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1. 发明授权

US5952374A Method for inhibiting the development of Alzheimer's disease and related dementias- and for preserving cognitive function 失效
标题翻译：抑制阿尔茨海默病和相关痴呆发展以及保持认知功能的方法
公开(公告)号：US5952374A
公开(公告)日：1999-09-14
申请号：US939691
申请日：1997-09-29
申请人： Thomas Boston Clarkson, Jr. , Mary Susan Anthony , Yuanlong Pan , Michael R. Adams , Doyle H. Waggle
发明人： Thomas Boston Clarkson, Jr. , Mary Susan Anthony , Yuanlong Pan , Michael R. Adams , Doyle H. Waggle
IPC分类号： A61K31/352 , A61K31/35
CPC分类号： A61K31/704 , A61K31/352
摘要： Methods for inhibiting the development and relieving the symptoms of Alzheimer's disease and related dementias are provided. A phytoestrogenic isoflavone compound is administered to a human predisposed to developing Alzheimer's disease or a related dementia, or having Alzheimer's disease or a related dementia, in an amount effective to inhibit the development or relieve the symptoms of the disease. The phytoestrogenic isoflavone compound is selected from at least one of genistein, genistin, 6'-OMal genistin, 6'-OAc genistin, daidzein, daidzin, 6'-OMal daidzin, 6'-OAc daidzin, glycitein, glycitin, 6'-OMal glycitin, or mixtures thereof. The phytoestrogenic isoflavone compound is effective to up-regulate choline acetyltransferase mRNA and nerve growth factor mRNA.
摘要翻译：提供了抑制阿尔茨海默病和相关痴呆症状的发展和缓解方法。将植物雌激素异黄酮化合物以有效抑制发育或缓解疾病症状的量给予倾向于发展为阿尔茨海默病或相关痴呆或具有阿尔茨海默病或相关痴呆的人。植物雌激素异黄酮化合物选自染料木黄酮，染料木苷，6'-OMal染料木素，6'-OAc染料木黄酮，黄豆苷原，黄豆苷，6'-OMal黄豆苷，6'-OAc黄豆苷苷，黄豆黄素， OMAL大豆蛋白，或其混合物。植物雌激素异黄酮化合物可有效上调胆碱乙酰转移酶mRNA和神经生长因子mRNA。

2. 发明授权

US07285297B1 Method of reducing low density liproprotein cholesterol concentration 失效
标题翻译：降低低密度脂蛋白胆固醇浓度的方法
公开(公告)号：US07285297B1
公开(公告)日：2007-10-23
申请号：US10461751
申请日：2003-06-13
申请人： Doyle H. Waggle , Susan M. Potter , Edna C. Henley
发明人： Doyle H. Waggle , Susan M. Potter , Edna C. Henley
IPC分类号： A01N65/00 , G01N31/00
CPC分类号： A61K31/78 , A23L33/11 , A23L33/185 , A23V2002/00 , A61K36/48 , Y10T436/104165 , A61K2300/00 , A23V2250/5488 , A23V2250/2116 , A23V2250/21368 , A23V2250/70 , A23V2250/156 , A23V2250/21372 , A23V2250/2136
摘要： The present invention is a composition comprising a plant sterol and a soy protein material and/or and isoflavone selected from genistein, daidzein, glycitein, biochanin A, formononetin, and their naturally occurring glycosides, where the plant sterol comprises at least 0.49% of the composition, by weight. The present invention is also a method for decreasing the blood concentration of total and LDL cholesterol in a human in which a plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.49%, by weight, of the combined weight of the plant sterol and the soy protein material and/or the isoflavone. The present invention is also a method for preventing or minimizing the development of atherosclerosis in a human in which a plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.49%, by weight, of the combined weight of the plant sterol and the soy protein material and/or the isoflavone.
摘要翻译：本发明是一种包含植物甾醇和大豆蛋白材料和/或异黄酮的组合物，其选自染料木黄酮，黄豆苷原，黄豆黄素，鹰嘴豆素A，form e酮及其天然存在的糖苷，其中植物甾醇包含至少0.49％组成，重量。本发明还是一种降低人类共同施用植物甾醇和大豆蛋白物质和/或异黄酮的人的总胆固醇和低密度脂蛋白胆固醇的血液浓度的方法，其中植物甾醇至少包含 0.49重量％的植物甾醇和大豆蛋白材料和/或异黄酮的总重量。本发明还是一种预防或最小化其中植物甾醇和大豆蛋白材料和/或异黄酮共同给予人的动脉粥样硬化发展的方法，其中植物甾醇包含至少0.49％（重量）植物甾醇和大豆蛋白材料和/或异黄酮的总重量。

