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1. 发明授权

US5158957A 2-substituted ergolines 失效
标题翻译： 2-取代的麦角碱
公开(公告)号：US5158957A
公开(公告)日：1992-10-27
申请号：US720996
申请日：1991-06-26
申请人： Thomas Brumby , Gerhard Sauer , Josef Heindl , Jonathan Turner , Gerhard Kuhne , Helmut Wachtel
发明人： Thomas Brumby , Gerhard Sauer , Josef Heindl , Jonathan Turner , Gerhard Kuhne , Helmut Wachtel
IPC分类号： A61K31/48 , A61P25/00 , A61P43/00 , C07D457/12
CPC分类号： C07D457/12
摘要： 2-Substituted ergolines ##STR1## wherein C.sub.2 C.sub.3 and C.sub.9 C.sub.10 represent a single of double bond;X is oxygen or sulfur;R.sup.2 is C.sub.1-10 alkyl, optionally halogen-substituted C.sub.2-10 alkenyl, CH.sub.2 YR.sup.3, CR.sup.12 (OR.sup.4)R.sup.5, CH.sub.2 --CHR.sup.9 --COR.sup.10 or COR.sup.12, whereinY is oxygen or sulfur,R.sup.3 is hydrogen, C.sub.1-4 alkyl, phenyl, C.sub.2-5 acyl or phenyl C.sub.1-4 alkyl,R.sup.4 is hydrogen or C.sub.2-5 acyl,R.sup.5 is C.sub.1-9 alkyl,R.sup.9 is COCH.sub.3 or COO-C.sub.1-4 alkyl,R.sup.10 is C.sub.1-4 alkyl or O-C.sub.1-4 alkyl,R.sup.12 is hydrogen or C.sub.1-9 alkyl; andR.sup.6 is C.sub.2-10 alkyl, C.sub.3-10 alkenyl or C.sub.4-10 cycloalkyl-C.sub.1-3 -alkyl,and acid addition salts, isomers and isomeric mixtures thereof are dopaminergic agonists and useful for treating Parkinson's Disease.
摘要翻译： 2-取代的ergolines 其中C2 C3和C9 C10表示单键的双键; X是氧或硫; R 2是C 1-10烷基，任选被卤素取代的C 2-10烯基，CH 2 YR 3，CR 12（OR 4）R 5，CH 2 -CHR 9 -CON 10或COR 12，其中Y是氧或硫，R 3是氢，C 1-4烷基，苯基， C2-5酰基或苯基C1-4烷基，R4是氢或C2-5酰基，R5是C1-9烷基，R9是COCH3或COO-C1-4烷基，R10是C1-4烷基或O-C1-4 烷基，R 12是氢或C 1-19烷基; 并且R 6是C 2-10烷基，C 3-10烯基或C 4-10环烷基-C 1-3烷基，其酸加成盐，异构体和异构体混合物是多巴胺能激动剂，可用于治疗帕金森病。

2. 发明授权

US5037832A 2-substituted ergolines 失效
标题翻译： 2-取代的麦角碱
公开(公告)号：US5037832A
公开(公告)日：1991-08-06
申请号：US380352
申请日：1989-07-17
申请人： Thomas Brumby , Gerhard Sauer , Josef Heindl , Jonathan Turner , Gerhard Kuhne , Helmut Wachtel
发明人： Thomas Brumby , Gerhard Sauer , Josef Heindl , Jonathan Turner , Gerhard Kuhne , Helmut Wachtel
IPC分类号： A61K31/48 , A61P25/00 , A61P43/00 , C07D457/12
CPC分类号： C07D457/12
摘要： 2-Substituted ergolines ##STR1## wherein C.sub.2 C.sub.3 and C.sub.9 C.sub.10 represent a single or double bond;X is oxygen or sulfur;R.sup.2 is C.sub.1-10 alkyl, optionally halogen-substituted C.sub.2-10 alkenyl, CH.sub.2 YR.sup.3, CR.sup.12 (OR.sup.4)R.sup.5, CH.sub.2 -CHR.sup.9 -COR.sup.10 or COR.sup.12, whereinY is oxygen or sulfur,R.sup.3 is hydrogen, C.sub.1-4 alkyl, phenyl, C.sub.2-5 acyl or phenyl C.sub.1-4 alkyl,R.sup.4 is hydrogen or C.sub.2-5 acyl,R.sup.5 is C.sub.1-9 alkyl,R.sup.9 is COCH.sub.3 or COO-C.sub.1-4 alkyl,R.sup.10 is C.sub.1-4 alkyl or O-C.sub.1-4 alkyl,R.sup.12 is hydrogen or C.sub.1-9 alkyl; andR.sup.6 is C.sub.2-10 alkyl, C.sub.3-10 alkenyl or C.sub.4-10 cycloalkyl-C.sub.1-3 -alkyl,and acid addition salts, isomers and isomeric mixtures thereof are dopaminergic agonists and useful for treating Parkinson's Disease.
摘要翻译： 2-取代的麦角糖苷其中C2 C3和C9 C10表示单键或双键; X是氧或硫; R 2是C 1-10烷基，任选被卤素取代的C 2-10烯基，CH 2 YR 3，CR 12（OR 4）R 5，CH 2 -CHR 9 -CON 10或COR 12，其中Y是氧或硫，R 3是氢，C 1-4烷基，苯基， C2-5酰基或苯基C1-4烷基，R4是氢或C2-5酰基，R5是C1-9烷基，R9是COCH3或COO-C1-4烷基，R10是C1-4烷基或O-C1-4 烷基，R 12是氢或C 1-19烷基; 并且R 6是C 2-10烷基，C 3-10烯基或C 4-10环烷基-C 1-3烷基，其酸加成盐，异构体和异构体混合物是多巴胺能激动剂，可用于治疗帕金森病。

