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1. 发明授权

US5061243A System and apparatus for the patient-controlled delivery of a beneficial agent, and set therefor 失效
标题翻译：用于患者控制递送有益药物的系统和装置，并设置其
公开(公告)号：US5061243A
公开(公告)日：1991-10-29
申请号：US308972
申请日：1989-02-08
申请人： David A. Winchell , Thomas A. Fowles , Richard Mitchell
发明人： David A. Winchell , Thomas A. Fowles , Richard Mitchell
IPC分类号： A61M5/152 , A61M5/14 , A61M5/142 , A61M5/175 , A61M31/00
CPC分类号： A61M5/14244 , A61M5/1424 , A61M2005/1405
摘要： An apparatus (60) and system (20) are disclosed for the patient-controlled delivery of an analgesic or other beneficial agent 142, while preventing administration of a toxic quantity of the beneficial agent. The invention permits delivery of fractional doses to a patient in quantities which are directly proportional to the time period since the last dose or fraction thereof was delivered to the patient. In the preferred embodiments the apparatus includes a housing (58) including a casing (88) and a back plate (86), the housing containing a control switch (84) for opening and closing downstream conduit (62) and for depressing a floating plate (100) that thereby compresses a dose reservoir (90) with the beneficial agent (142) therein. A spring (124) biases the control switch (84).
摘要翻译：公开了用于患者控制递送止痛剂或其它有益药物142的装置（60）和系统（20），同时防止施用有毒量的有益药剂。本发明允许以与上次剂量或其部分递送至患者后的时间段成正比的剂量向患者递送分数剂量。在优选实施例中，该装置包括壳体（58），其包括壳体（88）和背板（86），壳体包含用于打开和关闭下游导管（62）并用于按压浮板（100），由此在其中用有益剂（142）压缩剂量储存器（90）。弹簧（124）偏压控制开关（84）。

2. 发明授权

US4174238A Hermetically sealed tamperproof port protector and method of making frangible seal 失效
标题翻译：密封防撬口保护器和易碎密封方法
公开(公告)号：US4174238A
公开(公告)日：1979-11-13
申请号：US872287
申请日：1978-01-25
申请人： Thomas A. Fowles , David A. Winchell
发明人： Thomas A. Fowles , David A. Winchell
IPC分类号： A61J1/00 , A61J1/14 , B29C65/02 , B29C65/18 , B29C65/76 , B65D1/02 , B29C27/00
CPC分类号： B29C66/542 , A61J1/1406 , A61J1/1418 , A61J1/1431 , A61J1/1475 , A61J1/18 , B29C65/18 , B29C65/76 , B65D1/0238 , A61J1/1468 , B29C65/02 , B29C66/8322 , Y10S206/828 , Y10S215/03 , Y10S215/901 , Y10S229/927 , Y10T156/1043 , Y10T403/11 , Y10T428/15
摘要： A thermoplastic pharmaceutical solution container includes a neck portion having at least one port through the neck portion. A thermoplastic port protector or closure covers the port and defines a frangible section. The closure has a length to diameter ratio providing good mechanical advantage leverage to rupture the frangible section when the closure is pushed sideways. A seal is formed with the closure by forcing a die heated above the melting point of the plastic material into the neck portion, removing a portion of the port protector and forming a depression. The frangible section is formed in the vertical side wall of the depression.
摘要翻译：热塑性药液容器包括颈部，颈部具有通过颈部的至少一个口。热塑性端口保护器或盖子覆盖端口并限定易碎部分。封闭件具有长度与直径之比，其提供良好的机械优势杠杆作用，当封闭件被侧向推动时破裂脆性部分。通过迫使加热到塑料材料的熔点之上的模头进入颈部而形成密封件，去除端口保护器的一部分并形成凹陷。易碎部分形成在凹陷的垂直侧壁上。

3. 发明授权

US4091949A Antibackoff threaded ring closure using ratchet means 失效
标题翻译：使用棘轮手段的防滑螺纹环闭合
公开(公告)号：US4091949A
公开(公告)日：1978-05-30
申请号：US777751
申请日：1977-03-14
申请人： Thomas A. Fowles , David A. Winchell
发明人： Thomas A. Fowles , David A. Winchell
IPC分类号： B65D41/62 , B65D50/06
CPC分类号： B65D41/62 , B65D50/067
摘要： A ratchet mechanism is provided for preventing disassembly of an outer ring used to jack a hermetically sealed overcap from the neck of a container. The ratchet mechanism comprises a set of teeth on the outer ring which act in cooperation with a set of teeth on the overcap thereby providing a means for preventing rotation of the outer ring in a direction tending to unscrew the outer ring from the overcap, but permitting rotation of the outer ring in the jacking direction.
摘要翻译：提供了一种棘轮机构，用于防止用于将气密密封的顶盖从容器颈部拆卸出来。棘轮机构包括外环上的一组齿，其与顶盖上的一组齿配合起作用，从而提供一种用于防止外环沿着倾斜外环从顶盖旋转的方向旋转的装置，但允许外环在顶起方向上的旋转。