3. 发明授权

US06495141B2 Recovery of isoflavones from soy molasses 有权
标题翻译：从大豆糖蜜中回收异黄酮
公开(公告)号：US06495141B2
公开(公告)日：2002-12-17
申请号：US10016461
申请日：2001-10-19
申请人： Doyle H. Waggle , Barbara A. Bryan
发明人： Doyle H. Waggle , Barbara A. Bryan
IPC分类号： A01N6500
CPC分类号： C07D311/40 , C07D311/36 , C07H17/07
摘要： Isoflavone compositions derived from soy molasses are provided. In a first embodiment, an isoflavone material derived from soy molasses containing at least two isoflavones is provided, where at least one of the isoflavones is genistein. In a second embodiment, an isoflavone material derived from soy molasses containing at least two isoflavones is provided, where at least one of the isoflavones is daidzein.
摘要翻译：提供衍生自大豆糖蜜的异黄酮组合物。在第一实施方案中，提供衍生自含有至少两种异黄酮的大豆糖蜜的异黄酮物质，其中至少一种异黄酮是染料木黄酮。在第二实施方案中，提供衍生自含有至少两种异黄酮的大豆糖蜜的异黄酮物质，其中至少一种异黄酮是黄豆苷元。

4. 发明授权

US6132795A Vegetable protein composition containing an isoflavone depleted vegetable protein material with an isoflavone containing material 失效
标题翻译：含有含异黄酮的植物蛋白物质含有异黄酮的植物蛋白质组合物
公开(公告)号：US6132795A
公开(公告)日：2000-10-17
申请号：US044961
申请日：1998-03-15
申请人： James L. Holbrook , Doyle H. Waggle
发明人： James L. Holbrook , Doyle H. Waggle
IPC分类号： A23C9/13 , A23C11/10 , A23C19/093 , A23J1/14 , A23J3/14 , A23J3/16 , A23L1/30 , A23L1/305 , A23L2/38 , A23L2/39 , A23L2/52 , A23L2/66 , C07K14/415 , A23L1/20 , A23J1/00
CPC分类号： A23C11/106 , A23C9/1315 , A23J3/14 , A23J3/16 , A23L2/39 , A23L2/66 , A23L33/105 , A23L33/185
摘要： The present invention is a vegetable protein composition. The vegetable protein composition contains an isoflavone depleted vegetable protein material and an isoflavone containing material which is dispersed in the isoflavone depleted vegetable protein material. The composition may be used in foods to provide the nutritional benefits of the isoflavone depleted vegetable protein material while providing the health benefits of the isoflavone containing material. The invention also includes processes for forming such vegetable protein compositions.
摘要翻译：本发明是植物蛋白质组合物。植物蛋白质组合物含有异黄酮贫乏的植物蛋白质材料和含异黄酮的材料，其分散在异黄酮贫乏的植物蛋白材料中。该组合物可以用于食品中以提供异黄酮耗尽的植物蛋白材料的营养益处，同时提供含异黄酮的材料的健康益处。本发明还包括形成这种植物蛋白组合物的方法。