3. 发明授权

US5547958A N-(8.alpha.-ergolinyl)-amides 失效
标题翻译： N-（8α-麦角酰基） - 酰胺
公开(公告)号：US5547958A
公开(公告)日：1996-08-20
申请号：US364015
申请日：1994-12-27
申请人： Gerhard Sauer , Thomas Brumby , Helmut Wachtel , Jonathan Turner , Peter-Andreas Loschmann
发明人： Gerhard Sauer , Thomas Brumby , Helmut Wachtel , Jonathan Turner , Peter-Andreas Loschmann
IPC分类号： A61K31/48 , A61P43/00 , C07D457/12 , A61K31/44 , C07D457/02
CPC分类号： C07D457/12
摘要： 8.alpha.-acylamino ergolines are useful dopamine agonists.
摘要翻译： 8个α-酰基氨基高麦角碱是有用的多巴胺激动剂。

4. 发明授权

US5219862A 8 beta-substituted ergolines, process for their production and their use 失效
标题翻译： 8替代白蛋白，其生产过程及其使用
公开(公告)号：US5219862A
公开(公告)日：1993-06-15
申请号：US623933
申请日：1990-12-21
申请人： Gerhard Sauer , Thomas Brumby , Helmut Wachtel , Jonathan Turner , Peter A. Loschmann
发明人： Gerhard Sauer , Thomas Brumby , Helmut Wachtel , Jonathan Turner , Peter A. Loschmann
IPC分类号： A61K31/48 , A61P43/00 , C07D457/02 , C07D457/04 , C07D457/06
CPC分类号： C07D457/06 , C07D457/02
摘要： Compounds of formula I ##STR1## in which R.sup.2 means optionally substituted C.sub.1-7 alkyl, C.sub.2-7 alkenyl, CH.sub.2 --O--C.sub.1-4 alkyl or CH.sub.2 --S--C.sub.1-4 alkylR.sup.6 means C.sub.2-6 alkyl, C.sub.3-6 alkenyl or C.sub.3-5 -cycloalkyl-C.sub.1-2 alkyl andR.sup.8 means CH.sub.2 --X, ##STR2## in which X stands for CN, OCH.sub.3, SCH.sub.3 or CONH.sub.2 and R.sup.1 stands for hydrogen, halogen, methyl or methoxy, and R.sup.3 and R.sup.4 each mean C.sub.1-4 alkyl or (CH.sub.2).sub.n --N(CH.sub.3).sub.2, in which n=1-4, and their acid addition salts, the process for their production, their use as pharmaceutical agents as well as intermediate compounds are described.
摘要翻译： PCT No.PCT / DE90 / 00282 Sec。 371 1990年12月21日第 102（e）1990年12月21日日期PCT提交1990年4月6日PCT公布。 WO90 / 12796 PCT公开号日期：1990年11月1日。其中R 2表示任选取代的C 1-7烷基，C 2-7烯基，CH 2 -O-C 1-4烷基或CH 2 -S-C 1-4烷基R 6的式I化合物I表示 C2-6烷基，C3-6烯基或C3-5-环烷基-C1-2烷基，R8表示CH2-X，其中X代表CN，OCH3，SCH3或CONH2，R1代表氢，卤素，甲基或甲氧基，R3和R4各自表示C 1-4烷基或（CH 2）n N（CH 3）2，其中n = 1-4及其酸加成盐，其生产方法，其作为药剂用作以及中间体化合物。