4. 发明授权

US4511529A Method of making a bottle closure 失效
标题翻译：瓶盖封闭方法
公开(公告)号：US4511529A
公开(公告)日：1985-04-16
申请号：US468965
申请日：1983-02-23
申请人： Thomas A. Fowles , Glenn L. Slater , David A. Winchell
发明人： Thomas A. Fowles , Glenn L. Slater , David A. Winchell
IPC分类号： A61J1/00 , A61J1/14 , B65D1/02 , B65D51/18 , B29C17/07 , B29D3/00
CPC分类号： B65D51/18 , A61J1/1418 , A61J1/18 , B65D1/0238 , A61J1/1468 , B65D2251/0015 , B65D2251/0075
摘要： A one-piece integral plastic container is disclosed which has an outer closure or overcap removable along a frangible line of weakness, and a separately-formed inner closure that is maintained in sterile condition by the outer closure until the container contents are dispensed. The inner closure comprises a tubular member inserted in fluid-tight relationship within the container neck after the container body and neck are molded, but prior to formation of the outer closure. The tubular member thus provides the dispensing outlet for the container and is maintained in sterile condition by the overcap which encloses it.
摘要翻译：公开了一种整体式的塑料容器，其具有沿着易碎的弱线可移除的外部封闭件或顶盖，以及单独形成的内部封闭件，其通过外部封闭件保持在无菌状态，直到容器内容物被分配为止。内部封闭件包括在容器主体和颈部被模制之后但在形成外部封闭件之前在容器颈部内以流体密封的关系插入的管状构件。因此，管状构件提供用于容器的分配出口，并且通过封闭容器的顶盖将其保持在无菌状态。

5. 发明授权

US4378891A Bottle closure 失效
标题翻译：瓶盖关闭
公开(公告)号：US4378891A
公开(公告)日：1983-04-05
申请号：US306604
申请日：1981-09-29
申请人： Thomas A. Fowles , Glenn L. Slater , David A. Winchell
发明人： Thomas A. Fowles , Glenn L. Slater , David A. Winchell
IPC分类号： A61J1/00 , A61J1/14 , B65D1/02 , B65D51/18
CPC分类号： B65D51/18 , A61J1/1418 , A61J1/18 , B65D1/0238 , A61J1/1468 , A61M2207/00 , B65D2251/0015 , B65D2251/0075
摘要： A one-piece integral plastic container is disclosed which has an outer closure or overcap removable along a frangible line of weakness, and a separately-formed inner closure that is maintained in sterile condition by the outer closure until the container contents are dispensed. The inner closure comprises a tubular member inserted in fluid-tight relationship within the container neck after the container body and neck are molded, but prior to formation of the outer closure. The tubular member thus provides the dispensing outlet for the container and is maintained in sterile condition by the overcap which encloses it.
摘要翻译：公开了一种整体式的塑料容器，其具有沿着易碎的弱线可移除的外部封闭件或顶盖，以及单独形成的内部封闭件，其通过外部封闭件保持在无菌状态，直到容器内容物被分配为止。内部封闭件包括在容器主体和颈部被模制之后但在形成外部封闭件之前在容器颈部内以流体密封的关系插入的管状构件。因此，管状构件提供用于容器的分配出口，并且通过封闭容器的顶盖将其保持在无菌状态。

6. 发明授权

US4434904A Bottle closure 失效
标题翻译：瓶盖关闭
公开(公告)号：US4434904A
公开(公告)日：1984-03-06
申请号：US383486
申请日：1982-06-01
申请人： Richard D'Amico , Thomas A. Fowles , David A. Winchell
发明人： Richard D'Amico , Thomas A. Fowles , David A. Winchell
IPC分类号： B65D55/02 , B65D41/32
CPC分类号： B65D55/02
摘要： A plastic container and a three-piece closure system therefor are disclosed. The container has a threaded neck defining a dispensing outlet. A separate closure covers the dispensing outlet and is heat-sealed to the threaded neck, forming a frangible section which may be broken to remove the closure. An internally threaded jacking ring is threadedly received on the neck, and includes a plurality of inwardly directed flexible fingers, which snap into an annular groove in the closure when the jacking ring is threaded onto the neck. To break the frangible portion and open the container, the jacking ring is rotated in the direction to remove it, so that the jacking ring fingers press against the top edge of the recess in the closure and actually pry the closure away from the container neck.
摘要翻译：公开了一种塑料容器及其三件封闭系统。容器具有限定出分配出口的螺纹颈部。单独的封闭件覆盖分配出口并且被热密封到螺纹颈部，形成易碎部分，该部分可能被破坏以移除封闭件。内螺纹起重环螺纹地容纳在颈部上，并且包括多个向内指向的柔性指状物，当顶起环螺纹连接到颈部上时，该弹性指状物卡入封闭物中的环形槽中。为了破坏易碎部分并打开容器，顶起环沿着将其移开的方向旋转，使得顶起的环形指状物压靠在封闭物中的凹部的顶部边缘，并且实际上将盖子从容器颈部撬开。