5. 发明授权

US06572876B2 Administering a composition containing plant sterol, soy protein and isoflavone for reducing LDL-cholesterol 失效
标题翻译：管理含有植物甾醇，大豆蛋白和异黄酮的组合物，用于降低LDL-胆固醇
公开(公告)号：US06572876B2
公开(公告)日：2003-06-03
申请号：US09814649
申请日：2001-03-22
申请人： Doyle H. Waggle , Susan M. Potter , E. C. Henley
发明人： Doyle H. Waggle , Susan M. Potter , E. C. Henley
IPC分类号： A61K968
CPC分类号： A61K36/48 , A23L33/11 , A23L33/185 , A23V2002/00 , A61K31/78 , A61K2300/00 , A23V2250/5488 , A23V2250/2116 , A23V2250/2136 , A23V2250/70 , A23V2250/156 , A23V2250/21368 , A23V2250/21372
摘要： A composition is provided comprising a plant sterol and a soy protein material and/or and isoflavone selected from genistein, daidzein, glycitein, biochanin A, formononetin, and their naturally occurring glycosides, where the plant sterol comprises at least 0.49% of the composition, by weight. The present invention is also a method for decreasing the blood concentration of total and LDL cholesterol in a human in which the plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.49%, by weight, of the combined weight of the plant sterol and the soy protein material and/or the isoflavone. Also provided is a method for preventing or minimizing the development of atherosclerosis in a human in which a plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.49%, by weight, of the combined weight of the plant sterol and the soy protein material and/or the isoflavone. A preferred method involves co-administering to a human a plant sterol and a soy protein material containing at least 0.49% by weight soy protein and containing the isoflavone glycoside, glycitin. The plant sterol is at least 0.49% by combined weight of the co-administered plant sterol and soy protein material. The plant sterol can be B-sitosterol, campesterol, stigmasterol, sitostanol, or campestanol. Also an isoflavone can be administered in combination with the plant sterol and soy protein material. This isoflavone can be genistein, daidzein, glycitein, biochanin A, formononetin, and their naturally occurring glycosides and glycoside conjugates.
摘要翻译：提供了一种组合物，其包含植物甾醇和大豆蛋白材料和/或异黄酮，所述植物甾醇和/或异黄酮选自染料木黄酮，黄豆苷原，黄豆黄素，鹰嘴豆素A，海参素及其天然存在的糖苷，其中植物甾醇包含至少0.49％重量。本发明还是一种减少人类中总共和低密度脂蛋白胆固醇的血液浓度的方法，其中将植物甾醇和大豆蛋白物质和/或异黄酮共同施用于人，其中植物甾醇至少包含 0.49重量％的植物甾醇和大豆蛋白材料和/或异黄酮的总重量。还提供了一种预防或最小化动物动脉粥样硬化发展的方法，其中植物甾醇和大豆蛋白材料和/或异黄酮共同施用于人，其中植物甾醇包含至少0.49％，通过重量，植物甾醇和大豆蛋白材料和/或异黄酮的总重量。优选的方法包括向人类共同施用植物甾醇和含有至少0.49重量％大豆蛋白并含有异黄酮糖苷，大豆蛋白的大豆蛋白物质。植物甾醇与共同施用的植物甾醇和大豆蛋白材料的组合重量至少为0.49％。植物甾醇可以是β-谷甾醇，菜油甾醇，豆甾醇，谷甾醇或菜油甾烷醇。异黄酮也可以与植物甾醇和大豆蛋白材料组合施用。这种异黄酮可以是染料木素，黄豆苷元，黄豆黄素，鹰嘴豆素A，海参素及其天然存在的糖苷和糖苷共轭物。

