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1. 发明授权

US06489327B1 Tryptase inhibitors 失效
标题翻译：胰蛋白酶抑制剂
公开(公告)号：US06489327B1
公开(公告)日：2002-12-03
申请号：US09601317
申请日：2000-10-20
申请人： Thomas Bär , Thomas Martin , Josef Stadlwieser , Wolf-Rüdiger Ulrich , Andreas Dominik , Ulrich Thibaut , Daniela Bundschuh , Rolf Beume , Karl-Josef Goebel , Wolfram Bode , Luis Moroder , Pedro Jose Barbosa Pereira , Andreas Bergner , Robert Huber , Christian Sommerhoff , Norbert Schaschke
发明人： Thomas Bär , Thomas Martin , Josef Stadlwieser , Wolf-Rüdiger Ulrich , Andreas Dominik , Ulrich Thibaut , Daniela Bundschuh , Rolf Beume , Karl-Josef Goebel , Wolfram Bode , Luis Moroder , Pedro Jose Barbosa Pereira , Andreas Bergner , Robert Huber , Christian Sommerhoff , Norbert Schaschke
IPC分类号： A61K31495
CPC分类号： C07D213/81 , C07C279/16 , C07D211/58 , C07D213/82 , C07D295/185 , C07D295/215 , C07D401/14
摘要： The invention relates to novel inhibitors of human tryptase which are used in the pharmaceutical industry for the production of medicaments.
摘要翻译：本发明涉及用于药物工业用于生产药物的人类类胰蛋白酶的新型抑制剂。

2. 发明授权

US06613769B1 Tryptase inhibitors 失效
标题翻译：胰蛋白酶抑制剂
公开(公告)号：US06613769B1
公开(公告)日：2003-09-02
申请号：US09601318
申请日：2001-01-22
申请人： Wolfram Bode , Luis Moroder , Pedro Jose Barbosa Pereira , Andreas Bergner , Robert Huber , Christian Sommerhoff , Norbert Schaschke , Thomas Bär , Thomas Martin , Josef Stadlwieser , Wolf-Rüdiger Ulrich , Andreas Dominik , Ulrich Thibaut , Daniela Bundschuh , Rolf Beume , Karl-Josef Goebel
发明人： Wolfram Bode , Luis Moroder , Pedro Jose Barbosa Pereira , Andreas Bergner , Robert Huber , Christian Sommerhoff , Norbert Schaschke , Thomas Bär , Thomas Martin , Josef Stadlwieser , Wolf-Rüdiger Ulrich , Andreas Dominik , Ulrich Thibaut , Daniela Bundschuh , Rolf Beume , Karl-Josef Goebel
IPC分类号： A61K31495
CPC分类号： C07D213/81 , C07C237/22 , C07C279/16 , C07D211/58 , C07D213/82 , C07D295/185 , C07D295/215 , C07D401/14
摘要： The invention relates to bifunctional tryptase inhibitors of formula (I) wherein H1 and H2 comprise a Q group and L is a linker of formula and the conformation of the H1, H2 and L groups is such that the groups are separated by a distance of from 20 to 45 Å. Pharmaceutical compositions and crystal forms of the compounds are described in addition to methods for producing and identifying such compounds, as well as the use of such compounds in methods of treating allergic and inflammatory diseases.
摘要翻译：本发明涉及式（I）的双功能类胰蛋白酶抑制剂，其中H1和H2包含Q基团，L是式的连接体，并且H1，H2和L基团的构象使得基团被隔开距离为20 至45Å。除了制备和鉴定这些化合物的方法之外，还描述了化合物的药物组合物和晶体形式，以及这些化合物在治疗过敏性和炎性疾病的方法中的用途。

