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1. 发明申请

US20180102239A1 Methods and Apparatus for Tandem Collision-Induced Dissociation Cells 审中-公开
公开(公告)号：US20180102239A1
公开(公告)日：2018-04-12
申请号：US15836101
申请日：2017-12-08
申请人： Thermo Finnigan LLC
发明人： Alan E. SCHOEN , Harald OSER
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/005 , H01J49/0031 , H01J49/421
摘要： A mass spectrometer system comprises: (a) an ion source; (b) a mass filter; (c) a mass analyzer; (d) a partitioned ion fragmentation cell configured to receive ions from the mass filter and to outlet fragment ions to the mass analyzer comprising: (d1) a set of multipole rod electrodes; a housing enclosing the set of multipole rod electrodes and comprising an ion inlet and an ion outlet; (d2) a set of partitions within the housing separating the housing interior into a plurality of compartments; and (d3) a plurality of gas inlets, each gas inlet fluidically coupled to a source of a collision gas and to a respective compartment and having a respective inlet shutoff valve; and (e) a controller electrically coupled to each inlet shutoff valve and configured to independently control the pressure of collision gas within each compartment.

2. 发明申请

US20170162371A1 Methods and Apparatus for Tandem Collision-Induced Dissociation Cells 有权
公开(公告)号：US20170162371A1
公开(公告)日：2017-06-08
申请号：US14963123
申请日：2015-12-08
申请人： Thermo Finnigan LLC
发明人： Alan E. SCHOEN , Harald OSER
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/005 , H01J49/0031 , H01J49/421
摘要： A method for operating a mass spectrometer so as to detect or quantify analytes, comprises: (a) identifying a selected-reaction-monitoring (SRM) transition to be used for each respective analyte; (b) determining a time duration required for a fragmentation reaction corresponding to each identified transition to proceed to a threshold percentage of completion; and (c) for each analyte, performing the steps of (i) isolating ions corresponding to a precursor-ion mass-to-charge (m/z) ratio of the respective transition; (ii) fragmenting the respective isolated ions in one of two fragmentation cells or fragmentation cell portions; and (ii) mass analyzing for fragment ions corresponding to a product-ion m/z ratio of the respective transition, wherein, for each analyte, the fragmentation cell or fragmentation cell portion that is used for fragmenting the isolated ions is determined from the time duration determined for the respective analyte.

3. 发明申请

US20160314950A1 Methods for Broad-Stability Mass Analysis Using a Quadrupole Mass Filter 有权
标题翻译：使用四极质量过滤器进行广泛稳定质量分析的方法
公开(公告)号：US20160314950A1
公开(公告)日：2016-10-27
申请号：US14696237
申请日：2015-04-24
申请人： Thermo Finnigan LLC
发明人： Johnathan Wayne SMITH , Alan E. SCHOEN
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/42
摘要： A method of mass analysis comprises: generating ions from the sample; delivering the ions to a quadrupole; applying a radio frequency voltage, V, to rods of the quadrupole such that the instantaneous electrical potential of each rod is out of phase with each adjacent rod and a non-oscillatory voltage, U, across each pair of adjacent rods such that a subset of the ions having a range of mass-to-charge (m/z) ratios are selectively transmitted through the quadrupole; varying at least one of voltage U and voltage V such that the range of selectively transmitted m/z ratios is caused to vary and varying at least one additional operational parameter; acquiring a data set comprising a series of temporally-resolved images of spatial distribution patterns of transmitted ions at each combination of U, V and the at least one additional operating parameter; and mathematically deconvolving the data set to generate mass spectra.
摘要翻译：一种质量分析方法包括：从样品中产生离子; 将离子递送到四极杆; 对四极杆施加射频电压V，使得每个杆的瞬时电势与每个相邻的杆异相，并且跨越每对相邻杆的非振荡电压U，使得具有质量 - 电荷（m / z）比的范围的离子选择性地透过四极杆; 改变电压U和电压V中的至少一个，使得使选择性传输的m / z比的范围变化并改变至少一个额外的操作参数; 获取包括在U，V和所述至少一个附加操作参数的每个组合处的透射离子的空间分布图案的一系列时间分辨图像的数据集; 并数学解卷积数据集以产生质谱。