6. 发明授权

US6083553A Recovery of isoflavones from soy molasses 失效
标题翻译：从大豆糖蜜中回收异黄酮
公开(公告)号：US6083553A
公开(公告)日：2000-07-04
申请号：US92805
申请日：1998-06-05
申请人： Doyle H. Waggle , Barbara A. Bryan
发明人： Doyle H. Waggle , Barbara A. Bryan
IPC分类号： C07D311/40 , C07D311/36
CPC分类号： C07D311/40
摘要： Methods for recovering isoflavones and derivatives thereof from soy molasses are disclosed. In a first embodiment, a method is disclosed in which isoflavones are recovered from soy molasses. In a second embodiment, a method is disclosed whereby isoflavone conjugates present in soy molasses are converted to isoflavone glucosides, and an isoflavone glucoside material is recovered from the soy molasses. In a third embodiment, a method is disclosed in which isoflavones are converted to their aglucone form, and an aglucone isoflavone material is recovered from soy molasses.
摘要翻译：公开了从大豆糖蜜中回收异黄酮及其衍生物的方法。在第一实施方案中，公开了从大豆糖蜜中回收异黄酮的方法。在第二实施方案中，公开了一种存在于大豆糖蜜中的异黄酮共轭物转化为异黄酮糖苷的方法，从大豆糖蜜中回收异黄酮糖苷物质。在第三个实施方案中，公开了一种方法，其中将异黄酮转化为其配体形式，并且从大豆糖蜜中回收配基异黄酮材料。

7. 发明授权

US5919921A Recovery of isoflavones from soy molasses 失效
公开(公告)号：US5919921A
公开(公告)日：1999-07-06
申请号：US086658
申请日：1998-05-29
申请人： Doyle H. Waggle , Barbara A. Bryan
发明人： Doyle H. Waggle , Barbara A. Bryan
IPC分类号： C12P17/06 , A23J1/14 , A23J3/16 , C07D311/36 , C07D311/40 , C07H17/07 , C07H1/08 , A61K35/78 , C07H17/04
CPC分类号： C07D311/40 , C07D311/36 , C07H17/07
摘要： Methods for recovering isoflavones and derivatives thereof from soy molasses are disclosed. In a first embodiment, a method is disclosed in which isoflavones are recovered without any significant conversion of isoflavone conjugates to other forms. In a second embodiment, a method is disclosed whereby isoflavone conjugates are converted to glucosides while in the soy material prior to their recovery. In a third embodiment, a method is disclosed in which isoflavones are converted to their aglucone form while in the soy material and prior to their recovery. Also disclosed are various isoflavone enriched products obtained from soy molasses.

8. 发明授权

US06579534B2 Composition containing soy hypocotyl material and plant sterol for reducing LDL-cholesterol 有权
标题翻译：含有大豆下胚轴的物质和用于降低低密度脂蛋白胆固醇的植物甾醇的成分
公开(公告)号：US06579534B2
公开(公告)日：2003-06-17
申请号：US09826346
申请日：2001-04-04
申请人： Doyle H. Waggle , Susan M. Potter , Edna C. Henley
发明人： Doyle H. Waggle , Susan M. Potter , Edna C. Henley
IPC分类号： A61K968
CPC分类号： A61K36/48 , A23L33/11 , A23L33/185 , A23V2002/00 , A61K31/78 , A61K2300/00 , A23V2250/5488 , A23V2250/2116 , A23V2250/2136 , A23V2250/70 , A23V2250/156 , A23V2250/21368 , A23V2250/21372
摘要： A composition is provided comprising a plant sterol and a soy protein material and/or and isoflavone selected from genistein, daidzein, glycitein, biochanin A, formononetin, and their naturally occurring glycosides, where the plant sterol comprises at least 0.49% of the composition, by weight. The present invention is also a method for decreasing the blood concentration of total and LDL cholesterol in a human in which the plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.49%, by weight, of the combined weight of the plant sterol and the soy protein material and/or the isoflavone. Also provided is a method for preventing or minimizing the development of atherosclerosis in a human in which a plant sterol and a soy protein material and/or an isoflavone are co-administered to the human, where the plant sterol comprises at least 0.49%, by weight, of the combined weight of the plant sterol and the soy protein material and/or the isoflavone. A preferred composition contains soy hypocotyl material and at least 0.49% by weight plant sterol. The plant sterol can be B-sitosterol, campesterol, stigmasterol, sitostanol, or campestanol.
摘要翻译：提供了一种组合物，其包含植物甾醇和大豆蛋白材料和/或异黄酮，所述植物甾醇和/或异黄酮选自染料木黄酮，黄豆苷原，黄豆黄素，鹰嘴豆素A，海参素及其天然存在的糖苷，其中植物甾醇包含至少0.49％重量。本发明还是一种减少人类中总共和低密度脂蛋白胆固醇的血液浓度的方法，其中将植物甾醇和大豆蛋白物质和/或异黄酮共同施用于人，其中植物甾醇至少包含 0.49重量％的植物甾醇和大豆蛋白材料和/或异黄酮的总重量。还提供了一种预防或最小化动物动脉粥样硬化发展的方法，其中植物甾醇和大豆蛋白材料和/或异黄酮共同施用于人，其中植物甾醇包含至少0.49％，通过重量，植物甾醇和大豆蛋白材料和/或异黄酮的总重量。优选的组合物包含大豆下胚轴材料和至少0.49重量％的植物甾醇。植物甾醇可以是β-谷甾醇，菜油甾醇，豆甾醇，谷甾醇或菜油甾烷醇。

