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1. 发明授权

US09446192B2 Implantable pump with reservoir level detector 有权
标题翻译：带液位检测器的可植入泵
公开(公告)号：US09446192B2
公开(公告)日：2016-09-20
申请号：US12943093
申请日：2010-11-10
申请人： Thierry Utard , Jean-Sebastien Petithory , Philippe Margairaz , Rocco Crivelli , Alec Ginggen
发明人： Thierry Utard , Jean-Sebastien Petithory , Philippe Margairaz , Rocco Crivelli , Alec Ginggen
IPC分类号： A61K9/22 , A61M5/168 , A61M5/142
CPC分类号： A61M5/1684 , A61M5/14276 , A61M2205/3317 , A61M2205/3389
摘要： An implantable pump includes a base plate and a can that are parts of the pump housing. The base plate bottom divides the housing into a first electronics chamber and a second chamber. A bellows mechanism is connected to the base plate and is disposed within the second chamber. The bellow mechanism has an expandable sidewall and a bottom plate. The bellow mechanism divides the second chamber into a medicament receiving portion and a non-medicament-receiving portion. The bellow mechanism has an intermediate plate disposed within the medicament-receiving portion. A coil is disposed in a recess on the lower surface of the base plate, and the coil is spaced from an internal wall of the recess. The amount of fluid remaining in the implantable pump can be monitored by energizing the coil. A primary magnetic field is generated by the energized coil. A secondary magnetic field, which is dependant on the position of the bottom and intermediate plate of the bellow mechanism, couples back to the primary field affecting the electrical characteristics of the coil. The amount of fluid remaining in the reservoir is determined based on the resulting changes in the electrical characteristics of the coil.
摘要翻译：可植入泵包括作为泵壳体的部件的基板和罐。基板底部将壳体分成第一电子室和第二室。波纹管机构连接到基板并且设置在第二室内。波纹管机构具有可膨胀的侧壁和底板。波纹管机构将第二腔室分成药物接收部分和非药物接收部分。波纹管机构具有设置在药物接收部分内的中间板。线圈设置在基板的下表面上的凹部中，线圈与凹部的内壁间隔开。可以通过对线圈通电来监测可植入泵中剩余的流体量。由励磁线圈产生初级磁场。取决于波纹管机构的底板和中间板的位置的次级磁场耦合回到影响线圈的电特性的初级场。基于所得到的线圈的电特性的变化来确定储存器中剩余的流体的量。

2. 发明授权

US07905878B2 Implantable pump with reservoir level detector 有权
标题翻译：带液位检测器的可植入泵
公开(公告)号：US07905878B2
公开(公告)日：2011-03-15
申请号：US11552343
申请日：2006-10-24
申请人： Thierry Utard , Jean-Sebastien Petithory , Philippe Margairaz , Rocco Crivelli , Alec Ginggen
发明人： Thierry Utard , Jean-Sebastien Petithory , Philippe Margairaz , Rocco Crivelli , Alec Ginggen
IPC分类号： A61M37/00 , A61K9/22
CPC分类号： A61M5/1684 , A61M5/14276 , A61M2205/3317 , A61M2205/3389
摘要： An implantable pump includes a base plate and a can that are parts of the pump housing. The base plate bottom divides the housing into a first electronics chamber and a second chamber. A bellows mechanism is connected to the base plate and is disposed within the second chamber. The bellow mechanism has an expandable sidewall and a bottom plate. The bellow mechanism divides the second chamber into a medicament receiving portion and a non-medicament-receiving portion. The bellow mechanism has an intermediate plate disposed within the medicament-receiving portion. A coil is disposed in a recess on the lower surface of the base plate, and the coil is spaced from an internal wall of the recess. The amount of fluid remaining in the implantable pump can be monitored by energizing the coil. A primary magnetic field is generated by the energized coil. A secondary magnetic field, which is dependant on the position of the bottom and intermediate plate of the bellow mechanism, couples back to the primary field affecting the electrical characteristics of the coil. The amount of fluid remaining in the reservoir is determined based on the resulting changes in the electrical characteristics of the coil.
摘要翻译：可植入泵包括作为泵壳体的部件的基板和罐。基板底部将壳体分成第一电子室和第二室。波纹管机构连接到基板并且设置在第二室内。波纹管机构具有可膨胀的侧壁和底板。波纹管机构将第二腔室分成药物接收部分和非药物接收部分。波纹管机构具有设置在药物接收部分内的中间板。线圈设置在基板的下表面上的凹部中，线圈与凹部的内壁间隔开。可以通过对线圈通电来监测可植入泵中剩余的流体量。由励磁线圈产生初级磁场。取决于波纹管机构的底板和中间板的位置的次级磁场耦合回到影响线圈的电特性的初级场。基于所得到的线圈的电特性的变化来确定储存器中剩余的流体的量。