5. 发明授权

US5212178A 8.alpha.-acylamino ergolines and use as pharmaceutical agents 失效
标题翻译： 8（ALPHA）-ACYLAMINO ERGOLINES和用作药物代理
公开(公告)号：US5212178A
公开(公告)日：1993-05-18
申请号：US522751
申请日：1990-05-14
申请人： Gerhard Sauer , Thomas Brumby , Helmut Wachtel , Jonathan Turner , Peter-Andreas Loschmann
发明人： Gerhard Sauer , Thomas Brumby , Helmut Wachtel , Jonathan Turner , Peter-Andreas Loschmann
IPC分类号： A61K31/48 , A61P43/00 , C07D457/12
CPC分类号： C07D457/12
摘要： 8.alpha.-acylamino ergolines are useful dopamine agonists.
摘要翻译： 8个α-酰基氨基高麦角碱是有用的多巴胺激动剂。

6. 发明申请

US20140033793A1 CHROMATOGRAPHIC SYSTEM QUALITY CONTROL REFERENCE MATERIALS 有权
标题翻译：色谱系统质量控制参考材料
公开(公告)号：US20140033793A1
公开(公告)日：2014-02-06
申请号：US13957563
申请日：2013-08-02
申请人： Karen Thorson , Jonathan Turner
发明人： Karen Thorson , Jonathan Turner
IPC分类号： G01N33/00
CPC分类号： G01N33/0006 , G01N30/8665 , G01N2030/042
摘要： The invention provides compositions and methods for chromatographic analysis and system quality control. Compositions can include a reference material that comprises a standardized formulation of two or more compounds that can be used for benchmarking and troubleshooting the chromatographic system (e.g., which is not simply a standard solution for a particular analyte of interest). Methods can include obtaining a chromatogram from a reference material using a chromatographic system, wherein the reference material comprises a standardized formulation of two or more compounds that can be used for benchmarking and troubleshooting the chromatographic system; evaluating a difference between the chromatogram and a benchmark for the reference material on the chromatography system; and (i) analyzing a sample potentially comprising an analyte of interest, wherein the analyte of interest does not comprise any of the two or more compounds of the standardized formulation, or compounds substantially similar thereto, if the difference between the chromatogram and the benchmark is within a predetermined tolerance, or (ii) troubleshooting the chromatography system using the chromatogram if the difference between the chromatogram and the benchmark is not within the predetermined tolerance.
摘要翻译：本发明提供色谱分析和系统质量控制的组合物和方法。组合物可以包括参考材料，其包含两种或更多种化合物的标准化制剂，其可用于基准和排除色谱系统（例如，其不仅仅是特定分析物的标准溶液）。方法可以包括使用色谱系统从参考物质中获得色谱图，其中参考物质包含两种或更多种化合物的标准化配方，可用于对色谱系统进行基准化和故障排除; 评估色谱图和色谱系统上参考物质的基准之间的差异; （i）分析潜在地包含感兴趣分析物的样品，其中如果色谱图和基准值之间的差异是色谱图和基准值之间的差异，则所关注的分析物不包含标准化制剂的两种或更多种化合物或其基本相似的化合物在预定的容限范围内，或（ii）如果色谱图和基准值之间的差值不在预定的容限内，则使用色谱图对色谱系统进行故障排除。

7. 发明授权

US08515803B2 Triggering and conducting an automated survey 有权
标题翻译：触发和进行自动化调查
公开(公告)号：US08515803B2
公开(公告)日：2013-08-20
申请号：US13245854
申请日：2011-09-26
申请人： Karl Meyer , Jonathan Turner
发明人： Karl Meyer , Jonathan Turner
IPC分类号： G06Q10/00
CPC分类号： G06Q30/0203 , G06Q10/00 , G06Q10/0631 , G06Q10/06311 , G06Q30/016 , G06Q30/02 , G06Q30/0282
摘要： Systems and methods for initiating and conducting an automated survey are disclosed herein. According to some implementations, a computer-readable medium may be encoded with computer-executable instructions, wherein the computer-executable instructions includes logic adapted to receive a notification of the occurrence of a trigger event associated with a service performed for a customer. The computer-executable instructions further include logic adapted, in response to receiving the notification, to initiate an automated survey to be offered to a survey recipient. Additional logic is adapted to conduct the automated survey. The instructions also include logic adapted to receive survey result information from the survey recipient in response to the automated survey.
摘要翻译：本文公开了用于启动和进行自动测量的系统和方法。根据一些实施方式，计算机可读介质可以用计算机可执行指令编码，其中计算机可执行指令包括适于接收与为客户执行的服务相关联的触发事件的发生的通知的逻辑。计算机可执行指令还包括适于响应于接收到该通知的逻辑来启动向调查接收者提供的自动化调查。额外的逻辑适用于进行自动化调查。说明书还包括适用于从受访者接收调查结果信息以响应自动化调查的逻辑。