3. 发明申请

US20080242681A1 N-4-(6-(Hetero)Aryl-Pyrimidin-4-Ylaminophenyl)-Benzenesulfonamides as Kinase Inhibitors 审中-公开
标题翻译： N-4-（6-（杂）芳基 - 嘧啶-4-基氨基苯基） - 苯磺酰胺作为激酶抑制剂
公开(公告)号：US20080242681A1
公开(公告)日：2008-10-02
申请号：US10586121
申请日：2005-01-19
申请人： Johannes Barsig , Monika Baudler , Daniela Bundschuh , Florian Gantner , Ulrich Graedler , Isabelle Heit , Thomas Martin , Michaela Schaefer , Imre Schlemminger , Josef Stadlwieser , Wolf-Ruediger Ulrich
发明人： Johannes Barsig , Monika Baudler , Daniela Bundschuh , Florian Gantner , Ulrich Graedler , Isabelle Heit , Thomas Martin , Michaela Schaefer , Imre Schlemminger , Josef Stadlwieser , Wolf-Ruediger Ulrich
IPC分类号： A61K31/505 , C07D239/42 , A61P31/00 , A61P35/00 , A61P25/28 , A61P3/10 , A61P9/10 , A61P19/02 , A61P29/00 , A61P17/00 , A61P27/02
CPC分类号： C07D239/42 , C07D403/04 , C07D405/04 , C07D409/14
摘要： Compounds of a certain formula 1 in which R1 and R2 have the meanings indicated in the description are novel kinase inhibitors. Formula (1), in which R1 is phenyl, phenyl substituted by R3 and/or R4, naphthalenyl, naphthalenyl substituted by and/or R6, aryl1, aryl1 substituted by R7 and/or R8, R9, R10 or R11, R2 is phenyl, phenyl substituted by R12 and/or R13, naphthalenyl, naphthalenyl substituted by R14 and/or R15, aryl2, aryl2 substituted by R16 and/or R17 or a radical selected from Formula (2).
摘要翻译：其中R1和R2具有说明书所述含义的某种式1的化合物是新的激酶抑制剂。式（1）其中R 1为苯基，被R 3和/或R 4取代的苯基，被R 1和/或R 6取代的萘基，萘基，芳基，被R 7和/或R 8，R 9，R 10或R 11取代的芳基，被R 12和/或R 13取代的苯基，被R 14和/或R 15取代的萘基，萘基，芳基2，被R 16和/或R 17取代的芳基2或选自式（2）的基团。

4. 发明授权

US06962941B2 Tryptase inhibitors 失效
标题翻译：胰蛋白酶抑制剂
公开(公告)号：US06962941B2
公开(公告)日：2005-11-08
申请号：US10480925
申请日：2002-06-14
申请人： Thomas Martin , Wolf-Rüdiger Ulrich
发明人： Thomas Martin , Wolf-Rüdiger Ulrich
IPC分类号： A61K31/401 , A61K31/4025 , A61P1/02 , A61P1/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/04 , A61P11/06 , A61P11/08 , A61P13/10 , A61P17/00 , A61P17/06 , A61P25/28 , A61P27/14 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D207/16 , C07D403/12
CPC分类号： C07D207/16
摘要： The compounds of formula I in which M, B1, B2, R1, R2, R6, R7, K1 and K2 have the meanings as indicated in the description are novel active tryptase inhibitors.
摘要翻译：其中M，B1，B2，R1，R2，R6，R7，K1和K2具有如说明书中指出的含义的式I化合物是新的活性类胰蛋白酶抑制剂。

5. 发明申请

US20170058559A1 COLLARS FOR USE IN EITHER DRIVING POSTS INTO OR REMOVING POSTS FROM THE GROUND, AND RELATED METHODS 审中-公开
标题翻译：用于从地面移动或移除位置的相关方法以及相关方法
公开(公告)号：US20170058559A1
公开(公告)日：2017-03-02
申请号：US14834414
申请日：2015-08-24
申请人： Thomas Martin
发明人： Thomas Martin
IPC分类号： E04H17/26
CPC分类号： E04H17/263 , E02D7/00 , E04H17/265
摘要： A collar is provided that can be used to either drive posts into the ground or remove posts from the ground. The collar includes a first portion defining a post opening adapted for coupling about a post, and a second portion coupled to the first portion. The second portion includes a receiver adapted for receiving a tool for use in driving the post into the ground when the first portion is coupled about the post. The first portion defines an obtuse angle with respect to the second portion. The collar is configured to be positioned in a first orientation about a post when used to drive the post into the ground, and a second orientation, rotated approximately 180 degrees relative to the first orientation, when used to remove a post from the ground.
摘要翻译：提供一个领子，可用于将柱子推入地面或从地面移除柱子。套环包括限定适于联接在柱上的柱形开口的第一部分和联接到第一部分的第二部分。第二部分包括适于接收用于当第一部分围绕柱连接时用于将柱驱动到地面中的工具的接收器。第一部分限定相对于第二部分的钝角。套环被配置为当用于将柱子驱动到地面中时围绕柱子以第一取向定位，以及当用于从地面移除桩柱时，相对于第一取向旋转约180度的第二取向。