3. 发明申请

US20110060283A1 IMPLANTABLE PUMP WITH RESERVOIR LEVEL DETECTOR 审中-公开
标题翻译：具有储存水平检测器的可注入泵
公开(公告)号：US20110060283A1
公开(公告)日：2011-03-10
申请号：US12943093
申请日：2010-11-10
申请人： THIERRY UTARD , Jean-Sebastien Petithory , Philippe Margairaz , Rocco Crivelli , Alec Ginggen
发明人： THIERRY UTARD , Jean-Sebastien Petithory , Philippe Margairaz , Rocco Crivelli , Alec Ginggen
IPC分类号： A61M5/142
CPC分类号： A61M5/1684 , A61M5/14276 , A61M2205/3317 , A61M2205/3389
摘要： An implantable pump includes a base plate and a can that are parts of the pump housing. The base plate bottom divides the housing into a first electronics chamber and a second chamber. A bellows mechanism is connected to the base plate and is disposed within the second chamber. The bellow mechanism has an expandable sidewall and a bottom plate. The bellow mechanism divides the second chamber into a medicament receiving portion and a non-medicament-receiving portion. The bellow mechanism has an intermediate plate disposed within the medicament-receiving portion. A coil is disposed in a recess on the lower surface of the base plate, and the coil is spaced from an internal wall of the recess. The amount of fluid remaining in the implantable pump can be monitored by energizing the coil. A primary magnetic field is generated by the energized coil. A secondary magnetic field, which is dependant on the position of the bottom and intermediate plate of the bellow mechanism, couples back to the primary field affecting the electrical characteristics of the coil. The amount of fluid remaining in the reservoir is determined based on the resulting changes in the electrical characteristics of the coil.
摘要翻译：可植入泵包括作为泵壳体的部件的基板和罐。基板底部将壳体分成第一电子室和第二室。波纹管机构连接到基板并且设置在第二室内。波纹管机构具有可膨胀的侧壁和底板。波纹管机构将第二腔室分成药物接收部分和非药物接收部分。波纹管机构具有设置在药物接收部分内的中间板。线圈设置在基板的下表面上的凹部中，线圈与凹部的内壁间隔开。可以通过对线圈通电来监测可植入泵中剩余的流体量。由励磁线圈产生初级磁场。取决于波纹管机构的底板和中间板的位置的次级磁场耦合回到影响线圈的电特性的初级场。基于所得到的线圈的电特性的变化来确定储存器中剩余的流体的量。

4. 发明申请

US20070106280A1 IMPLANTABLE PUMP WITH RESERVOIR LEVEL DETECTOR 有权
标题翻译：具有储存水平检测器的可注入泵
公开(公告)号：US20070106280A1
公开(公告)日：2007-05-10
申请号：US11552343
申请日：2006-10-24
申请人： Thierry Utard , Jean-Sebastien Petithory , Philippe Margairaz , Rocco Crivelli , Alec Ginggen
发明人： Thierry Utard , Jean-Sebastien Petithory , Philippe Margairaz , Rocco Crivelli , Alec Ginggen
IPC分类号： A61K9/22
CPC分类号： A61M5/1684 , A61M5/14276 , A61M2205/3317 , A61M2205/3389
摘要： An implantable pump includes a base plate and a can that are parts of the pump housing. The base plate bottom divides the housing into a first electronics chamber and a second chamber. A bellows mechanism is connected to the base plate and is disposed within the second chamber. The bellow mechanism has an expandable sidewall and a bottom plate. The bellow mechanism divides the second chamber into a medicament receiving portion and a non-medicament-receiving portion. The bellow mechanism has an intermediate plate disposed within the medicament-receiving portion. A coil is disposed in a recess on the lower surface of the base plate, and the coil is spaced from an internal wall of the recess. The amount of fluid remaining in the implantable pump can be monitored by energizing the coil. A primary magnetic field is generated by the energized coil. A secondary magnetic field, which is dependant on the position of the bottom and intermediate plate of the bellow mechanism, couples back to the primary field affecting the electrical characteristics of the coil. The amount of fluid remaining in the reservoir is determined based on the resulting changes in the electrical characteristics of the coil.
摘要翻译：可植入泵包括作为泵壳体的部件的基板和罐。基板底部将壳体分成第一电子室和第二室。波纹管机构连接到基板并且设置在第二室内。波纹管机构具有可膨胀的侧壁和底板。波纹管机构将第二腔室分成药物接收部分和非药物接收部分。波纹管机构具有设置在药物接收部分内的中间板。线圈设置在基板的下表面上的凹部中，线圈与凹部的内壁间隔开。可以通过对线圈通电来监测可植入泵中剩余的流体量。由励磁线圈产生初级磁场。取决于波纹管机构的底板和中间板的位置的次级磁场耦合回到影响线圈的电特性的初级场。基于所得到的线圈的电特性的变化来确定储存器中剩余的流体的量。