4. 发明申请

US20150364302A1 Optimizing Drag Field Voltages in a Collision Cell for Multiple Reaction Monitoring (MRM) Tandem Mass Spectrometry 有权
标题翻译：在多反应监测（MRM）串联质谱法的碰撞池中优化阻力场电压
公开(公告)号：US20150364302A1
公开(公告)日：2015-12-17
申请号：US14742115
申请日：2015-06-17
申请人： Thermo Finnigan LLC
发明人： Oleg SILIVRA , Harald OSER , Joshua T. MAZE , Terry OLNEY , Alan E. SCHOEN
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/005 , H01J49/4215 , H01J49/4225 , H01J49/429
摘要： A collision cell has a plurality of rod electrodes arranged in opposed pairs around an axial centerline and a plurality of drag vanes arranged in the interstitial spaces between the rod electrodes. Operating the collision cell includes, applying a rod offset voltage to the rod electrodes, and varying an offset voltage applied to the drag vanes to identify a vane offset voltage with a maximum intensity for the transition. The method further includes varying a drag field by adjusting the voltages applied to drag vane terminals in opposite directions to identify a drag field value with a cross talk below a cross talk threshold, varying the vane offset voltage by adjusting the voltages applied to the drag vane terminals to maximize the intensity of the transition while preserving the drag field, and operating the collision cell at the vane offset voltage and drag field to monitor the transition.
摘要翻译：碰撞单元具有围绕轴向中心线相对排列的多个杆电极以及布置在杆电极之间的间隙空间中的多个牵引叶片。操作碰撞单元包括：向杆电极施加杆偏移电压，以及改变施加到牵引叶片的偏移电压，以识别具有用于转变的最大强度的叶片偏移电压。该方法还包括通过调整施加到相反方向上的牵引叶片端子的电压来改变阻力场，以通过串扰低于串扰阈值来识别阻力场值，通过调节施加到牵引叶片的电压来改变叶片偏移电压终端，以最大化过渡的强度，同时保持拖曳场，并且在叶片偏移电压和阻力场处操作碰撞单元以监视转换。

5. 发明申请

US20210035789A1 ION-TO-ELECTRON CONVERSION DYNODE FOR ION IMAGING APPLICATIONS 有权
公开(公告)号：US20210035789A1
公开(公告)日：2021-02-04
申请号：US16941124
申请日：2020-07-28
申请人： Thermo Finnigan LLC
发明人： Oleg SILIVRA , Alan E. SCHOEN , Johnathan W. SMITH , Berg A. TEHLIRIAN
IPC分类号： H01J43/24 , H01J49/02
摘要： A metal-channel conversion dynode comprises: a wafer comprising a first face and a second face parallel to the first face and having a thickness less than 1000 μm; and a plurality of channels passing through the wafer from the first face to the second face at an angle to a plane of the first face and a plane of the second face. In some embodiments, each inter-channel distance may be substantially the same as the wafer thickness. In some embodiments, the wafer is fabricated from tungsten. In some other embodiments, the wafer comprises a non-electrically conductive material that is fabricated by three-dimensional (3D) printing or other means and that is coated, on its faces and within its channels, with a metal or suitably conductive coating that produces secondary electrons upon impact by either positive or negative ions.