7. 外观设计

USD263504S Vacuum chamber for the transfer of parenteral liquids 失效
公开(公告)号：USD263504S
公开(公告)日：1982-03-23
申请号：US55218
申请日：1979-07-06
申请人： Thomas A. Fowles , David A. Winchell
设计人： Thomas A. Fowles , David A. Winchell

8. 外观设计

USD261985S Bottle 失效
公开(公告)号：USD261985S
公开(公告)日：1981-11-24
申请号：US73752
申请日：1979-09-10
申请人： Thomas A. Fowles , David A. Winchell
设计人： Thomas A. Fowles , David A. Winchell

9. 发明授权

US4177905A Closure system for containers 失效
标题翻译：集装箱封闭系统
公开(公告)号：US4177905A
公开(公告)日：1979-12-11
申请号：US912670
申请日：1978-06-05
申请人： David A. Winchell , Thomas A. Fowles
发明人： David A. Winchell , Thomas A. Fowles
IPC分类号： B65D41/04 , B65D41/62 , B65D55/08 , B65D41/54
CPC分类号： B65D55/0854 , B65D41/0442 , B65D41/62
摘要： A closure system is provided for a threaded container. A threaded closure cap has an annular skirt which engages a resilient gasket that is stretched over the bottle neck. The resilient gasket overlies a cap support flange which extends from the neck. Downward axial movement of the cap with respect to the container provides a vertical compressive force against the resilient gasket by the cap skirt. A heat shrinkable outer member surrounds the closure cap and provides a tamperproof seal with respect to the container.
摘要翻译：为螺纹容器提供封闭系统。螺纹封闭盖具有环形裙部，其接合在瓶颈上方延伸的弹性垫圈。弹性垫圈覆盖从颈部延伸的盖支撑凸缘。帽相对于容器的向下轴向运动通过帽裙提供抵靠弹性垫圈的垂直压缩力。热收缩外部构件围绕封闭盖并且相对于容器提供防篡改密封。

10. 发明授权

US4171236A Method of making frangible seal 失效
标题翻译：制作易碎印章的方法
公开(公告)号：US4171236A
公开(公告)日：1979-10-16
申请号：US886081
申请日：1978-03-13
申请人： David A. Winchell , Thomas A. Fowles
发明人： David A. Winchell , Thomas A. Fowles
IPC分类号： A61J1/00 , A61J1/14 , B29C65/02 , B29C65/18 , B29C65/76 , B65D1/02 , B65D41/32 , B65D41/62 , B29C27/02
CPC分类号： B29C66/542 , A61J1/1418 , A61J1/18 , B29C65/18 , B29C65/76 , B65D1/0238 , A61J1/1468 , B29C65/02 , B29C66/8322 , B29L2031/565 , B29L2031/7158 , Y10T156/1043
摘要： A method is provided for forming a fracturable seal of the type wherein a plastic cup-shaped closure is hermetically sealed to a plastic planar surface, such as the neck of pharmaceutical solution containers. The seal is formed with the closure by forcing a die heated above the melting point of the plastic material into the planar surface, with the sealing die also being in heat exchange relationship with a portion of the closure. Both the planar surface and the closure adjacent thereto become molten and the surface material is displaced to form a fused seal transverse to the surface. The surface is depressed at least 0.005 inch from its original height by the sealing action of the die, and a frangible section is formed in the vertical side wall of the depression. The seal will be fractured due to tension stress when the closure is removed from the surface.
摘要翻译：提供了一种用于形成这种类型的可破裂密封件的方法，其中塑料杯形封盖气密地密封到塑料平面表面，例如药物溶液容器的颈部。密封件通过将加热到塑料材料的熔点之上的模具强制进入平坦表面而形成有密封件，密封模具也与封闭件的一部分处于热交换关系。平面和与其相邻的封闭件都变得熔化，并且表面材料被移位以形成横向于表面的熔接密封。该表面通过模具的密封作用从其原始高度压下至少0.005英寸，并且在凹陷的垂直侧壁中形成易碎部分。当封闭物从表面移除时，密封件将因拉伸应力而断裂。

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