5. 发明授权

US11169010B2 Method for the calibration of an implantable sensor 有权
公开(公告)号：US11169010B2
公开(公告)日：2021-11-09
申请号：US12509834
申请日：2009-07-27
申请人： Rocco Crivelli , Danillo Roth , Alec Ginggen
发明人： Rocco Crivelli , Danillo Roth , Alec Ginggen
IPC分类号： A61B5/1495 , G01D11/24 , G01D18/00 , A61B5/0215 , G01L19/08 , A61B5/00 , G01L19/14 , G01D5/353
摘要： An implant includes a processor, RF communication circuitry, optical communication circuitry, a power source and a memory, all of which being hermetically sealed within a housing having a transparent window. Sensor readings are transmitted by RF using the RF communication circuitry to a remote reader after receiving interrogation signals from the reader. During calibration of the sensor, corrective coefficients are calculated by comparing actual sensor pressure readings with known pressure readings. The corrective coefficients are transmitted to the memory of the control circuitry using optical communication wherein modulated light is transmitted through the transparent window of the housing to the photo-detector.

6. 发明授权

US08929996B2 Dual power supply switching circuitry for use in a closed system 有权
公开(公告)号：US08929996B2
公开(公告)日：2015-01-06
申请号：US12381436
申请日：2009-03-11
申请人： Alec Ginggen , Rocco Crivelli
发明人： Alec Ginggen , Rocco Crivelli
IPC分类号： A61N1/08 , H02J7/02 , A61N1/378
CPC分类号： H02J7/025 , A61N1/3787 , H02J1/108 , H02J50/20
摘要： Optimal power switching circuitry for use in a closed system such as a TET system including an internal device separated from an external device by a boundary. The internal and external devices being powered by separate power sources. During telemetric communication from the external device to the internal device an external RF energy source is produced. If the power supplied by the external RF energy source produced during communication from the external device to the internal device exceeds that required for powering of the internal device, then the power switching circuitry cuts off power to the internal power source and instead draws power from the external RF energy source thereby conserving power consumed from the internal power source. The power switching circuitry may be implemented using either passive components (e.g., diodes) or active components (e.g., an analog switch).

7. 发明申请

US20090239478A1 Power regulation feedback to optimize robustness of wireless transmissions 有权
标题翻译：功率调节反馈以优化无线传输的鲁棒性
公开(公告)号：US20090239478A1
公开(公告)日：2009-09-24
申请号：US12322076
申请日：2009-01-28
申请人： Alec Ginggen , Rocco Crivelli
发明人： Alec Ginggen , Rocco Crivelli
IPC分类号： H04B7/00
CPC分类号： G06K7/0008 , G06K19/0701 , H04B5/0093 , H04B5/02 , Y02D70/42
摘要： A wireless communication system with power regulation feedback for improving the robustness of wireless communication transmissions between a receiver and an active emitter irrespective of the distance separation therebetween. The receiver receives wireless communications and detects a voltage induced therein. A feedback loop provides wireless transmission of power regulation feedback based on the detected voltage. The active emitter generates a power regulated data signal in which at least one of maximum and minimum bit voltage levels of respective logical high and low bits is adjusted based on the induced voltage received via the feedback loop. The RF power level, modulation index, and/or slew rate of a data signal emitted from the active emitter is regulated by adjusting at least one of maximum and minimum bit voltage levels of respective logical high and low bits based on voltage induced in the receiver during a previous communication from the active emitter.
摘要翻译：一种具有功率调节反馈的无线通信系统，用于改善接收机和有源发射器之间的无线通信传输的鲁棒性，而与它们之间的距离间隔无关。接收机接收无线通信并检测其中引起的电压。反馈回路基于检测到的电压提供功率调节反馈的无线传输。有源发射器产生功率调节数据信号，其中基于经由反馈回路接收的感应电压来调整相应的逻辑高电平和低位的最大和最小位电压电平中的至少一个。从有源发射器发射的数据信号的RF功率电平，调制指数和/或转换速率通过基于在接收机中感应的电压调节相应逻辑高位和低位的最大和最小位电压电平中的至少一个来调节在来自有源发射器的先前通信期间。

