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1. 发明授权

US11884641B2 Method for decomposing flavonoid glycoside and method for producing flavonoid 有权
公开(公告)号：US11884641B2
公开(公告)日：2024-01-30
申请号：US17263141
申请日：2019-07-26
申请人： Showa Denko Materials Co., Ltd.
发明人： Motohiro Arifuku , Yoshiaki Kurihara , Masato Kaneeda
IPC分类号： C07D311/40 , C07D311/30
CPC分类号： C07D311/40 , C07D311/30
摘要： Provided is a method for decomposing a flavonoid glycoside, wherein a flavonoid glycoside-containing raw material is hydrothermally treated to decompose a flavonoid glycoside into a flavonoid.

2. 发明授权

US11753389B2 Method for preparing dihydroquercetin 有权
公开(公告)号：US11753389B2
公开(公告)日：2023-09-12
申请号：US18008044
申请日：2022-05-07
申请人： HEFEI LIFEON PHARMACEUTICAL CO., LTD.
发明人： Junqiu Ji , Xiaochang Li , Bing Li , Qiao Li , Qing Miao , Limei Liu , Jinping Liu
IPC分类号： C07D311/32 , C07D311/40
CPC分类号： C07D311/32 , C07D311/40
摘要： The present disclosure provides a preparation method of dihydroquercetin, belonging to the field of synthesis of drugs. The method includes steps of: adjusting reaction solvent water to be alkaline with an alkalizing reagent, to obtain an alkaline aqueous solution; dissolving quercetin dihydrate in the alkaline aqueous solution, and adding a sulfite binary combined reducing agent to carry out reduction reaction, to obtain an endpoint reduction reaction solution; diluting the endpoint reduction reaction solution with water, and then acidizing, aging, and filtering the resultant to obtain a filtrate and a filter cake; subjecting the filtrate to extraction, washing, drying, and vacuum concentration to obtain a concentrated crude product; and repeatedly crystallizing the concentrated crude product to obtain dihydroquercetin. The preparation method of the present disclosure has readily available raw materials, a simple process, and low production costs, and is particularly suitable for industrial production.

3. 发明申请

US20170216176A1 COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS AND DELAYING AGING OF SKIN 审中-公开
公开(公告)号：US20170216176A1
公开(公告)日：2017-08-03
申请号：US15481492
申请日：2017-04-07
申请人： Phyto Tech Corp.
发明人： Steven Chen
IPC分类号： A61K8/49 , A61Q5/02 , A61Q5/12 , A61Q7/00
CPC分类号： A61K8/498 , A61K31/352 , A61K36/72 , A61K2236/33 , A61K2236/39 , A61K2236/51 , A61K2800/70 , A61Q5/02 , A61Q5/12 , A61Q7/00 , A61Q19/08 , C07D311/40
摘要： The invention provides methods of hair loss or inducing new hair growth, as well as methods of preventing hair loss, comprising applying an effective amount of a dihydromyricetin compound to the scalp. The invention also provides methods of delaying or reversing signs of aging skin comprising applying an effective amount of a dihydromyricetin compound to the skin. Also provided are cosmetic products (e.g., skin and hair products) comprising a dihydromyricetin compound and methods of making the same.

4. 发明授权

US09233096B2 Method of providing an anti-ulcer treatment with extracts and isolated flavonoids from Euphorbia cuneata 有权
标题翻译：用大戟属提取物和分离的黄酮提供抗溃疡治疗的方法
公开(公告)号：US09233096B2
公开(公告)日：2016-01-12
申请号：US14296711
申请日：2014-06-05
申请人： King Saud University
发明人： Amani S. Awaad , Reham Moustafa El-Meligy
IPC分类号： A61K31/352 , A61K36/47 , A61K31/7048 , A61K31/353 , C07D311/40 , C07H17/07
CPC分类号： A61K31/352 , A61K31/353 , A61K31/7048 , A61K36/47 , A61K2236/30 , C07D311/40 , C07H17/07
摘要： The present invention relates to methods of isolating flavonoids from Euphorbia cuneata, and a pharmaceutical composition comprising the flavonoids or the extracts or both of them for a use as anti-ulcer agent. The present invention further relates to a method of providing an anti-ulcer treatment to an animal in need thereof comprising administering to the animal a compound selected from 4′-methoxy-luteolin-7-O-rhamnoglucoside and aromadendrin. A method of providing an anti-ulcer treatment to an animal in need thereof comprising administering to the animal a compound selected from 4′-methoxy-luteolin-7-O-rhamnoglucoside and aromadendrin, in which the compound(s) are isolated from Euphorbia cuneata.
摘要翻译：本发明涉及从大戟属中分离黄酮类化合物的方法，以及包含类黄酮或其提取物或两者用作抗溃疡剂的药物组合物。本发明还涉及向有需要的动物提供抗溃疡治疗的方法，包括向动物施用选自4'-甲氧基 - 木犀草素-7-O-鼠李糖苷和芳香甙的化合物。向有需要的动物提供抗溃疡治疗的方法包括向动物施用选自4-甲氧基 - 木犀草素-7-O-鼠李糖苷和芳香苷的化合物，其中所述化合物与大戟分离 cuneata