8. 发明申请

US20110137808A1 ANALYZING SURVEY RESULTS 审中-公开
标题翻译：分析调查结果
公开(公告)号：US20110137808A1
公开(公告)日：2011-06-09
申请号：US12722463
申请日：2010-03-11
申请人： Karl Meyer , Jonathan Turner
发明人： Karl Meyer , Jonathan Turner
IPC分类号： G06Q10/00 , H04M1/64
摘要： Systems and method for analyzing results of an automated survey are disclosed herein. According to some implementations, a computer implemented method comprises receiving survey result information, where the survey result information includes information extracted from an automated survey offered to a survey recipient. The computer implemented method also comprises performing an analysis of the survey result information and determining if the analysis of the survey result information warrants one or more follow-up actions with a customer.
摘要翻译：本文公开了用于分析自动测量结果的系统和方法。根据一些实施方案，计算机实现的方法包括接收调查结果信息，其中调查结果信息包括从提供给调查接收者的自动调查中提取的信息。计算机实现的方法还包括对调查结果信息进行分析，并确定调查结果信息的分析是否保证与客户的一个或多个后续行动。

9. 发明申请

US20110137696A1 PERFORMING FOLLOW-UP ACTIONS BASED ON SURVEY RESULTS 审中-公开
标题翻译：根据调查结果进行后续行动
公开(公告)号：US20110137696A1
公开(公告)日：2011-06-09
申请号：US12722474
申请日：2010-03-11
申请人： Karl Meyer , Jonathan Turner
发明人： Karl Meyer , Jonathan Turner
IPC分类号： G06Q10/00 , G06Q99/00 , G06F3/048
摘要： Systems and methods for prompting follow-up actions in response to a survey. According to some implementations, a computer implemented method includes receiving survey result information that is extracted from an automated survey offered to a survey recipient. The method also includes receiving an indication that one or more follow-up actions are warranted based in part on an analysis of the survey result information and providing a notification to one or more individuals responsible for performing the one or more follow-up actions.
摘要翻译：响应调查采取后续行动的制度和方法。根据一些实施方案，计算机实现的方法包括接收从提供给调查接收者的自动调查中提取的调查结果信息。该方法还包括部分地基于对调查结果信息的分析并且向负责执行一个或多个后续动作的一个或多个个人提供通知来接收一个或多个后续动作的指示。

10. 发明申请

US20070007418A1 Brake system for wall arm 有权
标题翻译：墙臂制动系统
公开(公告)号：US20070007418A1
公开(公告)日：2007-01-11
申请号：US11414868
申请日：2006-05-01
申请人： David Lubbers , Paul Weil , D. Manlove , Brian Hoffman , Christian Reinke , Jonathan Turner , Stephen Hamberg
发明人： David Lubbers , Paul Weil , D. Manlove , Brian Hoffman , Christian Reinke , Jonathan Turner , Stephen Hamberg
IPC分类号： A47H1/10
CPC分类号： A61G12/005 , F16D63/008 , F16D2121/22 , F16M11/2014 , F16M11/2092 , F16M13/02 , F16M2200/024
摘要： An arm is pivotally coupled to a support structure at one end and a patient care equipment support, such as a service head, is pivotally coupled to the arm at the other end. The arm has a first portion and a second portion coupled to the first portion for extension and retraction relative to the first portion. Brakes are provided to brake the extension and retraction of the portions of the arm, to brake the pivoting movement of the arm relative to the support structure, and to brake the pivoting movement of the patient care equipment support relative to the arm. Each of the brakes is releasable.
摘要翻译：臂在一端枢转地联接到支撑结构，并且病人护理设备支撑件（例如服务头）在另一端枢转地联接到臂。臂具有第一部分和第二部分，其联接到第一部分以相对于第一部分进行伸缩。提供制动器以制动臂的部分的伸出和缩回，以制动臂相对于支撑结构的枢转运动，并且制动病人护理设备支撑件相对于手臂的枢转运动。每个制动器都是可释放的。

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