8. 发明申请

US20090228077A1 Dual power supply switching circuitry for use in a closed system 有权
标题翻译：用于封闭系统的双电源开关电路
公开(公告)号：US20090228077A1
公开(公告)日：2009-09-10
申请号：US12381436
申请日：2009-03-11
申请人： Alec Ginggen , Rocco Crivelli
发明人： Alec Ginggen , Rocco Crivelli
IPC分类号： A61N1/378
CPC分类号： H02J7/025 , A61N1/3787 , H02J1/108 , H02J50/20
摘要： Optimal power switching circuitry for use in a closed system such as a TET system including an internal device separated from an external device by a boundary. The internal and external devices being powered by separate power sources. During telemetric communication from the external device to the internal device an external RF energy source is produced. If the power supplied by the external RF energy source produced during communication from the external device to the internal device exceeds that required for powering of the internal device, then the power switching circuitry cuts off power to the internal power source and instead draws power from the external RF energy source thereby conserving power consumed from the internal power source. The power switching circuitry may be implemented using either passive components (e.g., diodes) or active components (e.g., an analog switch).
摘要翻译：用于诸如TET系统的封闭系统中的最佳功率切换电路，其包括通过边界与外部设备分离的内部设备。内部和外部设备由独立的电源供电。在从外部设备到内部设备的遥测通信期间，产生外部RF能量源。如果在从外部设备到内部设备的通信期间产生的外部RF能量源所提供的功率超过内部设备供电所需的功率，则功率开关电路切断内部电源的电源，从而节省从内部电源消耗的功率。功率开关电路可以使用无源组件（例如，二极管）或有源组件（例如，模拟开关）来实现。

9. 发明申请

US20090210033A1 Implant revision recognition by exchanging the revision data during transmission 有权
标题翻译：通过在传输过程中交换修订数据进行种植体修订识别
公开(公告)号：US20090210033A1
公开(公告)日：2009-08-20
申请号：US12070618
申请日：2008-02-19
申请人： Rocco Crivelli , Alec Ginggen
发明人： Rocco Crivelli , Alec Ginggen
IPC分类号： A61N1/02
CPC分类号： A61N1/37264 , G06F8/65
摘要： A system and method for establishing communication among a control device and an implantable medical device. The implantable medical device transmits to the control device identification information including a unique identification number associated with the implantable medical device and/or a current version of application software currently being utilized by the implantable medical device. Based on the extracted identification information, the control device correlates thereto a version of the application software from among the multiple versions of application software associated with the control device that is compatible with the recognized version of the application software currently being utilized by the implantable medical device.
摘要翻译：一种用于在控制装置和可植入医疗装置之间建立通信的系统和方法。可植入医疗装置向控制装置发送包括与可植入医疗装置相关联的唯一识别号码和/或可植入医疗装置当前使用的当前版本的应用软件的识别信息。基于所提取的识别信息，控制装置将与控制装置相关联的多个版本的应用软件的版本与可植入医疗装置当前正在使用的应用软件的识别版本兼容。

10. 发明申请

US20060246846A1 Power regulation feedback to optimize robustness of wireless transmissions 有权
公开(公告)号：US20060246846A1
公开(公告)日：2006-11-02
申请号：US11116806
申请日：2005-04-27
申请人： Alec Ginggen , Rocco Crivelli
发明人： Alec Ginggen , Rocco Crivelli
IPC分类号： H04B7/00
CPC分类号： G06K7/0008 , G06K19/0701 , H04B5/0093 , H04B5/02 , Y02D70/42
摘要： A wireless communication system with power regulation feedback for improving the robustness of wireless communication transmissions between a receiver and an active emitter irrespective of the distance separation therebetween. The receiver receives wireless communications and detects a voltage induced therein. A feedback loop provides wireless transmission of power regulation feedback based on the detected voltage. The active emitter generates a power regulated data signal in which at least one of maximum and minimum bit voltage levels of respective logical high and low bits is adjusted based on the induced voltage received via the feedback loop. The RF power level, modulation index, and/or slew rate of a data signal emitted from the active emitter is regulated by adjusting at least one of maximum and minimum bit voltage levels of respective logical high and low bits based on voltage induced in the receiver during a previous communication from the active emitter.

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