5. 发明申请

US20130237712A1 METHOD FOR ISOLATING FLAVONOID DIHYDROQUERCETIN (TAXIFOLIN) FROM CONIFER WOOD SPECIES 审中-公开
标题翻译：从混合物种中分离氟虫腈二氢睾酮（TAXIFOLIN）的方法
公开(公告)号：US20130237712A1
公开(公告)日：2013-09-12
申请号：US13417656
申请日：2012-03-12
申请人： Sergey V. Philippov , Igor M. Bogorodov
发明人： Sergey V. Philippov , Igor M. Bogorodov
IPC分类号： C07D311/40
CPC分类号： C07D311/40
摘要： A method for isolating flavonoid Dihydroquercetin (taxifolin) from wood parts including lower portions of the trunk, referred to as butt logs, bark and roots. The method includes extracting either the particle-reduced chip fraction obtained by chipping or subdividing into chips the butt logs and roots, or dry cork fraction of the bark or powdered bark obtained as a residue in finishing of mechanical wood products with a polar solvent. The method further includes recovering the extract. The wood used in the method is a hardwood or a coniferous wood selected from wood of Larix genus, spruce wood of the genus Picea, fir wood of the genus Abies, pine wood of the genus Pinus, and wood of Pseudotsuga genus. The isolated prime substance from all of the above genus is a flavonoid such as Dihydroquercetin (taxifolin).
摘要翻译：从包括树干下部的木质部分（称为对接原木，树皮和根部）中分离黄酮类二氢槲皮素（taxifolin）的方法。该方法包括提取通过在极性溶剂中机械木制品的精加工中将作为残留物的树皮或粉状树皮的切割或分割成碎片的碎屑或细分碎片或剥离的树皮或粉状树皮。该方法还包括回收提取物。该方法中使用的木材是选自木槿属的云杉木，云杉属云杉木，枞属杉木，松属松木，以及假竹and属木的硬木或针叶木。所有上述属的分离素都是类黄酮，如二氢槲皮素（taxifolin）。

6. 发明申请

US20070292540A1 Extracts and Methods Comprising Cinnamon Species 审中-公开
标题翻译：包括肉桂种类的提取物和方法
公开(公告)号：US20070292540A1
公开(公告)日：2007-12-20
申请号：US11690627
申请日：2007-03-23
申请人： Robert Gow , Dan Li , George Sypert , Randall Alberte
发明人： Robert Gow , Dan Li , George Sypert , Randall Alberte
IPC分类号： A61K36/54 , A23L1/28 , A61P39/06 , C07C29/00 , C07C39/12 , C07C39/18 , C07C47/54 , C07C63/04 , C07D311/04 , C07H17/02
CPC分类号： C07C47/232 , A23L27/12 , A23L33/105 , A23V2002/00 , A61K36/54 , C07C29/76 , C07C31/125 , C07C33/02 , C07C33/14 , C07C33/32 , C07C35/30 , C07C45/78 , C07C47/27 , C07C47/277 , C07C47/54 , C07C51/47 , C07C67/56 , C07D311/40 , C07H17/02 , Y02P20/544 , C07C57/44 , C07C69/618 , C07C69/007 , A23V2200/15 , A23V2250/708 , A23V2250/264 , C07C69/157
摘要： The present invention relates to extracts of cinnamon species plant material prepared by supercritical CO2 extractions methods.
摘要翻译：本发明涉及通过超临界CO 2萃取方法制备的肉桂种植物材料的提取物。