6. 发明申请

US20160172173A1 Cascaded-Signal-Intensifier-Based Ion Imaging Detector for Mass Spectrometer 有权
标题翻译：基于级联信号增强剂的离子成像检测器
公开(公告)号：US20160172173A1
公开(公告)日：2016-06-16
申请号：US14567744
申请日：2014-12-11
申请人： Thermo Finnigan LLC
发明人： Alan E. SCHOEN , Johnathan Wayne SMITH
IPC分类号： H01J49/02 , H01J49/00 , H01J49/42
CPC分类号： H01J49/025 , H01J43/045 , H01J49/0031 , H01J49/4215
摘要： A detector system for a mass spectrometer comprises: a metal channel dynode (MCD) comprising at least one perforated metal plate configured to receive the exiting ions and eject electrons in response; a plurality of electron-to-photon converters arranged in a parallel stacked configuration, each such converter comprising a substrate plate having a phosphor coating on a first face; and an electrode film disposed on the phosphor coating; at least one photocathode, each of the at least one photocathode disposed between a respective pair of the plurality of electron-to-photon converters; an optical detector optically coupled a last one of the electron-to-photon converters; and at least one direct current power supply configured to apply, in operation, a respective bias electrical potential to the MCD and each of the electrode films and photocathodes.
摘要翻译：用于质谱仪的检测器系统包括：金属通道倍增极（MCD），包括至少一个穿孔金属板，其被配置为接收出射离子并且响应地弹出电子; 多个以平行层叠结构布置的电子对光子转换器，每个这样的转换器包括在第一面上具有荧光体涂层的基板; 以及设置在所述荧光体涂层上的电极膜; 至少一个光电阴极，所述至少一个光电阴极中的每一个设置在相应的一对多个电子 - 光子转换器之间; 光学检测器，光电耦合最后一个电子 - 光子转换器; 以及至少一个直流电源，其被配置为在操作中向MCD和每个电极膜和光电阴极施加相应的偏置电位。

7. 发明公开

US20240087862A1 ION-TO-ELECTRON CONVERSION DYNODE FOR ION IMAGING APPLICATIONS 审中-公开
公开(公告)号：US20240087862A1
公开(公告)日：2024-03-14
申请号：US18511684
申请日：2023-11-16
申请人： Thermo Finnigan LLC
发明人： Oleg SILIVRA , Alan E. SCHOEN , Johnathan W. SMITH , Berg A. TEHLIRIAN
IPC分类号： H01J43/24 , H01J49/02
CPC分类号： H01J43/246 , H01J49/025
摘要： A metal-channel conversion dynode comprises: a wafer comprising a first face and a second face parallel to the first face and having a thickness less than 1000 μm; and a plurality of channels passing through the wafer from the first face to the second face at an angle to a plane of the first face and a plane of the second face. In some embodiments, each inter-channel distance may be substantially the same as the wafer thickness. In some embodiments, the wafer is fabricated from tungsten. In some other embodiments, the wafer comprises a non-electrically conductive material that is fabricated by three-dimensional (3D) printing or other means and that is coated, on its faces and within its channels, with a metal or suitably conductive coating that produces secondary electrons upon impact by either positive or negative ions.

8. 发明申请

US20160217990A1 SYSTEM FOR RECORDING SPATIAL AND TEMPORAL PROPERTIES OF IONS EMITTED FROM A QUADRUPOLE MASS FILTER 有权
标题翻译：用于记录从四重质量过滤器发射的离子的空间和时间性质的系统
公开(公告)号：US20160217990A1
公开(公告)日：2016-07-28
申请号：US15088406
申请日：2016-04-01
申请人： Thermo Finnigan LLC
发明人： Johnathan Wayne SMITH , Alan E. SCHOEN
IPC分类号： H01J49/02 , H01J49/42
CPC分类号： H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/42 , H01J49/4215 , H01J2237/24435
摘要： An ion detection system for a detecting a quantity of ions exiting from a mass analyzer of a mass spectrometer comprises: (a) photon generating means configured to receive the quantity of ions and to generate a quantity of photons that is proportional to the quantity of ions; (b) a linear array of photo-detectors configured along a line for detecting a variation of a portion of the quantity of generated photons along the line; and (c) an optical system for directing the portion of the quantity of photons from the photon generating means to the linear array of photo-detectors comprising: (c1) a first cylindrical lens having a first lens axis disposed parallel to the line; (c2) a second cylindrical lens or rod lens having a second lens axis disposed parallel to the line; and a doublet lens.
摘要翻译：用于检测从质谱仪的质量分析器离开的离子的量的离子检测系统包括：（a）光子产生装置，被配置为接收离子的量并产生与离子量成比例的一定量的光子 ; （b）沿着一条线构成的光电检测器的线性阵列，用于检测沿线产生的光子的一部分的变化; （c）用于将来自光子发生装置的光子量的一部分引导到光电检测器的线性阵列的光学系统，包括：（c1）具有平行于该线设置的第一透镜轴的第一柱面透镜; （c2）具有平行于所述线布置的第二透镜轴的第二柱面透镜或棒状透镜; 和双头透镜。