9. 发明授权

US5990291A Recovery of isoflavones from soy molasses 有权
标题翻译：从大豆糖蜜中回收异黄酮
公开(公告)号：US5990291A
公开(公告)日：1999-11-23
申请号：US204431
申请日：1998-12-03
申请人： Doyle H. Waggle , Barbara A. Bryan
发明人： Doyle H. Waggle , Barbara A. Bryan
IPC分类号： C12P17/06 , A23J1/14 , A23J3/16 , C07D311/36 , C07D311/40 , C07H17/07
CPC分类号： C07D311/40 , C07D311/36 , C07H17/07
摘要： Methods for recovering isoflavones and derivatives thereof from soy molasses are disclosed. In a first embodiment, a method is disclosed in which isoflavones are recovered without any significant conversion of isoflavone conjugates to other forms. In a second embodiment, a method is disclosed whereby isoflavone conjugates are converted to glucosides while in the soy material prior to their recovery. In a third embodiment, a method is disclosed in which isoflavones are converted to their aglucone form while in the soy material and prior to their recovery. Also disclosed are various isoflavone enriched products obtained from soy molasses.
摘要翻译：公开了从大豆糖蜜中回收异黄酮及其衍生物的方法。在第一个实施方案中，公开了一种方法，其中回收异黄酮而不将异黄酮共轭物转化为其它形式。在第二个实施方案中，公开了一种方法，其中异黄酮共轭物在其恢复之前在大豆原料中转化为葡糖苷。在第三个实施方案中，公开了一种方法，其中异黄酮在大豆原料中并在其恢复之前被转化为其配体形式。还公开了从大豆糖蜜获得的各种异黄酮富集产物。

10. 发明授权

US06680381B1 Recovery of isoflavones from soy molasses 有权
标题翻译：从大豆糖蜜中回收异黄酮
公开(公告)号：US06680381B1
公开(公告)日：2004-01-20
申请号：US10320792
申请日：2002-12-16
申请人： Doyle H. Waggle , Barbara A. Bryan
发明人： Doyle H. Waggle , Barbara A. Bryan
IPC分类号： C07D31136
CPC分类号： C07D311/40 , C07D311/36
摘要： A health supplement composition is disclosed. The health supplement composition contains a solid health supplement material that is separated from a condensed soy molasses material. The solid health supplement material contains at least two isoflavones where one of the isoflavones is either glycitein or glycitin.
摘要翻译：公开了一种健康补充剂组合物。健康补充剂组合物含有与冷凝的大豆糖蜜材料分离的固体健康补充物质。固体保健品含有至少两种异黄酮，其中一种异黄酮是黄豆黄素或大豆蛋白。

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