7. 发明申请

US20040018261A1 Method and use of extract of a member of Typhaceae's family 审中-公开
标题翻译：方法和使用提取物的一个成员的科学家
公开(公告)号：US20040018261A1
公开(公告)日：2004-01-29
申请号：US10621426
申请日：2003-07-16
发明人： Tong-Shui Zhou
IPC分类号： A61K035/78 , A61K031/7048
CPC分类号： A61K36/88 , A61K31/352 , A61K31/7048 , C07D311/30 , C07D311/40 , A61K2300/00
摘要： An extract of Typhae Pollen which is a traditional Chinese medicine consisting of flavonoids as active components includes at least one member of the group selected from kaempferol, quercetin and isorhamnetin and the derivatives of these active components. The present invention also relates to the degraded form of flavonoids, the metal derivatives formed with sodium and potassium salts, and the metal complex formed with a predetermined metal ion. The extract of Typhae Pollen is prepared by a plurality of extraction processes and has a plurality of functions for promoting health including lowering blood lipid level, preventing arteriosclerosis, promoting tolerance of brain and heart tissue under anaerobic condition, preventing blood platelet coagulation, preventing thrombosis and stop bleeding. The extract of Typhae Pollen of the present invention is also used for preventing and treating diseases related to blood vessels in brain and heart, and poor blood circulation induced diseases selecting from the group consisting of chest pain, stomachache, physical injuries, puerperium pain and menstruation.
摘要翻译：由黄酮作为活性成分组成的中药的香An提取物包括选自山奈酚，槲皮素和异鼠李素的至少一种成员和这些活性成分的衍生物。本发明还涉及降解形式的类黄酮，由钠和钾盐形成的金属衍生物以及与预定的金属离子形成的金属络合物。香e花提取物通过多种提取方法制备，具有促进健康的多种功能，包括降低血脂水平，预防动脉硬化，促进厌氧条件下脑和心脏组织的耐受性，预防血小板凝血，预防血栓形成和停止出血。本发明的花生花粉的提取物也用于预防和治疗与脑，心脏血管有关的疾病，以及选自胸痛，胃痛，身体损伤，产褥痛和月经的血液循环诱发疾病。

8. 发明申请

US20030147980A1 Extraction of flavonoids 失效
公开(公告)号：US20030147980A1
公开(公告)日：2003-08-07
申请号：US10169968
申请日：2002-10-22
发明人： Robert Gerard Wallace , Willfrits Gerald Burong
IPC分类号： A61K035/78
CPC分类号： C12P17/06 , C07D311/38 , C07D311/40
摘要： A method of producing an enriched flavonoid aglycone extract from starting material containing a suitable flavonoid glycoside and/or conjugate thereof comprising the steps of: (i) enzymatically converting the flavonoid glycoside or conjugate thereof into the flavonoid aglycone; (ii) adjusting the pH to render the flavonoid aglycone soluble and removing the insoluble fraction; and (iii) adjusting the pH to render the soluble flavonoid aglycone relatively insoluble and forming an extract containing the same.

9. 发明申请

US20030119759A1 Recovery of isoflavones from soy molasses 审中-公开
标题翻译：从大豆糖蜜中回收异黄酮
公开(公告)号：US20030119759A1
公开(公告)日：2003-06-26
申请号：US10283671
申请日：2002-10-30
申请人： Protein Technologies International, Inc.
发明人： Doyle H. Waggle , Barbara A. Bryan
IPC分类号： A61K031/7048 , A61K031/353
CPC分类号： C07D311/40 , C07D311/36 , C07H17/07
摘要： A health supplement composition is disclosed. The health supplement composition contains a solid health supplement material that is separated from a soy molasses material. The solid health supplement material contains at least least two isoflavones.
摘要翻译：公开了一种健康补充剂组合物。健康补充剂组合物含有与大豆糖蜜材料分离的固体保健补充剂。固体保健品至少含有两种异黄酮。

10. 发明授权

US06495141B2 Recovery of isoflavones from soy molasses 有权
标题翻译：从大豆糖蜜中回收异黄酮
公开(公告)号：US06495141B2
公开(公告)日：2002-12-17
申请号：US10016461
申请日：2001-10-19
申请人： Doyle H. Waggle , Barbara A. Bryan
发明人： Doyle H. Waggle , Barbara A. Bryan
IPC分类号： A01N6500
CPC分类号： C07D311/40 , C07D311/36 , C07H17/07
摘要： Isoflavone compositions derived from soy molasses are provided. In a first embodiment, an isoflavone material derived from soy molasses containing at least two isoflavones is provided, where at least one of the isoflavones is genistein. In a second embodiment, an isoflavone material derived from soy molasses containing at least two isoflavones is provided, where at least one of the isoflavones is daidzein.
摘要翻译：提供衍生自大豆糖蜜的异黄酮组合物。在第一实施方案中，提供衍生自含有至少两种异黄酮的大豆糖蜜的异黄酮物质，其中至少一种异黄酮是染料木黄酮。在第二实施方案中，提供衍生自含有至少两种异黄酮的大豆糖蜜的异黄酮物质，其中至少一种异黄酮是黄豆苷元。

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