6. 发明授权

US08544081B2 Secure network architecture 有权
标题翻译：安全的网络架构
公开(公告)号：US08544081B2
公开(公告)日：2013-09-24
申请号：US12515449
申请日：2007-11-20
申请人： Liwen He , Bryan Littlefair , Thomas Martin , Dinesh Kallath , Christopher Rutherford
发明人： Liwen He , Bryan Littlefair , Thomas Martin , Dinesh Kallath , Christopher Rutherford
IPC分类号： H04L9/00 , H04L29/06 , G06F15/16 , H04L12/66 , G06F13/00
CPC分类号： H04L63/0209 , H04L63/0272 , H04L63/20
摘要： The present invention provides a star-connected network (C1-C4, P1-P8) having a number of peripheral nodes (P1-P8) and a central control arrangement (C1-C4). Each peripheral node has means for restricting communications across the network to the central control arrangement using a respective encrypted connection unless the peripheral node has received explicit authorisation from the control arrangement to set up a direct connection with another peripheral node. The central control arrangement comprises: means for establishing an encrypted connection with each peripheral node; means for exchanging control packets with two or more peripheral nodes using two or more respective encrypted connections in order to set up an authorised connection between two peripheral nodes; a database storing security policy information specifying what connections between peripheral nodes are allowable; and authorisation means for authorising connections which are allowable according to the stored security policy information using the control packet exchanging means.
摘要翻译：本发明提供了具有多个外围节点（P1-P8）和中央控制装置（C1-C4）的星形连接网络（C1-C4，P1-P8）。每个外围节点具有用于通过使用相应的加密连接将跨越网络的通信限制到中央控制装置的装置，除非外围节点已经从控制装置接收到建立与另一外围节点的直接连接的显式授权。中央控制装置包括：用于与每个外围节点建立加密连接的装置; 用于使用两个或多个相应的加密连接与两个或多个外围节点交换控制分组的装置，以便在两个外围节点之间建立授权的连接; 存储指定外围节点之间的连接是允许的安全策略信息的数据库; 以及授权装置，用于根据所存储的安全策略信息，使用控制分组交换装置来授权可允许的连接。

7. 发明申请

US20130019111A1 SECURE DATA RECORDER 有权
标题翻译：安全数据记录仪
公开(公告)号：US20130019111A1
公开(公告)日：2013-01-17
申请号：US13638417
申请日：2011-03-30
申请人： Thomas Martin
发明人： Thomas Martin
IPC分类号： G06F21/24 , H04L9/14
CPC分类号： G06F21/62 , G06F21/78 , G06F2221/2107 , H04L9/0637 , H04L9/0822 , H04L9/0894
摘要： A method and apparatus for securely encrypting data is disclosed. Conventional protections against the loss or theft of sensitive data such as full disk encryption are not effective if the device is, or has recently been, running when captured or found because the keys used for full disk encryption will still be in memory and can be used to decrypt the data stored on the disk. Some devices, such as devices which gather sensitive data in use, must run in environments in which they might be captured by a person seeking access to the sensitive data already recorded by the device. An encryption method is proposed in which files on a recorder's persistent memory are initialised with pseudo-random masking data whilst the recorder is in a relatively secure environment. One or more parameters which can be used to re-create the pseudo-random masking data are encrypted with a public key using a public-key encryption algorithm and stored on the recorder. The device's memory is then purged to remove the one or more parameters. Later, when miming in a relatively insecure environment, the sensitive data is encrypted (414) using a symmetric encryption algorithm, and combined (418) with the masking data previously stored in the storage file. When the encrypted files are transferred to a reader device with access to the corresponding private key, the masking data can be recreated, the symmetric encryption reversed and the sensitive data recovered. However, an adversary without the private key cannot recreate the masking data, and is thus unable to recover the sensitive data even with the symmetric encryption key which he might successfully extract from the recorder's volatile memory.
摘要翻译：公开了一种用于安全加密数据的方法和装置。传统的防止诸如全磁盘加密等敏感数据的丢失或被盗的保护措施，如果设备在被捕获或发现时最近才运行，因为用于全磁盘加密的密钥仍然在内存中并可以使用解密存储在磁盘上的数据。某些设备（如收集使用中的敏感数据的设备）必须在寻求访问已被设备记录的敏感数据的用户捕获的环境中运行。提出了一种加密方法，其中记录器在永久存储器中的文件被初始化为伪随机屏蔽数据，同时记录器处于相对安全的环境中。可以用于重新创建伪随机屏蔽数据的一个或多个参数使用公钥加密算法用公钥加密并存储在记录器上。然后清除设备的内存以删除一个或多个参数。稍后，当在相对不安全的环境中模拟时，使用对称加密算法对敏感数据进行加密（414），并将先前存储在存储文件中的掩蔽数据组合（418）。当加密的文件被传送到具有访问相应的私钥的读取器设备时，可以重建掩蔽数据，对称加密被反转，敏感的数据被恢复。然而，没有私钥的对手不能重新创建掩蔽数据，因此即使使用他可能从记录器的易失性存储器中成功提取的对称加密密钥，也不能恢复敏感数据。

