放射性种子和间隔盒。该装置可以与标准近距离放射治疗柱塞和针头一起使用，所述针头和针分别联接到装载管的近端和远端。柱塞从盒室移除种子和间隔物，以预定的包装装置装载针头。

6. 发明授权

US07101333B2 Methods and apparatus for loading radioactive seeds into brachytherapy needles 失效
公开(公告)号：US07101333B2
公开(公告)日：2006-09-05
申请号：US10693598
申请日：2003-10-23
申请人： Thomas C. Green , Michael J. Horzewski , Jason Klofstad
发明人： Thomas C. Green , Michael J. Horzewski , Jason Klofstad
IPC分类号： A61M36/00 , A61M5/00
CPC分类号： A61M37/0069 , A61M5/329 , A61M2210/166 , A61N5/1007 , A61N5/1027 , A61N2005/1009 , A61N2005/101 , A61N2005/1011
摘要： Methods and apparatus are provided for loading therapeutic materials into brachytherapy needles. The apparatus comprises a loading tube with a lumen and two transverse slots, and radioactive seed and spacer cartridges slidably received within the transverse slots. The apparatus may be used in conjunction with a standard brachytherapy plunger and needle coupled to, respectively, the proximal and distal ends of the loading tube. The plunger dislodges seeds and spacers from the cartridge chambers to load the needle with a predetermined packing arrangement.

7. 发明授权

US06361487B1 Method and apparatus for brachytherapy treatment of prostate disease 失效
标题翻译：近距离放射治疗前列腺疾病的方法和装置
公开(公告)号：US06361487B1
公开(公告)日：2002-03-26
申请号：US09522282
申请日：2000-03-09
申请人： Thomas C. Green , Michael J. Horzewski
发明人： Thomas C. Green , Michael J. Horzewski
IPC分类号： A61M3600
CPC分类号： A61N5/1027 , A61M25/0105 , A61M2210/166 , A61N5/1007 , A61N2005/1011
摘要： Methods and apparatus are provided for brachytherapy treatment of prostate disease. The apparatus comprises a housing, a plunger, a needle, and a lock. The plunger is rigidly affixed to the housing. The lock selectively restricts motion of the needle relative to the plunger. The needle comprises a screw thread that engages the housing or plunger. Rotation of the needle with respect to the housing/plunger causes distal advancement or proximal retraction of the needle with respect to the plunger, providing improved control over delivery of radioactive seeds to a diseased portion of a prostate.
摘要翻译：为前列腺疾病的近距离放射治疗提供方法和装置。该装置包括壳体，柱塞，针和锁。柱塞刚性地固定在壳体上。该锁选择性地限制针相对于柱塞的运动。该针包括接合外壳或柱塞的螺纹。针相对于壳体/柱塞的旋转导致针相对于柱塞的远端前进或近端缩回，提供对放射性种子对前列腺的疾病部分的输送的改进的控制。

8. 发明授权

US06422997B1 Prostate visualization device and methods of use 失效
标题翻译：前列腺可视化装置及使用方法
公开(公告)号：US06422997B1
公开(公告)日：2002-07-23
申请号：US09648319
申请日：2000-08-25
申请人： Thomas C. Green , Michael J. Horzewski
发明人： Thomas C. Green , Michael J. Horzewski
IPC分类号： A61B132
CPC分类号： A61N5/1001 , A61M25/0075 , A61M25/1002 , A61M25/1011 , A61M2210/1085 , A61N5/1014 , A61N2005/1011
摘要： Methods and apparatus are provided for improved administration of brachytherapy in the treatment of prostate disease. More particularly, a prostate visualization device is provided comprising a disk-shaped bladder neck balloon that sealing engages and defines an enclosed space within a proximal region of a patient's bladder. The device is preferably coupled to a catheter for injection of echo-contrast agent into the enclosed space to facilitate imaging of the patient's bladder/prostate junction with an ultrasound system. The device may alternatively be radiopaque. Apparatus for selectively stiffening the catheter is also provided.
摘要翻译：为治疗前列腺疾病提供近距离放射治疗的方法和装置。更具体地，提供了前列腺可视化装置，其包括盘形膀胱颈部气囊，其密封地接合并限定了患者膀胱近端区域内的封闭空间。该装置优选地连接到用于将回声造影剂注射到封闭空间中的导管，以便于利用超声系统对患者膀胱/前列腺结的成像。该装置可以替代地不透射线。还提供了用于选择性加强导管的装置。