9. 发明申请

US20150311050A1 Method for Determining a Spectrum from Time-Varying Data 审中-公开
标题翻译：从时变数据中确定频谱的方法
公开(公告)号：US20150311050A1
公开(公告)日：2015-10-29
申请号：US14263947
申请日：2014-04-28
申请人： Thermo Finnigan LLC
发明人： Johnathan W. SMITH , Stephen P. BOYD , Alan E. SCHOEN , Sameer D. THARAKAN
IPC分类号： H01J49/00 , H01J49/02 , H01J49/26
CPC分类号： H01J49/0036 , G06K9/00563 , H01J49/0031 , H01J49/025 , H01J49/26
摘要： Non-negative contributions to a spectrum from time-varying spectroscopy data can be determined. Reference basis functions can transform spectroscopy data into an equation (e.g., an objective function). Each reference basis function can correspond to a different time and a different particle, e.g., a different mass. The objective function can include a noise vector that modifies the spectroscopy data to provide a solution that is constrained to be non-negative. The noise vector can be estimated by minimizing the objective function to obtain an estimated vector, which can be truncated that satisfies a given constraint. The noise vector can be computed from the difference of the estimated vector and the truncated vector, and be accumulated. The noise vector can be used to update the objective function, thereby providing a new estimated vector in an iterative loop.
摘要翻译：可以确定从时变光谱数据对光谱的非负值贡献。参考基函数可将光谱数据转换成方程式（例如目标函数）。每个参考基函数可以对应于不同的时间和不同的粒子，例如不同的质量。目标函数可以包括修改光谱数据以提供被限制为非负的解的噪声向量。噪声向量可以通过最小化目标函数来估计，以获得估计向量，其可以被截断以满足给定的约束。噪声向量可以根据估计向量和截断向量的差来计算，并被累积。可以使用噪声向量来更新目标函数，从而在迭代循环中提供新的估计向量。

10. 发明申请

US20140224980A1 Quadrupole Mass Spectrometer with Enhanced Sensitivity and Mass Resolving Power 有权
标题翻译：具有增强灵敏度和质量分辨能力的四极杆质谱仪
公开(公告)号：US20140224980A1
公开(公告)日：2014-08-14
申请号：US14256250
申请日：2014-04-18
申请人： Thermo Finnigan LLC
发明人： Alan E. SCHOEN , Robert A. GROTHE, JR.
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/4215 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/26 , H01J49/42 , H01J49/421
摘要： A novel method and mass spectrometer apparatus is introduced to spatially and temporally resolve images of one or more ion exit patterns of a multipole instrument. In particular, the methods and structures of the present invention measures the ion current as a function of time and spatial displacement in the beam cross-section of a quadrupole mass filter via an arrayed detector. The linearity of the detected quadrupole ion current in combination with it reproducible spatial-temporal structure enables the deconvolution of the contributions of signals from individual ion species in complex mixtures where both sensitivity and mass resolving power are essential.
摘要翻译：引入了一种新颖的方法和质谱仪装置来空间和时间地分辨多极仪器的一个或多个离子出口图案的图像。特别地，本发明的方法和结构通过阵列检测器测量作为四极质量过滤器的束横截面中时间和空间位移的函数的离子电流。检测到的四极离子电流的线性与可重复的空间 - 时间结构相结合使得能够在复杂混合物中来自各种离子物质的信号的贡献的反卷积，其中灵敏度和质量分辨能力都是必需的。

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