8. 发明申请

US20120329801A1 CRYSTALLINE FORMS FOR 5-AMINO-2, 3-DIHYDROPHTHALAZINE-1, 4-DIONE SODIUM SALT, PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION OF SAID FORMS 有权
标题翻译：用于5-氨基-2,3-二氢化哒嗪-1,4-二醇钠盐，含有它们的药物制剂和生产表面形态的方法的晶体形式
公开(公告)号：US20120329801A1
公开(公告)日：2012-12-27
申请号：US13582522
申请日：2011-03-01
申请人： Josef Breu , Wolfgang Brysch , Astrid Kaiser , Beate Ludescher , Gerrit Maass , Thomas Martin , Wolfgang Milius , Michael Niedermaier
发明人： Josef Breu , Wolfgang Brysch , Astrid Kaiser , Beate Ludescher , Gerrit Maass , Thomas Martin , Wolfgang Milius , Michael Niedermaier
IPC分类号： C07D237/32 , A61P37/00 , A61K31/502
CPC分类号： C07D237/32
摘要： The invention relates to the provision of two novel crystalline forms I and II for 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt. Surprisingly, it was discovered that form I and form II have differing immunological effects. This advantageous property is useful for immunospecific applications. In addition, both forms have advantageous physicochemical properties, which are useful in the production, further processing and/or use of a pharmaceutical preparation of form I or form II or a mixture of both.
摘要翻译：本发明涉及为5-氨基-2,3-二氢酞嗪-1,4-二酮钠盐提供两种新的结晶形式I和II。令人惊讶的是，发现I型和II型具有不同的免疫学作用。这种有利的性质可用于免疫特异性应用。此外，两种形式都具有有利的物理化学性质，其可用于生产，进一步加工和/或使用I型或II型药物制剂或两者的混合物。

9. 发明申请

US20100163364A1 CLUTCH SUPPORT 有权
标题翻译：离合支持
公开(公告)号：US20100163364A1
公开(公告)日：2010-07-01
申请号：US12642158
申请日：2009-12-18
申请人： Winfried Franz-Xaver Schulz , Thomas Martin , Patrick Isele , Friedel Lauscher
发明人： Winfried Franz-Xaver Schulz , Thomas Martin , Patrick Isele , Friedel Lauscher
IPC分类号： F16D47/00
CPC分类号： F16D21/06 , F16D2021/0661 , F16D2250/00
摘要： A clutch support for supporting a clutch hub of a clutch such that the clutch hub is rotatable is described. The clutch hub comprises a flange that is fixable at clutch housing or the like; a substantially cylindrical element for receiving the clutch hub such that the clutch hub is rotatable; and a sleeve with at least one groove formed therein for providing at least one channel that allows oil to be supplied to the clutch through this channel. The sleeve is manufactured substantially without any chip removing machining action. This achieves the goal to provide a clutch support that can be manufactured in a simple manner and at comparatively low cost.
摘要翻译：描述了用于支撑离合器的离合器毂以使得离合器毂能够旋转的离合器支架。离合器毂包括可在离合器壳体等处固定的凸缘; 大致圆柱形的元件，用于接收离合器毂，使得离合器毂可旋转; 以及具有形成在其中的至少一个凹槽的套筒，用于提供允许通过该通道将油供给到离合器的至少一个通道。套筒基本上没有进行任何切屑去除加工动作。这实现了提供可以以简单的方式并且以相对低的成本制造的离合器支撑件的目的。

10. 发明申请

US20070121828A1 3-way call detection system and method 有权
标题翻译： 3路呼叫检测系统及方法
公开(公告)号：US20070121828A1
公开(公告)日：2007-05-31
申请号：US11546376
申请日：2006-10-12
申请人： Thomas Martin
发明人： Thomas Martin
IPC分类号： H04M11/00
CPC分类号： H04M3/2281 , H04M1/68 , H04M3/305 , H04M3/56
摘要： Disclosed herein is a three-way call detection system and method for detecting the addition of a third party to a pre-existing telephonic connection between a first party and a second party. The system includes a meter for measuring the amplitude of a line voltage of a telephonic connection between two parties, a first filter to remove a frequency band from the line voltage, a white noise generator for generating a low level white noise signal in the removed frequency band, a coupler for combining the white noise signal with the filtered signal, to create an additive line voltage, a second filter that passes only a portion of the additive line voltage including at least a portion of the white noise signal, and a processor for monitoring the passed signal for a shift in amplitude level associated with the addition of a third party to the connection.
摘要翻译：本文公开了一种用于检测第三方对第一方和第二方之间的预先存在的电话连接的添加的三方通话检测系统和方法。该系统包括用于测量双方之间的电话连接的线路电压的幅度的仪表，用于从线路电压中去除频带的第一滤波器，用于在去除频率中产生低电平白噪声信号的白噪声发生器频带，用于将白噪声信号与滤波信号组合以产生添加线电压的耦合器，仅通过包括白噪声信号的至少一部分的添加线电压的一部分的第二滤波器，以及用于监视所通过的信号，以便与向该连接添加第三方相关联的幅度水平移位。

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