9. 发明授权

US06558309B2 Methods and apparatus for brachytherapy treatment of prostate disease 失效
标题翻译：近距离放射治疗前列腺疾病的方法和装置
公开(公告)号：US06558309B2
公开(公告)日：2003-05-06
申请号：US09802335
申请日：2001-03-09
申请人： Michael Hogendijk , Thomas C. Green
发明人： Michael Hogendijk , Thomas C. Green
IPC分类号： A61M3600
CPC分类号： A61N5/1027 , A61M25/0105 , A61M2210/166 , A61N5/1007 , A61N2005/1011
摘要： Methods and apparatus are provided for brachytherapy treatment of prostate disease for use in conjunction with needles containing a plurality of radioactive seeds. The apparatus comprises a housing and plunger assembly operable by a single clinician. The plunger is coupled to the housing, so that when the apparatus is actuated the needle is retracted against the plunger and the plurality of radioactive seeds is ejected.
摘要翻译：提供了用于与包含多个放射性种子的针头结合使用的前列腺疾病的近距离放射治疗方法和装置。该装置包括由单个临床医师操作的壳体和柱塞组件。柱塞联接到壳体，使得当该装置被致动时，针被靠在柱塞上缩回并且多个放射性种子被弹出。

10. 发明授权

US6111888A Deterministic serial bus communication system 失效
标题翻译：确定性串行总线通信系统
公开(公告)号：US6111888A
公开(公告)日：2000-08-29
申请号：US863531
申请日：1997-05-27
申请人： Thomas C. Green , Paul J. Hays , Allan L. Samson , Jeffrey S. Walker , Michael J. Zolock
发明人： Thomas C. Green , Paul J. Hays , Allan L. Samson , Jeffrey S. Walker , Michael J. Zolock
IPC分类号： H04L12/413 , H04L12/417 , H04L12/64 , H04L12/43
CPC分类号： H04L12/40026 , H04J3/0652 , H04L12/4035 , H04L12/4135 , H04L12/417 , H04L12/4015 , H04L12/64 , H04L2012/40215 , H04L7/08
摘要： An apparatus and method for deterministically communicating data between multiple nodes in a fashion that is consistent with the Controller Area Network ("CAN") communications protocol. The system applies to multiple nodes that functional blocks within an operating system environment and to multiple nodes that are each connected to a serial bus. The system utilizes standard CAN error checking, bus arbitration and message formatting and therefore uses standard CAN controllers and transceivers. One node on the bus is selected as the master node. The master node issues a periodic synchronization signal which defines time divisions within which the operations of each node and communications over the CAN bus are organized. Data, particularly real-time data, is transmitted between nodes on the CAN bus during a known time division. Standard CAN bus arbitration is used to ensure that real-time data is transmitted over the CAN bus prior to the transmission of non-real-time data. This ensures that real-time data is, if appropriate, transmitted during each time division.
摘要翻译：一种用于以与控制器局域网（“CAN”）通信协议一致的方式确定性地在多个节点之间传送数据的装置和方法。该系统将多个节点应用于操作系统环境中的功能块和各个连接到串行总线的多个节点。该系统采用标准CAN错误检查，总线仲裁和消息格式化，因此使用标准CAN控制器和收发器。总线上的一个节点被选为主节点。主节点发出周期性同步信号，其定义了每个节点的操作和通过CAN总线通信的时间分割。数据，特别是实时数据，在已知的分时间内，在CAN总线上的节点之间传输。标准CAN总线仲裁用于确保在传输非实时数据之前通过CAN总线传输实时数据。这确保了实时数据在适当的时候在每个时间划分期间传输。

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